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Identifier: 15644821

GI number: 15644821

Start: 197856

End: 200000

Strand: Reverse

Name: Not Available

Synonym: HP0192

Alternate gene names: 15644821

Gene position: 200000-197856 (Counterclockwise)

Preceding gene: 15644822

Following gene: 15644820

Centisome position: 11.99

GC content: 45.97

Gene sequence:

>2145_bases
ATGAAAATAACATATTGTGATGCGCTAATTATTGGAGGCGGACTAGCTGGGTTAAGGGCTAGTATCGCATGCAAACAAAA
GGGTTTAAACACCATCGTTTTAAGCCTAGTGCCTGTCAGGCGTTCGCACTCTGCAGCCGCTCAAGGGGGCATGCAAGCGA
GCCTTGCGAACGCTAAAAAAAGCGAGGGCGATAATGAAGATTTACACTTTTTAGACACGGTTAAGGGGAGCGATTGGGGG
TGCGATCAGCAAGTGGCTAGGATGTTTGTAACCACTGCTCCTAAAGCCATTAGGGAATTGGCCAGTTGGGGGGTGCCTTG
GACTAGGATTAAAAAGGGCGATAGGCCTGCGGTCGTCAATGGTGAGCATGTAACTATCACTGAAAGAGACGACAGGCATG
GTTATATCTTAAGCCGTGATTTTGGCGGCACTAAAAAATGGCGCACATGCTTTACGGCTGATGCCACAGGGCATACCATG
CTTTATGCGGTCGCTAATGAAGCCTTACACCACAAAGTGGATATTCAAGACAGAAAGGACATGCTCGCTTTCATTCATCA
TGATAATAAATGCTATGGGGCGGTGGTAAGGGATTTGATCACAGGCGAAATTTCAGCGTATGTTTCTAAAGGCACGCTTT
TAGCTACCGGAGGTTATGGGCGCGTGTATAAACACACCACTAACGCTGTGATTTGCGATGGAGCCGGGGCTGCAAGCGCC
TTAGAAACCGGCGTGGCTAAATTGGGCAACATGGAAGCGGTGCAATTCCACCCTACCGCTTTAGTGCCAAGCGGGATTTT
AATGACCGAAGGTTGCAGGGGCGATGGCGGTGTTTTAAGAGACAAGTTTGGCAGACGCTTCATGCCCGCTTATGAGCCGG
AGAAAAAAGAGCTTGCAAGCAGAGATGTGGTCTCAAGGCGGATTTTAGAGCATATCCAAAAAGGCTATGGAGCCAAATCG
CCTTATGGGGATCATGTGTGGCTGGATATTGCTATTTTAGGGCGTAACCATGTGGAAAAAAACTTAAGGGATGTGCGCGA
TATAGCCATGACTTTTGCGGGCATTGATCCGGCTGATAGCAAGGAACAAACCAAAGACAACATGCAAGGAGTGCCCGCAA
ATGAGCCTGAATACGGGCAAGCGATGGCCAAGCAAAAAGGCTGGATCCCCATAAAACCCATGCAACACTATTCTATGGGT
GGGGTTAGGACAAACCCTAAAGGCGAAACCCATTTAAAAGGCTTGTTTTGCGCGGGTGAAGCGGCATGCTGGGATTTGCA
TGGGTTTAACCGCTTGGGGGGTAATTCTGTGAGTGAAGCGGTGGTCGCTGGCATGATCATTGGGGATTATTTTGCCTCGC
ATTGTTTAGAAGCGCAAATTGAAATCAACACGCAAAAAGTTGAAGCTTTCATTAAAGAAAGCCAAGACTATATGCATTTT
TTATTGCATAATGAAGGCAAAGAAGATGTGTATGAAATTAGAGAGCGCATGAAAGAAGTCATGGATGAAAAAGTGGGCGT
TTTTAGAGAAGGCAAAAGGCTAGAAGAAGCCCTTAAAGAATTGCAAGAGCTTTATGCACGCTCCAAAAACATTTGCGTGA
AAAACAAGGTTTTACACAATAACCCTGAATTAGAAGACGCTTACCGCACCAAAAAAATGCTCAAACTCGCGCTTTGTATC
ACTCAAGGAGCGTTACTGCGCACTGAAAGCAGAGGGGCTCACACAAGGATTGACTACCCTAAAAGAGACGATGAAAAATG
GCTTAATCGGACTCTAGCGAGCTGGCCTAGCGCTGAGCAAGACATGCCCACGATTGAATACGAAGAATTAGATGTGATGA
AAATGGAAATCAGCCCTGATTTTAGGGGCTATGGCAAAAAGGGTAATTTCATCCCCCACCCCAAAAAAGAAGAGCGCGAC
GCTGAGATTTTGAAAACGATTTTAGAACTAGAAAAGCTTGGAAAAGACAGAATAGAAGTCCAACATGCGCTCATGCCTTT
TGAATTGCAAGAAAAATACAAGGCTAGGAATATGCGTTTAGAAGATGAGGAAGTCAGGGCTAGGGGGGAACATTTGTATT
CTTTCAATGTCCATGAGTTATTGGACCAACACAACGCTAACCTAAAAGGAGAACACCATGAGTGA

Upstream 100 bases:

>100_bases
TTACATTAAAAAAGGTTTAGAAAATAAGGAAAATGGCATTAAAACCATGCAAGAAGCCATAGAAGCTGATGGGAAATTCC
ACAAAGAATAAGGGTAGAAA

Downstream 100 bases:

>100_bases
TAATGAACGAACGATTGTAGTTAGAGTGCTAAAATTTGACCCTCAAAGCGCGGTGAGTAAGCCGCATTTTAAAGAGTATC
AGTTGAAAGAAACGCCATCC

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKKSEGDNEDLHFLDTVKGSDWG
CDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVNGEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTM
LYAVANEALHHKVDIQDRKDMLAFIHHDNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELASRDVVSRRILEHIQKGYGAKS
PYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADSKEQTKDNMQGVPANEPEYGQAMAKQKGWIPIKPMQHYSMG
GVRTNPKGETHLKGLFCAGEAACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKRLEEALKELQELYARSKNICVKNKVLHNNPELEDAYRTKKMLKLALCI
TQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQDMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERD
AEILKTILELEKLGKDRIEVQHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHELLDQHNANLKGEHHE

Sequences:

>Translated_714_residues
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKKSEGDNEDLHFLDTVKGSDWG
CDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVNGEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTM
LYAVANEALHHKVDIQDRKDMLAFIHHDNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELASRDVVSRRILEHIQKGYGAKS
PYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADSKEQTKDNMQGVPANEPEYGQAMAKQKGWIPIKPMQHYSMG
GVRTNPKGETHLKGLFCAGEAACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKRLEEALKELQELYARSKNICVKNKVLHNNPELEDAYRTKKMLKLALCI
TQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQDMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERD
AEILKTILELEKLGKDRIEVQHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHELLDQHNANLKGEHHE
>Mature_714_residues
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKKSEGDNEDLHFLDTVKGSDWG
CDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVNGEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTM
LYAVANEALHHKVDIQDRKDMLAFIHHDNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELASRDVVSRRILEHIQKGYGAKS
PYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADSKEQTKDNMQGVPANEPEYGQAMAKQKGWIPIKPMQHYSMG
GVRTNPKGETHLKGLFCAGEAACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKRLEEALKELQELYARSKNICVKNKVLHNNPELEDAYRTKKMLKLALCI
TQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQDMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERD
AEILKTILELEKLGKDRIEVQHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHELLDQHNANLKGEHHE

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=578, Percent_Identity=33.5640138408304, Blast_Score=280, Evalue=4e-75,
Organism=Escherichia coli, GI1786942, Length=600, Percent_Identity=35.6666666666667, Blast_Score=305, Evalue=7e-84,
Organism=Escherichia coli, GI1790597, Length=613, Percent_Identity=34.257748776509, Blast_Score=296, Evalue=4e-81,
Organism=Escherichia coli, GI1788928, Length=588, Percent_Identity=29.5918367346939, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17505833, Length=579, Percent_Identity=35.2331606217617, Blast_Score=295, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI17550100, Length=573, Percent_Identity=35.0785340314136, Blast_Score=291, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71986328, Length=483, Percent_Identity=24.0165631469979, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6322701, Length=644, Percent_Identity=33.3850931677019, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322416, Length=618, Percent_Identity=32.5242718446602, Blast_Score=281, Evalue=2e-76,
Organism=Drosophila melanogaster, GI17137288, Length=664, Percent_Identity=32.9819277108434, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24655642, Length=664, Percent_Identity=32.9819277108434, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24655647, Length=664, Percent_Identity=32.9819277108434, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24663005, Length=595, Percent_Identity=33.109243697479, Blast_Score=257, Evalue=2e-68,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 80122; Mature: 80122

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKK
CEEEEEEHEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCHHHHHHHHC
SEGDNEDLHFLDTVKGSDWGCDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVN
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCCCEEC
GEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTMLYAVANEALHHKVDIQDRKD
CCEEEEEECCCCCCEEEECCCCCCCHHCEEEEECCCCCEEEHHHHHHHHHCCCCCCCHHH
MLAFIHHDNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
HEEHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCEEEECCCCHHHH
LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELAS
HHHHHHHHCCCCEEEECCCEECCCCCEEECCCCCCCCCHHHHHCCCCCCCCCCHHHHHHH
RDVVSRRILEHIQKGYGAKSPYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADS
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
KEQTKDNMQGVPANEPEYGQAMAKQKGWIPIKPMQHYSMGGVRTNPKGETHLKGLFCAGE
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCHHCEEEECCC
AACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
CCEEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHH
LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKRLEEALKELQELYARSKNICVKNKVLHN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCEECC
NPELEDAYRTKKMLKLALCITQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQ
CCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
DMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERDAEILKTILELEKLGKDRIEV
CCCCCEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
QHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHELLDQHNANLKGEHHE
HHHHCCHHHHHHHHHHCCCCCHHHHHHCCCEEEECCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKK
CEEEEEEHEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCHHHHHHHHC
SEGDNEDLHFLDTVKGSDWGCDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVN
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCCCEEC
GEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTMLYAVANEALHHKVDIQDRKD
CCEEEEEECCCCCCEEEECCCCCCCHHCEEEEECCCCCEEEHHHHHHHHHCCCCCCCHHH
MLAFIHHDNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
HEEHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCEEEECCCCHHHH
LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELAS
HHHHHHHHCCCCEEEECCCEECCCCCEEECCCCCCCCCHHHHHCCCCCCCCCCHHHHHHH
RDVVSRRILEHIQKGYGAKSPYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADS
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
KEQTKDNMQGVPANEPEYGQAMAKQKGWIPIKPMQHYSMGGVRTNPKGETHLKGLFCAGE
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCHHCEEEECCC
AACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
CCEEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHH
LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKRLEEALKELQELYARSKNICVKNKVLHN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCEECC
NPELEDAYRTKKMLKLALCITQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQ
CCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
DMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERDAEILKTILELEKLGKDRIEV
CCCCCEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
QHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHELLDQHNANLKGEHHE
HHHHCCHHHHHHHHHHCCCCCHHHHHHCCCEEEECCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]