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Identifier: 15645809

GI number: 15645809

Start: 1265308

End: 1267386

Strand: Reverse

Name: Not Available

Synonym: HP1195

Alternate gene names: 15645809

Gene position: 1267386-1265308 (Counterclockwise)

Preceding gene: 15645810

Following gene: 15645808

Centisome position: 75.99

GC content: 45.17

Gene sequence:

>2079_bases
ATGGCTAGAAAAACCCCATTAAATAGGATCAGGAATATTGGTATCGCCGCTCACATTGACGCTGGGAAAACCACCACTTC
TGAAAGGATTTTATTCTATACAGGCGTGAGCCATAAGATTGGCGAAGTGCATGACGGCGCGGCGACAATGGATTGGATGG
AGCAAGAAAAAGAAAGAGGGATCACTATCACTTCTGCGGCAACGACTTGTTTTTGGAAGGATCACCAAATCAATTTGATT
GACACCCCAGGGCATGTGGATTTCACTATTGAAGTGGAACGATCCATGCGCGTGCTAGATGGCGCGGTTTCGGTGTTTTG
CTCGGTTGGGGGAGTGCAACCTCAAAGCGAGACCGTGTGGCGTCAAGCGAATAAATACGGCGTGCCTAGGATTGTTTTTG
TCAATAAAATGGATAGGATTGGAGCGAATTTCTATAATGTAGAAAACCAGATTAAGCTTCGCTTGAAAGCTAATCCTGTG
CCTATTAATATCCCTATTGGGGCTGAAGACACTTTCATTGGCGTGATTGATTTAGTCCAAATGAAAGCGATCGTTTGGAA
TAATGAAACCATGGGGGCCAAATACGATGTGGAAGAAATCCCTAGCGATTTGTTAGAAAAGGCTAAAGAATACCGAGAAA
AGCTTGTAGAAGCCGTAGCCGAGCAAGATGAAGCCTTGATGGAAAAGTATTTGGGCGGTGAAGAATTGAGTATTGAAGAA
ATCAAAAAAGGCATTAAAGCGGGTTGTTTGAACATGAGCCTTGTCCCTATGCTTTGTGGTTCTTCTTTTAAAAATAAAGG
CGTGCAGACCTTATTAGACGCAGTCATTGATTACTTACCAGCGCCTACGGAGGTTGTGGATATTAAGGGGATTGATCCAA
AAACCGAAGAAGAGGTTTTTGTGAAATCCAGCGATGATGGCGAGTTTGCCGGTTTGGCGTTTAAAATCATGACGGATCCT
TTTGTGGGCCAACTCACTTTTGTGCGCGTGTATCGCGGCAAGCTAGAGTCCGGTAGCTATGTGTATAACTCCACCAAAGA
CAAAAAAGAGCGCGTGGGAAGACTGCTTAAAATGCACTCCAATAAGAGAGAAGACATTAAAGAAGTTTATGCGGGTGAGA
TTTGCGCGTTTGTGGGCTTAAAAGACACGCTAACCGGGGACACGCTTTGCGATGAAAAAAATGCGGTGGTTTTAGAGAGA
ATGGAATTTCCTGAGCCAGTCATTCACATCGCTGTGGAGCCTAAAACGAAAGCAGACCAAGAAAAAATGGGCGTAGCGTT
AGGCAAGCTCGCTGAAGAAGATCCAAGCTTTAGGGTGATGACTCAAGAAGAAACCGGGCAAACCCTTATTGGTGGCATGG
GTGAATTGCACCTAGAAATCATCGTGGACAGGTTGAAGAGAGAATTTAAGGTGGAAGCTGAAATCGGTCAGCCGCAAGTC
GCCTTTAGAGAGACTATCCGCTCAAGCGTGAGCAAAGAGCATAAATACGCTAAGCAAAGCGGTGGTCGTGGGCAATACGG
GCATGTGTTTATCAAGCTTGAGCCTAAAGAGCCTGGCAGTGGGTATGAATTTGTGAATGAAATTTCTGGGGGCGTGATCC
CTAAAGAATATATCCCTGCGGTGGATAAGGGTATCCAAGAAGCGATGCAAAATGGCGTTTTGGCAGGCTATCCGGTGGTG
GATTTTAAAGTTACCCTTTATGATGGGAGCTACCATGATGTGGATTCTTCAGAAATGGCGTTTAAAATCGCTGGCTCTAT
GGCGTTTAAAGAAGCGAGTCGCGCGGCTAACCCGGTTTTACTAGAGCCTATGATGAAAGTGGAAGTGGAAGTCCCTGAAG
AATACATGGGCGATGTGATTGGCGATTTGAATAGAAGAAGAGGGCAAATCAATTCTATGGACGATAGATTAGGCTTGAAA
ATCGTGAACGCTTTTGTGCCGTTGGTGGAAATGTTTGGCTATTCTACGGATTTACGATCAGCCACCCAAGGGCGTGGGAC
TTACTCTATGGAGTTTGATCATTATGGCGAAGTGCCTAGCAATATCGCTAAGGAAATTGTAGAAAAGCGCAAAGGCTGA

Upstream 100 bases:

>100_bases
CTAGCGATAAGGGTGCGGCTTTTAAGAAAAAAGAAGATGTGCATAAAATGGCAGAAGCGAATAAAGCGTTCGCACACTAC
CGCTGGTAATTGGAGTTAGA

Downstream 100 bases:

>100_bases
TTTAATTATAACGCTCTCTTATTTTTAGGGGGTGTTATAGGTGCTGTTTAAACTTTTTCTCTTTTGGGTTTAAAAAGACT
TTTTGAGGGTTTTTATCCCT

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G [H]

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MARKTPLNRIRNIGIAAHIDAGKTTTSERILFYTGVSHKIGEVHDGAATMDWMEQEKERGITITSAATTCFWKDHQINLI
DTPGHVDFTIEVERSMRVLDGAVSVFCSVGGVQPQSETVWRQANKYGVPRIVFVNKMDRIGANFYNVENQIKLRLKANPV
PINIPIGAEDTFIGVIDLVQMKAIVWNNETMGAKYDVEEIPSDLLEKAKEYREKLVEAVAEQDEALMEKYLGGEELSIEE
IKKGIKAGCLNMSLVPMLCGSSFKNKGVQTLLDAVIDYLPAPTEVVDIKGIDPKTEEEVFVKSSDDGEFAGLAFKIMTDP
FVGQLTFVRVYRGKLESGSYVYNSTKDKKERVGRLLKMHSNKREDIKEVYAGEICAFVGLKDTLTGDTLCDEKNAVVLER
MEFPEPVIHIAVEPKTKADQEKMGVALGKLAEEDPSFRVMTQEETGQTLIGGMGELHLEIIVDRLKREFKVEAEIGQPQV
AFRETIRSSVSKEHKYAKQSGGRGQYGHVFIKLEPKEPGSGYEFVNEISGGVIPKEYIPAVDKGIQEAMQNGVLAGYPVV
DFKVTLYDGSYHDVDSSEMAFKIAGSMAFKEASRAANPVLLEPMMKVEVEVPEEYMGDVIGDLNRRRGQINSMDDRLGLK
IVNAFVPLVEMFGYSTDLRSATQGRGTYSMEFDHYGEVPSNIAKEIVEKRKG

Sequences:

