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Identifier: 15645354

GI number: 15645354

Start: 789377

End: 790696

Strand: Reverse

Name: Not Available

Synonym: HP0734

Alternate gene names: 15645354

Gene position: 790696-789377 (Counterclockwise)

Preceding gene: 15645355

Following gene: 15645353

Centisome position: 47.41

GC content: 41.21

Gene sequence:

>1320_bases
ATGCAAGTTAAAGAAAACAAACAACTCTGCTTAATTTCATTAGGTTGCTCTAAAAATTTGGTGGATTCAGAGGTGATGTT
AGGCAAGCTTTATAATTACACGCTCACTAATGACGCTAAGAGCGCTGATGTGATTTTGATCAACACTTGCGGGTTTATTG
AAAGCGCTAAACAAGAGAGTATCCAAACCATTCTCAACGCCGCCAAAGACAAAAAAGAGGGAGCGATTTTGATTGCGAGC
GGGTGCTTGAGCGAACGCTATAAAGATGAAATCAAAGAATTGATCCCTGAAGTGGATATTTTTACCGGCGTGGGGGATTA
TGACAAGATCGATATAATGATTGCTAAAAAACAAAACCAGTTCAGCGAGCAAGTGTTTTTAAGCGAGCATTACAACGCAC
GCATCATCACGGGATCGAGCGTGCATGCGTATGTGAAAATTTCTGAGGGTTGCAATCAAAAATGTTCTTTTTGCGCTATC
CCTAGCTTTAAGGGGAAATTGCAAAGCAGGGAATTGGACTCCATTTTAAAAGAAGTGGAAAATCTCGCGCTTAAAGGCTA
TACGGATATGACTTTTATCGCTCAAGACTCTAGCTCCTTTTTATACGATAAGGGGCAAAAAGACGGCTTGATCCAGCTCA
TTAGAGCGATTGATAAACAGCAAGCCTTAAAGAGCGCGCGTATTTTATATCTCTACCCCTCTAGCACCACGCTAGAGCTT
ATTGGCGCGATTGAAAGTTCGCCCATTTTTCAAAATTATTTTGACATGCCCATCCAGCACATCAGCGACTCCATGCTCAA
AAAGATGCGGCGCAACTCTAGCCAAGCGCACCATTTAAAGCTTTTAGATGCCATGAAGCAGGTTAAAGAAAGCTTTATCA
GAAGCACGATCATTGTAGGGCATCCGGAAGAAAATGAGAGCGAATTTGAAGAATTGAGCGCGTTTTTAGACGAGTTCCAG
TTTGATAGATTGAATATTTTTGCTTTCAGCGCTGAAGAAAACACGCATGCCTATTCTTTAGAAAAAGTGCCTAAAAAAAC
CATCAACGCTCGCATCAAAGCCTTGAATAAAATCGCTTTAAAGCACCAAAACCATTCCTTTAAGGCTTTGTTGAATAAGC
CCATTAAGGCGTTAGTGGAAAATAAAGAGGGCGAGTATTTTTACAAAGCAAGGGATCTCAGATGGGCGCCTGAAGTGGAT
GGGGAAATCTTGATCAATGATAGCGAACTAACCACCCCCTTAAAACCCGGGCATTATACGATTGCACCTAGCGAATTTAA
AGATAATATCCTACTCGCTAAGGTTTTAAGCCCTTTTTAA

Upstream 100 bases:

>100_bases
ACAAGCGCGAAATACAAAGCCGATGCGTTTTTAAAAGACGCTCCTGAATGGATTGATTTCTTTTGGGAAGTGGATTTGAA
AAACTTAAAAAGCCATTAAC

Downstream 100 bases:

>100_bases
AAGTTAGCCATAAGGCTAAAAGCACGGCTAAAGCGTGGCTAAAGCGTGGCTGGAGCGTGGGGGTTTGCGTTTTTTTTTTT
TTGTTAAAATGCGTCAGAAA

Product: hypothetical protein

Products: NA

Alternate protein names: S12 MTTase; S12 methylthiotransferase; Ribosome maturation factor RimO [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MQVKENKQLCLISLGCSKNLVDSEVMLGKLYNYTLTNDAKSADVILINTCGFIESAKQESIQTILNAAKDKKEGAILIAS
GCLSERYKDEIKELIPEVDIFTGVGDYDKIDIMIAKKQNQFSEQVFLSEHYNARIITGSSVHAYVKISEGCNQKCSFCAI
PSFKGKLQSRELDSILKEVENLALKGYTDMTFIAQDSSSFLYDKGQKDGLIQLIRAIDKQQALKSARILYLYPSSTTLEL
IGAIESSPIFQNYFDMPIQHISDSMLKKMRRNSSQAHHLKLLDAMKQVKESFIRSTIIVGHPEENESEFEELSAFLDEFQ
FDRLNIFAFSAEENTHAYSLEKVPKKTINARIKALNKIALKHQNHSFKALLNKPIKALVENKEGEYFYKARDLRWAPEVD
GEILINDSELTTPLKPGHYTIAPSEFKDNILLAKVLSPF

Sequences:

>Translated_439_residues
MQVKENKQLCLISLGCSKNLVDSEVMLGKLYNYTLTNDAKSADVILINTCGFIESAKQESIQTILNAAKDKKEGAILIAS
GCLSERYKDEIKELIPEVDIFTGVGDYDKIDIMIAKKQNQFSEQVFLSEHYNARIITGSSVHAYVKISEGCNQKCSFCAI
PSFKGKLQSRELDSILKEVENLALKGYTDMTFIAQDSSSFLYDKGQKDGLIQLIRAIDKQQALKSARILYLYPSSTTLEL
IGAIESSPIFQNYFDMPIQHISDSMLKKMRRNSSQAHHLKLLDAMKQVKESFIRSTIIVGHPEENESEFEELSAFLDEFQ
FDRLNIFAFSAEENTHAYSLEKVPKKTINARIKALNKIALKHQNHSFKALLNKPIKALVENKEGEYFYKARDLRWAPEVD
GEILINDSELTTPLKPGHYTIAPSEFKDNILLAKVLSPF
>Mature_439_residues
MQVKENKQLCLISLGCSKNLVDSEVMLGKLYNYTLTNDAKSADVILINTCGFIESAKQESIQTILNAAKDKKEGAILIAS
GCLSERYKDEIKELIPEVDIFTGVGDYDKIDIMIAKKQNQFSEQVFLSEHYNARIITGSSVHAYVKISEGCNQKCSFCAI
PSFKGKLQSRELDSILKEVENLALKGYTDMTFIAQDSSSFLYDKGQKDGLIQLIRAIDKQQALKSARILYLYPSSTTLEL
IGAIESSPIFQNYFDMPIQHISDSMLKKMRRNSSQAHHLKLLDAMKQVKESFIRSTIIVGHPEENESEFEELSAFLDEFQ
FDRLNIFAFSAEENTHAYSLEKVPKKTINARIKALNKIALKHQNHSFKALLNKPIKALVENKEGEYFYKARDLRWAPEVD
GEILINDSELTTPLKPGHYTIAPSEFKDNILLAKVLSPF

Specific function: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 [H]

COG id: COG0621

COG function: function code J; 2-methylthioadenine synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MTTase N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI93277076, Length=371, Percent_Identity=24.2587601078167, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI28872782, Length=392, Percent_Identity=26.0204081632653, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI28872784, Length=392, Percent_Identity=26.0204081632653, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1787057, Length=432, Percent_Identity=31.0185185185185, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1786882, Length=394, Percent_Identity=26.6497461928934, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17553146, Length=456, Percent_Identity=22.8070175438596, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356207, Length=443, Percent_Identity=23.9277652370203, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI19922432, Length=378, Percent_Identity=22.4867724867725, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR005839
- InterPro:   IPR020612
- InterPro:   IPR013848
- InterPro:   IPR012340
- InterPro:   IPR007197
- InterPro:   IPR005840 [H]

Pfam domain/function: PF04055 Radical_SAM; PF00919 UPF0004 [H]

EC number: NA

Molecular weight: Translated: 49634; Mature: 49634

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS01278 UPF0004

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVKENKQLCLISLGCSKNLVDSEVMLGKLYNYTLTNDAKSADVILINTCGFIESAKQES
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHEEEECCCCCCCCEEEEECCCCHHHHHHHH
IQTILNAAKDKKEGAILIASGCLSERYKDEIKELIPEVDIFTGVGDYDKIDIMIAKKQNQ
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEECCCCC
FSEQVFLSEHYNARIITGSSVHAYVKISEGCNQKCSFCAIPSFKGKLQSRELDSILKEVE
HHHHHHHHCCCCEEEEECCCEEEEEEECCCCCCCCCEEECCCHHCHHHHHHHHHHHHHHH
NLALKGYTDMTFIAQDSSSFLYDKGQKDGLIQLIRAIDKQQALKSARILYLYPSSTTLEL
HHHHCCCCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHH
IGAIESSPIFQNYFDMPIQHISDSMLKKMRRNSSQAHHLKLLDAMKQVKESFIRSTIIVG
HCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCEEEEE
HPEENESEFEELSAFLDEFQFDRLNIFAFSAEENTHAYSLEKVPKKTINARIKALNKIAL
CCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
KHQNHSFKALLNKPIKALVENKEGEYFYKARDLRWAPEVDGEILINDSELTTPLKPGHYT
HCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEE
IAPSEFKDNILLAKVLSPF
ECCCHHCCCEEEEHHCCCC
>Mature Secondary Structure
MQVKENKQLCLISLGCSKNLVDSEVMLGKLYNYTLTNDAKSADVILINTCGFIESAKQES
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHEEEECCCCCCCCEEEEECCCCHHHHHHHH
IQTILNAAKDKKEGAILIASGCLSERYKDEIKELIPEVDIFTGVGDYDKIDIMIAKKQNQ
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEECCCCC
FSEQVFLSEHYNARIITGSSVHAYVKISEGCNQKCSFCAIPSFKGKLQSRELDSILKEVE
HHHHHHHHCCCCEEEEECCCEEEEEEECCCCCCCCCEEECCCHHCHHHHHHHHHHHHHHH
NLALKGYTDMTFIAQDSSSFLYDKGQKDGLIQLIRAIDKQQALKSARILYLYPSSTTLEL
HHHHCCCCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHH
IGAIESSPIFQNYFDMPIQHISDSMLKKMRRNSSQAHHLKLLDAMKQVKESFIRSTIIVG
HCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCEEEEE
HPEENESEFEELSAFLDEFQFDRLNIFAFSAEENTHAYSLEKVPKKTINARIKALNKIAL
CCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
KHQNHSFKALLNKPIKALVENKEGEYFYKARDLRWAPEVDGEILINDSELTTPLKPGHYT
HCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEE
IAPSEFKDNILLAKVLSPF
ECCCHHCCCEEEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA