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The map label for this gene is hemC

Identifier: 15644865

GI number: 15644865

Start: 246629

End: 247549

Strand: Reverse

Name: hemC

Synonym: HP0237

Alternate gene names: 15644865

Gene position: 247549-246629 (Counterclockwise)

Preceding gene: 15644866

Following gene: 15644864

Centisome position: 14.84

GC content: 43.11

Gene sequence:

>921_bases
GTGGGAAATTTAGTGATTGGCTCTAGGGGGAGCGAATTAGCCTTATGGCAAGCGAATCACATTAAAGAACGCCTGAAAAA
AGAATGCTTGATAGAAAGCGAAATTCAAATCGTTAAGACTAAGGGCGATAAAATCTTAGACACCCCTTTAAATAAGATCG
GCGGTAAGGGGCTATTCACTAAGGAATTAGAAGAATTGCTTTTAAAGGGCGCAATTGATTTGGCGGTGCATTCTTTAAAA
GACGTGCCGGTCGTGTTTGAAAAGGGGTTAGACTTGGCATGCATCACCAAAAGGGCTGATGTGAGGGACACTTTTTTAAG
CGTGAAATTCCCTGATTTGATGAGTTTGCCTAAAGGGGCAAAGGTTGGCACGACTTCTTTAAGGCGCTCTATGCAGATCA
AATTAAAGCGCCAGGATTTGGACACAGAAAGCTTGAGAGGGAATGTCCAAACCCGTTTGAAAAAGCTTGAATGCGGAGAA
TTTGACGCTATCATTTTAGCTGAAGCCGGGTTGTGCCGCCTAGAAATTCAAGGAGCGAAATACCGCAAGGCTTTTAGCGT
AGAAGAAATGATTCCTAGCATGGGTCAGGGGGCTTTAGGGGTAGAAATGCTCAAAAACCACAAGCATTTTGCCACGCTTC
AAAAACTCAACGACGAGAAAAGCGCGTTTTGCTGCCGTTTAGAAAGGGAGTTTATCAAGGGGCTTAATGGAGGGTGTCAG
ATCCCTATAGGCGTGCATGCGAGTTTAATGGGCGATAGGGTTAAAATCCAGGCGGTTTTAGGCTTGCCTAACGGGAAAGA
AGTCATTACTAAAGAAAAACAAGGGGATAAAACTAAAGCGTTTGATTTAGTTCAAGAGCTTTTAGAAGAATTTTTGCAAA
GCGGGGCTAAAGAGATTTTAGAAAAGGCGCAGTTGTTTTAA

Upstream 100 bases:

>100_bases
GAATGCATCAAACGCGCTAATTTGGAAAAACAAACGATTAAAGACATTGAATTAGAAGAAAAAATTTTAGAAATGTTAGA
AAGCGAATAAGGGGGAGTGA

Downstream 100 bases:

>100_bases
TGCGTTTGTTTATCGCGCTAGTTTTGTTTTGGTGGTGGTTAAGCTTGAACGCTAAAGAAGCGGATTTTATCTCTGATTTA
GAATACGGGATGGCTCTTTA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MGNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGAIDLAVHSLK
DVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGE
FDAIILAEAGLCRLEIQGAKYRKAFSVEEMIPSMGQGALGVEMLKNHKHFATLQKLNDEKSAFCCRLEREFIKGLNGGCQ
IPIGVHASLMGDRVKIQAVLGLPNGKEVITKEKQGDKTKAFDLVQELLEEFLQSGAKEILEKAQLF

Sequences:

>Translated_306_residues
MGNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGAIDLAVHSLK
DVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGE
FDAIILAEAGLCRLEIQGAKYRKAFSVEEMIPSMGQGALGVEMLKNHKHFATLQKLNDEKSAFCCRLEREFIKGLNGGCQ
IPIGVHASLMGDRVKIQAVLGLPNGKEVITKEKQGDKTKAFDLVQELLEEFLQSGAKEILEKAQLF
>Mature_305_residues
GNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGAIDLAVHSLKD
VPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGEF
DAIILAEAGLCRLEIQGAKYRKAFSVEEMIPSMGQGALGVEMLKNHKHFATLQKLNDEKSAFCCRLEREFIKGLNGGCQI
PIGVHASLMGDRVKIQAVLGLPNGKEVITKEKQGDKTKAFDLVQELLEEFLQSGAKEILEKAQLF

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=250, Percent_Identity=42.8, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI66933009, Length=250, Percent_Identity=42.8, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI48994974, Length=300, Percent_Identity=46.6666666666667, Blast_Score=249, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=37.0716510903427, Blast_Score=169, Evalue=4e-43,
Organism=Drosophila melanogaster, GI20130425, Length=256, Percent_Identity=40.234375, Blast_Score=167, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33940; Mature: 33809

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFT
CCCEEECCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCEEHHCCHHHHCCCCCCH
KELEELLLKGAIDLAVHSLKDVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGA
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCCCHHHHHEEEECCHHHCCCCCC
KVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGEFDAIILAEAGLCRLEIQGAK
CCCHHHHHHHHHEEEHHCCCCHHHHCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCH
YRKAFSVEEMIPSMGQGALGVEMLKNHKHFATLQKLNDEKSAFCCRLEREFIKGLNGGCQ
HHHHCCHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEE
IPIGVHASLMGDRVKIQAVLGLPNGKEVITKEKQGDKTKAFDLVQELLEEFLQSGAKEIL
EEECCHHHHCCCEEEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKAQLF
HHHCCC
>Mature Secondary Structure 
GNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFT
CCEEECCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCEEHHCCHHHHCCCCCCH
KELEELLLKGAIDLAVHSLKDVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGA
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCCCHHHHHEEEECCHHHCCCCCC
KVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGEFDAIILAEAGLCRLEIQGAK
CCCHHHHHHHHHEEEHHCCCCHHHHCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCH
YRKAFSVEEMIPSMGQGALGVEMLKNHKHFATLQKLNDEKSAFCCRLEREFIKGLNGGCQ
HHHHCCHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEE
IPIGVHASLMGDRVKIQAVLGLPNGKEVITKEKQGDKTKAFDLVQELLEEFLQSGAKEIL
EEECCHHHHCCCEEEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKAQLF
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA