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Identifier: 15645508

GI number: 15645508

Start: 944087

End: 944857

Strand: Reverse

Name: Not Available

Synonym: HP0890

Alternate gene names: 15645508

Gene position: 944857-944087 (Counterclockwise)

Preceding gene: 15645510

Following gene: 15645507

Centisome position: 56.65

GC content: 41.63

Gene sequence:

>771_bases
ATGCTGTTAGATCAAGGGTATAAAGTCTATGCGCTCTCTAGGCATGCGACTTTGTGCGTGGCATTAAACCATGCGTTATG
CGAGAGCGTTGATATTGATGTGAGCGATTCTAACGCTTTAAAAGAAGTGTTTTCAAACATCAGCGCTAAAGAAAAATATT
GCGATGTTTTGATCAATTCCGCCGGTTATGGGGTGTTTGGGAGCGTGGAAGACACGCCCATTGAAGAGGTTAAAAAGCAA
TTTAGCGTGAATTTTTTCGCCCTTTGTGAAGTGGTGCAGTTTTGTTTGCCTTTATTAAAAAATAAGCCCCATTCTAAGAT
TTTTAACCTTTCTTCCATAGCAGGGCGTGTGAGCATGCTCTTTTTAGGCCATTACAGCGCGAGTAAGCATGCCTTAGAGG
CTTATAGCGATGCCTTGCGTTTAGAGCTCAAACCCTTTAACGTTCAAGTGTGTTTGATTGAGCCAGGCCCGGTGAAAAGC
AATTGGGAAAAAACCGCTTTTTCAGTTGAGAATTTTGAGAGCGAAGATAGCCTTTATGCGTTAGAAGTGAATGCGGCTAA
AAGCTTTTATTCTGGCGTGTATCAAAACGCCCTAAGCCCTAAAGCCGTGGCGCAAAAAATCGTTTTTCTTAGCATGAGTC
AAAAAATCAAGGCCCGTTATTTGATCGGCTTAAAAACCCAACTATTGTTAGCGTTGTATCAAATCCTCCCGAGTAGTTGG
TATGATTCTTTGTTCAGATTAATCGTTCTTAAAAGGAAGCGTGATGCTTAA

Upstream 100 bases:

>100_bases
ATAAGAGAGTTGGCGTTAGATAATGGGCGAGAAAAAAGAAAGCCAAAAGGTGGCGGTTATCACTGGGGCGAGTTCTGGGA
TTGGGTTGGAGTGTGCGTTA

Downstream 100 bases:

>100_bases
AACCTATCATATCGCCTTAGCTTGCGTGATTTTAGCGGTGGTGGTGCTGTTGTTTGGAGGGGAGTCCTTGAGCTTGGAAG
AATGGCAAGAAGTGTGCCTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MLLDQGYKVYALSRHATLCVALNHALCESVDIDVSDSNALKEVFSNISAKEKYCDVLINSAGYGVFGSVEDTPIEEVKKQ
FSVNFFALCEVVQFCLPLLKNKPHSKIFNLSSIAGRVSMLFLGHYSASKHALEAYSDALRLELKPFNVQVCLIEPGPVKS
NWEKTAFSVENFESEDSLYALEVNAAKSFYSGVYQNALSPKAVAQKIVFLSMSQKIKARYLIGLKTQLLLALYQILPSSW
YDSLFRLIVLKRKRDA

Sequences:

>Translated_256_residues
MLLDQGYKVYALSRHATLCVALNHALCESVDIDVSDSNALKEVFSNISAKEKYCDVLINSAGYGVFGSVEDTPIEEVKKQ
FSVNFFALCEVVQFCLPLLKNKPHSKIFNLSSIAGRVSMLFLGHYSASKHALEAYSDALRLELKPFNVQVCLIEPGPVKS
NWEKTAFSVENFESEDSLYALEVNAAKSFYSGVYQNALSPKAVAQKIVFLSMSQKIKARYLIGLKTQLLLALYQILPSSW
YDSLFRLIVLKRKRDA
>Mature_256_residues
MLLDQGYKVYALSRHATLCVALNHALCESVDIDVSDSNALKEVFSNISAKEKYCDVLINSAGYGVFGSVEDTPIEEVKKQ
FSVNFFALCEVVQFCLPLLKNKPHSKIFNLSSIAGRVSMLFLGHYSASKHALEAYSDALRLELKPFNVQVCLIEPGPVKS
NWEKTAFSVENFESEDSLYALEVNAAKSFYSGVYQNALSPKAVAQKIVFLSMSQKIKARYLIGLKTQLLLALYQILPSSW
YDSLFRLIVLKRKRDA

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

Homologues:

Organism=Homo sapiens, GI7657478, Length=214, Percent_Identity=30.3738317757009, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI20149619, Length=213, Percent_Identity=28.6384976525822, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI40548397, Length=163, Percent_Identity=33.7423312883436, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI214010158, Length=163, Percent_Identity=33.7423312883436, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI214010156, Length=163, Percent_Identity=33.7423312883436, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI22758144, Length=163, Percent_Identity=33.7423312883436, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI22507405, Length=147, Percent_Identity=35.3741496598639, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI223718074, Length=246, Percent_Identity=26.8292682926829, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI44680136, Length=138, Percent_Identity=32.6086956521739, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI44680133, Length=138, Percent_Identity=32.6086956521739, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI17738292, Length=138, Percent_Identity=32.6086956521739, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI150247226, Length=140, Percent_Identity=35, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4504503, Length=151, Percent_Identity=30.4635761589404, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4503817, Length=146, Percent_Identity=29.4520547945205, Blast_Score=71, Evalue=9e-13,
Organism=Escherichia coli, GI1786701, Length=243, Percent_Identity=29.6296296296296, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1787820, Length=213, Percent_Identity=26.2910798122066, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17570069, Length=183, Percent_Identity=32.2404371584699, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557780, Length=105, Percent_Identity=35.2380952380952, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71997402, Length=137, Percent_Identity=32.8467153284672, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507613, Length=271, Percent_Identity=25.0922509225092, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32563809, Length=271, Percent_Identity=25.0922509225092, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=133, Percent_Identity=34.5864661654135, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21358495, Length=178, Percent_Identity=26.9662921348315, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357041, Length=160, Percent_Identity=28.75, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): VDLC_HELPY (O05730)

Other databases:

- EMBL:   U94318
- EMBL:   AE000511
- PIR:   B64631
- PIR:   T09452
- RefSeq:   NP_207683.1
- ProteinModelPortal:   O05730
- SMR:   O05730
- GeneID:   899418
- GenomeReviews:   AE000511_GR
- KEGG:   hpy:HP0890
- NMPDR:   fig|85962.1.peg.880
- TIGR:   HP_0890
- HOGENOM:   HBG750976
- ProtClustDB:   CLSK496259
- GO:   GO:0005488
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PRINTS:   PR00081
- PRINTS:   PR00080

Pfam domain/function: PF00106 adh_short

EC number: 1.-.-.- [C]

Molecular weight: Translated: 28656; Mature: 28656

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00061 ADH_SHORT

Important sites: ACT_SITE 153-153 BINDING 140-140

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLDQGYKVYALSRHATLCVALNHALCESVDIDVSDSNALKEVFSNISAKEKYCDVLINS
CCCCCCCEEEEEECCCEEEEHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCC
AGYGVFGSVEDTPIEEVKKQFSVNFFALCEVVQFCLPLLKNKPHSKIFNLSSIAGRVSML
CCCCEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHH
FLGHYSASKHALEAYSDALRLELKPFNVQVCLIEPGPVKSNWEKTAFSVENFESEDSLYA
EEECCCCHHHHHHHHHHHHEEEEECCEEEEEEECCCCCCCCCHHHHEEHHCCCCCCCEEE
LEVNAAKSFYSGVYQNALSPKAVAQKIVFLSMSQKIKARYLIGLKTQLLLALYQILPSSW
EEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YDSLFRLIVLKRKRDA
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLLDQGYKVYALSRHATLCVALNHALCESVDIDVSDSNALKEVFSNISAKEKYCDVLINS
CCCCCCCEEEEEECCCEEEEHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCC
AGYGVFGSVEDTPIEEVKKQFSVNFFALCEVVQFCLPLLKNKPHSKIFNLSSIAGRVSML
CCCCEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHH
FLGHYSASKHALEAYSDALRLELKPFNVQVCLIEPGPVKSNWEKTAFSVENFESEDSLYA
EEECCCCHHHHHHHHHHHHEEEEECCEEEEEEECCCCCCCCCHHHHEEHHCCCCCCCEEE
LEVNAAKSFYSGVYQNALSPKAVAQKIVFLSMSQKIKARYLIGLKTQLLLALYQILPSSW
EEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YDSLFRLIVLKRKRDA
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9139899; 9252185