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The map label for this gene is thrS

Identifier: 15618715

GI number: 15618715

Start: 911864

End: 913771

Strand: Reverse

Name: thrS

Synonym: CPn0806

Alternate gene names: 15618715

Gene position: 913771-911864 (Counterclockwise)

Preceding gene: 15618717

Following gene: 15618714

Centisome position: 74.28

GC content: 42.09

Gene sequence:

>1908_bases
ATGATTCAAGTAACTTGTGATCAAAAAAATTATGAAGTACTCGAAGGTACTACAGCAGCGGAACTCGCTAAACAATTAAA
AAATTCTCATCAATTCATTGGTGTTCTCATTAACGAACGCCCTAGAGATCTTTCCACCCACCTAAACGAAGGCGACACCT
TAGTATTTCTGACTTCCGAAGATCCCGAAGGACGAGAAATTTTTCTTCATACTTCTGCCCATCTTCTAGCCCAAGCCGTA
TTGCGTTTATGGCCTGATGCAATTCCTACAATCGGCCCTGTCATCGACCATGGCTTTTACTATGATTTTGCCAATCTTTC
CATTAGCGAAAGTGATTTCCCGTTAATTGAAGATACAGTAAAACAAATTGTTGATGAAAAGCTTGCGATTTCTCGCTTTA
CTTATGGCGATAAGCAACAAGCTTTAGCACAATTCCCACAGAATCCATTTAAGACAGAGTTGATTCGTGAGCTTCCTGAA
AATGAAGAAATTTCTGCCTATAGCCAAGGGGAGTTTTTTGATCTTTGCCGAGGTCCTCACCTTCCCTCTACAGCTCATGT
AAAAGCGTTTAAAGTCTTACGCACATCTGCAGCTTATTGGCGAGGGGATCCTTCTCGAGAATCTTTAGTACGTATTTACG
GAACTTCGTTTCCTACATCTAAGGAACTTCGAGCACATTTAGAGCAAATTGAGGAAGCAAAAAAACGGGACCACCGTGTT
TTGGGGGCCAAGTTAGATCTATTTTCTCAGCAAGAAAGTTCTCCTGGAATGCCCTTCTTCCATCCTCGCGGTATGATTGT
TTGGGATGCATTGATTCGTTATTGGAAGCAGCTGCACACAGCTGCGGGTTATAAGGAAATCCTAACGCCACAGTTGATGA
ATCGTCAGTTATGGGAAGTTTCAGGCCACTGGGACAATTATAAAGCAAACATGTACACACTGCAAATCGACGATGAAGAT
TATGCCATTAAGCCCATGAACTGCCCAGGATGCATGCTCTATTATAAAACCCGCTTGCATAGTTATAAGGAGTTCCCTCT
ACGTGTAGCAGAAGTTGGTCATGTCCATCGTCAAGAAGCTTCGGGAGCCCTTTCAGGGTTAATGCGTGTCCGTGCGTTCC
ACCAAGATGATGCTCATGTATTTCTTACTCCAGAGCAAGTCGAAGAGGAAACTTTGAATATTCTTCAGTTAGTTTCTACA
CTGTACGGTACATTTGGATTAGAGTATCACCTGGAACTCTCCACACGTCCAGAAAAAGATACGATTGGGGATGATTCTCT
ATGGGAGCTAGCAACAGATGCCTTAAATCGAGCATTAGTTCAGTCCGGGACACCCTTCATTGTTCGTCCAGGAGAAGGTG
CTTTTTACGGTCCTAAAATTGATATCCATGTTAAAGATGCGATTCAAAGAACATGGCAATGTGGAACCATCCAGTTAGAC
ATGTTCCTTCCAGAGCGTTTCGAATTAGAATACACCACAGCTCAAGGAACTAAGAGTGTTCCTGTGATGTTACATCGGGC
TCTTTTTGGTTCTATAGAACGCTTTTTAGGAATTCTGATTGAGAACTTCAAAGGAAGATTCCCCTTATGGTTAAGTCCTG
AGCAAGTGCGTATCATCACAGTTGCTGATCGCCATATTCCTAGAGCGAAAGAGCTCGAGGAAGCGTGGAAACGTTTAGGC
TTAGTCGTCACCTTAGACGATTCTAGTGAGTCTGTAAGTAAAAAGATTCGCAATGCCCAAAACATGCAGGTCAATTACAT
GATCACTCTTGGAGATCATGAAATTAATGAAAATGTACTCGCAGTACGCACCCGAGATAACCGAGTGATTAATGATGTCT
CTGTAGAGAGATTCTTAAACACTATACTTGAAGAAAAGAACTCTTTAAGTTTAACTGCATTATTGTAG

Upstream 100 bases:

>100_bases
AATAAAAGTTTTTTTATAAAAAAAAGCTTCTTGCTTTGATCAAAAAAAACACTAAAATGCTAACAACGAAAGTCCCCCTA
ACATGGAGGCGTGGAACAAG

Downstream 100 bases:

>100_bases
TTGCTAAGGATTTTTGAGGATACGCATCAAGAATGAAGACCATCGCTGTAAACAGCTTTAAAGGTGGAACAGCAAAAACA
TCAACAACCCTTCATCTTGG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MIQVTCDQKNYEVLEGTTAAELAKQLKNSHQFIGVLINERPRDLSTHLNEGDTLVFLTSEDPEGREIFLHTSAHLLAQAV
LRLWPDAIPTIGPVIDHGFYYDFANLSISESDFPLIEDTVKQIVDEKLAISRFTYGDKQQALAQFPQNPFKTELIRELPE
NEEISAYSQGEFFDLCRGPHLPSTAHVKAFKVLRTSAAYWRGDPSRESLVRIYGTSFPTSKELRAHLEQIEEAKKRDHRV
LGAKLDLFSQQESSPGMPFFHPRGMIVWDALIRYWKQLHTAAGYKEILTPQLMNRQLWEVSGHWDNYKANMYTLQIDDED
YAIKPMNCPGCMLYYKTRLHSYKEFPLRVAEVGHVHRQEASGALSGLMRVRAFHQDDAHVFLTPEQVEEETLNILQLVST
LYGTFGLEYHLELSTRPEKDTIGDDSLWELATDALNRALVQSGTPFIVRPGEGAFYGPKIDIHVKDAIQRTWQCGTIQLD
MFLPERFELEYTTAQGTKSVPVMLHRALFGSIERFLGILIENFKGRFPLWLSPEQVRIITVADRHIPRAKELEEAWKRLG
LVVTLDDSSESVSKKIRNAQNMQVNYMITLGDHEINENVLAVRTRDNRVINDVSVERFLNTILEEKNSLSLTALL

Sequences:

>Translated_635_residues
MIQVTCDQKNYEVLEGTTAAELAKQLKNSHQFIGVLINERPRDLSTHLNEGDTLVFLTSEDPEGREIFLHTSAHLLAQAV
LRLWPDAIPTIGPVIDHGFYYDFANLSISESDFPLIEDTVKQIVDEKLAISRFTYGDKQQALAQFPQNPFKTELIRELPE
NEEISAYSQGEFFDLCRGPHLPSTAHVKAFKVLRTSAAYWRGDPSRESLVRIYGTSFPTSKELRAHLEQIEEAKKRDHRV
LGAKLDLFSQQESSPGMPFFHPRGMIVWDALIRYWKQLHTAAGYKEILTPQLMNRQLWEVSGHWDNYKANMYTLQIDDED
YAIKPMNCPGCMLYYKTRLHSYKEFPLRVAEVGHVHRQEASGALSGLMRVRAFHQDDAHVFLTPEQVEEETLNILQLVST
LYGTFGLEYHLELSTRPEKDTIGDDSLWELATDALNRALVQSGTPFIVRPGEGAFYGPKIDIHVKDAIQRTWQCGTIQLD
MFLPERFELEYTTAQGTKSVPVMLHRALFGSIERFLGILIENFKGRFPLWLSPEQVRIITVADRHIPRAKELEEAWKRLG
LVVTLDDSSESVSKKIRNAQNMQVNYMITLGDHEINENVLAVRTRDNRVINDVSVERFLNTILEEKNSLSLTALL
>Mature_635_residues
MIQVTCDQKNYEVLEGTTAAELAKQLKNSHQFIGVLINERPRDLSTHLNEGDTLVFLTSEDPEGREIFLHTSAHLLAQAV
LRLWPDAIPTIGPVIDHGFYYDFANLSISESDFPLIEDTVKQIVDEKLAISRFTYGDKQQALAQFPQNPFKTELIRELPE
NEEISAYSQGEFFDLCRGPHLPSTAHVKAFKVLRTSAAYWRGDPSRESLVRIYGTSFPTSKELRAHLEQIEEAKKRDHRV
LGAKLDLFSQQESSPGMPFFHPRGMIVWDALIRYWKQLHTAAGYKEILTPQLMNRQLWEVSGHWDNYKANMYTLQIDDED
YAIKPMNCPGCMLYYKTRLHSYKEFPLRVAEVGHVHRQEASGALSGLMRVRAFHQDDAHVFLTPEQVEEETLNILQLVST
LYGTFGLEYHLELSTRPEKDTIGDDSLWELATDALNRALVQSGTPFIVRPGEGAFYGPKIDIHVKDAIQRTWQCGTIQLD
MFLPERFELEYTTAQGTKSVPVMLHRALFGSIERFLGILIENFKGRFPLWLSPEQVRIITVADRHIPRAKELEEAWKRLG
LVVTLDDSSESVSKKIRNAQNMQVNYMITLGDHEINENVLAVRTRDNRVINDVSVERFLNTILEEKNSLSLTALL

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=620, Percent_Identity=39.8387096774194, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI38202255, Length=583, Percent_Identity=41.1663807890223, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI20070344, Length=650, Percent_Identity=38.1538461538462, Blast_Score=441, Evalue=1e-123,
Organism=Escherichia coli, GI1788013, Length=586, Percent_Identity=40.9556313993174, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71984192, Length=612, Percent_Identity=38.8888888888889, Blast_Score=465, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71984184, Length=612, Percent_Identity=38.8888888888889, Blast_Score=465, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322112, Length=581, Percent_Identity=40.9638554216867, Blast_Score=480, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322654, Length=400, Percent_Identity=40.25, Blast_Score=302, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24583839, Length=589, Percent_Identity=41.7657045840407, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24583842, Length=589, Percent_Identity=41.7657045840407, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI28574141, Length=589, Percent_Identity=41.7657045840407, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_CHLPN (Q9Z7A0)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   D86591
- PIR:   G72034
- RefSeq:   NP_225001.1
- RefSeq:   NP_300863.1
- RefSeq:   NP_445602.1
- RefSeq:   NP_877107.1
- ProteinModelPortal:   Q9Z7A0
- SMR:   Q9Z7A0
- PHCI-2DPAGE:   Q9Z7A0
- GeneID:   1467514
- GeneID:   894780
- GeneID:   919573
- GeneID:   963549
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP1065
- KEGG:   cpn:CPn0806
- KEGG:   cpt:CpB0835
- TIGR:   CP_1065
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   Q9Z7A0
- ProtClustDB:   PRK00413
- BioCyc:   CPNE115711:CP_1065-MONOMER
- BioCyc:   CPNE115713:CPN0806-MONOMER
- BioCyc:   CPNE138677:CPJ0806-MONOMER
- BioCyc:   CPNE182082:CPB0835-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR016155
- InterPro:   IPR004095
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF54285 Mo_synth/thiamin_syn_S_b-grasp; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 72686; Mature: 72686

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQVTCDQKNYEVLEGTTAAELAKQLKNSHQFIGVLINERPRDLSTHLNEGDTLVFLTSE
CEEEEECCCCCEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHCCCCCEEEEEECC
DPEGREIFLHTSAHLLAQAVLRLWPDAIPTIGPVIDHGFYYDFANLSISESDFPLIEDTV
CCCCCEEEEECHHHHHHHHHHHHCCHHCCCHHHHHHCCCEEEECCCEECCCCCCHHHHHH
KQIVDEKLAISRFTYGDKQQALAQFPQNPFKTELIRELPENEEISAYSQGEFFDLCRGPH
HHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCC
LPSTAHVKAFKVLRTSAAYWRGDPSRESLVRIYGTSFPTSKELRAHLEQIEEAKKRDHRV
CCCCHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEE
LGAKLDLFSQQESSPGMPFFHPRGMIVWDALIRYWKQLHTAAGYKEILTPQLMNRQLWEV
HHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCHHHEE
SGHWDNYKANMYTLQIDDEDYAIKPMNCPGCMLYYKTRLHSYKEFPLRVAEVGHVHRQEA
CCCCCCEECEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SGALSGLMRVRAFHQDDAHVFLTPEQVEEETLNILQLVSTLYGTFGLEYHLELSTRPEKD
HHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
TIGDDSLWELATDALNRALVQSGTPFIVRPGEGAFYGPKIDIHVKDAIQRTWQCGTIQLD
CCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEEHHHHHHCCCCCEEEEE
MFLPERFELEYTTAQGTKSVPVMLHRALFGSIERFLGILIENFKGRFPLWLSPEQVRIIT
EECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEE
VADRHIPRAKELEEAWKRLGLVVTLDDSSESVSKKIRNAQNMQVNYMITLGDHEINENVL
EECCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEE
AVRTRDNRVINDVSVERFLNTILEEKNSLSLTALL
EEEECCCCEEHHHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure
MIQVTCDQKNYEVLEGTTAAELAKQLKNSHQFIGVLINERPRDLSTHLNEGDTLVFLTSE
CEEEEECCCCCEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHCCCCCEEEEEECC
DPEGREIFLHTSAHLLAQAVLRLWPDAIPTIGPVIDHGFYYDFANLSISESDFPLIEDTV
CCCCCEEEEECHHHHHHHHHHHHCCHHCCCHHHHHHCCCEEEECCCEECCCCCCHHHHHH
KQIVDEKLAISRFTYGDKQQALAQFPQNPFKTELIRELPENEEISAYSQGEFFDLCRGPH
HHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCC
LPSTAHVKAFKVLRTSAAYWRGDPSRESLVRIYGTSFPTSKELRAHLEQIEEAKKRDHRV
CCCCHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEE
LGAKLDLFSQQESSPGMPFFHPRGMIVWDALIRYWKQLHTAAGYKEILTPQLMNRQLWEV
HHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCHHHEE
SGHWDNYKANMYTLQIDDEDYAIKPMNCPGCMLYYKTRLHSYKEFPLRVAEVGHVHRQEA
CCCCCCEECEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SGALSGLMRVRAFHQDDAHVFLTPEQVEEETLNILQLVSTLYGTFGLEYHLELSTRPEKD
HHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
TIGDDSLWELATDALNRALVQSGTPFIVRPGEGAFYGPKIDIHVKDAIQRTWQCGTIQLD
CCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEEHHHHHHCCCCCEEEEE
MFLPERFELEYTTAQGTKSVPVMLHRALFGSIERFLGILIENFKGRFPLWLSPEQVRIIT
EECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEE
VADRHIPRAKELEEAWKRLGLVVTLDDSSESVSKKIRNAQNMQVNYMITLGDHEINENVL
EECCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEE
AVRTRDNRVINDVSVERFLNTILEEKNSLSLTALL
EEEECCCCEEHHHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362