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The map label for this gene is xseA

Identifier: 15618970

GI number: 15618970

Start: 1218156

End: 1219820

Strand: Reverse

Name: xseA

Synonym: CPn1062

Alternate gene names: 15618970

Gene position: 1219820-1218156 (Counterclockwise)

Preceding gene: 15618973

Following gene: 15618969

Centisome position: 99.15

GC content: 43.6

Gene sequence:

>1665_bases
ATGTCATCGCCTCCACAGGCTGTTGCATCCCTAACTGAACGCATTAAGACTCTTCTTGAGTCCAATTTTTGTCAGATCAT
AGTGAAGGGCGAGCTTAGCAACGTCTCCCTACAACCAAGTGGTCATCTCTATTTTGGGATTAAGGATAGCCAAGCGTTTC
TTAATGGTGCCTTTTTTCATTTTAAAAGTAAGTACTATGACCGCAAACCCAAAGATGGGGATGCAGTTATTATTCATGGG
AAGCTTGCGGTCTATGCTCCTAGAGGACAATACCAAATTGTAGCCCATGCTTTGGTTTACGCTGGAGAGGGCGATCTCCT
ACAAAAATTTGAAGAAACAAAAAGACGTCTGACTGCTGAAGGGTATTTCGCAACTGAAAAAAAGAAGCCCCTCCCCTTTG
CTCCTCAATGCATTGGCGTCATTACTAGCCCAACAGGAGCTGTGATCCAAGATATCTTACGTGTACTCTCCCGGCGTGCT
CGCAACTATAAAATTTTAGTTTATCCCGTCACTGTCCAAGGGAACTCTGCAGCTCATGAAATCTCCAAGGCTATTGAAGT
GATGAACGCTGAGAACCTCGCTGACGTTCTTATTATTGCTCGGGGAGGAGGAAGTATTGAAGATCTCTGGGCCTTTAACG
AAGAAATCTTAGTTAAAGCCATTCATGCAAGCACAATCCCTATTGTCTCTGCTGTCGGCCATGAAACTGATTACACTTTA
TGTGACTTTGCTTCTGATGTGCGTGCTCCCACTCCTTCTGCAGCCGCAGAGATCGTCTGTAAAAGTAGCGAAGAGCAAGT
TCAGGTGTTCGAGGGATACCTCCGCCATCTACTCTCACACTCTCGCCAACTCCTCACATCAAAAAAACAGCAATTGCTTC
CCTGGAGACGCTTTTTAGATCGCGCAGAATTCTATACTACAGCACAACAGCAACTCGACTCTATTGAGATCGCTATTCAA
AAAGGTGTCCAAGGGAAAATTCACGAAAGCAAACAACGCTATGACAACATCTCGCGGTGGCTCCAAGGAGATCTTGTTTC
CCGCATGACCTGCCGACTGCAAAGTTTGAAAAAAATGCTTTCACAAGCCCTATCCCATAAAGCACTTTCTCTCCAAGTAC
GTTGCCACCAACTAAAGAAAAGCCTTACCTATCCTCGCCAAATCCAACAGGCATCACAGAAATTATCCCCTTGGCGTCAA
CAGCTAGACACCCTAATTTCACGACGCCTCCACTACCAAAAAGAAGAATATTTTCATAAACACACACGACTCAAGCATGC
TCACAATGTCTTAGAGCAACAGCTCCGTAGCCATGTGCAGAAACTGGAACTATTAGGCAGACGTCTATCGAGAGGATGCG
AGCTAAATCTACAAAACCAAAAAATCGCCTATGCAAATGTCAAGGAAACTTTAGCAACAATTCTAGAACGTCGTTACGAA
AATTCTGTTGCCCGCTACTCTGCGCTAAAAGAACAACTTCACTCTTTAAATCCGAAAAATGTTTTAAAACGCGGGTATGC
AATGCTCTTTGACTTTAATGAAAATTCCGCTATGATTTCCGTAGACAGCTTACAAGAAAATGCTCGTGTAAGGATTCAGT
TGCAAGATGGCGAGGCCATTTTAACTGTCACAAATATTGAAATTTGTAAACTTATAAAAGGCTAA

Upstream 100 bases:

>100_bases
CCGCATACTTTCCCGACAGAATCAATGATTTTTTAATAGTTTTCTATCAGAAAATCACTTACTCTAAAGTCACTGAATTC
TCTAGAGAGGCTTTCCTGTT

Downstream 100 bases:

>100_bases
ATCATGGAAGAGGTCCCCTTCGAAAATGCAATGCAACGACTAGAAGAAATTGTTGACCTTATGAATCAACCCACGACTTC
TTTGGATGCATCTCTAGCCC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSSPPQAVASLTERIKTLLESNFCQIIVKGELSNVSLQPSGHLYFGIKDSQAFLNGAFFHFKSKYYDRKPKDGDAVIIHG
KLAVYAPRGQYQIVAHALVYAGEGDLLQKFEETKRRLTAEGYFATEKKKPLPFAPQCIGVITSPTGAVIQDILRVLSRRA
RNYKILVYPVTVQGNSAAHEISKAIEVMNAENLADVLIIARGGGSIEDLWAFNEEILVKAIHASTIPIVSAVGHETDYTL
CDFASDVRAPTPSAAAEIVCKSSEEQVQVFEGYLRHLLSHSRQLLTSKKQQLLPWRRFLDRAEFYTTAQQQLDSIEIAIQ
KGVQGKIHESKQRYDNISRWLQGDLVSRMTCRLQSLKKMLSQALSHKALSLQVRCHQLKKSLTYPRQIQQASQKLSPWRQ
QLDTLISRRLHYQKEEYFHKHTRLKHAHNVLEQQLRSHVQKLELLGRRLSRGCELNLQNQKIAYANVKETLATILERRYE
NSVARYSALKEQLHSLNPKNVLKRGYAMLFDFNENSAMISVDSLQENARVRIQLQDGEAILTVTNIEICKLIKG

Sequences:

>Translated_554_residues
MSSPPQAVASLTERIKTLLESNFCQIIVKGELSNVSLQPSGHLYFGIKDSQAFLNGAFFHFKSKYYDRKPKDGDAVIIHG
KLAVYAPRGQYQIVAHALVYAGEGDLLQKFEETKRRLTAEGYFATEKKKPLPFAPQCIGVITSPTGAVIQDILRVLSRRA
RNYKILVYPVTVQGNSAAHEISKAIEVMNAENLADVLIIARGGGSIEDLWAFNEEILVKAIHASTIPIVSAVGHETDYTL
CDFASDVRAPTPSAAAEIVCKSSEEQVQVFEGYLRHLLSHSRQLLTSKKQQLLPWRRFLDRAEFYTTAQQQLDSIEIAIQ
KGVQGKIHESKQRYDNISRWLQGDLVSRMTCRLQSLKKMLSQALSHKALSLQVRCHQLKKSLTYPRQIQQASQKLSPWRQ
QLDTLISRRLHYQKEEYFHKHTRLKHAHNVLEQQLRSHVQKLELLGRRLSRGCELNLQNQKIAYANVKETLATILERRYE
NSVARYSALKEQLHSLNPKNVLKRGYAMLFDFNENSAMISVDSLQENARVRIQLQDGEAILTVTNIEICKLIKG
>Mature_553_residues
SSPPQAVASLTERIKTLLESNFCQIIVKGELSNVSLQPSGHLYFGIKDSQAFLNGAFFHFKSKYYDRKPKDGDAVIIHGK
LAVYAPRGQYQIVAHALVYAGEGDLLQKFEETKRRLTAEGYFATEKKKPLPFAPQCIGVITSPTGAVIQDILRVLSRRAR
NYKILVYPVTVQGNSAAHEISKAIEVMNAENLADVLIIARGGGSIEDLWAFNEEILVKAIHASTIPIVSAVGHETDYTLC
DFASDVRAPTPSAAAEIVCKSSEEQVQVFEGYLRHLLSHSRQLLTSKKQQLLPWRRFLDRAEFYTTAQQQLDSIEIAIQK
GVQGKIHESKQRYDNISRWLQGDLVSRMTCRLQSLKKMLSQALSHKALSLQVRCHQLKKSLTYPRQIQQASQKLSPWRQQ
LDTLISRRLHYQKEEYFHKHTRLKHAHNVLEQQLRSHVQKLELLGRRLSRGCELNLQNQKIAYANVKETLATILERRYEN
SVARYSALKEQLHSLNPKNVLKRGYAMLFDFNENSAMISVDSLQENARVRIQLQDGEAILTVTNIEICKLIKG

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=258, Percent_Identity=47.6744186046512, Blast_Score=267, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_CHLPN (Q9Z6J7)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   C72002
- PIR:   C86623
- RefSeq:   NP_225256.1
- RefSeq:   NP_301117.1
- RefSeq:   NP_445326.1
- RefSeq:   NP_877376.1
- GeneID:   1467784
- GeneID:   894865
- GeneID:   919829
- GeneID:   963738
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0787
- KEGG:   cpn:CPn1062
- KEGG:   cpt:CpB1105
- TIGR:   CP_0787
- HOGENOM:   HBG634411
- OMA:   SSQIRCA
- PhylomeDB:   Q9Z6J7
- ProtClustDB:   PRK00286
- BioCyc:   CPNE115711:CP_0787-MONOMER
- BioCyc:   CPNE115713:CPN1062-MONOMER
- BioCyc:   CPNE138677:CPJ1062-MONOMER
- BioCyc:   CPNE182082:CPB1105-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L

EC number: =3.1.11.6

Molecular weight: Translated: 62912; Mature: 62781

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPPQAVASLTERIKTLLESNFCQIIVKGELSNVSLQPSGHLYFGIKDSQAFLNGAFFH
CCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCEEEEEECCHHHHHHHHHH
FKSKYYDRKPKDGDAVIIHGKLAVYAPRGQYQIVAHALVYAGEGDLLQKFEETKRRLTAE
HHHHHCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GYFATEKKKPLPFAPQCIGVITSPTGAVIQDILRVLSRRARNYKILVYPVTVQGNSAAHE
CEEECCCCCCCCCCCHHHHEEECCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHH
ISKAIEVMNAENLADVLIIARGGGSIEDLWAFNEEILVKAIHASTIPIVSAVGHETDYTL
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHH
CDFASDVRAPTPSAAAEIVCKSSEEQVQVFEGYLRHLLSHSRQLLTSKKQQLLPWRRFLD
HHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAEFYTTAQQQLDSIEIAIQKGVQGKIHESKQRYDNISRWLQGDLVSRMTCRLQSLKKML
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQALSHKALSLQVRCHQLKKSLTYPRQIQQASQKLSPWRQQLDTLISRRLHYQKEEYFHK
HHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTRLKHAHNVLEQQLRSHVQKLELLGRRLSRGCELNLQNQKIAYANVKETLATILERRYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHH
NSVARYSALKEQLHSLNPKNVLKRGYAMLFDFNENSAMISVDSLQENARVRIQLQDGEAI
HHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEECCCCEEEEECCCCCCCEEEEEEECCCEE
LTVTNIEICKLIKG
EEECCHHHHHHCCC
>Mature Secondary Structure 
SSPPQAVASLTERIKTLLESNFCQIIVKGELSNVSLQPSGHLYFGIKDSQAFLNGAFFH
CCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCEEEEEECCHHHHHHHHHH
FKSKYYDRKPKDGDAVIIHGKLAVYAPRGQYQIVAHALVYAGEGDLLQKFEETKRRLTAE
HHHHHCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GYFATEKKKPLPFAPQCIGVITSPTGAVIQDILRVLSRRARNYKILVYPVTVQGNSAAHE
CEEECCCCCCCCCCCHHHHEEECCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHH
ISKAIEVMNAENLADVLIIARGGGSIEDLWAFNEEILVKAIHASTIPIVSAVGHETDYTL
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHH
CDFASDVRAPTPSAAAEIVCKSSEEQVQVFEGYLRHLLSHSRQLLTSKKQQLLPWRRFLD
HHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAEFYTTAQQQLDSIEIAIQKGVQGKIHESKQRYDNISRWLQGDLVSRMTCRLQSLKKML
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQALSHKALSLQVRCHQLKKSLTYPRQIQQASQKLSPWRQQLDTLISRRLHYQKEEYFHK
HHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTRLKHAHNVLEQQLRSHVQKLELLGRRLSRGCELNLQNQKIAYANVKETLATILERRYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHH
NSVARYSALKEQLHSLNPKNVLKRGYAMLFDFNENSAMISVDSLQENARVRIQLQDGEAI
HHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEECCCCEEEEECCCCCCCEEEEEEECCCEE
LTVTNIEICKLIKG
EEECCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362