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The map label for this gene is groEL_3

Identifier: 15618807

GI number: 15618807

Start: 1028901

End: 1030460

Strand: Reverse

Name: groEL_3

Synonym: CPn0898

Alternate gene names: 15618807

Gene position: 1030460-1028901 (Counterclockwise)

Preceding gene: 15618815

Following gene: 15618806

Centisome position: 83.76

GC content: 40.32

Gene sequence:

>1560_bases
ATGTCCGAACAGGAAAAATTATCTAATTACAATGCTGATAAAAAACTTTTTTCAGGGATAGATAAACTTTTCCAGATAGT
AAAGGGATCGTATGGTCCCAAGCAATCCCTCTCCCCAACTTCTTTCTTTAAAGAGCGTGGCTTCTACGCTATTTCACAAA
CAGAACTTTCGAATTCCTATGAAAATCTCGGTGTAGATTTTGCGAAAGCTATGGTGAATAAAATTCATAAGGAACACAGC
GACGGCGCGACTACTGGACTTATTTTACTCCATGCAATTTTACAGGAAAGCTATGCAGCTTTAGAAAAGGGAATCTCCAC
ACACAAGCTCATTGCCTCTTTAAAATTGCAGGGAGAAAAGCTTCAGGAAGCCTTACAACAACAATCTTGGCCTATTAAAG
ATGCTCTAAAAGTTCGCAATATTATTTTTTCTTCTCTACACATGCCCACCATTGCCGATCATTTTTACAATGCTTTTTCT
GTGGTAGGCCCTGAGGGTCTTATCTCCATCACTAAGGAGAGAGAAAACGACAAAACTTCCATGGATGTCTTTCAAGGATT
TAAAATTCCTGCAGGGTATGCTTCGACGTATTTTGTTTCTGATACAGCGTCTCGTCTAACTAGAATTGCTCATCCTCTAA
TTCTGATCACAGATAGAAAGATCTCTATGATTCACTCCTTACTTCCCCTACTCCAAGAAATTTCAGAACAAAACCAGCAC
CTCATCATTTTCTGTGAAGATATCGATCCAGACGTACTTGCTACCCTTGTTGTTAACAAATTGCAAGGGCTCTTGCAAGT
AACTGTAGTCACCATTCCTCAACTCTCTACTACAAATCAAGAATTAGCCGAGGATATTGCTTTATTTACTGGGACCCACA
TTTGTCCTTGCCAAGAAGCATCTCATGTTTTAGCTCCTGAGATGGTCACTTTAGGGTCCTGTCTATCTATAGAAATCTCA
GAGTCACAAACGACACTCATTGGAGGCCTACATATCCCGGAAGTCCTGACCTTAAAGACGCGACAATTAGCAGAAGAAAT
ACGCACGACCTCATGCCTTGAAACAAAAAAAAGGCTAATCAAAAGCACAAATAGGCTCCAAAGTTCGGTAGCCATTCTTC
CTACTGATGAAGATAACGAACCTTTATATACCCTCGCTCTTAAGATTATGGAATCTGCTTTAAGTCGTGGGTATGTTCCT
GGAGGAGGCGTTGCATTGTTCTATGCATCTTTAACTTTAGGGACTCCTAAAGATGATGCTGATGAGAATAGTATTGCAAT
TTCTCTCTTACAGAAGGCCTGTTGTGCTCCTCTGAAGCTCTTGGCAACCAATGCAGACTTGGATGGGGATGCCGTGATTG
CTAAGCTCTCCTCACTTGGAACAACAAGCCTAGGAATCAGTGTGTTTTCTAGAGAAATTGAAGATCTTATTGCTGGTGGA
ATCTTAGATTCGTTAGCTACGACATCTACAATCCTAGCCCAAGCCTTAGATACAGCGATTCTCGTTCTCTCTTCTAAAAT
TTTAATTTTAGAAAATCAATATGAGATTTCTACGCTCTGA

Upstream 100 bases:

>100_bases
ATCCCCGGTTCGATTCCGGGTGCCACCTTTCCTACTGAAGGTATTGTGAACTAAAAAACGACTTGGTAGTGTAAAAATTT
TACGTCTACTGGGGGTTTGC

Downstream 100 bases:

>100_bases
TCTTCTCTTATAAAATTAATAAACCCCTTGGTATCAATCATTTGGGATAGCCCCTTAGAATCTTGACTCTAAGGGCTTCT
CCTTAGAGATCGATCTTTGT

Product: heat shock protein-60

Products: NA

Alternate protein names: GroEL protein 3; Protein Cpn60 3 [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MSEQEKLSNYNADKKLFSGIDKLFQIVKGSYGPKQSLSPTSFFKERGFYAISQTELSNSYENLGVDFAKAMVNKIHKEHS
DGATTGLILLHAILQESYAALEKGISTHKLIASLKLQGEKLQEALQQQSWPIKDALKVRNIIFSSLHMPTIADHFYNAFS
VVGPEGLISITKERENDKTSMDVFQGFKIPAGYASTYFVSDTASRLTRIAHPLILITDRKISMIHSLLPLLQEISEQNQH
LIIFCEDIDPDVLATLVVNKLQGLLQVTVVTIPQLSTTNQELAEDIALFTGTHICPCQEASHVLAPEMVTLGSCLSIEIS
ESQTTLIGGLHIPEVLTLKTRQLAEEIRTTSCLETKKRLIKSTNRLQSSVAILPTDEDNEPLYTLALKIMESALSRGYVP
GGGVALFYASLTLGTPKDDADENSIAISLLQKACCAPLKLLATNADLDGDAVIAKLSSLGTTSLGISVFSREIEDLIAGG
ILDSLATTSTILAQALDTAILVLSSKILILENQYEISTL

Sequences:

>Translated_519_residues
MSEQEKLSNYNADKKLFSGIDKLFQIVKGSYGPKQSLSPTSFFKERGFYAISQTELSNSYENLGVDFAKAMVNKIHKEHS
DGATTGLILLHAILQESYAALEKGISTHKLIASLKLQGEKLQEALQQQSWPIKDALKVRNIIFSSLHMPTIADHFYNAFS
VVGPEGLISITKERENDKTSMDVFQGFKIPAGYASTYFVSDTASRLTRIAHPLILITDRKISMIHSLLPLLQEISEQNQH
LIIFCEDIDPDVLATLVVNKLQGLLQVTVVTIPQLSTTNQELAEDIALFTGTHICPCQEASHVLAPEMVTLGSCLSIEIS
ESQTTLIGGLHIPEVLTLKTRQLAEEIRTTSCLETKKRLIKSTNRLQSSVAILPTDEDNEPLYTLALKIMESALSRGYVP
GGGVALFYASLTLGTPKDDADENSIAISLLQKACCAPLKLLATNADLDGDAVIAKLSSLGTTSLGISVFSREIEDLIAGG
ILDSLATTSTILAQALDTAILVLSSKILILENQYEISTL
>Mature_518_residues
SEQEKLSNYNADKKLFSGIDKLFQIVKGSYGPKQSLSPTSFFKERGFYAISQTELSNSYENLGVDFAKAMVNKIHKEHSD
GATTGLILLHAILQESYAALEKGISTHKLIASLKLQGEKLQEALQQQSWPIKDALKVRNIIFSSLHMPTIADHFYNAFSV
VGPEGLISITKERENDKTSMDVFQGFKIPAGYASTYFVSDTASRLTRIAHPLILITDRKISMIHSLLPLLQEISEQNQHL
IIFCEDIDPDVLATLVVNKLQGLLQVTVVTIPQLSTTNQELAEDIALFTGTHICPCQEASHVLAPEMVTLGSCLSIEISE
SQTTLIGGLHIPEVLTLKTRQLAEEIRTTSCLETKKRLIKSTNRLQSSVAILPTDEDNEPLYTLALKIMESALSRGYVPG
GGVALFYASLTLGTPKDDADENSIAISLLQKACCAPLKLLATNADLDGDAVIAKLSSLGTTSLGISVFSREIEDLIAGGI
LDSLATTSTILAQALDTAILVLSSKILILENQYEISTL

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=522, Percent_Identity=23.9463601532567, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI31542947, Length=522, Percent_Identity=23.9463601532567, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1790586, Length=519, Percent_Identity=25.0481695568401, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17555558, Length=514, Percent_Identity=24.124513618677, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323288, Length=519, Percent_Identity=27.7456647398844, Blast_Score=173, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24641193, Length=513, Percent_Identity=26.3157894736842, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24641191, Length=513, Percent_Identity=26.3157894736842, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI45550936, Length=513, Percent_Identity=25.5360623781676, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45550132, Length=513, Percent_Identity=25.5360623781676, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45550935, Length=513, Percent_Identity=25.5360623781676, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17864606, Length=520, Percent_Identity=25.3846153846154, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24584129, Length=514, Percent_Identity=24.9027237354086, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19921262, Length=514, Percent_Identity=24.9027237354086, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56552; Mature: 56421

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQEKLSNYNADKKLFSGIDKLFQIVKGSYGPKQSLSPTSFFKERGFYAISQTELSNSY
CCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEHHHHHCCH
ENLGVDFAKAMVNKIHKEHSDGATTGLILLHAILQESYAALEKGISTHKLIASLKLQGEK
HHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LQEALQQQSWPIKDALKVRNIIFSSLHMPTIADHFYNAFSVVGPEGLISITKERENDKTS
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHEEEHHHCCCCCHH
MDVFQGFKIPAGYASTYFVSDTASRLTRIAHPLILITDRKISMIHSLLPLLQEISEQNQH
HHHHHCCCCCCCCCCEEEECHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
LIIFCEDIDPDVLATLVVNKLQGLLQVTVVTIPQLSTTNQELAEDIALFTGTHICPCQEA
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCHHC
SHVLAPEMVTLGSCLSIEISESQTTLIGGLHIPEVLTLKTRQLAEEIRTTSCLETKKRLI
CCCCCCHHHHHCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSTNRLQSSVAILPTDEDNEPLYTLALKIMESALSRGYVPGGGVALFYASLTLGTPKDDA
HHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEHEEHHCCCCCCCCC
DENSIAISLLQKACCAPLKLLATNADLDGDAVIAKLSSLGTTSLGISVFSREIEDLIAGG
CCHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ILDSLATTSTILAQALDTAILVLSSKILILENQYEISTL
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
>Mature Secondary Structure 
SEQEKLSNYNADKKLFSGIDKLFQIVKGSYGPKQSLSPTSFFKERGFYAISQTELSNSY
CCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEHHHHHCCH
ENLGVDFAKAMVNKIHKEHSDGATTGLILLHAILQESYAALEKGISTHKLIASLKLQGEK
HHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LQEALQQQSWPIKDALKVRNIIFSSLHMPTIADHFYNAFSVVGPEGLISITKERENDKTS
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHEEEHHHCCCCCHH
MDVFQGFKIPAGYASTYFVSDTASRLTRIAHPLILITDRKISMIHSLLPLLQEISEQNQH
HHHHHCCCCCCCCCCEEEECHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
LIIFCEDIDPDVLATLVVNKLQGLLQVTVVTIPQLSTTNQELAEDIALFTGTHICPCQEA
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCHHC
SHVLAPEMVTLGSCLSIEISESQTTLIGGLHIPEVLTLKTRQLAEEIRTTSCLETKKRLI
CCCCCCHHHHHCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSTNRLQSSVAILPTDEDNEPLYTLALKIMESALSRGYVPGGGVALFYASLTLGTPKDDA
HHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEHEEHHCCCCCCCCC
DENSIAISLLQKACCAPLKLLATNADLDGDAVIAKLSSLGTTSLGISVFSREIEDLIAGG
CCHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ILDSLATTSTILAQALDTAILVLSSKILILENQYEISTL
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA