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The map label for this gene is lysS

Identifier: 15606442

GI number: 15606442

Start: 844743

End: 846536

Strand: Direct

Name: lysS

Synonym: aq_1202

Alternate gene names: 15606442

Gene position: 844743-846536 (Clockwise)

Preceding gene: 15606440

Following gene: 15606444

Centisome position: 54.45

GC content: 44.82

Gene sequence:

>1794_bases
GTGCTTTCCCTCCTTTCCTCAGAGATCTTTTTTTCTGCCATACAATATAATTTATCCCTTATGGAAGAGGTAAGACTCAA
AAAGCTCCAGGAACTCAGGGAAAAAGGAATAAACCCCTACCCCTACAGGTTTGAAGTTACGGACTTTATAGGAAACATAA
GGAAACAGTACGAGGAAGAGCCTCCTGAGAACTACAAAGTTCGGGTTAAAGGTGTGGCTAAAAGGGTTTCCAGAACGGAA
AACGGCTACATGGTAAGGCTTGCAGACGAGAAGGGGATAGAGATACTTGTCTTCACGAAGGAGGAAGGGTTAAAACCAAA
GGAAAGTTATACTTTTGAAGGGATTTTAAAAAGGGTTGAAGGAAAACTCAGCCTGGTGGAAGCCGTTCTCACTGAGGAAG
AAGGGGAAGAAGTTTACAAGATAAAGGAACAGTTTGATTACGACCCAAACTTCAGACCCGTTTCCTTGGCGGGAAGACTC
GTTTCTATGAGAAGTATGGGGAAGGCTATATTCGGACACATTCAGGATCTCACGGGAAAGATACAGATATACCTCAAAAA
AGACGTAATAGGCGAGGAAAAGCTGAAGTTCTTTAACGATTACATAGACGTAGGGGATATTGTAGGAGTAAGGGGGAAGC
TCTTTAGAACGAACACGGGAGAGCTCACCGTTGAAGTTGAAGAGTACCAACTCCTCGCAAAGTCCCTGCACCCACTTCCG
GAAAAGTGGCACGGGCTCAAGGACGTGGAAGTTCGCTACAGGCAAAGGTACCTTGACCTTATCGCTAACCCCGAGGCGAG
AAGGATATTCATGCTGAGGACCAAACTCATAACGGAAATGCGGAAGTTCTTTGAGATGCACGGATTTATAGAGGTGGAAA
CTCCCATACTCCAGCCAATAGCGAGCGGTGCAAACGCAAGACCCTTCGTGACTTATCACAACTTCCTTGAAACAGAGCTT
TACCTCAGGATAGCCCCGGAACTCTACCTCAAGAGATTAATCGTAGGAGGCTTTCCGAGGGTTTACGAGATAGGAAAGAA
CTTCAGGAACGAGAGCGTGGACAGGACACACAACCCAGAATTTACTATGGTTGAGTTTTACGCCGCTTACTGGGATTACC
ACGACCTTATAAAGTTTACAGAGGATATGTTCGTTTATCTCCTTGAAAAAACCTTAGGAACTCTGAAGGTAAAGTACGGA
GAGTGGGAGCTTGATTTTTCACCGCCTTTTAAGAAGGTTCGCTACTTTGACCTCTTAAAAGAGAAGACCGGAAAGGATAA
GGACTTTTTCCTGAAAGACCTTGAAGGCTTGAGGAAGCTAGCCAAGGAACTTGAAATTCCCGATGTAGAGAGGATGACTC
ACGCAAAGCTCCTTGACAAAGTTTTTGAAAAGGTTGCGGAGGAAGATTTAATCCAACCTACATTCGTAATAGACTTTCCG
AAAATCCTCTCACCTCTTGCGAAAACCCACAGGGAGGACCCCGACCTCGTTGAGAGATTTGAGCTTATCATCGCACGTTA
CGAGGTGGCGAACGCATACACCGAGCTGAACGATCCCTTTGACCAAAAGGAAAGATTTTTAGAGCAGCTCAAAGAAAAGC
AAATGGGTGACGAAGAGGCTATGGATATGGATGAGGACTTTATAAGGGCACTTGAATACGGAATGCCTCCTACCGCAGGT
GAAGGTATAGGAATAGACAGACTAGTTATGATATTGGCAAATACGGACTCTATCAGAGAGGTTATTCTCTTCCCTCAATT
AAAGCCGGAAAAAAAGAAGAAGGAAGCCCCTTAA

Upstream 100 bases:

>100_bases
GGGAGGGATGCAGAACTCCATGAATTTAAAGAACTCTCTCCTGAGCTCTTCCAGTTCCTTTTCCATACTCGGAACTTTTA
ATTCTTCAGCGGTTTGAGTA

Downstream 100 bases:

>100_bases
GGGGCTACCCAGTTCCCGTTTTCTATTAATTCTTCAGGAGAAACTTTTTCCTGAACCTTCTGGGATATCTTGTAAGAGCA
GAACTCCGGTCCGCACATAG

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MLSLLSSEIFFSAIQYNLSLMEEVRLKKLQELREKGINPYPYRFEVTDFIGNIRKQYEEEPPENYKVRVKGVAKRVSRTE
NGYMVRLADEKGIEILVFTKEEGLKPKESYTFEGILKRVEGKLSLVEAVLTEEEGEEVYKIKEQFDYDPNFRPVSLAGRL
VSMRSMGKAIFGHIQDLTGKIQIYLKKDVIGEEKLKFFNDYIDVGDIVGVRGKLFRTNTGELTVEVEEYQLLAKSLHPLP
EKWHGLKDVEVRYRQRYLDLIANPEARRIFMLRTKLITEMRKFFEMHGFIEVETPILQPIASGANARPFVTYHNFLETEL
YLRIAPELYLKRLIVGGFPRVYEIGKNFRNESVDRTHNPEFTMVEFYAAYWDYHDLIKFTEDMFVYLLEKTLGTLKVKYG
EWELDFSPPFKKVRYFDLLKEKTGKDKDFFLKDLEGLRKLAKELEIPDVERMTHAKLLDKVFEKVAEEDLIQPTFVIDFP
KILSPLAKTHREDPDLVERFELIIARYEVANAYTELNDPFDQKERFLEQLKEKQMGDEEAMDMDEDFIRALEYGMPPTAG
EGIGIDRLVMILANTDSIREVILFPQLKPEKKKKEAP

Sequences:

>Translated_597_residues
MLSLLSSEIFFSAIQYNLSLMEEVRLKKLQELREKGINPYPYRFEVTDFIGNIRKQYEEEPPENYKVRVKGVAKRVSRTE
NGYMVRLADEKGIEILVFTKEEGLKPKESYTFEGILKRVEGKLSLVEAVLTEEEGEEVYKIKEQFDYDPNFRPVSLAGRL
VSMRSMGKAIFGHIQDLTGKIQIYLKKDVIGEEKLKFFNDYIDVGDIVGVRGKLFRTNTGELTVEVEEYQLLAKSLHPLP
EKWHGLKDVEVRYRQRYLDLIANPEARRIFMLRTKLITEMRKFFEMHGFIEVETPILQPIASGANARPFVTYHNFLETEL
YLRIAPELYLKRLIVGGFPRVYEIGKNFRNESVDRTHNPEFTMVEFYAAYWDYHDLIKFTEDMFVYLLEKTLGTLKVKYG
EWELDFSPPFKKVRYFDLLKEKTGKDKDFFLKDLEGLRKLAKELEIPDVERMTHAKLLDKVFEKVAEEDLIQPTFVIDFP
KILSPLAKTHREDPDLVERFELIIARYEVANAYTELNDPFDQKERFLEQLKEKQMGDEEAMDMDEDFIRALEYGMPPTAG
EGIGIDRLVMILANTDSIREVILFPQLKPEKKKKEAP
>Mature_597_residues
MLSLLSSEIFFSAIQYNLSLMEEVRLKKLQELREKGINPYPYRFEVTDFIGNIRKQYEEEPPENYKVRVKGVAKRVSRTE
NGYMVRLADEKGIEILVFTKEEGLKPKESYTFEGILKRVEGKLSLVEAVLTEEEGEEVYKIKEQFDYDPNFRPVSLAGRL
VSMRSMGKAIFGHIQDLTGKIQIYLKKDVIGEEKLKFFNDYIDVGDIVGVRGKLFRTNTGELTVEVEEYQLLAKSLHPLP
EKWHGLKDVEVRYRQRYLDLIANPEARRIFMLRTKLITEMRKFFEMHGFIEVETPILQPIASGANARPFVTYHNFLETEL
YLRIAPELYLKRLIVGGFPRVYEIGKNFRNESVDRTHNPEFTMVEFYAAYWDYHDLIKFTEDMFVYLLEKTLGTLKVKYG
EWELDFSPPFKKVRYFDLLKEKTGKDKDFFLKDLEGLRKLAKELEIPDVERMTHAKLLDKVFEKVAEEDLIQPTFVIDFP
KILSPLAKTHREDPDLVERFELIIARYEVANAYTELNDPFDQKERFLEQLKEKQMGDEEAMDMDEDFIRALEYGMPPTAG
EGIGIDRLVMILANTDSIREVILFPQLKPEKKKKEAP

