Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15645210

GI number: 15645210

Start: 615309

End: 615965

Strand: Reverse

Name: Not Available

Synonym: HP0585

Alternate gene names: 15645210

Gene position: 615965-615309 (Counterclockwise)

Preceding gene: 15645211

Following gene: 15645209

Centisome position: 36.93

GC content: 41.4

Gene sequence:

>657_bases
GTGAAAATGGGTTTAAAACGCGCTAAAACTCACCAAAAAGCCCAACAAATCAAAGAGCTGCTTTTAAAACATTACCCCAA
CCAAACCACCGAATTGCGCCATAAAAACCCCTATGAATTATTGGTGGCGACCATTTTAAGCGCTCAATGCACGGACGCTA
GAGTGAATCAAATAACGCCCAAGTTATTTGAAAAATACCCGAGCGTGAACGATTTAGCCCTCGCTTCTTTAGAAGAAGTT
AAAGAGATCATTAAATCCGTTTCTTATTTTAACAATAAAAGCAAGCATTTAATCAGTATGGCGCAAAAAGTGGTTAGGGA
TTTTAAGGGCGTTATCCCCTCTACGCAAAAAGAATTGATGAGTTTAGATGGCGTGGGGCAAAAAACCGCTAATGTGGTGC
TTTCAGTGTGCTTTGATGCAAATTGTATAGCCGTAGATACCCATGTGTTCCGTGCAACACACCGCTTAGGCTTAAGCAAT
GCTAAAGATCCCATTAAAACCGAAGAAGAACTCAGCGATCTGTTTAAAGACAACCTGTCCAAACTCCACCATGCCTTAAT
CTTGTTTGGCCGCTACACCTGCAAGGCTAAAAACCCCTTATGCGGCGCGTGTTTTTTAAAGGAATTTTGCGTTTCTAAAG
CTAGCTTTAAAGCGTAG

Upstream 100 bases:

>100_bases
ATTATTCCATGAAAAAAGCCACGCTTTCGGTTAAAATCAACCGCATTCAAGTGGCTTTAAGATCCCATGAAGCACAATAC
CTTGTCATCAAAGAAAGCGT

Downstream 100 bases:

>100_bases
TGGCTTTATTTGTTATAAAATTTATAGTAAAATTAAGATTTTATAATCAAAGTCAAATCATTCTTGAAAGAGTAGAGTTT
TATGTCAGAAACAGAAGCTA

Product: endonuclease III (nth)

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MKMGLKRAKTHQKAQQIKELLLKHYPNQTTELRHKNPYELLVATILSAQCTDARVNQITPKLFEKYPSVNDLALASLEEV
KEIIKSVSYFNNKSKHLISMAQKVVRDFKGVIPSTQKELMSLDGVGQKTANVVLSVCFDANCIAVDTHVFRATHRLGLSN
AKDPIKTEEELSDLFKDNLSKLHHALILFGRYTCKAKNPLCGACFLKEFCVSKASFKA

Sequences:

>Translated_218_residues
MKMGLKRAKTHQKAQQIKELLLKHYPNQTTELRHKNPYELLVATILSAQCTDARVNQITPKLFEKYPSVNDLALASLEEV
KEIIKSVSYFNNKSKHLISMAQKVVRDFKGVIPSTQKELMSLDGVGQKTANVVLSVCFDANCIAVDTHVFRATHRLGLSN
AKDPIKTEEELSDLFKDNLSKLHHALILFGRYTCKAKNPLCGACFLKEFCVSKASFKA
>Mature_218_residues
MKMGLKRAKTHQKAQQIKELLLKHYPNQTTELRHKNPYELLVATILSAQCTDARVNQITPKLFEKYPSVNDLALASLEEV
KEIIKSVSYFNNKSKHLISMAQKVVRDFKGVIPSTQKELMSLDGVGQKTANVVLSVCFDANCIAVDTHVFRATHRLGLSN
AKDPIKTEEELSDLFKDNLSKLHHALILFGRYTCKAKNPLCGACFLKEFCVSKASFKA

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=187, Percent_Identity=28.3422459893048, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI115298654, Length=187, Percent_Identity=28.3422459893048, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI115298652, Length=187, Percent_Identity=28.3422459893048, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI6912520, Length=187, Percent_Identity=28.3422459893048, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI115298650, Length=187, Percent_Identity=28.3422459893048, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI115298648, Length=187, Percent_Identity=28.3422459893048, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4505471, Length=177, Percent_Identity=27.683615819209, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1787920, Length=202, Percent_Identity=39.6039603960396, Blast_Score=143, Evalue=7e-36,
Organism=Escherichia coli, GI1789331, Length=187, Percent_Identity=26.2032085561497, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17554540, Length=181, Percent_Identity=31.4917127071823, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45550361, Length=179, Percent_Identity=29.0502793296089, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 24508; Mature: 24508

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMGLKRAKTHQKAQQIKELLLKHYPNQTTELRHKNPYELLVATILSAQCTDARVNQITP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCH
KLFEKYPSVNDLALASLEEVKEIIKSVSYFNNKSKHLISMAQKVVRDFKGVIPSTQKELM
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
SLDGVGQKTANVVLSVCFDANCIAVDTHVFRATHRLGLSNAKDPIKTEEELSDLFKDNLS
HHCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
KLHHALILFGRYTCKAKNPLCGACFLKEFCVSKASFKA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKMGLKRAKTHQKAQQIKELLLKHYPNQTTELRHKNPYELLVATILSAQCTDARVNQITP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCH
KLFEKYPSVNDLALASLEEVKEIIKSVSYFNNKSKHLISMAQKVVRDFKGVIPSTQKELM
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
SLDGVGQKTANVVLSVCFDANCIAVDTHVFRATHRLGLSNAKDPIKTEEELSDLFKDNLS
HHCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
KLHHALILFGRYTCKAKNPLCGACFLKEFCVSKASFKA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]