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Identifier: 15645827

GI number: 15645827

Start: 1288538

End: 1290604

Strand: Reverse

Name: Not Available

Synonym: HP1213

Alternate gene names: 15645827

Gene position: 1290604-1288538 (Counterclockwise)

Preceding gene: 15645828

Following gene: 15645826

Centisome position: 77.38

GC content: 41.07

Gene sequence:

>2067_bases
ATGGATTTTATCACCATCAATTCTAGTAACAAAACCGAAGAGTTCGCTCTCAAACAAGTGGCCAAACAAGCCACCAGCTC
TCTTTTATACCGATTAGGAAAAACCATTATTTTAGCGAGCGTGTGCGTGGAAAGAGAGCCTGTGAGTGAAGATTTTCTGC
CTTTAGTGGTGCAGTTTTTAGAAAAATCTTATGCAGCCGGAAAGATCCCGGGCGGTTTTGTTAAAAGAGAAGGCAGGGCG
CAAGATTTTGAAATCTTAACCTCTAGGCTCATAGACAGGACTTTACGCCCTTTATTCCCTAAAGACTACCGCTACCCTAC
ACAGATCACTTTAATGGTTTTAAGCCATGATATTGAAAATGACTTGCAGGTTTCTGCTTTAAACGCCGCTTCAGCCGCTC
TCTTTTTGGCCCATATCGCTCCTATTAAAAGCGTGAGCGCTTGCAGGATCGCTAGGATGGATAACGAATTTATCATTAAC
CCTAGCGCAAGCCTTTTGAATCAATCCAGTTTGGATTTGTTCGTGTCTGGAACGAAAGAGAGTTTGAACATGATAGAAAT
GCGCTCTTTGGGGCAAAAATTGAACGCTTTAGAAGAGCCTTTAATGTTAGAAGCTTTAGAATTGGCTCAAAAAAGTTTGG
AAGAAACTTGCACGCTTTATGAAGAGATTTTCACGCCCCACCAAAACGAGCTGTTTTTCAAAGAGAGCCAAGGAATAGTC
TTTAATGAAAGGCTGTTAGATTTATTGAAAAATCAGTATTTTGATGAAATCATCAAAGGCATTGAAAGTTCTGCTTTGAG
CGAGCGAGAAAATGTTTTCAATGAAATTGCCAGAAAAATCAGTGAAGCCCACTCAGAATTCAGTTTAGAAGAAATTGAAT
TGTCTTTAGAAAAAGTGAAAAAGACTGAGATAAGACGCATGATCATTAAGGATAAAATCCGCCCGGATAAGCGCGCGTTA
GAAGAAGTGCGGCCCATTTTGATAGAGAGCGATTTGCTCCCTATGGCGCATAGCTCCATTTTATTCACTAGGGGGCAAAC
TCAAAGCTTAGTGGTAGGGGTTTTAGGCACGGATAATGACGCTCAAACCCATGAGAGTTTGGAGCATAAAGCTCCCATTA
AAGAGCGCTTCATGTTTCATTATAATTTCCCTCCTTTCTGCGTGGGCGAAGCGAGTTCTATTGGCGCGGCTTCAAGGCGT
GAATTAGGGCATGGGAATTTGGCTAAAAGAGCCTTAGAAACGAGCATTAAAAATAAAGAGCAGGTGATACGATTGGTTTC
TGAGATTTTAGAAAGCAATGGTTCAAGCTCAATGGCGAGCGTGTGCGCAGGCTCTTTAGCCCTTTATGCAAGCGGTGTGG
AAATTTACGATTTAGTCGCTGGGGTGGCTATGGGCATGGTGAGCGAAGGGCAAGATCACGCTATTTTAAGCGATATTAGC
GGCTTAGAAGACGCAGAAGGCGATATGGATTTTAAGATTGCTGGGAATTTAGAAGGCATTACGGCCATGCAAATGGATAC
CAAAATGAGCGGTATCAAGCTAGAAATTTTATACCAAGCCTTACTCCAAGCCAAAGAAGCACGGAAACATATTTTAAAAA
TCATGCATGAAGCGAAAGAAAAGATTGTGATCAATTTTTCCCATTTGCCCACAACGGAGATTTTTAATGTCGCACCCGAT
AAAATTGTAGAAATTATCGGTCAAGGGGGGCGTGTGATTAAAGAGATAGTAGAAAAGTTTGAAGTTAAAATTGATTTGAA
CAAACCGAGCGGTGAAGTGAAAATCATGGGGAATAAAGAGCGCGTTTTAAAGACTAAGGAATTTATTTTAAACTACTTGC
ATTCTTTAGATCAAGAATTGGAGCAATACGCTATTGATGAGGTATTAGAAGCTCAAGTGAAACGAATCGTGGATTTTGGG
GCGTTTTTAAGCTTGCCTAAGGGGGGCGAAGGCTTGTTAAGAAAGCAAAACATGGACAAGTGTCAAGTGGTTTTAAAAGA
AGGCGATAGCATCAGGTGTAGGGTGATTAGCTTCAATAAGGGTAAAATCGCTTTAGATTTGGCTTAA

Upstream 100 bases:

>100_bases
TGGAGCATCATTATAAAGAACTCAAGCGATTAAGCAATGAAGAAGTTGAAAAATACTTGGGCGCTAACAACATGCCTAAT
TTAAAAAAGGAACATTAAAT

Downstream 100 bases:

>100_bases
AATTTTAAAAAGCGTTTTTTAAAAGCGTTTTTAAGCTAGTTTGTATTAAAATAAATTCTTGCTTGTATTTTTGAAAGTAG
AGGAACGATTCGAAATGAAA

Product: polynucleotide phosphorylase/polyadenylase

Products: NA

Alternate protein names: Polynucleotide phosphorylase; PNPase [H]

Number of amino acids: Translated: 688; Mature: 688

Protein sequence:

>688_residues
MDFITINSSNKTEEFALKQVAKQATSSLLYRLGKTIILASVCVEREPVSEDFLPLVVQFLEKSYAAGKIPGGFVKREGRA
QDFEILTSRLIDRTLRPLFPKDYRYPTQITLMVLSHDIENDLQVSALNAASAALFLAHIAPIKSVSACRIARMDNEFIIN
PSASLLNQSSLDLFVSGTKESLNMIEMRSLGQKLNALEEPLMLEALELAQKSLEETCTLYEEIFTPHQNELFFKESQGIV
FNERLLDLLKNQYFDEIIKGIESSALSERENVFNEIARKISEAHSEFSLEEIELSLEKVKKTEIRRMIIKDKIRPDKRAL
EEVRPILIESDLLPMAHSSILFTRGQTQSLVVGVLGTDNDAQTHESLEHKAPIKERFMFHYNFPPFCVGEASSIGAASRR
ELGHGNLAKRALETSIKNKEQVIRLVSEILESNGSSSMASVCAGSLALYASGVEIYDLVAGVAMGMVSEGQDHAILSDIS
GLEDAEGDMDFKIAGNLEGITAMQMDTKMSGIKLEILYQALLQAKEARKHILKIMHEAKEKIVINFSHLPTTEIFNVAPD
KIVEIIGQGGRVIKEIVEKFEVKIDLNKPSGEVKIMGNKERVLKTKEFILNYLHSLDQELEQYAIDEVLEAQVKRIVDFG
AFLSLPKGGEGLLRKQNMDKCQVVLKEGDSIRCRVISFNKGKIALDLA

Sequences:

