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Identifier: 15644792

GI number: 15644792

Start: 171427

End: 172398

Strand: Reverse

Name: Not Available

Synonym: HP0163

Alternate gene names: 15644792

Gene position: 172398-171427 (Counterclockwise)

Preceding gene: 15644793

Following gene: 15644791

Centisome position: 10.34

GC content: 39.92

Gene sequence:

>972_bases
ATGTTCAAACGATTGAGAAGATTACGAAGCAGCGAAAACTTAAGGGCAATGCTAAGAGAAACGCGTCTAAATATTGATGA
TTTCATCGCTCCCTTATTTGTCATAGAAAGCGATAGTTGTATTAAAAATGAAATCAGTTCCATGCCTGGCGTTTATCAAA
TGAGCATGGAGCCTCTTTTAAAAGAATGCGAAGAATTAGTGGGTTTAGGCGTCAAAGCCGTTTTATTGTTTGGCATTCCT
AAACATAAGGACGCTACAGGAAGCCATGCGTTAAACAAGGATCATATTGTCGCAAAAGCCGCCAAAGAGATTAAAAAACG
ATTCAAGGATTTAATCGTTATAGCGGATTTGTGTTTTTGTGAATACACCGACCATGGGCATTGCGGGATTTTAGAAAACG
CTTCTGTGTCTAACGATAAAACGCTAGAGATTTTAAATCTTCAAGGGCTTATTTTAGCTGAAAGCGGTGTGGATATTCTA
GCCCCAAGCAACATGATGGATGGCAATGTTTTAAGCTTGAGGAAAACGCTAGATAACGCCGGCTATACCCACACGCCCAT
CATGAGCTATTCCACTAAATTTGCGAGCAGTTACTATGGGCCTTTTAGAGATGTAGCCAATTCTGCGCCGAGTTTTGGCG
ATCGCAAAAGCTATCAAATGGATTACGCTAATCAAAAAGAAGCGCTTTTAGAAAGTTTAGAAGATGAGAAACAGGGCGCG
GATATTTTAATGGTGAAACCGGCTTTGGCGTATTTGGATATTGTTAAAGAAATTAGAGATCACACTTTGCTCCCTTTAGC
GCTCTATAATGTGAGCGGGGAATACGCCATGCTCAAACTCGCTCAAAAACACAACCTGATCAACTATGAAAGCGTTTTAT
TGGAAACGATGACTTGTTTTAAAAGAGCGGGAGCGGATATGATTATTAGCTATCATGCTAAAGAAGTGGCTAACTTATTA
CAAAGGAATTGA

Upstream 100 bases:

>100_bases
AGCTACCCCCCCCCCCCCCGAAAATTTGAGAGAAGTGAGCGGAATGAAGGGGATAGAAAAAGCCAATTGTGGGGTTAAAG
AAAAACAATAAAGAGAGAAC

Downstream 100 bases:

>100_bases
ATGGGACGAGCGTTTGAATACAGAAGAGCGGCTAAAGAAAAACGATGGGATAAGATGAGTAAGGTTTTCCCAAAGCTCGC
TAAAGCGATCACTCTAGCGG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MFKRLRRLRSSENLRAMLRETRLNIDDFIAPLFVIESDSCIKNEISSMPGVYQMSMEPLLKECEELVGLGVKAVLLFGIP
KHKDATGSHALNKDHIVAKAAKEIKKRFKDLIVIADLCFCEYTDHGHCGILENASVSNDKTLEILNLQGLILAESGVDIL
APSNMMDGNVLSLRKTLDNAGYTHTPIMSYSTKFASSYYGPFRDVANSAPSFGDRKSYQMDYANQKEALLESLEDEKQGA
DILMVKPALAYLDIVKEIRDHTLLPLALYNVSGEYAMLKLAQKHNLINYESVLLETMTCFKRAGADMIISYHAKEVANLL
QRN

Sequences:

>Translated_323_residues
MFKRLRRLRSSENLRAMLRETRLNIDDFIAPLFVIESDSCIKNEISSMPGVYQMSMEPLLKECEELVGLGVKAVLLFGIP
KHKDATGSHALNKDHIVAKAAKEIKKRFKDLIVIADLCFCEYTDHGHCGILENASVSNDKTLEILNLQGLILAESGVDIL
APSNMMDGNVLSLRKTLDNAGYTHTPIMSYSTKFASSYYGPFRDVANSAPSFGDRKSYQMDYANQKEALLESLEDEKQGA
DILMVKPALAYLDIVKEIRDHTLLPLALYNVSGEYAMLKLAQKHNLINYESVLLETMTCFKRAGADMIISYHAKEVANLL
QRN
>Mature_323_residues
MFKRLRRLRSSENLRAMLRETRLNIDDFIAPLFVIESDSCIKNEISSMPGVYQMSMEPLLKECEELVGLGVKAVLLFGIP
KHKDATGSHALNKDHIVAKAAKEIKKRFKDLIVIADLCFCEYTDHGHCGILENASVSNDKTLEILNLQGLILAESGVDIL
APSNMMDGNVLSLRKTLDNAGYTHTPIMSYSTKFASSYYGPFRDVANSAPSFGDRKSYQMDYANQKEALLESLEDEKQGA
DILMVKPALAYLDIVKEIRDHTLLPLALYNVSGEYAMLKLAQKHNLINYESVLLETMTCFKRAGADMIISYHAKEVANLL
QRN

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=306, Percent_Identity=41.5032679738562, Blast_Score=243, Evalue=2e-64,
Organism=Escherichia coli, GI87081728, Length=318, Percent_Identity=50.9433962264151, Blast_Score=315, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6321398, Length=313, Percent_Identity=37.0607028753994, Blast_Score=206, Evalue=3e-54,
Organism=Drosophila melanogaster, GI21358291, Length=302, Percent_Identity=36.7549668874172, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36203; Mature: 36203

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKRLRRLRSSENLRAMLRETRLNIDDFIAPLFVIESDSCIKNEISSMPGVYQMSMEPLL
CHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHEEECCCHHHHHHHHHCCCEEHHHHHHHH
KECEELVGLGVKAVLLFGIPKHKDATGSHALNKDHIVAKAAKEIKKRFKDLIVIADLCFC
HHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYTDHGHCGILENASVSNDKTLEILNLQGLILAESGVDILAPSNMMDGNVLSLRKTLDNA
CCCCCCCCCEECCCCCCCCCEEEEEECCEEEEECCCCCEECCCCCCCCHHHHHHHHHHCC
GYTHTPIMSYSTKFASSYYGPFRDVANSAPSFGDRKSYQMDYANQKEALLESLEDEKQGA
CCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
DILMVKPALAYLDIVKEIRDHTLLPLALYNVSGEYAMLKLAQKHNLINYESVLLETMTCF
CEEEECHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
KRAGADMIISYHAKEVANLLQRN
HHCCCHHEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MFKRLRRLRSSENLRAMLRETRLNIDDFIAPLFVIESDSCIKNEISSMPGVYQMSMEPLL
CHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHEEECCCHHHHHHHHHCCCEEHHHHHHHH
KECEELVGLGVKAVLLFGIPKHKDATGSHALNKDHIVAKAAKEIKKRFKDLIVIADLCFC
HHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYTDHGHCGILENASVSNDKTLEILNLQGLILAESGVDILAPSNMMDGNVLSLRKTLDNA
CCCCCCCCCEECCCCCCCCCEEEEEECCEEEEECCCCCEECCCCCCCCHHHHHHHHHHCC
GYTHTPIMSYSTKFASSYYGPFRDVANSAPSFGDRKSYQMDYANQKEALLESLEDEKQGA
CCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
DILMVKPALAYLDIVKEIRDHTLLPLALYNVSGEYAMLKLAQKHNLINYESVLLETMTCF
CEEEECHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
KRAGADMIISYHAKEVANLLQRN
HHCCCHHEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]