>Translated_692_residues
MARKTPLNRIRNIGIAAHIDAGKTTTSERILFYTGVSHKIGEVHDGAATMDWMEQEKERGITITSAATTCFWKDHQINLI
DTPGHVDFTIEVERSMRVLDGAVSVFCSVGGVQPQSETVWRQANKYGVPRIVFVNKMDRIGANFYNVENQIKLRLKANPV
PINIPIGAEDTFIGVIDLVQMKAIVWNNETMGAKYDVEEIPSDLLEKAKEYREKLVEAVAEQDEALMEKYLGGEELSIEE
IKKGIKAGCLNMSLVPMLCGSSFKNKGVQTLLDAVIDYLPAPTEVVDIKGIDPKTEEEVFVKSSDDGEFAGLAFKIMTDP
FVGQLTFVRVYRGKLESGSYVYNSTKDKKERVGRLLKMHSNKREDIKEVYAGEICAFVGLKDTLTGDTLCDEKNAVVLER
MEFPEPVIHIAVEPKTKADQEKMGVALGKLAEEDPSFRVMTQEETGQTLIGGMGELHLEIIVDRLKREFKVEAEIGQPQV
AFRETIRSSVSKEHKYAKQSGGRGQYGHVFIKLEPKEPGSGYEFVNEISGGVIPKEYIPAVDKGIQEAMQNGVLAGYPVV
DFKVTLYDGSYHDVDSSEMAFKIAGSMAFKEASRAANPVLLEPMMKVEVEVPEEYMGDVIGDLNRRRGQINSMDDRLGLK
IVNAFVPLVEMFGYSTDLRSATQGRGTYSMEFDHYGEVPSNIAKEIVEKRKG
>Mature_691_residues
ARKTPLNRIRNIGIAAHIDAGKTTTSERILFYTGVSHKIGEVHDGAATMDWMEQEKERGITITSAATTCFWKDHQINLID
TPGHVDFTIEVERSMRVLDGAVSVFCSVGGVQPQSETVWRQANKYGVPRIVFVNKMDRIGANFYNVENQIKLRLKANPVP
INIPIGAEDTFIGVIDLVQMKAIVWNNETMGAKYDVEEIPSDLLEKAKEYREKLVEAVAEQDEALMEKYLGGEELSIEEI
KKGIKAGCLNMSLVPMLCGSSFKNKGVQTLLDAVIDYLPAPTEVVDIKGIDPKTEEEVFVKSSDDGEFAGLAFKIMTDPF
VGQLTFVRVYRGKLESGSYVYNSTKDKKERVGRLLKMHSNKREDIKEVYAGEICAFVGLKDTLTGDTLCDEKNAVVLERM
EFPEPVIHIAVEPKTKADQEKMGVALGKLAEEDPSFRVMTQEETGQTLIGGMGELHLEIIVDRLKREFKVEAEIGQPQVA
FRETIRSSVSKEHKYAKQSGGRGQYGHVFIKLEPKEPGSGYEFVNEISGGVIPKEYIPAVDKGIQEAMQNGVLAGYPVVD
FKVTLYDGSYHDVDSSEMAFKIAGSMAFKEASRAANPVLLEPMMKVEVEVPEEYMGDVIGDLNRRRGQINSMDDRLGLKI
VNAFVPLVEMFGYSTDLRSATQGRGTYSMEFDHYGEVPSNIAKEIVEKRKG

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=696, Percent_Identity=46.264367816092, Blast_Score=600, Evalue=1e-171,
Organism=Homo sapiens, GI19923640, Length=727, Percent_Identity=39.0646492434663, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI25306287, Length=727, Percent_Identity=36.5887207702889, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI25306283, Length=450, Percent_Identity=41.3333333333333, Blast_Score=322, Evalue=9e-88,
Organism=Homo sapiens, GI4503483, Length=465, Percent_Identity=27.5268817204301, Blast_Score=121, Evalue=3e-27,
Organism=Homo sapiens, GI157426893, Length=150, Percent_Identity=37.3333333333333, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI94966754, Length=137, Percent_Identity=39.4160583941606, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI310132016, Length=118, Percent_Identity=39.8305084745763, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI310110807, Length=118, Percent_Identity=39.8305084745763, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI310123363, Length=118, Percent_Identity=39.8305084745763, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI1789738, Length=703, Percent_Identity=66.7140825035562, Blast_Score=954, Evalue=0.0,
Organism=Escherichia coli, GI1790835, Length=487, Percent_Identity=26.4887063655031, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI48994988, Length=163, Percent_Identity=39.2638036809816, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1788922, Length=152, Percent_Identity=37.5, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17533571, Length=682, Percent_Identity=43.108504398827, Blast_Score=545, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17556745, Length=720, Percent_Identity=29.8611111111111, Blast_Score=326, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17506493, Length=499, Percent_Identity=26.4529058116232, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17557151, Length=156, Percent_Identity=39.1025641025641, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=141, Percent_Identity=34.7517730496454, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71988811, Length=141, Percent_Identity=34.7517730496454, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323098, Length=688, Percent_Identity=42.5872093023256, Blast_Score=559, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6322359, Length=791, Percent_Identity=33.5018963337547, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6324707, Length=518, Percent_Identity=26.8339768339768, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320593, Length=518, Percent_Identity=26.8339768339768, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323320, Length=154, Percent_Identity=36.3636363636364, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=147, Percent_Identity=36.734693877551, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324761, Length=130, Percent_Identity=33.8461538461538, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582462, Length=700, Percent_Identity=44.2857142857143, Blast_Score=599, Evalue=1e-171,
Organism=Drosophila melanogaster, GI221458488, Length=732, Percent_Identity=33.7431693989071, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24585711, Length=450, Percent_Identity=28.2222222222222, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24585713, Length=450, Percent_Identity=28.2222222222222, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24585709, Length=450, Percent_Identity=28.2222222222222, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI78706572, Length=158, Percent_Identity=36.7088607594937, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28574573, Length=143, Percent_Identity=36.3636363636364, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 77022; Mature: 76891

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTPLNRIRNIGIAAHIDAGKTTTSERILFYTGVSHKIGEVHDGAATMDWMEQEKERG
CCCCCHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCC
ITITSAATTCFWKDHQINLIDTPGHVDFTIEVERSMRVLDGAVSVFCSVGGVQPQSETVW
EEEEECCEEEEEECCEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RQANKYGVPRIVFVNKMDRIGANFYNVENQIKLRLKANPVPINIPIGAEDTFIGVIDLVQ
HHHHHCCCCEEEEEECHHHHCCCEEECCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHH
MKAIVWNNETMGAKYDVEEIPSDLLEKAKEYREKLVEAVAEQDEALMEKYLGGEELSIEE
HHHHEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IKKGIKAGCLNMSLVPMLCGSSFKNKGVQTLLDAVIDYLPAPTEVVDIKGIDPKTEEEVF
HHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEE
VKSSDDGEFAGLAFKIMTDPFVGQLTFVRVYRGKLESGSYVYNSTKDKKERVGRLLKMHS
EECCCCCCEEEEEEEEECCCCCCHHHEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHC
NKREDIKEVYAGEICAFVGLKDTLTGDTLCDEKNAVVLERMEFPEPVIHIAVEPKTKADQ
CCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCCCH
EKMGVALGKLAEEDPSFRVMTQEETGQTLIGGMGELHLEIIVDRLKREFKVEAEIGQPQV
HHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCHHHHHHHHHHHHHHHEEEEECCCCCHH
AFRETIRSSVSKEHKYAKQSGGRGQYGHVFIKLEPKEPGSGYEFVNEISGGVIPKEYIPA
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHH
VDKGIQEAMQNGVLAGYPVVDFKVTLYDGSYHDVDSSEMAFKIAGSMAFKEASRAANPVL
HHHHHHHHHHCCCEECCCEEEEEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCEE
LEPMMKVEVEVPEEYMGDVIGDLNRRRGQINSMDDRLGLKIVNAFVPLVEMFGYSTDLRS
ECCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
ATQGRGTYSMEFDHYGEVPSNIAKEIVEKRKG
HHCCCCEEEEECCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARKTPLNRIRNIGIAAHIDAGKTTTSERILFYTGVSHKIGEVHDGAATMDWMEQEKERG
CCCCHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCC
ITITSAATTCFWKDHQINLIDTPGHVDFTIEVERSMRVLDGAVSVFCSVGGVQPQSETVW
EEEEECCEEEEEECCEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RQANKYGVPRIVFVNKMDRIGANFYNVENQIKLRLKANPVPINIPIGAEDTFIGVIDLVQ
HHHHHCCCCEEEEEECHHHHCCCEEECCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHH
MKAIVWNNETMGAKYDVEEIPSDLLEKAKEYREKLVEAVAEQDEALMEKYLGGEELSIEE
HHHHEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IKKGIKAGCLNMSLVPMLCGSSFKNKGVQTLLDAVIDYLPAPTEVVDIKGIDPKTEEEVF
HHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEE
VKSSDDGEFAGLAFKIMTDPFVGQLTFVRVYRGKLESGSYVYNSTKDKKERVGRLLKMHS
EECCCCCCEEEEEEEEECCCCCCHHHEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHC
NKREDIKEVYAGEICAFVGLKDTLTGDTLCDEKNAVVLERMEFPEPVIHIAVEPKTKADQ
CCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCCCH
EKMGVALGKLAEEDPSFRVMTQEETGQTLIGGMGELHLEIIVDRLKREFKVEAEIGQPQV
HHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCHHHHHHHHHHHHHHHEEEEECCCCCHH
AFRETIRSSVSKEHKYAKQSGGRGQYGHVFIKLEPKEPGSGYEFVNEISGGVIPKEYIPA
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHH
VDKGIQEAMQNGVLAGYPVVDFKVTLYDGSYHDVDSSEMAFKIAGSMAFKEASRAANPVL
HHHHHHHHHHCCCEECCCEEEEEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCEE
LEPMMKVEVEVPEEYMGDVIGDLNRRRGQINSMDDRLGLKIVNAFVPLVEMFGYSTDLRS
ECCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
ATQGRGTYSMEFDHYGEVPSNIAKEIVEKRKG
HHCCCCEEEEECCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA