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Identifier: 15645832

GI number: 15645832

Start: 1294117

End: 1295391

Strand: Reverse

Name: Not Available

Synonym: HP1218

Alternate gene names: 15645832

Gene position: 1295391-1294117 (Counterclockwise)

Preceding gene: 15645834

Following gene: 15645831

Centisome position: 77.67

GC content: 38.82

Gene sequence:

>1275_bases
ATGAAAGATAACAATAACTATAATGTTTTAATTGTGGGGAATAAGGGGCGAGAGTATGCTTTGGCTCAAAGGCTTCAGCA
AGATGAGCGAGTGAATGCTTTGTATTTTTGTTTGGGTAATGGTGGCACTCAAGATTTAGGCGAGAATCTGGAATGCGAAC
ATTACGAGCATATCGTGGAATTAGCCCTGAAAAAACAGATCCATTTAGCCATCATTTCAGAAGAAGAGTTTTTGGTTTTA
GGGCTTACAGAAATGCTAGAAAAAGCGGGGATTTTAGTGTTTGGGGCTTCTAAAGAAGCGGCTAAGTTAGAGGCTTCTAA
AAGCTATATGAAAGCTTTTGTTAAAGAGTGTGGCATCAAAAGTGCGTCTTACTTTGAAACAAACGACTTAAAAGAAGCTT
TGAGTTACATTCAAAACGCTTCTTTCCCCTTAGTCATTAAAGCGTTGAATAAAAACACAAGCATTGTCTATCAAGAAGAA
GAAGCGATAAAAATCCTTGAAGACGCTTTCAAACAAAGCAATGAGCCTGTGATTATAGAGCCTTTTTTAGAGGGATTTGA
GCTTTCAGTTACAGCGCTCATAGCCAATGATGATTTTATCTTGTTGCCCTTTTGCCAAAACTACAAACGCTTATTAGAGG
GGGATAATGGGGTCAATACGGGGGGTATGGGGGCCATCGCTCCTGCAAACTTTTTCTCTAATGAATTAGAAGAGAAAATA
AAAAATCATATCTTTAAACCCACTTTAGAGAAACTTCAGGCTGACAACACGCCTTTTAAAGGGGTTTTACTCGCTGAAAT
TGTAATCATAGAAGAAAAAGGCGTTTTAGAGCCGTATTTATTGGATTTTAGCGTGCGTTTTAAAGACATTGAATGCCAGA
CGATTTTACCCCTTTTAGAAAGCTCGCTTTTAGATTTGTGTTTGGCCACAGCCAAAGGGGAATTACATTCTCTTGAATTG
GTGTTTTCTAAAGAATTTGTGATGAGTGTGGCGCTTGTTTCTAGGAATTACCCCACTAGCTCTTCGCCCAAACAAACCCT
TTATATTGATCCGGTTGATGAAAAAAAGGGTCATTTGATTTTAGGGGAGGTGGAGCAGGATAATGGCGTGTTTGAAAGCA
GTGGGGGGAGGGTGATCTTTGCCATTGGTAGGGGAAAATCCTTATTAGAAGCCAGAAACCATGCTTATGAAATCGCTCAA
AAGGTGCATTTTGAAGGCATGTTTTATCGCAAGGATATTGGTTTTAAGGTGTTAGATTTGAAAGAATATTCTTAA

Upstream 100 bases:

>100_bases
GAAAATCCTCCTAGCCTTATTAGTGTAGGTTTGTTGAACTTATGCGCATGTAAAAGTAGCGGTCATCTGGGTTTAAAAAC
AACCACATTGCAGGAAAGAC

Downstream 100 bases:

>100_bases
AGGTTAAAGTTTAAGACAAACCAAAGAGTTTGTCTTGTTTGTTTTTGAATGCACTCTCCAAATTTAGAAAAAGAAGAAAC
CGAAATCATAGAAACACTCC

Product: glycinamide ribonucleotide synthetase (purD)

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKDNNNYNVLIVGNKGREYALAQRLQQDERVNALYFCLGNGGTQDLGENLECEHYEHIVELALKKQIHLAIISEEEFLVL
GLTEMLEKAGILVFGASKEAAKLEASKSYMKAFVKECGIKSASYFETNDLKEALSYIQNASFPLVIKALNKNTSIVYQEE
EAIKILEDAFKQSNEPVIIEPFLEGFELSVTALIANDDFILLPFCQNYKRLLEGDNGVNTGGMGAIAPANFFSNELEEKI
KNHIFKPTLEKLQADNTPFKGVLLAEIVIIEEKGVLEPYLLDFSVRFKDIECQTILPLLESSLLDLCLATAKGELHSLEL
VFSKEFVMSVALVSRNYPTSSSPKQTLYIDPVDEKKGHLILGEVEQDNGVFESSGGRVIFAIGRGKSLLEARNHAYEIAQ
KVHFEGMFYRKDIGFKVLDLKEYS

Sequences:

>Translated_424_residues
MKDNNNYNVLIVGNKGREYALAQRLQQDERVNALYFCLGNGGTQDLGENLECEHYEHIVELALKKQIHLAIISEEEFLVL
GLTEMLEKAGILVFGASKEAAKLEASKSYMKAFVKECGIKSASYFETNDLKEALSYIQNASFPLVIKALNKNTSIVYQEE
EAIKILEDAFKQSNEPVIIEPFLEGFELSVTALIANDDFILLPFCQNYKRLLEGDNGVNTGGMGAIAPANFFSNELEEKI
KNHIFKPTLEKLQADNTPFKGVLLAEIVIIEEKGVLEPYLLDFSVRFKDIECQTILPLLESSLLDLCLATAKGELHSLEL
VFSKEFVMSVALVSRNYPTSSSPKQTLYIDPVDEKKGHLILGEVEQDNGVFESSGGRVIFAIGRGKSLLEARNHAYEIAQ
KVHFEGMFYRKDIGFKVLDLKEYS
>Mature_424_residues
MKDNNNYNVLIVGNKGREYALAQRLQQDERVNALYFCLGNGGTQDLGENLECEHYEHIVELALKKQIHLAIISEEEFLVL
GLTEMLEKAGILVFGASKEAAKLEASKSYMKAFVKECGIKSASYFETNDLKEALSYIQNASFPLVIKALNKNTSIVYQEE
EAIKILEDAFKQSNEPVIIEPFLEGFELSVTALIANDDFILLPFCQNYKRLLEGDNGVNTGGMGAIAPANFFSNELEEKI
KNHIFKPTLEKLQADNTPFKGVLLAEIVIIEEKGVLEPYLLDFSVRFKDIECQTILPLLESSLLDLCLATAKGELHSLEL
VFSKEFVMSVALVSRNYPTSSSPKQTLYIDPVDEKKGHLILGEVEQDNGVFESSGGRVIFAIGRGKSLLEARNHAYEIAQ
KVHFEGMFYRKDIGFKVLDLKEYS

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=427, Percent_Identity=33.2552693208431, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI209869995, Length=427, Percent_Identity=33.2552693208431, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI209869993, Length=427, Percent_Identity=33.2552693208431, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI28416899, Length=427, Percent_Identity=33.2552693208431, Blast_Score=222, Evalue=6e-58,
Organism=Escherichia coli, GI1790438, Length=431, Percent_Identity=28.7703016241299, Blast_Score=205, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17567511, Length=438, Percent_Identity=32.4200913242009, Blast_Score=197, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6321203, Length=448, Percent_Identity=31.0267857142857, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI62471619, Length=437, Percent_Identity=30.8924485125858, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24582400, Length=441, Percent_Identity=30.8390022675737, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 47505; Mature: 47505

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDNNNYNVLIVGNKGREYALAQRLQQDERVNALYFCLGNGGTQDLGENLECEHYEHIVE
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCHHHHHHHHH
LALKKQIHLAIISEEEFLVLGLTEMLEKAGILVFGASKEAAKLEASKSYMKAFVKECGIK
HHHHCCEEEEEECCCCEEEEEHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
SASYFETNDLKEALSYIQNASFPLVIKALNKNTSIVYQEEEAIKILEDAFKQSNEPVIIE
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHCCCCCEEEE
PFLEGFELSVTALIANDDFILLPFCQNYKRLLEGDNGVNTGGMGAIAPANFFSNELEEKI
CCCCCCEEEEEEEEECCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
KNHIFKPTLEKLQADNTPFKGVLLAEIVIIEEKGVLEPYLLDFSVRFKDIECQTILPLLE
HHCCCCHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCEEEEEEEEEEECCCHHHHHHHHH
SSLLDLCLATAKGELHSLELVFSKEFVMSVALVSRNYPTSSSPKQTLYIDPVDEKKGHLI
HHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCEE
LGEVEQDNGVFESSGGRVIFAIGRGKSLLEARNHAYEIAQKVHFEGMFYRKDIGFKVLDL
EEEEECCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEE
KEYS
ECCC
>Mature Secondary Structure
MKDNNNYNVLIVGNKGREYALAQRLQQDERVNALYFCLGNGGTQDLGENLECEHYEHIVE
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCHHHHHHHHH
LALKKQIHLAIISEEEFLVLGLTEMLEKAGILVFGASKEAAKLEASKSYMKAFVKECGIK
HHHHCCEEEEEECCCCEEEEEHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
SASYFETNDLKEALSYIQNASFPLVIKALNKNTSIVYQEEEAIKILEDAFKQSNEPVIIE
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHCCCCCEEEE
PFLEGFELSVTALIANDDFILLPFCQNYKRLLEGDNGVNTGGMGAIAPANFFSNELEEKI
CCCCCCEEEEEEEEECCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
KNHIFKPTLEKLQADNTPFKGVLLAEIVIIEEKGVLEPYLLDFSVRFKDIECQTILPLLE
HHCCCCHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCEEEEEEEEEEECCCHHHHHHHHH
SSLLDLCLATAKGELHSLELVFSKEFVMSVALVSRNYPTSSSPKQTLYIDPVDEKKGHLI
HHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCEE
LGEVEQDNGVFESSGGRVIFAIGRGKSLLEARNHAYEIAQKVHFEGMFYRKDIGFKVLDL
EEEEECCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEE
KEYS
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]