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The map label for this gene is lpxB

Identifier: 15606605

GI number: 15606605

Start: 1016881

End: 1017951

Strand: Direct

Name: lpxB

Synonym: aq_1427

Alternate gene names: 15606605

Gene position: 1016881-1017951 (Clockwise)

Preceding gene: 15606604

Following gene: 15606606

Centisome position: 65.55

GC content: 37.35

Gene sequence:

>1071_bases
GTGAAAAAGATATTCCTCTCTTTAGCGGATCGCTCTGCCTCCAATTACGTGTATGAAATACTTAAGGAAGGCTTTGAGGA
GTACGAAATCTACGGACTTACTGACGAAAAACTGGAAAAAATAGGCGTAAAAAGTGTGGCAAGGTATTCTGAAATATCCA
CGGTAGGACTGATAGAAGCGCTTCCAAAAGTATTTAAATTCTTAAAAATTTACAGAAAAATCCTTAAAAACTTAAAAAAT
ACTGACACCCTAATAGCATGCGATGCTCCGGCCCTTAACTTAAGGCTTATAAAAGATGCGAGAAAACTCGGAGTAAAGCG
GATTATTTACTTCATATCTCCTCAAGTGTGGGCTTGGAAGCCAAAAAGAGCGGAGATTATAGCCAATTACTGCGATCACG
TAATAGTAATCCTCCCGTTTGAAAAAAAGATTTATAGAAAATTCCCGAACTTGAAAGTTCACTACGTAGGACACCCCCTA
GTGGATTTGGTAAAACCTCAAAAAACAAAAGAAGAATTTATGAAAGCTTTCAAAAAAGAGCCACTGCCCCTACTTCTCGG
AAGCAGGGAAGGTGAAATAAGGAGACATGTTAAATTATTAAAGGGAATAATTGAAGAATTAAAAAAGAGTTTTGACGTAA
TTTCTCCGACTTTTAGAGAATTTTCAAAGTTTATTGAGAGAGAACTTAAAGTGAAAACCCTTACGTACGAAGGGGCTTCT
TACGACTGCTTCTTTTACTCAAAAGCCTCACTAATAGCCTCGGGAACAGCTTCCTTAGAGGCGGGAATTGCGGGAAACCC
TCACGTGGTTTATTACAAGGTAAACCCGATTACCTACTTTCTTGGGAAAAGACTTGTAAAAGTTCCCTACATAAGTTTAG
TAAACATACTTTTAAAGGAAGAAGTAGTTCCAGAGTTTATCCAAAAAAGTTCAGATGAGATACTGAAAGGTTTTGAAAAG
GTTTACAAAAACGAAGAAGAAATTAAGGAAAAACTTGGAACGTTGAAGTTTATCCTCGGTGAGAGGTTCGTTATAAGGAA
GCTCAGGGAGTTGTTCTTGGAAATAGTATAG

Upstream 100 bases:

>100_bases
CTTACAAAAACGGCAGTAAAGAACTGATAGGAATGGCGGAGGAAGTAAAGAGTATATTTGAAGAAATTATTGATATGATA
AAGGCGAGAATAGAAAAGAA

Downstream 100 bases:

>100_bases
TTTTAAAGTATGCTCAGGTTTGAGGATTGGGAACTCGCGGTAGTTATAATTCTCACGAGGTTTATGGAAGCAATAGCGAT
AATAATAAGCATATACCTCG

Product: lipid A disaccharide synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKKIFLSLADRSASNYVYEILKEGFEEYEIYGLTDEKLEKIGVKSVARYSEISTVGLIEALPKVFKFLKIYRKILKNLKN
TDTLIACDAPALNLRLIKDARKLGVKRIIYFISPQVWAWKPKRAEIIANYCDHVIVILPFEKKIYRKFPNLKVHYVGHPL
VDLVKPQKTKEEFMKAFKKEPLPLLLGSREGEIRRHVKLLKGIIEELKKSFDVISPTFREFSKFIERELKVKTLTYEGAS
YDCFFYSKASLIASGTASLEAGIAGNPHVVYYKVNPITYFLGKRLVKVPYISLVNILLKEEVVPEFIQKSSDEILKGFEK
VYKNEEEIKEKLGTLKFILGERFVIRKLRELFLEIV

Sequences:

>Translated_356_residues
MKKIFLSLADRSASNYVYEILKEGFEEYEIYGLTDEKLEKIGVKSVARYSEISTVGLIEALPKVFKFLKIYRKILKNLKN
TDTLIACDAPALNLRLIKDARKLGVKRIIYFISPQVWAWKPKRAEIIANYCDHVIVILPFEKKIYRKFPNLKVHYVGHPL
VDLVKPQKTKEEFMKAFKKEPLPLLLGSREGEIRRHVKLLKGIIEELKKSFDVISPTFREFSKFIERELKVKTLTYEGAS
YDCFFYSKASLIASGTASLEAGIAGNPHVVYYKVNPITYFLGKRLVKVPYISLVNILLKEEVVPEFIQKSSDEILKGFEK
VYKNEEEIKEKLGTLKFILGERFVIRKLRELFLEIV
>Mature_356_residues
MKKIFLSLADRSASNYVYEILKEGFEEYEIYGLTDEKLEKIGVKSVARYSEISTVGLIEALPKVFKFLKIYRKILKNLKN
TDTLIACDAPALNLRLIKDARKLGVKRIIYFISPQVWAWKPKRAEIIANYCDHVIVILPFEKKIYRKFPNLKVHYVGHPL
VDLVKPQKTKEEFMKAFKKEPLPLLLGSREGEIRRHVKLLKGIIEELKKSFDVISPTFREFSKFIERELKVKTLTYEGAS
YDCFFYSKASLIASGTASLEAGIAGNPHVVYYKVNPITYFLGKRLVKVPYISLVNILLKEEVVPEFIQKSSDEILKGFEK
VYKNEEEIKEKLGTLKFILGERFVIRKLRELFLEIV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=307, Percent_Identity=30.2931596091205, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_AQUAE (O67420)

Other databases:

- EMBL:   AE000657
- PIR:   B70424
- RefSeq:   NP_213985.1
- ProteinModelPortal:   O67420
- GeneID:   1192951
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1427
- NMPDR:   fig|224324.1.peg.1000
- HOGENOM:   HBG584837
- OMA:   NMELALN
- PhylomeDB:   O67420
- ProtClustDB:   CLSK2299698
- BioCyc:   AAEO224324:AQ_1427-MONOMER
- BRENDA:   2.4.1.182
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 41300; Mature: 41300

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIFLSLADRSASNYVYEILKEGFEEYEIYGLTDEKLEKIGVKSVARYSEISTVGLIEA
CCCEEEEHHCCCHHHHHHHHHHHCHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LPKVFKFLKIYRKILKNLKNTDTLIACDAPALNLRLIKDARKLGVKRIIYFISPQVWAWK
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECC
PKRAEIIANYCDHVIVILPFEKKIYRKFPNLKVHYVGHPLVDLVKPQKTKEEFMKAFKKE
CHHHHHHHHHCCCEEEEEECHHHHHHHCCCCEEEECCCCHHHHCCCCHHHHHHHHHHHCC
PLPLLLGSREGEIRRHVKLLKGIIEELKKSFDVISPTFREFSKFIERELKVKTLTYEGAS
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEECCCC
YDCFFYSKASLIASGTASLEAGIAGNPHVVYYKVNPITYFLGKRLVKVPYISLVNILLKE
EEEEEEECHHHHHCCCCHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
EVVPEFIQKSSDEILKGFEKVYKNEEEIKEKLGTLKFILGERFVIRKLRELFLEIV
HHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKIFLSLADRSASNYVYEILKEGFEEYEIYGLTDEKLEKIGVKSVARYSEISTVGLIEA
CCCEEEEHHCCCHHHHHHHHHHHCHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LPKVFKFLKIYRKILKNLKNTDTLIACDAPALNLRLIKDARKLGVKRIIYFISPQVWAWK
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECC
PKRAEIIANYCDHVIVILPFEKKIYRKFPNLKVHYVGHPLVDLVKPQKTKEEFMKAFKKE
CHHHHHHHHHCCCEEEEEECHHHHHHHCCCCEEEECCCCHHHHCCCCHHHHHHHHHHHCC
PLPLLLGSREGEIRRHVKLLKGIIEELKKSFDVISPTFREFSKFIERELKVKTLTYEGAS
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEECCCC
YDCFFYSKASLIASGTASLEAGIAGNPHVVYYKVNPITYFLGKRLVKVPYISLVNILLKE
EEEEEEECHHHHHCCCCHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
EVVPEFIQKSSDEILKGFEKVYKNEEEIKEKLGTLKFILGERFVIRKLRELFLEIV
HHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320