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The map label for this gene is thiD

Identifier: 15606959

GI number: 15606959

Start: 1377795

End: 1378562

Strand: Direct

Name: thiD

Synonym: aq_1960

Alternate gene names: 15606959

Gene position: 1377795-1378562 (Clockwise)

Preceding gene: 15606958

Following gene: 15606966

Centisome position: 88.81

GC content: 39.45

Gene sequence:

>768_bases
ATGATAGCCCTCAGTATTGCAGGGTTTGACAACAGCGGTGGAGCGGGAACCTTAGCGGATATAAGAACATTTAAGCACTT
CGGTATTTACGGAGTTGCCGTAATAACCGCCCTGGCGGTTCAAAACACCCAAAAGGTTTACGAGGTATTTCCCATTCCGC
CGGATGTAGTTAAGGAAGAGCTGAAAGCAATATTTGAGGACTTTCCGATAAAGGGTGTAAAGATAGGTATGCTTGCAAAT
AAAGAAATAGCGGAAGTGGTTTACGAAACTCTTAAGAGTAAAAAAACAAACTTTATAGTTCTTGATCCCGTTTTTCGTTC
AAAGTCAGGAAGGGAACTTCTTTCAGAAGAAGGGGTTGAGTTTCTAAAAAGTGAGTTTATTAAAATCGTTGACCTAATTA
CTCCAAACGTTCCAGAGGCAGAAATTCTTTGCGGAGAAGAGATAAAGAGTTTAGAAGACGTAAAAAATTGTGCCCAAAAA
ATTTATTCCTTAGGGGCTAAAAGCGTGCTTATAAAGGGCGGGCACTTGAAAGGAAACTATGCGATAGATATTCTTTACGA
CGGAAAGAGTTTTTATGAGTTTAAAGCTCCCAAAATTGCAGGAAAAACTCCGAGAGGGACGGGTTGTGTTTATTCCTCTG
CAATCCTTGCCAATTACCTGAGGCACAAAGACCTAATAAAAGCGATAAAAACAGCGAAAGATTTCATTACAGAAGCTATA
AAAAACAGTAAAAAACTCGGAAAAGGCTACGAGATTATGGACTTTTGA

Upstream 100 bases:

>100_bases
AAGACGAAAAAACGATCCACTTTGTAGTTTGCAGAAGCGGGGCGAGTCTGGAAGGTTGTTACGGAGAGGTGTTTGCAGAA
GGCTACATAATAAAGAAGAA

Downstream 100 bases:

>100_bases
AACTCTGAATAAAGTACTCAAAGACTTTGAAGAAATCCTGAAAGTGGTTTGACATGGTGATCGTTATTAACGGAAGTGAT
AGGAGGAGTATTATAAGCCC

Product: HMP-P kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MIALSIAGFDNSGGAGTLADIRTFKHFGIYGVAVITALAVQNTQKVYEVFPIPPDVVKEELKAIFEDFPIKGVKIGMLAN
KEIAEVVYETLKSKKTNFIVLDPVFRSKSGRELLSEEGVEFLKSEFIKIVDLITPNVPEAEILCGEEIKSLEDVKNCAQK
IYSLGAKSVLIKGGHLKGNYAIDILYDGKSFYEFKAPKIAGKTPRGTGCVYSSAILANYLRHKDLIKAIKTAKDFITEAI
KNSKKLGKGYEIMDF

Sequences:

>Translated_255_residues
MIALSIAGFDNSGGAGTLADIRTFKHFGIYGVAVITALAVQNTQKVYEVFPIPPDVVKEELKAIFEDFPIKGVKIGMLAN
KEIAEVVYETLKSKKTNFIVLDPVFRSKSGRELLSEEGVEFLKSEFIKIVDLITPNVPEAEILCGEEIKSLEDVKNCAQK
IYSLGAKSVLIKGGHLKGNYAIDILYDGKSFYEFKAPKIAGKTPRGTGCVYSSAILANYLRHKDLIKAIKTAKDFITEAI
KNSKKLGKGYEIMDF
>Mature_255_residues
MIALSIAGFDNSGGAGTLADIRTFKHFGIYGVAVITALAVQNTQKVYEVFPIPPDVVKEELKAIFEDFPIKGVKIGMLAN
KEIAEVVYETLKSKKTNFIVLDPVFRSKSGRELLSEEGVEFLKSEFIKIVDLITPNVPEAEILCGEEIKSLEDVKNCAQK
IYSLGAKSVLIKGGHLKGNYAIDILYDGKSFYEFKAPKIAGKTPRGTGCVYSSAILANYLRHKDLIKAIKTAKDFITEAI
KNSKKLGKGYEIMDF

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family

Homologues:

Organism=Escherichia coli, GI1788420, Length=251, Percent_Identity=39.8406374501992, Blast_Score=188, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6325378, Length=249, Percent_Identity=31.7269076305221, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324997, Length=249, Percent_Identity=34.136546184739, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324517, Length=249, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THID_AQUAE (O67772)

Other databases:

- EMBL:   AE000657
- PIR:   H70467
- RefSeq:   NP_214341.1
- ProteinModelPortal:   O67772
- SMR:   O67772
- GeneID:   1193669
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1960
- NMPDR:   fig|224324.1.peg.1356
- HOGENOM:   HBG476673
- OMA:   LNIGHGH
- PhylomeDB:   O67772
- BioCyc:   AAEO224324:AQ_1960-MONOMER
- BRENDA:   2.7.4.7
- InterPro:   IPR013749
- InterPro:   IPR004399
- TIGRFAMs:   TIGR00097

Pfam domain/function: PF08543 Phos_pyr_kin

EC number: =2.7.1.49; =2.7.4.7

Molecular weight: Translated: 28066; Mature: 28066

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: BINDING 41-41

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALSIAGFDNSGGAGTLADIRTFKHFGIYGVAVITALAVQNTQKVYEVFPIPPDVVKEE
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHEECCCCHHHHHHH
LKAIFEDFPIKGVKIGMLANKEIAEVVYETLKSKKTNFIVLDPVFRSKSGRELLSEEGVE
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEECHHHCCCCHHHHHHHHHHH
FLKSEFIKIVDLITPNVPEAEILCGEEIKSLEDVKNCAQKIYSLGAKSVLIKGGHLKGNY
HHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCEECCCE
AIDILYDGKSFYEFKAPKIAGKTPRGTGCVYSSAILANYLRHKDLIKAIKTAKDFITEAI
EEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNSKKLGKGYEIMDF
HHHHHHCCCCCCCCC
>Mature Secondary Structure
MIALSIAGFDNSGGAGTLADIRTFKHFGIYGVAVITALAVQNTQKVYEVFPIPPDVVKEE
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHEECCCCHHHHHHH
LKAIFEDFPIKGVKIGMLANKEIAEVVYETLKSKKTNFIVLDPVFRSKSGRELLSEEGVE
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEECHHHCCCCHHHHHHHHHHH
FLKSEFIKIVDLITPNVPEAEILCGEEIKSLEDVKNCAQKIYSLGAKSVLIKGGHLKGNY
HHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCEECCCE
AIDILYDGKSFYEFKAPKIAGKTPRGTGCVYSSAILANYLRHKDLIKAIKTAKDFITEAI
EEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNSKKLGKGYEIMDF
HHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320