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Identifier: 15645448

GI number: 15645448

Start: 880765

End: 882210

Strand: Reverse

Name: Not Available

Synonym: HP0829

Alternate gene names: 15645448

Gene position: 882210-880765 (Counterclockwise)

Preceding gene: 15645449

Following gene: 15645447

Centisome position: 52.89

GC content: 44.26

Gene sequence:

>1446_bases
ATGAGAATTTTACAAAGGGCTTTGACTTTTGAAGATGTGTTGATGGTGCCTAGAAAGTCTAGCGTTTTACCTAAAGATGT
GAGCTTAAAGTCTCGCTTAACTAAAAACATTCGTTTGAATATCCCCTTTATCAGTGCGGCTATGGATACGGTTACAGAGC
ATAAAACCGCTATCGCTATGGCGCGCCTTGGGGGTATTGGCATCGTGCATAAAAACATGGATATTCAAACGCAAGTTAAA
GAAATCACTAAGGTTAAAAAAAGCGAGAGCGGGGTGATTAATGATCCTATTTTTATCCATGCGCACAGGACGCTAGCGGA
CGCTAAAGTCATAACGGATAATTACAAGATTTCAGGCGTGCCTGTGGTAGATGATAAGGGGTTGTTGATTGGGATTTTAA
CCAACAGAGATGTGCGCTTTGAAACCGATTTGAGTAAAAAAGTGGGCGATGTGATGACTAAAATGCCTTTAGTTACCGCT
CATGTGGGTATCAGTTTGGATGAAGCGAGCGATTTGATGCACAAGCATAAGATTGAAAAATTGCCCATTGTGGATAAAGA
TAATGTCTTAAAAGGCTTGATCACGATCAAAGATATTCAAAAACGCATTGAATACCCTGAGGCCAATAAAGATGATTTTG
GGAGGTTGAGAGTGGGGGCGGCTATTGGAGTGGGGCAGTTGGATAGGGCTGAGATGTTAGTTAAAGCGGGGGTGGATGCA
CTGGTGCTAGACAGCGCACATGGGCATTCAGCCAATATCTTACACACTTTAGAAGAGATTAAAAAAAGCTTGGTAGTGGA
TGTGATTGTGGGGAATGTGGTTACTAAAGAAGCCACAAGCGATTTGATTAGCGCGGGAGCAGACGCTATTAAAGTGGGTA
TTGGGCCAGGAAGCATTTGCACCACTAGGATTGTGGCTGGGGTGGGAATGCCCCAAGTGAGCGCGATTGATAATTGCGTA
GAAGTGGCGTCTAAATTTGATATTCCTGTGATTGCAGATGGAGGGATCCGCTATTCAGGCGATGTGGCTAAGGCTTTGGC
TTTGGGGGCATCAAGCGTGATGATAGGCTCTTTACTCGCTGGCACAGAAGAATCTCCTGGGGATTTTATGATCTATCAAG
GGAGGCAATATAAAAGCTATAGGGGCATGGGCAGCATTGGGGCTATGACTAAAGGGAGCTCTGATAGGTATTTTCAAGAG
GGCGTAGCGAGTGAAAAGTTAGTCCCAGAAGGCATTGAAGGGCGTGTGCCTTATCGTGGTAAGGTTTCGGATATGATTTT
CCAATTAGTAGGGGGCGTGCGCTCTTCTATGGGGTATCAGGGGGCGAAAAATATTTTGGAATTGTATCAAAACGCTGAAT
TTGTAGAAATCACTAGCGCGGGGTTAAAAGAAAGCCATGTGCATGGCGTGGATATTACTAAAGAAGCCCCTAATTATTAT
GGGTGA

Upstream 100 bases:

>100_bases
GATGCAATTCATTGCTAAGGCTTTTGATGAGCAAAGCCTTTTAGATGTTTCTTACGCTTTAGAGCAAGAATTAGATTTAA
AATTAGATTAAGGATAGAAA

Downstream 100 bases:

>100_bases
ATTGTAAAAGAAAACAAGACAAATCGTTAAAAAACTCGTTAAAAAGCTTGGTTTAATGAGTTTTTAAAACTTAATTGCTA
CAATTAAGGAAATTTTCAAT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNIRLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVK
EITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVGISLDEASDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAIKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G

Sequences:

>Translated_481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNIRLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVK
EITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVGISLDEASDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAIKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G
>Mature_481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNIRLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVK
EITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVGISLDEASDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAIKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=40.9185803757829, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=39.6659707724426, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=39.6659707724426, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=39.6659707724426, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=39.6659707724426, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI217035152, Length=486, Percent_Identity=39.5061728395062, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=39.0396659707724, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=37.160751565762, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI50541954, Length=258, Percent_Identity=38.7596899224806, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI50541952, Length=258, Percent_Identity=38.7596899224806, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI50541948, Length=258, Percent_Identity=38.7596899224806, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI50541956, Length=258, Percent_Identity=38.7596899224806, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=38.6178861788618, Blast_Score=155, Evalue=8e-38,
Organism=Escherichia coli, GI1788855, Length=483, Percent_Identity=55.2795031055901, Blast_Score=480, Evalue=1e-136,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=37.10407239819, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=476, Percent_Identity=36.344537815126, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=38.5714285714286, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17560440, Length=254, Percent_Identity=37.7952755905512, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322012, Length=481, Percent_Identity=40.956340956341, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6323585, Length=481, Percent_Identity=40.3326403326403, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=481, Percent_Identity=41.7879417879418, Blast_Score=329, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=337, Percent_Identity=40.9495548961424, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=42.3728813559322, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641071, Length=480, Percent_Identity=39.375, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24641073, Length=480, Percent_Identity=39.375, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=39.7727272727273, Blast_Score=273, Evalue=2e-73,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51803; Mature: 51803

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNIRLNIPFISAAMDTVTEHKTAIAM
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHH
ARLGGIGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGV
HHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHCCCEEEECCEEECCE
PVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLDEASDLMHKHKIEK
EEECCCCEEEEEEECCCEEEECHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHH
LPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCE
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAIKVGIGPGSIC
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCHHH
TTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLA
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHHC
GTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRG
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
KVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
G
C
>Mature Secondary Structure
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNIRLNIPFISAAMDTVTEHKTAIAM
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHH
ARLGGIGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGV
HHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHCCCEEEECCEEECCE
PVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLDEASDLMHKHKIEK
EEECCCCEEEEEEECCCEEEECHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHH
LPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCE
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAIKVGIGPGSIC
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCHHH
TTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLA
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHHC
GTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRG
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
KVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]