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Identifier: 15644801

GI number: 15644801

Start: 178712

End: 179887

Strand: Reverse

Name: Not Available

Synonym: HP0172

Alternate gene names: 15644801

Gene position: 179887-178712 (Counterclockwise)

Preceding gene: 15644802

Following gene: 15644800

Centisome position: 10.79

GC content: 37.93

Gene sequence:

>1176_bases
ATGATTAGTTTTAAAGAAGCTCTAAAAATCCATTCTAGCATTCCCATAAAACCCTTAGAAATAGAGGTTATCTCTTTGTT
TGAAAGCATAGGGCGTATTTTAGCAGAGGATATTATTTGTATTCACGCCTTGCCTAAATTCAATCAAAGCGCAATGGATG
GCTATGGGTTTAAAATGCAGGATTTAGGCAAAAAAACTCAAGTCGTTCAGCGCATCTTTGCCGGGGATGATGTGAGCGCT
TTAGAAGTTAAAGAGAATGAATGCGTTAAAATCATGACTGGAGCGATGGTGCCAAAGGGAATAGAAACGATTGTCCCTAT
AGAATGCATGCTAGAAAGCCATACAAATTTCGCTCTAGCTCCCAAAGATTTTAAAATAAACGCCAATATCCGTCAAAAGG
GCGAAAACGCTTCTTTAAACAGCGTGTTAGTCCCTAAAAATACCCGTTTGAATTACGGGCATATCGCGCTCATTGCCTCT
CAAGGGTTAAAAGAAATCAAAGCGTTCAGGAAATTAAAAATCGCTTTATTTAGCAGCGGCGATGAATTAGTGCCTTTAGG
GCAAAACGCCCTAGAATGCCAAGTTTATGATGTGAATTCAGTGGGTATTTTCAACATGCTTAAAAACTACAACACGCATT
TTCTAGGGGTTTTAAAAGACGATAAAAATTTACAGCTTAAAATACTTGAATCACAAGACTATGATGTCATCCTTTCAAGC
GCAGGGGTGAGTGTGGGGGATAAAGACTTTTTTAAAGACGCTTTGAAAGAAAAAAACGCCCTTTTTTATTATGAAAAAGT
CAATCTCAAACCTGGAAAACCGGTAACTTTAGCCCGACTCAATCAAAGTATGATTATAGGCTTACCGGGTAATCCTTTAA
GTTGCTTATTGGTTTTACGGGTTTTGATTTTACCCTTATTGGAGCGCTTATCCTTGAATAAAGATTTTAAACTAAAACCC
TTTAAGGCTCAAATCAATGCCCCTTTAAAGCTTAAAGGCGAACGTGCGCATTTAATTTTAGGCAACTATTCAAACCACCA
ATTCATTCCTTACAACAACAACCGCTATGACTCAGGAGCGATTCAAGCCCTTGCGCGAGTGGATTCTATCGCTTTGATTG
ATGAAGGAGTTAGATTAGTTCAGGGCGAAATTGAAATTTTAAGGTTTGAAAATTAA

Upstream 100 bases:

>100_bases
TGTGGGCATTATCTTAATCGCTTCGGCTATCATGGGGCGTTTTAAAGAAGAAATCAGCCTGGCCTTTAGCGCCATTAGCA
AAATCTTTTAAAGGATAAAC

Downstream 100 bases:

>100_bases
AATGGCTTTTAACAATGCTATAATGATAAGTTCAAAACCCCACTCATAAAGGTTCTGTTTGTGGATAACTACACCTATAG
CGAATTGTTAAAAAGCTTGC

Product: molybdopterin biosynthesis protein (moeA)

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MISFKEALKIHSSIPIKPLEIEVISLFESIGRILAEDIICIHALPKFNQSAMDGYGFKMQDLGKKTQVVQRIFAGDDVSA
LEVKENECVKIMTGAMVPKGIETIVPIECMLESHTNFALAPKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIAS
QGLKEIKAFRKLKIALFSSGDELVPLGQNALECQVYDVNSVGIFNMLKNYNTHFLGVLKDDKNLQLKILESQDYDVILSS
AGVSVGDKDFFKDALKEKNALFYYEKVNLKPGKPVTLARLNQSMIIGLPGNPLSCLLVLRVLILPLLERLSLNKDFKLKP
FKAQINAPLKLKGERAHLILGNYSNHQFIPYNNNRYDSGAIQALARVDSIALIDEGVRLVQGEIEILRFEN

Sequences:

>Translated_391_residues
MISFKEALKIHSSIPIKPLEIEVISLFESIGRILAEDIICIHALPKFNQSAMDGYGFKMQDLGKKTQVVQRIFAGDDVSA
LEVKENECVKIMTGAMVPKGIETIVPIECMLESHTNFALAPKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIAS
QGLKEIKAFRKLKIALFSSGDELVPLGQNALECQVYDVNSVGIFNMLKNYNTHFLGVLKDDKNLQLKILESQDYDVILSS
AGVSVGDKDFFKDALKEKNALFYYEKVNLKPGKPVTLARLNQSMIIGLPGNPLSCLLVLRVLILPLLERLSLNKDFKLKP
FKAQINAPLKLKGERAHLILGNYSNHQFIPYNNNRYDSGAIQALARVDSIALIDEGVRLVQGEIEILRFEN
>Mature_391_residues
MISFKEALKIHSSIPIKPLEIEVISLFESIGRILAEDIICIHALPKFNQSAMDGYGFKMQDLGKKTQVVQRIFAGDDVSA
LEVKENECVKIMTGAMVPKGIETIVPIECMLESHTNFALAPKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIAS
QGLKEIKAFRKLKIALFSSGDELVPLGQNALECQVYDVNSVGIFNMLKNYNTHFLGVLKDDKNLQLKILESQDYDVILSS
AGVSVGDKDFFKDALKEKNALFYYEKVNLKPGKPVTLARLNQSMIIGLPGNPLSCLLVLRVLILPLLERLSLNKDFKLKP
FKAQINAPLKLKGERAHLILGNYSNHQFIPYNNNRYDSGAIQALARVDSIALIDEGVRLVQGEIEILRFEN

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=350, Percent_Identity=25.7142857142857, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI10880983, Length=350, Percent_Identity=25.7142857142857, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1787049, Length=324, Percent_Identity=36.4197530864198, Blast_Score=202, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI25147659, Length=354, Percent_Identity=25.7062146892655, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17562606, Length=322, Percent_Identity=24.223602484472, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136978, Length=279, Percent_Identity=30.1075268817204, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24638841, Length=279, Percent_Identity=30.1075268817204, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43593; Mature: 43593

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISFKEALKIHSSIPIKPLEIEVISLFESIGRILAEDIICIHALPKFNQSAMDGYGFKMQ
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHH
DLGKKTQVVQRIFAGDDVSALEVKENECVKIMTGAMVPKGIETIVPIECMLESHTNFALA
HCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCCCEECHHHEECCCCCEEEC
PKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIASQGLKEIKAFRKLKIALFSSG
CCCEEEECCHHCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHEEEEEECCC
DELVPLGQNALECQVYDVNSVGIFNMLKNYNTHFLGVLKDDKNLQLKILESQDYDVILSS
CCEEECCCCCEEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEEEEC
AGVSVGDKDFFKDALKEKNALFYYEKVNLKPGKPVTLARLNQSMIIGLPGNPLSCLLVLR
CCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCHHHHHHHHH
VLILPLLERLSLNKDFKLKPFKAQINAPLKLKGERAHLILGNYSNHQFIPYNNNRYDSGA
HHHHHHHHHHCCCCCCEECCCHHCCCCCEEECCCEEEEEEECCCCCEEECCCCCCCCHHH
IQALARVDSIALIDEGVRLVQGEIEILRFEN
HHHHHHHHHHEEHHHCHHEEECCEEEEEECC
>Mature Secondary Structure
MISFKEALKIHSSIPIKPLEIEVISLFESIGRILAEDIICIHALPKFNQSAMDGYGFKMQ
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHH
DLGKKTQVVQRIFAGDDVSALEVKENECVKIMTGAMVPKGIETIVPIECMLESHTNFALA
HCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCCCEECHHHEECCCCCEEEC
PKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIASQGLKEIKAFRKLKIALFSSG
CCCEEEECCHHCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHEEEEEECCC
DELVPLGQNALECQVYDVNSVGIFNMLKNYNTHFLGVLKDDKNLQLKILESQDYDVILSS
CCEEECCCCCEEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEEEEC
AGVSVGDKDFFKDALKEKNALFYYEKVNLKPGKPVTLARLNQSMIIGLPGNPLSCLLVLR
CCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCHHHHHHHHH
VLILPLLERLSLNKDFKLKPFKAQINAPLKLKGERAHLILGNYSNHQFIPYNNNRYDSGA
HHHHHHHHHHCCCCCCEECCCHHCCCCCEEECCCEEEEEEECCCCCEEECCCCCCCCHHH
IQALARVDSIALIDEGVRLVQGEIEILRFEN
HHHHHHHHHHEEHHHCHHEEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]