>Translated_688_residues
MDFITINSSNKTEEFALKQVAKQATSSLLYRLGKTIILASVCVEREPVSEDFLPLVVQFLEKSYAAGKIPGGFVKREGRA
QDFEILTSRLIDRTLRPLFPKDYRYPTQITLMVLSHDIENDLQVSALNAASAALFLAHIAPIKSVSACRIARMDNEFIIN
PSASLLNQSSLDLFVSGTKESLNMIEMRSLGQKLNALEEPLMLEALELAQKSLEETCTLYEEIFTPHQNELFFKESQGIV
FNERLLDLLKNQYFDEIIKGIESSALSERENVFNEIARKISEAHSEFSLEEIELSLEKVKKTEIRRMIIKDKIRPDKRAL
EEVRPILIESDLLPMAHSSILFTRGQTQSLVVGVLGTDNDAQTHESLEHKAPIKERFMFHYNFPPFCVGEASSIGAASRR
ELGHGNLAKRALETSIKNKEQVIRLVSEILESNGSSSMASVCAGSLALYASGVEIYDLVAGVAMGMVSEGQDHAILSDIS
GLEDAEGDMDFKIAGNLEGITAMQMDTKMSGIKLEILYQALLQAKEARKHILKIMHEAKEKIVINFSHLPTTEIFNVAPD
KIVEIIGQGGRVIKEIVEKFEVKIDLNKPSGEVKIMGNKERVLKTKEFILNYLHSLDQELEQYAIDEVLEAQVKRIVDFG
AFLSLPKGGEGLLRKQNMDKCQVVLKEGDSIRCRVISFNKGKIALDLA
>Mature_688_residues
MDFITINSSNKTEEFALKQVAKQATSSLLYRLGKTIILASVCVEREPVSEDFLPLVVQFLEKSYAAGKIPGGFVKREGRA
QDFEILTSRLIDRTLRPLFPKDYRYPTQITLMVLSHDIENDLQVSALNAASAALFLAHIAPIKSVSACRIARMDNEFIIN
PSASLLNQSSLDLFVSGTKESLNMIEMRSLGQKLNALEEPLMLEALELAQKSLEETCTLYEEIFTPHQNELFFKESQGIV
FNERLLDLLKNQYFDEIIKGIESSALSERENVFNEIARKISEAHSEFSLEEIELSLEKVKKTEIRRMIIKDKIRPDKRAL
EEVRPILIESDLLPMAHSSILFTRGQTQSLVVGVLGTDNDAQTHESLEHKAPIKERFMFHYNFPPFCVGEASSIGAASRR
ELGHGNLAKRALETSIKNKEQVIRLVSEILESNGSSSMASVCAGSLALYASGVEIYDLVAGVAMGMVSEGQDHAILSDIS
GLEDAEGDMDFKIAGNLEGITAMQMDTKMSGIKLEILYQALLQAKEARKHILKIMHEAKEKIVINFSHLPTTEIFNVAPD
KIVEIIGQGGRVIKEIVEKFEVKIDLNKPSGEVKIMGNKERVLKTKEFILNYLHSLDQELEQYAIDEVLEAQVKRIVDFG
AFLSLPKGGEGLLRKQNMDKCQVVLKEGDSIRCRVISFNKGKIALDLA

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction [H]

COG id: COG1185

COG function: function code J; Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI188528628, Length=691, Percent_Identity=32.7062228654124, Blast_Score=311, Evalue=2e-84,
Organism=Escherichia coli, GI145693187, Length=690, Percent_Identity=35.6521739130435, Blast_Score=391, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI115534063, Length=664, Percent_Identity=30.7228915662651, Blast_Score=268, Evalue=8e-72,
Organism=Drosophila melanogaster, GI281362905, Length=605, Percent_Identity=34.7107438016529, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24651641, Length=605, Percent_Identity=34.7107438016529, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24651643, Length=605, Percent_Identity=34.7107438016529, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI161079377, Length=544, Percent_Identity=35.6617647058824, Blast_Score=291, Evalue=1e-78,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1000 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 3328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001247
- InterPro:   IPR015847
- InterPro:   IPR004087
- InterPro:   IPR004088
- InterPro:   IPR018111
- InterPro:   IPR012340
- InterPro:   IPR012162
- InterPro:   IPR015848
- InterPro:   IPR003029
- InterPro:   IPR020568
- InterPro:   IPR022967 [H]

Pfam domain/function: PF00013 KH_1; PF01138 RNase_PH; PF03725 RNase_PH_C; PF00575 S1 [H]

EC number: =2.7.7.8 [H]

Molecular weight: Translated: 76896; Mature: 76896

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50084 KH_TYPE_1 ; PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFITINSSNKTEEFALKQVAKQATSSLLYRLGKTIILASVCVEREPVSEDFLPLVVQFL
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EKSYAAGKIPGGFVKREGRAQDFEILTSRLIDRTLRPLFPKDYRYPTQITLMVLSHDIEN
HHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHCCCC
DLQVSALNAASAALFLAHIAPIKSVSACRIARMDNEFIINPSASLLNQSSLDLFVSGTKE
CCEEEHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCEEECCCHHHHCCCCCEEEEECCHH
SLNMIEMRSLGQKLNALEEPLMLEALELAQKSLEETCTLYEEIFTPHQNELFFKESQGIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCE
FNERLLDLLKNQYFDEIIKGIESSALSERENVFNEIARKISEAHSEFSLEEIELSLEKVK
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
KTEIRRMIIKDKIRPDKRALEEVRPILIESDLLPMAHSSILFTRGQTQSLVVGVLGTDND
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHCCCEEEECCCCCEEEEEEEECCCC
AQTHESLEHKAPIKERFMFHYNFPPFCVGEASSIGAASRRELGHGNLAKRALETSIKNKE
HHHHHHHHHCCCHHHCEEEEECCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCHH
QVIRLVSEILESNGSSSMASVCAGSLALYASGVEIYDLVAGVAMGMVSEGQDHAILSDIS
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHC
GLEDAEGDMDFKIAGNLEGITAMQMDTKMSGIKLEILYQALLQAKEARKHILKIMHEAKE
CCCCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIVINFSHLPTTEIFNVAPDKIVEIIGQGGRVIKEIVEKFEVKIDLNKPSGEVKIMGNKE
EEEEEECCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHHHEEEEEECCCCCCEEEECCHH
RVLKTKEFILNYLHSLDQELEQYAIDEVLEAQVKRIVDFGAFLSLPKGGEGLLRKQNMDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHH
CQVVLKEGDSIRCRVISFNKGKIALDLA
HHHHHHCCCCEEEEEEEECCCEEEEEEC
>Mature Secondary Structure
MDFITINSSNKTEEFALKQVAKQATSSLLYRLGKTIILASVCVEREPVSEDFLPLVVQFL
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EKSYAAGKIPGGFVKREGRAQDFEILTSRLIDRTLRPLFPKDYRYPTQITLMVLSHDIEN
HHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHCCCC
DLQVSALNAASAALFLAHIAPIKSVSACRIARMDNEFIINPSASLLNQSSLDLFVSGTKE
CCEEEHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCEEECCCHHHHCCCCCEEEEECCHH
SLNMIEMRSLGQKLNALEEPLMLEALELAQKSLEETCTLYEEIFTPHQNELFFKESQGIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCE
FNERLLDLLKNQYFDEIIKGIESSALSERENVFNEIARKISEAHSEFSLEEIELSLEKVK
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
KTEIRRMIIKDKIRPDKRALEEVRPILIESDLLPMAHSSILFTRGQTQSLVVGVLGTDND
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHCCCEEEECCCCCEEEEEEEECCCC
AQTHESLEHKAPIKERFMFHYNFPPFCVGEASSIGAASRRELGHGNLAKRALETSIKNKE
HHHHHHHHHCCCHHHCEEEEECCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCHH
QVIRLVSEILESNGSSSMASVCAGSLALYASGVEIYDLVAGVAMGMVSEGQDHAILSDIS
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHC
GLEDAEGDMDFKIAGNLEGITAMQMDTKMSGIKLEILYQALLQAKEARKHILKIMHEAKE
CCCCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIVINFSHLPTTEIFNVAPDKIVEIIGQGGRVIKEIVEKFEVKIDLNKPSGEVKIMGNKE
EEEEEECCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHHHEEEEEECCCCCCEEEECCHH
RVLKTKEFILNYLHSLDQELEQYAIDEVLEAQVKRIVDFGAFLSLPKGGEGLLRKQNMDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHH
CQVVLKEGDSIRCRVISFNKGKIALDLA
HHHHHHCCCCEEEEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA