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The map label for this gene is hemD [H]

Identifier: 15606833

GI number: 15606833

Start: 1249334

End: 1250086

Strand: Direct

Name: hemD [H]

Synonym: aq_1771

Alternate gene names: 15606833

Gene position: 1249334-1250086 (Clockwise)

Preceding gene: 15606830

Following gene: 15606834

Centisome position: 80.53

GC content: 33.33

Gene sequence:

>753_bases
GTGTGGATGTATATTCATAAGATCATGAAACTTTCTTACAAAAGAGTTATCCTAACGAGGGAACTTGAGGATATAAAAAA
GGATAAACCTCTCTTTGAAAGAGAAGGCTTTAAAGTTTTGGAGCTTCCCTTAATACAAACAAAAGTTCTTGAGTTTAACC
TTCCCGATGAAGAATTTGATTACATTGTTTTTCAAAGCAAAAAAGCGGTTAAAATTTTTCTTGGCAAGGTAAATCTTAAA
GGAAACAAAAAAATTGTAGCTGTAGGGAAAAAAACGGCGGAGGAATTGGAAAAATTAGGGTATAAAGCGGATTTCATTCC
GGAAAATGAAAGTGCAAAGGGCTTGATAGAACTCTTTAAAAGATTACCTAAAGGAAAGGTTCTAATTCCACGTTCTAAAA
TAGGCAGAACAGAGTTAATAAAGTTTTTAAAGGAAACGAGCTTTGAAGTTTTTGCGTTGGATGTTTACACAACTGAATAC
GTTTTTTATACAAGAGAAGAACTCCTGGAAAAACTAAACAAAGGAGACTTTATTATCTTTTACAGTCCATCGGCGGTGAA
GGCATTTTTTGCAAATTTGCAAATGCATAAAATTCCAAAGGATAGTTTGAGCCTTAAATTTGTAGCGATTGGTAAAACTA
CAAAAGAGGAATTACAGAAACACTCTGTTAAAAACGTTATTACCTCTGAAAGACCGAGTACTGAGGATATTGTCAAGAAA
CTAAAAGAATTGGCACGTGATTTGCAAAAATAA

Upstream 100 bases:

>100_bases
AACCGCACCGATGGTTATGAGTTTCTAATGTACCGTGTGGAGTTGAAAGTGGAAAATGCTGCAAAAACAAAAAGGAAAAA
GCTGAGGTTCCTAATGTACC

Downstream 100 bases:

>100_bases
TTACGGTATGGGATTAGAAAAGACGGTTAAAGAGAAATTAAGCTTTGAGGGTGTCGGTATACACACAGGTGAATACTCAA
AATTAATCATACATCCCGAA

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MWMYIHKIMKLSYKRVILTRELEDIKKDKPLFEREGFKVLELPLIQTKVLEFNLPDEEFDYIVFQSKKAVKIFLGKVNLK
GNKKIVAVGKKTAEELEKLGYKADFIPENESAKGLIELFKRLPKGKVLIPRSKIGRTELIKFLKETSFEVFALDVYTTEY
VFYTREELLEKLNKGDFIIFYSPSAVKAFFANLQMHKIPKDSLSLKFVAIGKTTKEELQKHSVKNVITSERPSTEDIVKK
LKELARDLQK

Sequences:

>Translated_250_residues
MWMYIHKIMKLSYKRVILTRELEDIKKDKPLFEREGFKVLELPLIQTKVLEFNLPDEEFDYIVFQSKKAVKIFLGKVNLK
GNKKIVAVGKKTAEELEKLGYKADFIPENESAKGLIELFKRLPKGKVLIPRSKIGRTELIKFLKETSFEVFALDVYTTEY
VFYTREELLEKLNKGDFIIFYSPSAVKAFFANLQMHKIPKDSLSLKFVAIGKTTKEELQKHSVKNVITSERPSTEDIVKK
LKELARDLQK
>Mature_250_residues
MWMYIHKIMKLSYKRVILTRELEDIKKDKPLFEREGFKVLELPLIQTKVLEFNLPDEEFDYIVFQSKKAVKIFLGKVNLK
GNKKIVAVGKKTAEELEKLGYKADFIPENESAKGLIELFKRLPKGKVLIPRSKIGRTELIKFLKETSFEVFALDVYTTEY
VFYTREELLEKLNKGDFIIFYSPSAVKAFFANLQMHKIPKDSLSLKFVAIGKTTKEELQKHSVKNVITSERPSTEDIVKK
LKELARDLQK

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 29143; Mature: 29143

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWMYIHKIMKLSYKRVILTRELEDIKKDKPLFEREGFKVLELPLIQTKVLEFNLPDEEFD
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEECCEEEEEEEECCCCCCCC
YIVFQSKKAVKIFLGKVNLKGNKKIVAVGKKTAEELEKLGYKADFIPENESAKGLIELFK
EEEEECCCEEEEEEEEEEECCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RLPKGKVLIPRSKIGRTELIKFLKETSFEVFALDVYTTEYVFYTREELLEKLNKGDFIIF
HCCCCCEEECHHHCCHHHHHHHHHHCCCEEEEEEEEEHHHHEEEHHHHHHHCCCCCEEEE
YSPSAVKAFFANLQMHKIPKDSLSLKFVAIGKTTKEELQKHSVKNVITSERPSTEDIVKK
ECCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
LKELARDLQK
HHHHHHHHCC
>Mature Secondary Structure
MWMYIHKIMKLSYKRVILTRELEDIKKDKPLFEREGFKVLELPLIQTKVLEFNLPDEEFD
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEECCEEEEEEEECCCCCCCC
YIVFQSKKAVKIFLGKVNLKGNKKIVAVGKKTAEELEKLGYKADFIPENESAKGLIELFK
EEEEECCCEEEEEEEEEEECCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RLPKGKVLIPRSKIGRTELIKFLKETSFEVFALDVYTTEYVFYTREELLEKLNKGDFIIF
HCCCCCEEECHHHCCHHHHHHHHHHCCCEEEEEEEEEHHHHEEEHHHHHHHCCCCCEEEE
YSPSAVKAFFANLQMHKIPKDSLSLKFVAIGKTTKEELQKHSVKNVITSERPSTEDIVKK
ECCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
LKELARDLQK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]