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The map label for this gene is guaB_2

Identifier: 15618983

GI number: 15618983

Start: 213238

End: 213501

Strand: Reverse

Name: guaB_2

Synonym: CPn0172a

Alternate gene names: 15618983

Gene position: 213501-213238 (Counterclockwise)

Preceding gene: 15618097

Following gene: 15618096

Centisome position: 17.35

GC content: 37.5

Gene sequence:

>264_bases
ATGGAAGAAGCCTTAACTTTTGATGATGTTCTTTTAATCCCCCAATATTCTGAAATACTTCCTTCTGAAGTGTCCTTGAA
AACGGCCATTTCAAAAACCCTCTCTCTAAATATACCGATTCTTTCAGCTGCTATGGATTCTGTCACAGAAACAGCCATGG
CACTAGCTTTAGCTCAAGAAGGTGGTTTGGGAATCTTACATAAAAATATGAGCGAAGTAGAACAAAGCTCATCTGTGAGA
AAAATTAAAGAAGCCTATCCTTAA

Upstream 100 bases:

>100_bases
CTTCTTAAGATTCGAAGGAATGTCACGAATCATGAAAAAAGCATTGACAGTATAGCAGGGGATCATTGACTATCCTTTAA
AGTGTCCTATTGTAGCATAC

Downstream 100 bases:

>100_bases
GCTCCCATAGGAGCCGCTATAGGCATTGGTCCTTTAGGAATTTCAAGAGCGCATCATCTTGTGGAAGCTGGAGCAAATGT
TCTAGTCATTGACACAGCTC

Product: inosine 5'-monophosphase dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 87; Mature: 87

Protein sequence:

>87_residues
MEEALTFDDVLLIPQYSEILPSEVSLKTAISKTLSLNIPILSAAMDSVTETAMALALAQEGGLGILHKNMSEVEQSSSVR
KIKEAYP

Sequences:

>Translated_87_residues
MEEALTFDDVLLIPQYSEILPSEVSLKTAISKTLSLNIPILSAAMDSVTETAMALALAQEGGLGILHKNMSEVEQSSSVR
KIKEAYP
>Mature_87_residues
MEEALTFDDVLLIPQYSEILPSEVSLKTAISKTLSLNIPILSAAMDSVTETAMALALAQEGGLGILHKNMSEVEQSSSVR
KIKEAYP

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=82, Percent_Identity=39.0243902439024, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI156616279, Length=82, Percent_Identity=37.8048780487805, Blast_Score=76, Evalue=6e-15,
Organism=Homo sapiens, GI217035146, Length=82, Percent_Identity=37.8048780487805, Blast_Score=76, Evalue=6e-15,
Organism=Homo sapiens, GI34328928, Length=82, Percent_Identity=37.8048780487805, Blast_Score=76, Evalue=6e-15,
Organism=Homo sapiens, GI34328930, Length=82, Percent_Identity=37.8048780487805, Blast_Score=76, Evalue=6e-15,
Organism=Homo sapiens, GI217035152, Length=84, Percent_Identity=35.7142857142857, Blast_Score=69, Evalue=7e-13,
Organism=Homo sapiens, GI217035148, Length=69, Percent_Identity=37.6811594202899, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788855, Length=83, Percent_Identity=59.0361445783133, Blast_Score=109, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71994385, Length=81, Percent_Identity=39.5061728395062, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994389, Length=81, Percent_Identity=39.5061728395062, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322012, Length=84, Percent_Identity=39.2857142857143, Blast_Score=77, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323464, Length=81, Percent_Identity=39.5061728395062, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323585, Length=80, Percent_Identity=42.5, Blast_Score=74, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319352, Length=80, Percent_Identity=38.75, Blast_Score=71, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641071, Length=82, Percent_Identity=41.4634146341463, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24641073, Length=82, Percent_Identity=41.4634146341463, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 9379; Mature: 9379

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEALTFDDVLLIPQYSEILPSEVSLKTAISKTLSLNIPILSAAMDSVTETAMALALAQE
CCCCCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GGLGILHKNMSEVEQSSSVRKIKEAYP
CCCEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEEALTFDDVLLIPQYSEILPSEVSLKTAISKTLSLNIPILSAAMDSVTETAMALALAQE
CCCCCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GGLGILHKNMSEVEQSSSVRKIKEAYP
CCCEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA