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The map label for this gene is tktA

Identifier: 15606828

GI number: 15606828

Start: 1243042

End: 1245111

Strand: Direct

Name: tktA

Synonym: aq_1765

Alternate gene names: 15606828

Gene position: 1243042-1245111 (Clockwise)

Preceding gene: 15606827

Following gene: 15606829

Centisome position: 80.13

GC content: 47.78

Gene sequence:

>2070_bases
ATGGTAGTCCAGCTTGATCAAATACACTTTTTCATTTTTCATGAAGTCCTTAAAATATTTAAAACTATGCCTCAGCTTTT
TAAAACCTCTAAAAAAATCGACGAGCTGGTTATAAACACTATTCGCTTTTTGAGCGTTGATATGGTCGAAAGGGCAAAAT
CAGGACACCCCGGAATGCCCCTCGGAGCTTCCCACATAGTTTATCTGCTTTACGACAGGATAATGAAGTACAACCCTAAA
AATCCCAATTGGTTTAACAGGGATAGGTTTATACTCTCTGCGGGCCACGGAAGTGCAATGCTCTATGCAGCCTTCTACAT
GTTCGGATTTGACCTGACTCTTGAGGATCTAAAAGCCTTCAGGCAACTAAACAGCAAAACTCCGGGACACCCCGAATACG
GACTCACTCCCGGCGTTGAGGTGACTACCGGAAACCTCGGACAGGGATTCGGGAATGCGGTTGGGATGGCGATGGCTGAG
AAATTTTTGTCCCACTACTTTAACAGGGAAGGATACCCCGTTATAGATCACTACACCTACGTCCTTGTATCGGATGGGGA
CTTAATGGAGGGTGTTTCTTACGAGGCTGCATCCCTTGCGGGACACTTTAAGTTAAACAAGTTAATAGCAATATGGGACA
ACAACCACATAACTATAGACGGAGACACTAAGCTTACGTGGACGGAAGACGTCTTAAAAAGGTTTGAAGCCCTCGGTTGG
GAAGTGTACCACCTGGAAGACGGGTACAACTTGGATCTTCTGGAAGAAACGATTCTAAAAGCAAAAGAAAGCGACAAGCC
CACCTTTATATCCGTGAGGACGCACATAGGTTACGGAACGCCCCTTCAGGATACACCGGAAGTCCACGGGAAGCCTATGG
GCAAAGAGATAGTGGAGGAAACCAAGAAGAAGTTCGGCTGGCCACTTGAGGAGTTTTACGTCCCCGAAGAGGCACTCAAT
TATACGAGAAGGAAAGTTGAAGAGGGGAAAGCTCTCGAAGAAGAGTGGAACAAACTTTACGCCGAATACAGGGAAAAATA
CCCCGACCTTGCCCAGACGCTTGAGAAGGCTCTTAACAAGGAGTGGAGTTTAGACTGGCTTGAAAAAGTAGAGGAATTCA
AAGAAGACATGCCTACCAGAAAAGCCTCGGGGAAAGTGCTCAACGTAATGGCGGATTACATACCCACCATGATTGGCGGT
TCGGCGGACCTTTCGGAATCCGTGAACACAGTGTTGAAAAAGTACGGAGATTTTGAAGCCGACACACCTACAGGAAGGAA
CGTTCACTACGGTGTCAGGGAACACGCCATGGGAACGATTCTCAACGGCATGGCTTACCACGGAGGAATACTCCCTTACG
GCGGTACTTTCCTCATATTCTCGGAGTACATGAGACCCGCTATAAGAACGGCAGCACTCGCAAACCTACAGGTAATCTTC
GTTTACTCTCATGACTCCATAGGTCTGGGAGAGGACGGTCCTACCCACCAACCCGTTGAACAACTTTGGAGCCTGAGGAG
CATACCCAACCTCTGGGTAGTAAGACCCGCCGACGCAAACGAGGTGAAGTACGCGTGGGAGATAGCCCTGAAGAGGAAAA
ACGGCCCCACGGCCATAATACTCACGAGACAAAAAGTAAAAACCATAGACAGATCCAAGTACGCCTCTCCGGAAGGCGTA
AGGAAAGGGGCTTACGTTATAGCTGATACAGAAGGAAAACCGGATGTTGTAATCATCGCAACAGGTTCGGAAGTTCAGGT
TGCACTCGGAGCGAAAGAGATACTGGAACAAAAAGGAATAAAAACGAGAGTGGTTAATATGGCTTGCTGTGAACTCTTCG
AAGAACAGCCCGAAGAGTACAAAAGGGAAGTTCTGCCTCCCGAAGTTACGAAGAGGGTAGCCGTTGAAGCGGGAAGGGAC
ACGGGCTGGTATAAGTACGTAGGAAGCGACGGACTCGTTATTAGCCTGAACGAGTTCGGTAAGTCCGCTCCCGGAAGCGT
TCTCTTTGAGTATTACGGCTTTACACCGGAAAACGTGGCCAATAAGGTAATTGAAAAGTGGTTTTCCTGA

Upstream 100 bases:

>100_bases
CTGGCGGGAGTCGAACCCGCAACCTCGGGATCCGTAGTCCCGCGCTCTATCCAGTTGAGCTACAGCCCGTACCAAGTTAA
TAATTTTAATCCCTTGCCCT

Downstream 100 bases:

>100_bases
TTTATAATTATTTATTCGGTAGGAGGGTGTAGCTCAGTTGGTAGAGCGGGGGACTGTGGATCCCCGTGTCGCGGGTTCGA
GTCCCGTCACCCTCCCCATT

Product: transketolase

Products: NA

Alternate protein names: TK

Number of amino acids: Translated: 689; Mature: 689

Protein sequence:

>689_residues
MVVQLDQIHFFIFHEVLKIFKTMPQLFKTSKKIDELVINTIRFLSVDMVERAKSGHPGMPLGASHIVYLLYDRIMKYNPK
NPNWFNRDRFILSAGHGSAMLYAAFYMFGFDLTLEDLKAFRQLNSKTPGHPEYGLTPGVEVTTGNLGQGFGNAVGMAMAE
KFLSHYFNREGYPVIDHYTYVLVSDGDLMEGVSYEAASLAGHFKLNKLIAIWDNNHITIDGDTKLTWTEDVLKRFEALGW
EVYHLEDGYNLDLLEETILKAKESDKPTFISVRTHIGYGTPLQDTPEVHGKPMGKEIVEETKKKFGWPLEEFYVPEEALN
YTRRKVEEGKALEEEWNKLYAEYREKYPDLAQTLEKALNKEWSLDWLEKVEEFKEDMPTRKASGKVLNVMADYIPTMIGG
SADLSESVNTVLKKYGDFEADTPTGRNVHYGVREHAMGTILNGMAYHGGILPYGGTFLIFSEYMRPAIRTAALANLQVIF
VYSHDSIGLGEDGPTHQPVEQLWSLRSIPNLWVVRPADANEVKYAWEIALKRKNGPTAIILTRQKVKTIDRSKYASPEGV
RKGAYVIADTEGKPDVVIIATGSEVQVALGAKEILEQKGIKTRVVNMACCELFEEQPEEYKREVLPPEVTKRVAVEAGRD
TGWYKYVGSDGLVISLNEFGKSAPGSVLFEYYGFTPENVANKVIEKWFS

Sequences:

>Translated_689_residues
MVVQLDQIHFFIFHEVLKIFKTMPQLFKTSKKIDELVINTIRFLSVDMVERAKSGHPGMPLGASHIVYLLYDRIMKYNPK
NPNWFNRDRFILSAGHGSAMLYAAFYMFGFDLTLEDLKAFRQLNSKTPGHPEYGLTPGVEVTTGNLGQGFGNAVGMAMAE
KFLSHYFNREGYPVIDHYTYVLVSDGDLMEGVSYEAASLAGHFKLNKLIAIWDNNHITIDGDTKLTWTEDVLKRFEALGW
EVYHLEDGYNLDLLEETILKAKESDKPTFISVRTHIGYGTPLQDTPEVHGKPMGKEIVEETKKKFGWPLEEFYVPEEALN
YTRRKVEEGKALEEEWNKLYAEYREKYPDLAQTLEKALNKEWSLDWLEKVEEFKEDMPTRKASGKVLNVMADYIPTMIGG
SADLSESVNTVLKKYGDFEADTPTGRNVHYGVREHAMGTILNGMAYHGGILPYGGTFLIFSEYMRPAIRTAALANLQVIF
VYSHDSIGLGEDGPTHQPVEQLWSLRSIPNLWVVRPADANEVKYAWEIALKRKNGPTAIILTRQKVKTIDRSKYASPEGV
RKGAYVIADTEGKPDVVIIATGSEVQVALGAKEILEQKGIKTRVVNMACCELFEEQPEEYKREVLPPEVTKRVAVEAGRD
TGWYKYVGSDGLVISLNEFGKSAPGSVLFEYYGFTPENVANKVIEKWFS
>Mature_689_residues
MVVQLDQIHFFIFHEVLKIFKTMPQLFKTSKKIDELVINTIRFLSVDMVERAKSGHPGMPLGASHIVYLLYDRIMKYNPK
NPNWFNRDRFILSAGHGSAMLYAAFYMFGFDLTLEDLKAFRQLNSKTPGHPEYGLTPGVEVTTGNLGQGFGNAVGMAMAE
KFLSHYFNREGYPVIDHYTYVLVSDGDLMEGVSYEAASLAGHFKLNKLIAIWDNNHITIDGDTKLTWTEDVLKRFEALGW
EVYHLEDGYNLDLLEETILKAKESDKPTFISVRTHIGYGTPLQDTPEVHGKPMGKEIVEETKKKFGWPLEEFYVPEEALN
YTRRKVEEGKALEEEWNKLYAEYREKYPDLAQTLEKALNKEWSLDWLEKVEEFKEDMPTRKASGKVLNVMADYIPTMIGG
SADLSESVNTVLKKYGDFEADTPTGRNVHYGVREHAMGTILNGMAYHGGILPYGGTFLIFSEYMRPAIRTAALANLQVIF
VYSHDSIGLGEDGPTHQPVEQLWSLRSIPNLWVVRPADANEVKYAWEIALKRKNGPTAIILTRQKVKTIDRSKYASPEGV
RKGAYVIADTEGKPDVVIIATGSEVQVALGAKEILEQKGIKTRVVNMACCELFEEQPEEYKREVLPPEVTKRVAVEAGRD
TGWYKYVGSDGLVISLNEFGKSAPGSVLFEYYGFTPENVANKVIEKWFS

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family

Homologues:

Organism=Homo sapiens, GI205277463, Length=572, Percent_Identity=28.6713286713287, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI4507521, Length=572, Percent_Identity=28.6713286713287, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI133778974, Length=579, Percent_Identity=28.3246977547496, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI225637459, Length=572, Percent_Identity=24.8251748251748, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI225637463, Length=496, Percent_Identity=25.8064516129032, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI225637461, Length=496, Percent_Identity=25.6048387096774, Blast_Score=128, Evalue=2e-29,
Organism=Escherichia coli, GI1788808, Length=656, Percent_Identity=46.1890243902439, Blast_Score=607, Evalue=1e-174,
Organism=Escherichia coli, GI48994911, Length=658, Percent_Identity=45.4407294832827, Blast_Score=592, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI17539652, Length=580, Percent_Identity=27.7586206896552, Blast_Score=181, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6325331, Length=665, Percent_Identity=46.015037593985, Blast_Score=566, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319593, Length=665, Percent_Identity=43.7593984962406, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45551847, Length=675, Percent_Identity=26.0740740740741, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI45550715, Length=675, Percent_Identity=26.0740740740741, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24666278, Length=583, Percent_Identity=27.2727272727273, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24645119, Length=634, Percent_Identity=26.0252365930599, Blast_Score=157, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TKT_AQUAE (O67642)

Other databases:

- EMBL:   AE000657
- PIR:   H70451
- RefSeq:   NP_214208.1
- ProteinModelPortal:   O67642
- SMR:   O67642
- GeneID:   1193357
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1765
- NMPDR:   fig|224324.1.peg.1223
- HOGENOM:   HBG565885
- OMA:   ASHIVYL
- PhylomeDB:   O67642
- ProtClustDB:   CLSK2299824
- BioCyc:   AAEO224324:AQ_1765-MONOMER
- BRENDA:   2.2.1.1
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- PANTHER:   PTHR11624:SF1
- SMART:   SM00861
- TIGRFAMs:   TIGR00232

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.1

Molecular weight: Translated: 77983; Mature: 77983

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVQLDQIHFFIFHEVLKIFKTMPQLFKTSKKIDELVINTIRFLSVDMVERAKSGHPGMP
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LGASHIVYLLYDRIMKYNPKNPNWFNRDRFILSAGHGSAMLYAAFYMFGFDLTLEDLKAF
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHH
RQLNSKTPGHPEYGLTPGVEVTTGNLGQGFGNAVGMAMAEKFLSHYFNREGYPVIDHYTY
HHHCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECEEE
VLVSDGDLMEGVSYEAASLAGHFKLNKLIAIWDNNHITIDGDTKLTWTEDVLKRFEALGW
EEEECCCHHCCCCHHHHHHHHHEEEEEEEEEEECCEEEECCCCEEEEHHHHHHHHHHCCE
EVYHLEDGYNLDLLEETILKAKESDKPTFISVRTHIGYGTPLQDTPEVHGKPMGKEIVEE
EEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHH
TKKKFGWPLEEFYVPEEALNYTRRKVEEGKALEEEWNKLYAEYREKYPDLAQTLEKALNK
HHHHHCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
EWSLDWLEKVEEFKEDMPTRKASGKVLNVMADYIPTMIGGSADLSESVNTVLKKYGDFEA
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
DTPTGRNVHYGVREHAMGTILNGMAYHGGILPYGGTFLIFSEYMRPAIRTAALANLQVIF
CCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEE
VYSHDSIGLGEDGPTHQPVEQLWSLRSIPNLWVVRPADANEVKYAWEIALKRKNGPTAII
EEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEEECCCCEEEE
LTRQKVKTIDRSKYASPEGVRKGAYVIADTEGKPDVVIIATGSEVQVALGAKEILEQKGI
EEHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCEEEECCHHHHHHHCCC
KTRVVNMACCELFEEQPEEYKREVLPPEVTKRVAVEAGRDTGWYKYVGSDGLVISLNEFG
HHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEECCCCEEEEEHHCC
KSAPGSVLFEYYGFTPENVANKVIEKWFS
CCCCCCEEHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVQLDQIHFFIFHEVLKIFKTMPQLFKTSKKIDELVINTIRFLSVDMVERAKSGHPGMP
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LGASHIVYLLYDRIMKYNPKNPNWFNRDRFILSAGHGSAMLYAAFYMFGFDLTLEDLKAF
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHH
RQLNSKTPGHPEYGLTPGVEVTTGNLGQGFGNAVGMAMAEKFLSHYFNREGYPVIDHYTY
HHHCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECEEE
VLVSDGDLMEGVSYEAASLAGHFKLNKLIAIWDNNHITIDGDTKLTWTEDVLKRFEALGW
EEEECCCHHCCCCHHHHHHHHHEEEEEEEEEEECCEEEECCCCEEEEHHHHHHHHHHCCE
EVYHLEDGYNLDLLEETILKAKESDKPTFISVRTHIGYGTPLQDTPEVHGKPMGKEIVEE
EEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHH
TKKKFGWPLEEFYVPEEALNYTRRKVEEGKALEEEWNKLYAEYREKYPDLAQTLEKALNK
HHHHHCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
EWSLDWLEKVEEFKEDMPTRKASGKVLNVMADYIPTMIGGSADLSESVNTVLKKYGDFEA
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
DTPTGRNVHYGVREHAMGTILNGMAYHGGILPYGGTFLIFSEYMRPAIRTAALANLQVIF
CCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEE
VYSHDSIGLGEDGPTHQPVEQLWSLRSIPNLWVVRPADANEVKYAWEIALKRKNGPTAII
EEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEEECCCCEEEE
LTRQKVKTIDRSKYASPEGVRKGAYVIADTEGKPDVVIIATGSEVQVALGAKEILEQKGI
EEHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCEEEECCHHHHHHHCCC
KTRVVNMACCELFEEQPEEYKREVLPPEVTKRVAVEAGRDTGWYKYVGSDGLVISLNEFG
HHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEECCCCEEEEEHHCC
KSAPGSVLFEYYGFTPENVANKVIEKWFS
CCCCCCEEHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320