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Identifier: 15645766

GI number: 15645766

Start: 1213522

End: 1214868

Strand: Reverse

Name: Not Available

Synonym: HP1152

Alternate gene names: 15645766

Gene position: 1214868-1213522 (Counterclockwise)

Preceding gene: 15645767

Following gene: 15645765

Centisome position: 72.84

GC content: 40.83

Gene sequence:

>1347_bases
ATGTTTCAAGCGTTAAGCGATGGGTTTAAAAACGCGCTCAATAAAATCCGCTTTCAAGATGATGAAAAAGCGCTAGACAG
AGCGTTAGATGAATTGAAAAAAACGCTCTTAAAAAACGATGTGCATCATAAAGTGGCTAGAGAATTGCTCAAAAAAGTGG
AAAGTCAAACTAAACTTAATGGCATTGGTAAGCAGCAATTTTTAGACGCTTTAGAAAAGAGTTTGTTAGAAATTTTAAGC
GCTAAAGGGAGCAGTGGTTTCACTTTCGCTCAAACGCCCCCAACTGTGGTTTTAATGGCCGGTTTGCAAGGGAGCGGTAA
GACAACCACCACCGCTAAACTCGCTCATTATTTAAAAACCAAAAATAAAAAAGTGCTTTTATGCGCATGCGATTTGCAAC
GCCTAGCGGCAGTGGAGCAATTAAAGGTTTTGGGCGAACAGGTGGGCGTGGAAGTTTTTTATGAAGAAAATAAAAGCGTG
AAAGAAATCGCTAGCAACGCTTTAAAAAGGGCTAAAGAAGCGCAATTTGATGTTTTGCTCGTGGATAGCGCGGGGCGTTT
AGCCATTGATAAAGAGCTTATGCAAGAATTAAAAGAAGTTAAAGAAATCTTAAACCCCCATGAAGTGCTGTATGTCGCAG
ACGCATTGAGCGGGCAAGATGGCGTCAAAAGCGCGAACACCTTTAATGAAGAAATAGGCGTGAGTGGGGTGGTGTTAAGC
AAATTTGATAGCGATTCTAAAGGGGGTATCGCCTTAGGCATCACTTACCAATTAGGCTTACCCTTGCGTTTTATTGGGAG
CGGGGAAAAAATCCCTGATTTAGACGTGTTTGTGCCTGAAAGAATTGTGGGGCGTTTGATGGGGGCTGGAGATATTGTCT
CGCTCGCTGAAAAAACCGCTAGCGTTTTAAACCCTAATGAAGCCAAAGATTTAAGCAAAAAACTCAAAAAAGGGCAATTC
ACTTTCAATGACTTTTTAAACCAGATTGAAAAAGTGAAAAAATTAGGCTCTATGAGTTCTCTAATCTCTATGATTCCAGG
TTTAGGGAATATGGCAAGCGCGTTAAAAGACACGGATTTAGAAAGCTCTTTAGAAGTGAAAAAAATCAAGGCTATGGTCA
ATTCCATGACCAAAAAAGAGCAAGAAAACCCCGAGATTTTAAACGGCAGCCGAAGAAAAAGGATCGCTTTAGGGAGCGGT
TTAGAAGTGTCTGAAATCAATCGCATCATCAAACGCTTTGATCAAGCGAGCAAAATGGCGAAACGCTTAACCAATAAAAA
GGGTATTAGCGATTTGATGAATCTAATGAGTCAGGCTAAAAATCAAACGCCCCCTAAAATGCGCTAA

Upstream 100 bases:

>100_bases
TAGAAAAAGCTAAAGAGAGTTTAAAAACGCTTTTAGAAAAAGAAAGTAAAATTAAGCAAGAATTGGACTTGTTAGAACAA
CCATAATAAAAGGATAGAAA

Downstream 100 bases:

>100_bases
CTTTTAAGCATGTTTTGGGTGCTTTTGTTGTATAATCTCAAATTTAATACGAATATTTTAGGAGATTTTTGTAATGACAG
TCATTAGACTCACTCGTATC

Product: signal recognition particle protein (ffh)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKLNGIGKQQFLDALEKSLLEILS
AKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
KEIASNALKRAKEAQFDVLLVDSAGRLAIDKELMQELKEVKEILNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIVSLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSLISMIPGLGNMASALKDTDLESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR

Sequences:

>Translated_448_residues
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKLNGIGKQQFLDALEKSLLEILS
AKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
KEIASNALKRAKEAQFDVLLVDSAGRLAIDKELMQELKEVKEILNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIVSLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSLISMIPGLGNMASALKDTDLESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR
>Mature_448_residues
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKLNGIGKQQFLDALEKSLLEILS
AKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
KEIASNALKRAKEAQFDVLLVDSAGRLAIDKELMQELKEVKEILNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIVSLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSLISMIPGLGNMASALKDTDLESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=447, Percent_Identity=31.3199105145414, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI226371618, Length=404, Percent_Identity=31.4356435643564, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI295424842, Length=301, Percent_Identity=29.2358803986711, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI23308697, Length=301, Percent_Identity=29.2358803986711, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI89061728, Length=157, Percent_Identity=35.031847133758, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1788963, Length=428, Percent_Identity=40.4205607476636, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1789874, Length=231, Percent_Identity=37.6623376623377, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=438, Percent_Identity=31.0502283105023, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=200, Percent_Identity=36, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=426, Percent_Identity=30.9859154929577, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6320498, Length=224, Percent_Identity=32.5892857142857, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17647949, Length=440, Percent_Identity=29.7727272727273, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24641198, Length=299, Percent_Identity=30.1003344481605, Blast_Score=122, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49176; Mature: 49176

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKLN
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIGKQQFLDALEKSLLEILSAKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKT
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHC
KNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSVKEIASNALKRAKEAQFDVLL
CCCEEEEEECCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEE
VDSAGRLAIDKELMQELKEVKEILNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
ECCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHCCCCCCCCHHHHHHHHCCCCEEEE
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIVSLAEKTA
CCCCCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
SVLNPNEAKDLSKKLKKGQFTFNDFLNQIEKVKKLGSMSSLISMIPGLGNMASALKDTDL
HHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
ESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSGLEVSEINRIIKRFDQASKMA
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
KRLTNKKGISDLMNLMSQAKNQTPPKMR
HHHHCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKLN
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIGKQQFLDALEKSLLEILSAKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKT
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHC
KNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSVKEIASNALKRAKEAQFDVLL
CCCEEEEEECCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEE
VDSAGRLAIDKELMQELKEVKEILNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
ECCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHCCCCCCCCHHHHHHHHCCCCEEEE
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIVSLAEKTA
CCCCCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
SVLNPNEAKDLSKKLKKGQFTFNDFLNQIEKVKKLGSMSSLISMIPGLGNMASALKDTDL
HHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
ESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSGLEVSEINRIIKRFDQASKMA
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
KRLTNKKGISDLMNLMSQAKNQTPPKMR
HHHHCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]