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Identifier: 15645197

GI number: 15645197

Start: 604312

End: 604851

Strand: Reverse

Name: Not Available

Synonym: HP0572

Alternate gene names: 15645197

Gene position: 604851-604312 (Counterclockwise)

Preceding gene: 15645198

Following gene: 15645196

Centisome position: 36.26

GC content: 43.33

Gene sequence:

>540_bases
ATGAATGAAACGCTCAAAGAAGAACTTTTACAAAGCATCAGAGAAGTGAAAGACTACCCTAAAAAAGGGATTTTATTCAA
AGACATTACCACGCTACTCAACTACCCTAAACTCTTTAACAAACTCATTGACACGCTCAAAAAACGCTATCTCGCTCTCA
ATATAGACTTTATCGTGGGCATTGAAGCGAGAGGGTTTATTTTAGGCTCTGCTCTCGCTTATGCGCTTGGGGTGGGTTTT
GTGCCTGTGAGGAAAAAGGGCAAACTCCCCGCACACACCCTATCTCAAAGCTACAGCCTAGAATACGGGAGCGACAGCAT
AGAAATCCACTCCGACGCTTTTAGGGGAATTAAGGGGGTAAGGGTGGTGTTGATTGATGATTTATTAGCCACTGGAGGCA
CAGCTTTAGCGAGCCTTGAGCTTATCAAAGCCCTACAAGCCGAATGCATAGAAGCATGCTTTTTGATAGGGTTAAAAGAA
TTACCGGGTATCCAACTTTTAGAAGAACGCGTGAAAACCTTTTGTTTGTTAGAGTGCTAG

Upstream 100 bases:

>100_bases
TCGTATTAAAGAATTGGAGCAAAAAATAGAAGCTCTCCTTTAAAAACGCTATAATAAATCAAAATTCTACAACCAATCCG
TTATATTAAAGGAAATCAAA

Downstream 100 bases:

>100_bases
AATAAGGGTGAATTTTGGAAGAATACATCATTGACTTATGGAATCAGCATGCAGCGACTTGGGGGTATCTCATTTTATTT
GGGTGGAGTATTTTAGAAGG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MNETLKEELLQSIREVKDYPKKGILFKDITTLLNYPKLFNKLIDTLKKRYLALNIDFIVGIEARGFILGSALAYALGVGF
VPVRKKGKLPAHTLSQSYSLEYGSDSIEIHSDAFRGIKGVRVVLIDDLLATGGTALASLELIKALQAECIEACFLIGLKE
LPGIQLLEERVKTFCLLEC

Sequences:

>Translated_179_residues
MNETLKEELLQSIREVKDYPKKGILFKDITTLLNYPKLFNKLIDTLKKRYLALNIDFIVGIEARGFILGSALAYALGVGF
VPVRKKGKLPAHTLSQSYSLEYGSDSIEIHSDAFRGIKGVRVVLIDDLLATGGTALASLELIKALQAECIEACFLIGLKE
LPGIQLLEERVKTFCLLEC
>Mature_179_residues
MNETLKEELLQSIREVKDYPKKGILFKDITTLLNYPKLFNKLIDTLKKRYLALNIDFIVGIEARGFILGSALAYALGVGF
VPVRKKGKLPAHTLSQSYSLEYGSDSIEIHSDAFRGIKGVRVVLIDDLLATGGTALASLELIKALQAECIEACFLIGLKE
LPGIQLLEERVKTFCLLEC

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=45.6140350877193, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=47.2, Blast_Score=112, Evalue=2e-25,
Organism=Escherichia coli, GI1786675, Length=172, Percent_Identity=50, Blast_Score=166, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17509087, Length=163, Percent_Identity=46.0122699386503, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=174, Percent_Identity=42.5287356321839, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=167, Percent_Identity=38.3233532934132, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136334, Length=166, Percent_Identity=38.5542168674699, Blast_Score=106, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19846; Mature: 19846

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNETLKEELLQSIREVKDYPKKGILFKDITTLLNYPKLFNKLIDTLKKRYLALNIDFIVG
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEE
IEARGFILGSALAYALGVGFVPVRKKGKLPAHTLSQSYSLEYGSDSIEIHSDAFRGIKGV
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEECHHHHCCCCCH
RVVLIDDLLATGGTALASLELIKALQAECIEACFLIGLKELPGIQLLEERVKTFCLLEC
HHHEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNETLKEELLQSIREVKDYPKKGILFKDITTLLNYPKLFNKLIDTLKKRYLALNIDFIVG
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEE
IEARGFILGSALAYALGVGFVPVRKKGKLPAHTLSQSYSLEYGSDSIEIHSDAFRGIKGV
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEECHHHHCCCCCH
RVVLIDDLLATGGTALASLELIKALQAECIEACFLIGLKELPGIQLLEERVKTFCLLEC
HHHEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA