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The map label for this gene is fabF [H]

Identifier: 15606798

GI number: 15606798

Start: 1207398

End: 1208645

Strand: Direct

Name: fabF [H]

Synonym: aq_1717

Alternate gene names: 15606798

Gene position: 1207398-1208645 (Clockwise)

Preceding gene: 15606797

Following gene: 15606799

Centisome position: 77.83

GC content: 48.8

Gene sequence:

>1248_bases
ATGAAGAGAAGAGTTGTTATCACCGGCATCGGGGCGGTTACGCCCCTTGGAACAGGCGTAAAGAAGTTCTGGGAAAACCT
TGTAAAGGGTGTAAGCGGTGTTGATTACATAAAGAGCTTTAACCCCGACGAATACGGAATACCCGTAAAGATAGCGGCGG
AAGTAAAGGACTTTAATCCAGAAGACTTTATGGATAAAAAAGAGGCGAGAAAAGCCTCCCGCTTTGTCCAGTTTGCAATA
GCTGCGGTAAAGGAAGCCCTTGAAGACAGCGGACTCCTTGAAAGTGAGTACGACCCTTACAGAGTAGGGGTAATTATAGG
GACAGGAATTGGCGGTCTCAAGGATATAGAAGATCAGACTTTAATCCTTAAAGAAAAGGGAGCGAGAAGGGTATCTCCCT
TTTTCATACCCTACGGCATATCCAACATGGCTTCGGGGCTTGTGGCCATAAAGTGGGGCTTTAAAGGTCCAAATTACTGC
GTGACTTCCGCCTGTGCTACGGGAAACCACGCTATAGGAGACGCCTTCAGACTCATTCAAAAGGGTGATATAGACATTGC
TATAGCGGGAGGAACGGAAGCTGCGATAACCCCCCTCGGTGTTGCGGGATTTGCATCCATGAAGGCACTCTCTACGAGGA
ACGACGAGCCCCAGAAAGCTTCAAGACCCTTTGACAGGGACAGGGACGGCTTCGTAATGGGAGAAGGAGCAGGAATACTG
ATTTTGGAAGAATACGAGAGGGCAAAGGCAAGGGGTGCGAAGATATACGCTGAACTCGTGGGCTACGGTGCAACCGACGA
CGCTTACCACATAACTTCCCCCCACGAGTGCGGTGAGGGAGCTTACGAGTGCATGAGGTTAGCACTGGAAGACGCTGGAA
TTAAACCCGAAGAGGTGGATTACATAAACGCCCACGGAACATCAACACCGCTCAACGACAAAACAGAGACGATGGCGATA
AAGCAGCTCTTCGGAGAACACGCATACAAACTTAAAATTTCTTCAAACAAGTCCATGATAGGGCACCTGCTCGGAGCCGC
AGCGGCTGTGGAAGCTGTAGCAACGATAAAAACCATAGAAACTGGAGTGATACCTCCTACCATTAACCTGGAAAACCCCG
ATCCAGAGTGTGATCTGGACTACGTTCCAAACAAAGCCGTGGAATACCCCGTAAGGGTTGCACTTTCTAACGCCTTTGGT
TTTGGAGGAACTAACGCAACGCTAGTGTTCAGAAAAATAGAAGAATGA

Upstream 100 bases:

>100_bases
CCTTTGAAGAGGAGTTCGGTATTGAGATCCCTGACGAGGACGCGGAAAAGATACAGACTGTCGGGGATGTAATAAATTAC
CTTAAAGAAAAGGTAGGAGG

Downstream 100 bases:

>100_bases
GGGTAATACTCGCATCCACCTCTCCCCGTCGCTCTCAAATCCTTTCACTTCTGGGTATTGAGTTTGAAGTAATTCCCGCA
AAAGTAGAAGAGGAAGTTAT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MKRRVVITGIGAVTPLGTGVKKFWENLVKGVSGVDYIKSFNPDEYGIPVKIAAEVKDFNPEDFMDKKEARKASRFVQFAI
AAVKEALEDSGLLESEYDPYRVGVIIGTGIGGLKDIEDQTLILKEKGARRVSPFFIPYGISNMASGLVAIKWGFKGPNYC
VTSACATGNHAIGDAFRLIQKGDIDIAIAGGTEAAITPLGVAGFASMKALSTRNDEPQKASRPFDRDRDGFVMGEGAGIL
ILEEYERAKARGAKIYAELVGYGATDDAYHITSPHECGEGAYECMRLALEDAGIKPEEVDYINAHGTSTPLNDKTETMAI
KQLFGEHAYKLKISSNKSMIGHLLGAAAAVEAVATIKTIETGVIPPTINLENPDPECDLDYVPNKAVEYPVRVALSNAFG
FGGTNATLVFRKIEE

Sequences:

>Translated_415_residues
MKRRVVITGIGAVTPLGTGVKKFWENLVKGVSGVDYIKSFNPDEYGIPVKIAAEVKDFNPEDFMDKKEARKASRFVQFAI
AAVKEALEDSGLLESEYDPYRVGVIIGTGIGGLKDIEDQTLILKEKGARRVSPFFIPYGISNMASGLVAIKWGFKGPNYC
VTSACATGNHAIGDAFRLIQKGDIDIAIAGGTEAAITPLGVAGFASMKALSTRNDEPQKASRPFDRDRDGFVMGEGAGIL
ILEEYERAKARGAKIYAELVGYGATDDAYHITSPHECGEGAYECMRLALEDAGIKPEEVDYINAHGTSTPLNDKTETMAI
KQLFGEHAYKLKISSNKSMIGHLLGAAAAVEAVATIKTIETGVIPPTINLENPDPECDLDYVPNKAVEYPVRVALSNAFG
FGGTNATLVFRKIEE
>Mature_415_residues
MKRRVVITGIGAVTPLGTGVKKFWENLVKGVSGVDYIKSFNPDEYGIPVKIAAEVKDFNPEDFMDKKEARKASRFVQFAI
AAVKEALEDSGLLESEYDPYRVGVIIGTGIGGLKDIEDQTLILKEKGARRVSPFFIPYGISNMASGLVAIKWGFKGPNYC
VTSACATGNHAIGDAFRLIQKGDIDIAIAGGTEAAITPLGVAGFASMKALSTRNDEPQKASRPFDRDRDGFVMGEGAGIL
ILEEYERAKARGAKIYAELVGYGATDDAYHITSPHECGEGAYECMRLALEDAGIKPEEVDYINAHGTSTPLNDKTETMAI
KQLFGEHAYKLKISSNKSMIGHLLGAAAAVEAVATIKTIETGVIPPTINLENPDPECDLDYVPNKAVEYPVRVALSNAFG
FGGTNATLVFRKIEE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=50.7142857142857, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI223972627, Length=165, Percent_Identity=52.7272727272727, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI41872631, Length=430, Percent_Identity=24.8837209302326, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=52.5423728813559, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=37.5, Blast_Score=262, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=39.7590361445783, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=44.5736434108527, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI212642053, Length=427, Percent_Identity=25.2927400468384, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=412, Percent_Identity=25.4854368932039, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=41.4253897550111, Blast_Score=312, Evalue=7e-86,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=44.3914081145585, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI221330659, Length=427, Percent_Identity=25.9953161592506, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19920632, Length=427, Percent_Identity=25.9953161592506, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24581345, Length=425, Percent_Identity=24.4705882352941, Blast_Score=121, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44697; Mature: 44697

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00098 THIOLASE_1 ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRVVITGIGAVTPLGTGVKKFWENLVKGVSGVDYIKSFNPDEYGIPVKIAAEVKDFNP
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEEEECCCCCC
EDFMDKKEARKASRFVQFAIAAVKEALEDSGLLESEYDPYRVGVIIGTGIGGLKDIEDQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCE
LILKEKGARRVSPFFIPYGISNMASGLVAIKWGFKGPNYCVTSACATGNHAIGDAFRLIQ
EEEECCCCCCCCCEEEECCHHHHHCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHH
KGDIDIAIAGGTEAAITPLGVAGFASMKALSTRNDEPQKASRPFDRDRDGFVMGEGAGIL
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEE
ILEEYERAKARGAKIYAELVGYGATDDAYHITSPHECGEGAYECMRLALEDAGIKPEEVD
EEECHHHHHHCCHHEEEHHHCCCCCCCCEECCCCHHHCHHHHHHHHHHHHHCCCCCCCCC
YINAHGTSTPLNDKTETMAIKQLFGEHAYKLKISSNKSMIGHLLGAAAAVEAVATIKTIE
EEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
TGVIPPTINLENPDPECDLDYVPNKAVEYPVRVALSNAFGFGGTNATLVFRKIEE
CCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MKRRVVITGIGAVTPLGTGVKKFWENLVKGVSGVDYIKSFNPDEYGIPVKIAAEVKDFNP
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEEEECCCCCC
EDFMDKKEARKASRFVQFAIAAVKEALEDSGLLESEYDPYRVGVIIGTGIGGLKDIEDQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCE
LILKEKGARRVSPFFIPYGISNMASGLVAIKWGFKGPNYCVTSACATGNHAIGDAFRLIQ
EEEECCCCCCCCCEEEECCHHHHHCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHH
KGDIDIAIAGGTEAAITPLGVAGFASMKALSTRNDEPQKASRPFDRDRDGFVMGEGAGIL
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEE
ILEEYERAKARGAKIYAELVGYGATDDAYHITSPHECGEGAYECMRLALEDAGIKPEEVD
EEECHHHHHHCCHHEEEHHHCCCCCCCCEECCCCHHHCHHHHHHHHHHHHHCCCCCCCCC
YINAHGTSTPLNDKTETMAIKQLFGEHAYKLKISSNKSMIGHLLGAAAAVEAVATIKTIE
EEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
TGVIPPTINLENPDPECDLDYVPNKAVEYPVRVALSNAFGFGGTNATLVFRKIEE
CCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]