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The map label for this gene is lpxC

Identifier: 15618562

GI number: 15618562

Start: 733987

End: 734835

Strand: Reverse

Name: lpxC

Synonym: CPn0652

Alternate gene names: 15618562

Gene position: 734835-733987 (Counterclockwise)

Preceding gene: 15618563

Following gene: 15618561

Centisome position: 59.73

GC content: 39.46

Gene sequence:

>849_bases
ATGTTAGAACGAACTCAAAGAACGTTAAAGCGAGAGGTTCGCTATTCTGGAGTGGGAATTCACTTAGGGAAGTCCTCAAC
TCTCCATTTGCAACCTGCACAAACAAATACAGGTATTGTTTTTCAAAGACAGTCTGCCTCAGGTAACTACGAAAATGTCC
CTGCTTTACTAGATCATGTCTACACTACAGGAAGAAGTACAACATTATCTAGGGGTAGTGCTGTAATCGCCACTGTCGAA
CATCTTATGGCAGCATTGCGATCTAACAATATAGATAATCTAATTATCCAATGTAGTGGAGAGGAAATCCCCATAGGGGA
TGGAAGCTCAAATGTCTTTGTTGAGTTAATCGATCAAGCAGGTATTTGTGAACAAGAAGATAAGGTTTCCATTGCGAGAC
TAACACGTCCTGTATATTATCAACATCAGGACATTTTTTTAGCAGCCTTTCCCTCTGATGAGCTGAAGATTTCCTATACG
TTGCATTATCCTCAAAGTTCAACAATAGGGACTCAATACAAATCTTTGGTGATTAATGAAGAGTCTTTTCGCCAGGAAAT
TGCTCCTTGTAGAACATTTGCTCTATACAATGAGCTATGTTTCTTAATGGAAAAGGGGCTAATTGGAGGGGGATGTTTGG
ATAATGCTGTAGTTTTTAAGGACGATGGTATTATTAGTAGAGGACAATTAAGATTTGCCGATGAACCAGTACGACATAAA
ATACTGGATCTGATTGGAGATCTTTCCTTAGTTGGCAGGCCTTTTGTTGCGCATGTATTAGCTGTCGGCTCCGGCCACTC
CTCCAATATTGCTTTTGGTAAAAAAATTTTGGAAGCATTAGAACTATAA

Upstream 100 bases:

>100_bases
TCTGTGCAGTCAGTTATCTAGGAGGAGGATTCTTAGGATATCGCTTGCTTGCTAAAAAAGAAATTCGATAATATACGGAG
ACTCGTTGTCAGGTTTTTAC

Downstream 100 bases:

>100_bases
AGAAAGAATAAATGAATCAACCCTCTGTCATCAAATTACGCGAATTATTAGATTTACTCCCCCACAGATATCCTTTTTTA
TTAGTGGATAAAGTTTTATC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MLERTQRTLKREVRYSGVGIHLGKSSTLHLQPAQTNTGIVFQRQSASGNYENVPALLDHVYTTGRSTTLSRGSAVIATVE
HLMAALRSNNIDNLIIQCSGEEIPIGDGSSNVFVELIDQAGICEQEDKVSIARLTRPVYYQHQDIFLAAFPSDELKISYT
LHYPQSSTIGTQYKSLVINEESFRQEIAPCRTFALYNELCFLMEKGLIGGGCLDNAVVFKDDGIISRGQLRFADEPVRHK
ILDLIGDLSLVGRPFVAHVLAVGSGHSSNIAFGKKILEALEL

Sequences:

>Translated_282_residues
MLERTQRTLKREVRYSGVGIHLGKSSTLHLQPAQTNTGIVFQRQSASGNYENVPALLDHVYTTGRSTTLSRGSAVIATVE
HLMAALRSNNIDNLIIQCSGEEIPIGDGSSNVFVELIDQAGICEQEDKVSIARLTRPVYYQHQDIFLAAFPSDELKISYT
LHYPQSSTIGTQYKSLVINEESFRQEIAPCRTFALYNELCFLMEKGLIGGGCLDNAVVFKDDGIISRGQLRFADEPVRHK
ILDLIGDLSLVGRPFVAHVLAVGSGHSSNIAFGKKILEALEL
>Mature_282_residues
MLERTQRTLKREVRYSGVGIHLGKSSTLHLQPAQTNTGIVFQRQSASGNYENVPALLDHVYTTGRSTTLSRGSAVIATVE
HLMAALRSNNIDNLIIQCSGEEIPIGDGSSNVFVELIDQAGICEQEDKVSIARLTRPVYYQHQDIFLAAFPSDELKISYT
LHYPQSSTIGTQYKSLVINEESFRQEIAPCRTFALYNELCFLMEKGLIGGGCLDNAVVFKDDGIISRGQLRFADEPVRHK
ILDLIGDLSLVGRPFVAHVLAVGSGHSSNIAFGKKILEALEL

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=277, Percent_Identity=36.101083032491, Blast_Score=157, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_CHLPN (Q9Z7Q2)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   A86572
- PIR:   C81615
- PIR:   E72051
- RefSeq:   NP_224848.1
- RefSeq:   NP_300708.1
- RefSeq:   NP_444647.1
- RefSeq:   NP_876950.1
- ProteinModelPortal:   Q9Z7Q2
- SMR:   Q9Z7Q2
- PHCI-2DPAGE:   Q9Z7Q2
- GeneID:   1467357
- GeneID:   895280
- GeneID:   919413
- GeneID:   963026
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0095
- KEGG:   cpn:CPn0652
- KEGG:   cpt:CpB0678
- TIGR:   CP_0095
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   Q9Z7Q2
- ProtClustDB:   PRK13186
- BioCyc:   CPNE115711:CP_0095-MONOMER
- BioCyc:   CPNE115713:CPN0652-MONOMER
- BioCyc:   CPNE138677:CPJ0652-MONOMER
- BioCyc:   CPNE182082:CPB0678-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 31037; Mature: 31037

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERTQRTLKREVRYSGVGIHLGKSSTLHLQPAQTNTGIVFQRQSASGNYENVPALLDHV
CCCHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCEEEEECCCCCCCCCHHHHHHHH
YTTGRSTTLSRGSAVIATVEHLMAALRSNNIDNLIIQCSGEEIPIGDGSSNVFVELIDQA
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCCCCCCHHHEEEHHC
GICEQEDKVSIARLTRPVYYQHQDIFLAAFPSDELKISYTLHYPQSSTIGTQYKSLVINE
CCCCCCCCHHHHHHCCCCEEECCEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHEEECH
ESFRQEIAPCRTFALYNELCFLMEKGLIGGGCLDNAVVFKDDGIISRGQLRFADEPVRHK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEECCEEEECCCHHHHH
ILDLIGDLSLVGRPFVAHVLAVGSGHSSNIAFGKKILEALEL
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLERTQRTLKREVRYSGVGIHLGKSSTLHLQPAQTNTGIVFQRQSASGNYENVPALLDHV
CCCHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCEEEEECCCCCCCCCHHHHHHHH
YTTGRSTTLSRGSAVIATVEHLMAALRSNNIDNLIIQCSGEEIPIGDGSSNVFVELIDQA
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCCCCCCHHHEEEHHC
GICEQEDKVSIARLTRPVYYQHQDIFLAAFPSDELKISYTLHYPQSSTIGTQYKSLVINE
CCCCCCCCHHHHHHCCCCEEECCEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHEEECH
ESFRQEIAPCRTFALYNELCFLMEKGLIGGGCLDNAVVFKDDGIISRGQLRFADEPVRHK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEECCEEEECCCHHHHH
ILDLIGDLSLVGRPFVAHVLAVGSGHSSNIAFGKKILEALEL
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362