Click here to switch to the map view.

The map label for this gene is pbp3

Identifier: 15618334

GI number: 15618334

Start: 464873

End: 466834

Strand: Reverse

Name: pbp3

Synonym: CPn0419

Alternate gene names: 15618334

Gene position: 466834-464873 (Counterclockwise)

Preceding gene: 15618335

Following gene: 15618333

Centisome position: 37.95

GC content: 44.24

Gene sequence:

>1962_bases
ATGAGCTACCGTAAACGTTCGACTCTAATTGTTCTAGGAGTGTTTGCTCTTTATGCTCTTCTAGTATTGCGTTATTATAA
AATTCAAATTTGTGAAGGAGACCACTGGGCCGCAGAAGCTCTCGGGCAACACGAATTTTGTGTCCGTGATCCTTTTCGAA
GGGGCACCTTTTTTGCTAACACGACAGTACGTAAGGGAGACAAAGACCTTCAGCAGCCTTTCGCTGTCGATATTACAAAA
TTTCACCTTTGTGCAGATCCTTTAGCTATTCCCGAATGTCATCGTGATGAGATCATCCAAGGGATTCTCCAATTTATTGA
GGGGCAGACCTACGACGACCTCTCCCTAAAGTTAGATAAGAAATCTCGGTATTGTAAGCTGTATCCTTTATTAGATGTTT
CTGTCCATGACCGGCTATCCCTTTGGTGGAAAGGATATGCAACAAAGCATCGCTTACCAACAAACGCCCTATTTTTTATT
ACGGACTACCAACGCTCGTATCCTTTTGGGAAGCTCCTTGGACAAGTTCTCCATACCTTAAGAGAAATTAAGGATGAGAA
AACAGGAAAAGCCTTTCCCACAGGCGGGATGGAGGCGTACTTTAATCATATTCTGGAAGGGGACGTTGGAGAGAGAAAGC
TGTTGCGTTCTCCTTTGAACCGTTTAGATACGAATCGTGTTATCAAACTGCCTAAAGATGGCTCTGATATCTACCTTACG
ATCAATCCTGTGATCCAGACCATTGCAGAGGAAGAACTCGAACGGGGCGTGCTAGAAGCTAAAGCCCAGGGGGGTAGGCT
CATTCTAATGAACTCCCAAACAGGAGAGATTCTTGCACTGGCTCAATATCCGTTTTTCGATCCCACAAATTATAAGGAAT
ACTTCAATAACAAAGAGCGCATCGAACATACGAAGGTATCTTTTGTGAGCGATGTTTTTGAACCCGGGTCGATCATGAAA
CCTTTGACTGTGGCGATTGCTTTACAAGCTAACGAAGAGGCTAGCTTAAAATCGCAGAAAAAGATTTTTGATCCTGAAGA
ACCTATCGATGTGACCAGGACACTCTTCCCTGGACGAAAAGGATCTCCGCTTAAGGATATTTCTAGAAACTCTCAATTGA
ATATGTACATGGCTATCCAGAAATCTTCGAATGTCTATGTAGCTCAGCTGGCTGACCGCATCATACAATCTTTAGGAGTG
GCCTGGTACCAACAGAAGTTGCTAGCTCTGGGATTTGGAAGAAAAACAGGGATCGAGCTTCCCAGTGAGGCCTCTGGTTT
GGTGCCTTCTCCCCATCGTTTCCATATTAATGGTTCCCTGGAATGGTCCTTATCTACTCCATATTCTTTGGCTATGGGAT
ATAATATTTTGGCAACAGGGATACAAATGGTTCAAGCCTACGCTATCCTTGCAAACGGAGGTTATGCCGTCCGGCCCACT
TTAGTAAAAAAGATCGTCTCTGCTTCAGGAGAGGAATATCATCTTCCTACTAAAGAGAAGACACGACTCTTTTCAGAAGA
AATTACTAGAGAAGTTGTTCGTGCCATGCGTTTTACAACGTTACCCGGAGGTTCGGGATTTCGAGCCTCTCCTAAGCATC
ACTCTAGTGCTGGGAAAACAGGAACTACAGAAAAGATGATTCATGGAAAATATGATAAACGCCGTCATATTGCTTCTTTT
ATAGGTTTTACTCCCGTAGAGAGCTCGGAGGGAAATTTCCCACCTTTAGTGATGCTCGTCTCCATAGATGATCCTGAATA
TGGTTTGCGAGCCGACGGCACGAAAAATTATATGGGGGGGCGTTGTGCGGCACCCATTTTTTCTAGGGTTGCTGACCGCA
CACTCCTCTATTTAGGGATTCTTCCAGACAAGAAGCTAAGAAATTGCGACGAAGAAGCTGCTGCATTAAAGCGTCTCTAT
GAAGAATGGAATCGTTCTCCGAAACAAGGGGGAACGAGGTGA

Upstream 100 bases:

>100_bases
GATAAAATAGAAAGACCTGATCATTTGATGGAAATAGCAGCTCTTCCCGAATACCAATATTTGGAATATCCCTCAGAAGA
AAGTATCAGTCTTTTATCCT

Downstream 100 bases:

>100_bases
GGATCTCTATTTCCATCTTGCTATAGACTTTTACCGTTGAGCAAAGACTCTCTATCAGAGAGCCCGTCTCCTCTTTATCC
TCTATGAGTAGTTTATGTTA

Product: transglycolase/transpeptidase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MSYRKRSTLIVLGVFALYALLVLRYYKIQICEGDHWAAEALGQHEFCVRDPFRRGTFFANTTVRKGDKDLQQPFAVDITK
FHLCADPLAIPECHRDEIIQGILQFIEGQTYDDLSLKLDKKSRYCKLYPLLDVSVHDRLSLWWKGYATKHRLPTNALFFI
TDYQRSYPFGKLLGQVLHTLREIKDEKTGKAFPTGGMEAYFNHILEGDVGERKLLRSPLNRLDTNRVIKLPKDGSDIYLT
INPVIQTIAEEELERGVLEAKAQGGRLILMNSQTGEILALAQYPFFDPTNYKEYFNNKERIEHTKVSFVSDVFEPGSIMK
PLTVAIALQANEEASLKSQKKIFDPEEPIDVTRTLFPGRKGSPLKDISRNSQLNMYMAIQKSSNVYVAQLADRIIQSLGV
AWYQQKLLALGFGRKTGIELPSEASGLVPSPHRFHINGSLEWSLSTPYSLAMGYNILATGIQMVQAYAILANGGYAVRPT
LVKKIVSASGEEYHLPTKEKTRLFSEEITREVVRAMRFTTLPGGSGFRASPKHHSSAGKTGTTEKMIHGKYDKRRHIASF
IGFTPVESSEGNFPPLVMLVSIDDPEYGLRADGTKNYMGGRCAAPIFSRVADRTLLYLGILPDKKLRNCDEEAAALKRLY
EEWNRSPKQGGTR

Sequences:

>Translated_653_residues
MSYRKRSTLIVLGVFALYALLVLRYYKIQICEGDHWAAEALGQHEFCVRDPFRRGTFFANTTVRKGDKDLQQPFAVDITK
FHLCADPLAIPECHRDEIIQGILQFIEGQTYDDLSLKLDKKSRYCKLYPLLDVSVHDRLSLWWKGYATKHRLPTNALFFI
TDYQRSYPFGKLLGQVLHTLREIKDEKTGKAFPTGGMEAYFNHILEGDVGERKLLRSPLNRLDTNRVIKLPKDGSDIYLT
INPVIQTIAEEELERGVLEAKAQGGRLILMNSQTGEILALAQYPFFDPTNYKEYFNNKERIEHTKVSFVSDVFEPGSIMK
PLTVAIALQANEEASLKSQKKIFDPEEPIDVTRTLFPGRKGSPLKDISRNSQLNMYMAIQKSSNVYVAQLADRIIQSLGV
AWYQQKLLALGFGRKTGIELPSEASGLVPSPHRFHINGSLEWSLSTPYSLAMGYNILATGIQMVQAYAILANGGYAVRPT
LVKKIVSASGEEYHLPTKEKTRLFSEEITREVVRAMRFTTLPGGSGFRASPKHHSSAGKTGTTEKMIHGKYDKRRHIASF
IGFTPVESSEGNFPPLVMLVSIDDPEYGLRADGTKNYMGGRCAAPIFSRVADRTLLYLGILPDKKLRNCDEEAAALKRLY
EEWNRSPKQGGTR
>Mature_652_residues
SYRKRSTLIVLGVFALYALLVLRYYKIQICEGDHWAAEALGQHEFCVRDPFRRGTFFANTTVRKGDKDLQQPFAVDITKF
HLCADPLAIPECHRDEIIQGILQFIEGQTYDDLSLKLDKKSRYCKLYPLLDVSVHDRLSLWWKGYATKHRLPTNALFFIT
DYQRSYPFGKLLGQVLHTLREIKDEKTGKAFPTGGMEAYFNHILEGDVGERKLLRSPLNRLDTNRVIKLPKDGSDIYLTI
NPVIQTIAEEELERGVLEAKAQGGRLILMNSQTGEILALAQYPFFDPTNYKEYFNNKERIEHTKVSFVSDVFEPGSIMKP
LTVAIALQANEEASLKSQKKIFDPEEPIDVTRTLFPGRKGSPLKDISRNSQLNMYMAIQKSSNVYVAQLADRIIQSLGVA
WYQQKLLALGFGRKTGIELPSEASGLVPSPHRFHINGSLEWSLSTPYSLAMGYNILATGIQMVQAYAILANGGYAVRPTL
VKKIVSASGEEYHLPTKEKTRLFSEEITREVVRAMRFTTLPGGSGFRASPKHHSSAGKTGTTEKMIHGKYDKRRHIASFI
GFTPVESSEGNFPPLVMLVSIDDPEYGLRADGTKNYMGGRCAAPIFSRVADRTLLYLGILPDKKLRNCDEEAAALKRLYE
EWNRSPKQGGTR

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=570, Percent_Identity=27.719298245614, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1786854, Length=514, Percent_Identity=21.7898832684825, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 73665; Mature: 73533

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYRKRSTLIVLGVFALYALLVLRYYKIQICEGDHWAAEALGQHEFCVRDPFRRGTFFAN
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHCCCCCCHHCCCCCCCCEEEC
TTVRKGDKDLQQPFAVDITKFHLCADPLAIPECHRDEIIQGILQFIEGQTYDDLSLKLDK
CCCCCCCHHHHCCCEEEHEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECC
KSRYCKLYPLLDVSVHDRLSLWWKGYATKHRLPTNALFFITDYQRSYPFGKLLGQVLHTL
CCCEEEEEEEEECCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
REIKDEKTGKAFPTGGMEAYFNHILEGDVGERKLLRSPLNRLDTNRVIKLPKDGSDIYLT
HHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEECCCCCCEEEEE
INPVIQTIAEEELERGVLEAKAQGGRLILMNSQTGEILALAQYPFFDPTNYKEYFNNKER
EHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCHHHHCCCHHH
IEHTKVSFVSDVFEPGSIMKPLTVAIALQANEEASLKSQKKIFDPEEPIDVTRTLFPGRK
HHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHCCCCC
GSPLKDISRNSQLNMYMAIQKSSNVYVAQLADRIIQSLGVAWYQQKLLALGFGRKTGIEL
CCCHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PSEASGLVPSPHRFHINGSLEWSLSTPYSLAMGYNILATGIQMVQAYAILANGGYAVRPT
CCCCCCCCCCCCEEEECCEEEEECCCCCHHHHCHHHHHHHHHHHHHHHHEECCCEEECHH
LVKKIVSASGEEYHLPTKEKTRLFSEEITREVVRAMRFTTLPGGSGFRASPKHHSSAGKT
HHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCC
GTTEKMIHGKYDKRRHIASFIGFTPVESSEGNFPPLVMLVSIDDPEYGLRADGTKNYMGG
CCCHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
RCAAPIFSRVADRTLLYLGILPDKKLRNCDEEAAALKRLYEEWNRSPKQGGTR
CHHHHHHHHHHHCEEEEEECCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SYRKRSTLIVLGVFALYALLVLRYYKIQICEGDHWAAEALGQHEFCVRDPFRRGTFFAN
CCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHCCCCCCHHCCCCCCCCEEEC
TTVRKGDKDLQQPFAVDITKFHLCADPLAIPECHRDEIIQGILQFIEGQTYDDLSLKLDK
CCCCCCCHHHHCCCEEEHEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECC
KSRYCKLYPLLDVSVHDRLSLWWKGYATKHRLPTNALFFITDYQRSYPFGKLLGQVLHTL
CCCEEEEEEEEECCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
REIKDEKTGKAFPTGGMEAYFNHILEGDVGERKLLRSPLNRLDTNRVIKLPKDGSDIYLT
HHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEECCCCCCEEEEE
INPVIQTIAEEELERGVLEAKAQGGRLILMNSQTGEILALAQYPFFDPTNYKEYFNNKER
EHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCHHHHCCCHHH
IEHTKVSFVSDVFEPGSIMKPLTVAIALQANEEASLKSQKKIFDPEEPIDVTRTLFPGRK
HHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHCCCCC
GSPLKDISRNSQLNMYMAIQKSSNVYVAQLADRIIQSLGVAWYQQKLLALGFGRKTGIEL
CCCHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PSEASGLVPSPHRFHINGSLEWSLSTPYSLAMGYNILATGIQMVQAYAILANGGYAVRPT
CCCCCCCCCCCCEEEECCEEEEECCCCCHHHHCHHHHHHHHHHHHHHHHEECCCEEECHH
LVKKIVSASGEEYHLPTKEKTRLFSEEITREVVRAMRFTTLPGGSGFRASPKHHSSAGKT
HHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCC
GTTEKMIHGKYDKRRHIASFIGFTPVESSEGNFPPLVMLVSIDDPEYGLRADGTKNYMGG
CCCHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
RCAAPIFSRVADRTLLYLGILPDKKLRNCDEEAAALKRLYEEWNRSPKQGGTR
CHHHHHHHHHHHCEEEEEECCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]