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The map label for this gene is map

Identifier: 15618917

GI number: 15618917

Start: 1158183

End: 1159058

Strand: Reverse

Name: map

Synonym: CPn1009

Alternate gene names: 15618917

Gene position: 1159058-1158183 (Counterclockwise)

Preceding gene: 15618918

Following gene: 15618914

Centisome position: 94.21

GC content: 43.26

Gene sequence:

>876_bases
ATGAAAAGAAACGACCCTTGCTGGTGCGGCAGTGGACGTAAATGGAAACAGTGCCACTACCCTCAACCCCCAAAAATGTC
TCCAGAAGCCTTAAAACAACACTACGCCTCGCAATATAATATCCTACTCAAAACCCCAGAACAGAAAGCAAAAATCTATA
ACGCCTGCCAAATTACAGCAAGAATTCTAGATGAGCTATGCAAAGCATCTCAAAAGGGCGTCACTACAAATGAGTTGGAT
GAGCTCTCCCAAGAGCTCCATAAGAAATATGACGCGATTGCCGCTCCATTCCATTACGGCTCACCACCATTTCCAAAAAC
AATCTGCACATCATTAAACGAAGTGATCTGTCACGGGATTCCTAACGATATCCCACTAAAAGACGGTGATATCATGAATA
TAGATGTGTCCTGCATTGTGGATGGCTACTATGGAGACTGTAGCCGCATGGTCATGATCGGAGAGGTGCCAGAAATTAAA
AAGAAGATATGCCAAGCAGCTTTGGAATGTCTTAACGATTCTATAGCCATTTTAAAACCTGGTATTCCCCTCTGTGAAAT
TGGAGAAGCTATAGAAGCACGTGCAGACACCTATGGATTTTCTGTAGTAGACCAATTTGTAGGACATGGCGTTGGAATTG
AGTTTCACGAAAACCCCTACGTGCCACATTATAGAAACCGCTCCATGATTCCTCTAGCACCAGGGATGATCTTCACTATA
GAGCCTATGATTAATGTAGGAAAAAAAGAAGGCGTTGTAGACCCCAAAAATCAATGGGAAGCACGCACATGCGATAATCA
ACCCAGCGCACAATGGGAACACACTATAGCAATTACAGAGACAGGCTACGAGATACTAACTCTTCTAAATGACTGA

Upstream 100 bases:

>100_bases
AGAGACTCTTCGGTATTGCTTTACTACTTATGTCGGTAAACCTTATGTTGAAAGGGATCTCAATAGCGTTTAATATAGGC
TTTTACATCGGGTGATCCTT

Downstream 100 bases:

>100_bases
CTTCTTCTTCCAAAATCTCTATGCGCTCTAAGAGCCCTTGAATCATAGAGATATCATCAAAAGATATGTCTTGCTTTGTG
AGTTCTTCCTTCTTCTTCAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKRNDPCWCGSGRKWKQCHYPQPPKMSPEALKQHYASQYNILLKTPEQKAKIYNACQITARILDELCKASQKGVTTNELD
ELSQELHKKYDAIAAPFHYGSPPFPKTICTSLNEVICHGIPNDIPLKDGDIMNIDVSCIVDGYYGDCSRMVMIGEVPEIK
KKICQAALECLNDSIAILKPGIPLCEIGEAIEARADTYGFSVVDQFVGHGVGIEFHENPYVPHYRNRSMIPLAPGMIFTI
EPMINVGKKEGVVDPKNQWEARTCDNQPSAQWEHTIAITETGYEILTLLND

Sequences:

>Translated_291_residues
MKRNDPCWCGSGRKWKQCHYPQPPKMSPEALKQHYASQYNILLKTPEQKAKIYNACQITARILDELCKASQKGVTTNELD
ELSQELHKKYDAIAAPFHYGSPPFPKTICTSLNEVICHGIPNDIPLKDGDIMNIDVSCIVDGYYGDCSRMVMIGEVPEIK
KKICQAALECLNDSIAILKPGIPLCEIGEAIEARADTYGFSVVDQFVGHGVGIEFHENPYVPHYRNRSMIPLAPGMIFTI
EPMINVGKKEGVVDPKNQWEARTCDNQPSAQWEHTIAITETGYEILTLLND
>Mature_291_residues
MKRNDPCWCGSGRKWKQCHYPQPPKMSPEALKQHYASQYNILLKTPEQKAKIYNACQITARILDELCKASQKGVTTNELD
ELSQELHKKYDAIAAPFHYGSPPFPKTICTSLNEVICHGIPNDIPLKDGDIMNIDVSCIVDGYYGDCSRMVMIGEVPEIK
KKICQAALECLNDSIAILKPGIPLCEIGEAIEARADTYGFSVVDQFVGHGVGIEFHENPYVPHYRNRSMIPLAPGMIFTI
EPMINVGKKEGVVDPKNQWEARTCDNQPSAQWEHTIAITETGYEILTLLND

Specific function: Removes the amino-terminal methionine from nascent proteins

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family

Homologues:

Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=41.2, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI164420681, Length=273, Percent_Identity=38.4615384615385, Blast_Score=182, Evalue=4e-46,
Organism=Escherichia coli, GI1786364, Length=254, Percent_Identity=44.4881889763779, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1788728, Length=250, Percent_Identity=23.6, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789275, Length=268, Percent_Identity=25.7462686567164, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71996291, Length=275, Percent_Identity=40, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6323273, Length=253, Percent_Identity=41.897233201581, Blast_Score=189, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24583427, Length=274, Percent_Identity=39.051094890511, Blast_Score=194, Evalue=7e-50,
Organism=Drosophila melanogaster, GI21355531, Length=269, Percent_Identity=40.5204460966543, Blast_Score=187, Evalue=5e-48,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): AMPM_CHLPN (Q9Z6Q0)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   A81531
- PIR:   E72008
- PIR:   F86616
- RefSeq:   NP_225203.1
- RefSeq:   NP_301064.1
- RefSeq:   NP_445382.2
- RefSeq:   NP_877319.2
- ProteinModelPortal:   Q9Z6Q0
- SMR:   Q9Z6Q0
- MEROPS:   M24.001
- GeneID:   1467726
- GeneID:   894643
- GeneID:   919776
- GeneID:   963127
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0844
- KEGG:   cpn:CPn1009
- KEGG:   cpt:CpB1046
- TIGR:   CP_0844
- HOGENOM:   HBG299384
- OMA:   DGYYGDT
- ProtClustDB:   PRK12318
- BioCyc:   CPNE115711:CP_0844-MONOMER
- BioCyc:   CPNE115713:CPN1009-MONOMER
- BioCyc:   CPNE138677:CPJ1009-MONOMER
- BioCyc:   CPNE182082:CPB1046-MONOMER
- BRENDA:   3.4.11.18
- GO:   GO:0006508
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467
- InterPro:   IPR004027
- Gene3D:   G3DSA:3.90.230.10
- PANTHER:   PTHR10804:SF13
- PANTHER:   PTHR10804
- PRINTS:   PR00599
- TIGRFAMs:   TIGR00500

Pfam domain/function: PF00557 Peptidase_M24; PF02810 SEC-C; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.11.18

Molecular weight: Translated: 32597; Mature: 32597

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00680 MAP_1

Important sites: BINDING 118-118 BINDING 216-216

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNDPCWCGSGRKWKQCHYPQPPKMSPEALKQHYASQYNILLKTPEQKAKIYNACQITA
CCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHH
RILDELCKASQKGVTTNELDELSQELHKKYDAIAAPFHYGSPPFPKTICTSLNEVICHGI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
PNDIPLKDGDIMNIDVSCIVDGYYGDCSRMVMIGEVPEIKKKICQAALECLNDSIAILKP
CCCCCCCCCCEEEEEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECC
GIPLCEIGEAIEARADTYGFSVVDQFVGHGVGIEFHENPYVPHYRNRSMIPLAPGMIFTI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEECCCEEEEE
EPMINVGKKEGVVDPKNQWEARTCDNQPSAQWEHTIAITETGYEILTLLND
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEECC
>Mature Secondary Structure
MKRNDPCWCGSGRKWKQCHYPQPPKMSPEALKQHYASQYNILLKTPEQKAKIYNACQITA
CCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHH
RILDELCKASQKGVTTNELDELSQELHKKYDAIAAPFHYGSPPFPKTICTSLNEVICHGI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
PNDIPLKDGDIMNIDVSCIVDGYYGDCSRMVMIGEVPEIKKKICQAALECLNDSIAILKP
CCCCCCCCCCEEEEEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECC
GIPLCEIGEAIEARADTYGFSVVDQFVGHGVGIEFHENPYVPHYRNRSMIPLAPGMIFTI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEECCCEEEEE
EPMINVGKKEGVVDPKNQWEARTCDNQPSAQWEHTIAITETGYEILTLLND
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362