Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15644701

GI number: 15644701

Start: 74747

End: 75334

Strand: Reverse

Name: Not Available

Synonym: HP0071

Alternate gene names: 15644701

Gene position: 75334-74747 (Counterclockwise)

Preceding gene: 15644702

Following gene: 15644700

Centisome position: 4.52

GC content: 43.54

Gene sequence:

>588_bases
ATGCTAGGACTTGTATTGTTATATGTTGGGATTGTTTTAATCAGCAATGGGATTTGCGGGTTAACCAAAGTCGATCCTAA
AAGCACTGCGGTGATGAACTTTTTTGTGGGCGGACTTTCCATTATTTGTAATATAGTTGTCATCACTTATTCTGCACTCC
ACCCTACAGCCCCTGTAGAAGGTGCTGAAGATATTGCTCAAGTATCGCACCATTTGACTAGTTTCTATGGACCAGCGACT
GGGTTATTGTTTGGTTTCACCTACTTGTATGCGGCTATCAACCACACTTTTGGTTTGGATTGGAGGCCCTACTCTTGGTA
TAGCTTATTCGTAGCGATCAACACGATTCCTGCTGCGATTTTATCCCACTATAGCGATATGCTTGATGACCACAAAGTGT
TAGGCATCACTGAAGGCGATTGGTGGGCGATCATTTGGTTGGCTTGGGGTGTTTTGTGGCTTACCGCTTTCATTGAAAAC
ATCTTGAAAATCCCTTTAGGGAAATTCACTCCATGGCTTGCTATCATTGAGGGTATTTTAACCGCTTGGATCCCTGCTTG
GTTGCTCTTTATCCAACACTGGGTGTGA

Upstream 100 bases:

>100_bases
TTTTGTCAATTTACTATTTTTCTTTATGATTAGCTCAAGCAACAAAAGTTATTCGTAAGGTGCGTTTGTTGTAAAAATTT
TTGTTTGGAAGGAAAAGGCA

Downstream 100 bases:

>100_bases
GATGATCATAGAGCGTTTAGTTGGCAATCTAAGGGATTTAAACCCCTTGGATTTCAGCGTGGATCATGTGGATTTGGAAT
GGTTTGAAACGAGGAAAAAA

Product: urease accessory protein UreI

Products: NA

Alternate protein names: Urease accessory protein ureI [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIICNIVVITYSALHPTAPVEGAEDIAQVSHHLTSFYGPAT
GLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTIPAAILSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIEN
ILKIPLGKFTPWLAIIEGILTAWIPAWLLFIQHWV

Sequences:

>Translated_195_residues
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIICNIVVITYSALHPTAPVEGAEDIAQVSHHLTSFYGPAT
GLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTIPAAILSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIEN
ILKIPLGKFTPWLAIIEGILTAWIPAWLLFIQHWV
>Mature_195_residues
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIICNIVVITYSALHPTAPVEGAEDIAQVSHHLTSFYGPAT
GLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTIPAAILSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIEN
ILKIPLGKFTPWLAIIEGILTAWIPAWLLFIQHWV

Specific function: Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AmiS/UreI family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003211 [H]

Pfam domain/function: PF02293 AmiS_UreI [H]

EC number: NA

Molecular weight: Translated: 21706; Mature: 21706

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIICNIVVITYSALHPTAPVE
CHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GAEDIAQVSHHLTSFYGPATGLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTIPAAI
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIENILKIPLGKFTPWLAIIEGIL
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
TAWIPAWLLFIQHWV
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIICNIVVITYSALHPTAPVE
CHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GAEDIAQVSHHLTSFYGPATGLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTIPAAI
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIENILKIPLGKFTPWLAIIEGIL
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
TAWIPAWLLFIQHWV
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]