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The map label for this gene is mpp [C]

Identifier: 15606492

GI number: 15606492

Start: 899259

End: 900560

Strand: Direct

Name: mpp [C]

Synonym: aq_1271

Alternate gene names: 15606492

Gene position: 899259-900560 (Clockwise)

Preceding gene: 15606491

Following gene: 15606496

Centisome position: 57.97

GC content: 44.32

Gene sequence:

>1302_bases
ATGATTAAGTTCTTAATTCTGGGGGTTATCTTGATGGTTCAGGTTCTGACAGCTCAAGAGCTTTACATAAGAGACCTTCC
AAACGGTGCAAAACTCATAGTAAAGCCAAGGGACGACACCGAAGCGGTTGCCCTTCATGTCTGGTTCAGGGTGGGATCGG
TTTACGAGAAGTACGACGAGAAGGGAATGGCTCACTTTCTGGAGCACATGCTCTTTAACGGAACTGAGAAGTACAAGTAC
GGGGAGATAGACAGGATAATAGAGAGTTTAGGGGGAAACATAAACGCCGGAACTTCAAAGGATTACACCTACTACCACGT
GGAAATAGCCCACCCTTACTGGAAACAGGCTTTAGAGGTCCTCTACCAGCTCACCATGAAGGCGACGCTGGACGAGGAGA
TGATAGAAAAGGAAAAACCTATAGTAATTGAGGAGCTAAGGCGGGGTAAGGACAACCCTACGACAGTTCTGTGGGAAGAA
TTCGAGAAGCTCGTTTACAAAGTATCCCCCTACAGGTTTCCGATTATAGGCTTTGAGGAGACTATAAGGAAGTTCACGAG
GGAAAAACTCCTGAAGTTTTACAAATCCTTCTACCAGCCTAGAAACATGGCTGTAGTCATAGTGGGAAAGGTTAATCCCA
AGGAAGTGGAAGAAGAAGTTATGAAAACCTTTGGAAAGGAAGAAGGAAGACCAGTTCCCAAAGTTCAGATACCCACAGAA
CCCGAACAGATAGGTATAAGGTTTAAAAAACTCAAAGACCCCAGAATTGAAAAGGCTTACTGGATTATAGGCTGGAGGGT
TCCAGCTATTGGAAAGACTGATTACAAAGGGCTTCTGGTTTTCAGTGAAATCCTCTGTGGAGGAAGGATTTCTGTATTCT
ACAGGGAGCTGAGGGAAAAGGGACTCGTTTACTCGTACTCCTGCGGAGACATGGGTAGACCTAGGGATAATATCTTCATT
ATAACGGCTACTTTCCCTCCCGAAAACTATGAAAAAGTCAAGAAGAGGGTGTTTGAACTTCTTAAGGAAACTTACGAGAA
CTTAACCGATGAGCAGGTGGAAGAGGCAAAGAGCAGGATAATAAACTCAAGGCTCTTTGAAGAGGAGAGAGTTGAAAACG
ATGCCTTTGATATAGGCTACTCCTACACTGTCGTGAGGGATCTGGACTTTTACAGGTTCTTTGATAAGAACCTGAGCAGG
GTAAGAAGAGTGGACGTTATGAGGATATTCGAAAGGTACATAAAGGAGGATAAGTACTCGGAAATCCTTATGGTGCCTGA
AGATGGAAATAAAGCCGAGTGA

Upstream 100 bases:

>100_bases
CTCAGGGTGGTAAAACCGTTAGCTTTGCCTCTCGCACTCATAATCACCTTGTCCATAGCTGGAATTCACTTAGTATTTAT
TTTGAGAAGGAAGAAGAAAA

Downstream 100 bases:

>100_bases
TGTAAAGGCTCAAACTTCCATCTTCTTTGCGTCCGCCCATATCCACTCAAGTCCATAGTACTCCCTAGTTTCGGGCGTGA
ATATGTGGACTATCGTGTCT

Product: processing protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MIKFLILGVILMVQVLTAQELYIRDLPNGAKLIVKPRDDTEAVALHVWFRVGSVYEKYDEKGMAHFLEHMLFNGTEKYKY
GEIDRIIESLGGNINAGTSKDYTYYHVEIAHPYWKQALEVLYQLTMKATLDEEMIEKEKPIVIEELRRGKDNPTTVLWEE
FEKLVYKVSPYRFPIIGFEETIRKFTREKLLKFYKSFYQPRNMAVVIVGKVNPKEVEEEVMKTFGKEEGRPVPKVQIPTE
PEQIGIRFKKLKDPRIEKAYWIIGWRVPAIGKTDYKGLLVFSEILCGGRISVFYRELREKGLVYSYSCGDMGRPRDNIFI
ITATFPPENYEKVKKRVFELLKETYENLTDEQVEEAKSRIINSRLFEEERVENDAFDIGYSYTVVRDLDFYRFFDKNLSR
VRRVDVMRIFERYIKEDKYSEILMVPEDGNKAE

Sequences:

>Translated_433_residues
MIKFLILGVILMVQVLTAQELYIRDLPNGAKLIVKPRDDTEAVALHVWFRVGSVYEKYDEKGMAHFLEHMLFNGTEKYKY
GEIDRIIESLGGNINAGTSKDYTYYHVEIAHPYWKQALEVLYQLTMKATLDEEMIEKEKPIVIEELRRGKDNPTTVLWEE
FEKLVYKVSPYRFPIIGFEETIRKFTREKLLKFYKSFYQPRNMAVVIVGKVNPKEVEEEVMKTFGKEEGRPVPKVQIPTE
PEQIGIRFKKLKDPRIEKAYWIIGWRVPAIGKTDYKGLLVFSEILCGGRISVFYRELREKGLVYSYSCGDMGRPRDNIFI
ITATFPPENYEKVKKRVFELLKETYENLTDEQVEEAKSRIINSRLFEEERVENDAFDIGYSYTVVRDLDFYRFFDKNLSR
VRRVDVMRIFERYIKEDKYSEILMVPEDGNKAE
>Mature_433_residues
MIKFLILGVILMVQVLTAQELYIRDLPNGAKLIVKPRDDTEAVALHVWFRVGSVYEKYDEKGMAHFLEHMLFNGTEKYKY
GEIDRIIESLGGNINAGTSKDYTYYHVEIAHPYWKQALEVLYQLTMKATLDEEMIEKEKPIVIEELRRGKDNPTTVLWEE
FEKLVYKVSPYRFPIIGFEETIRKFTREKLLKFYKSFYQPRNMAVVIVGKVNPKEVEEEVMKTFGKEEGRPVPKVQIPTE
PEQIGIRFKKLKDPRIEKAYWIIGWRVPAIGKTDYKGLLVFSEILCGGRISVFYRELREKGLVYSYSCGDMGRPRDNIFI
ITATFPPENYEKVKKRVFELLKETYENLTDEQVEEAKSRIINSRLFEEERVENDAFDIGYSYTVVRDLDFYRFFDKNLSR
VRRVDVMRIFERYIKEDKYSEILMVPEDGNKAE

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=260, Percent_Identity=25.7692307692308, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI46593007, Length=206, Percent_Identity=23.3009708737864, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI155969707, Length=234, Percent_Identity=30.3418803418803, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI156071450, Length=325, Percent_Identity=25.5384615384615, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI156071452, Length=329, Percent_Identity=25.8358662613982, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787770, Length=314, Percent_Identity=23.5668789808917, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71999683, Length=207, Percent_Identity=27.0531400966184, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17557500, Length=241, Percent_Identity=29.8755186721992, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17553678, Length=224, Percent_Identity=23.2142857142857, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71994338, Length=259, Percent_Identity=30.1158301158301, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25146563, Length=259, Percent_Identity=30.1158301158301, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI32566665, Length=259, Percent_Identity=30.1158301158301, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI25146566, Length=259, Percent_Identity=30.1158301158301, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI72001443, Length=249, Percent_Identity=28.9156626506024, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71982342, Length=196, Percent_Identity=29.0816326530612, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI115533970, Length=195, Percent_Identity=29.7435897435897, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=251, Percent_Identity=27.4900398406374, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323421, Length=244, Percent_Identity=27.8688524590164, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357875, Length=386, Percent_Identity=22.020725388601, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24646943, Length=386, Percent_Identity=22.020725388601, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221513245, Length=230, Percent_Identity=30.8695652173913, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 51162; Mature: 51162

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKFLILGVILMVQVLTAQELYIRDLPNGAKLIVKPRDDTEAVALHVWFRVGSVYEKYDE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
KGMAHFLEHMLFNGTEKYKYGEIDRIIESLGGNINAGTSKDYTYYHVEIAHPYWKQALEV
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHH
LYQLTMKATLDEEMIEKEKPIVIEELRRGKDNPTTVLWEEFEKLVYKVSPYRFPIIGFEE
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECHHH
TIRKFTREKLLKFYKSFYQPRNMAVVIVGKVNPKEVEEEVMKTFGKEEGRPVPKVQIPTE
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEECCCC
PEQIGIRFKKLKDPRIEKAYWIIGWRVPAIGKTDYKGLLVFSEILCGGRISVFYRELREK
HHHHCCCHHHCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHC
GLVYSYSCGDMGRPRDNIFIITATFPPENYEKVKKRVFELLKETYENLTDEQVEEAKSRI
CCEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
INSRLFEEERVENDAFDIGYSYTVVRDLDFYRFFDKNLSRVRRVDVMRIFERYIKEDKYS
HHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EILMVPEDGNKAE
CEEEECCCCCCCC
>Mature Secondary Structure
MIKFLILGVILMVQVLTAQELYIRDLPNGAKLIVKPRDDTEAVALHVWFRVGSVYEKYDE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
KGMAHFLEHMLFNGTEKYKYGEIDRIIESLGGNINAGTSKDYTYYHVEIAHPYWKQALEV
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHH
LYQLTMKATLDEEMIEKEKPIVIEELRRGKDNPTTVLWEEFEKLVYKVSPYRFPIIGFEE
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECHHH
TIRKFTREKLLKFYKSFYQPRNMAVVIVGKVNPKEVEEEVMKTFGKEEGRPVPKVQIPTE
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEECCCC
PEQIGIRFKKLKDPRIEKAYWIIGWRVPAIGKTDYKGLLVFSEILCGGRISVFYRELREK
HHHHCCCHHHCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHC
GLVYSYSCGDMGRPRDNIFIITATFPPENYEKVKKRVFELLKETYENLTDEQVEEAKSRI
CCEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
INSRLFEEERVENDAFDIGYSYTVVRDLDFYRFFDKNLSRVRRVDVMRIFERYIKEDKYS
HHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EILMVPEDGNKAE
CEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]