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=456, Percent_Identity=47.3684210526316, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI194272210, Length=456, Percent_Identity=47.3684210526316, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI45439306, Length=350, Percent_Identity=21.7142857142857, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1790571, Length=441, Percent_Identity=50.1133786848073, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1789256, Length=442, Percent_Identity=48.4162895927602, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI87082379, Length=321, Percent_Identity=31.1526479750779, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788173, Length=287, Percent_Identity=27.5261324041812, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17535925, Length=456, Percent_Identity=47.5877192982456, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17535927, Length=456, Percent_Identity=47.5877192982456, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71994340, Length=456, Percent_Identity=47.5877192982456, Blast_Score=403, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17551876, Length=479, Percent_Identity=22.1294363256785, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32566633, Length=255, Percent_Identity=25.0980392156863, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320242, Length=469, Percent_Identity=44.3496801705757, Blast_Score=382, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324256, Length=490, Percent_Identity=31.8367346938775, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323011, Length=347, Percent_Identity=27.0893371757925, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24640851, Length=457, Percent_Identity=45.9518599562363, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24640849, Length=457, Percent_Identity=45.9518599562363, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI17136276, Length=478, Percent_Identity=25.1046025104602, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24584738, Length=269, Percent_Identity=25.2788104089219, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_AQUAE (O67258)

Other databases:

- EMBL:   AE000657
- PIR:   G70403
- RefSeq:   NP_213822.1
- ProteinModelPortal:   O67258
- SMR:   O67258
- GeneID:   1192604
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1202
- NMPDR:   fig|224324.1.peg.837
- HOGENOM:   HBG631383
- OMA:   CVNPSFI
- PhylomeDB:   O67258
- ProtClustDB:   PRK00484
- BioCyc:   AAEO224324:AQ_1202-MONOMER
- BRENDA:   6.1.1.6
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 70025; Mature: 70025

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLLSSEIFFSAIQYNLSLMEEVRLKKLQELREKGINPYPYRFEVTDFIGNIRKQYEEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCC
PPENYKVRVKGVAKRVSRTENGYMVRLADEKGIEILVFTKEEGLKPKESYTFEGILKRVE
CCCCCEEEHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHH
GKLSLVEAVLTEEEGEEVYKIKEQFDYDPNFRPVSLAGRLVSMRSMGKAIFGHIQDLTGK
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IQIYLKKDVIGEEKLKFFNDYIDVGDIVGVRGKLFRTNTGELTVEVEEYQLLAKSLHPLP
EEEEEECCCCCHHHHHHHHHHHCHHHHHCCCCEEEECCCCCEEEEHHHHHHHHHHHCCCC
EKWHGLKDVEVRYRQRYLDLIANPEARRIFMLRTKLITEMRKFFEMHGFIEVETPILQPI
HHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHH
ASGANARPFVTYHNFLETELYLRIAPELYLKRLIVGGFPRVYEIGKNFRNESVDRTHNPE
HCCCCCCCEEHHHHHHHHHHHEEECHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCC
FTMVEFYAAYWDYHDLIKFTEDMFVYLLEKTLGTLKVKYGEWELDFSPPFKKVRYFDLLK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEECCCCCHHHHHHHHHHH
EKTGKDKDFFLKDLEGLRKLAKELEIPDVERMTHAKLLDKVFEKVAEEDLIQPTFVIDFP
HHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECH
KILSPLAKTHREDPDLVERFELIIARYEVANAYTELNDPFDQKERFLEQLKEKQMGDEEA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHH
MDMDEDFIRALEYGMPPTAGEGIGIDRLVMILANTDSIREVILFPQLKPEKKKKEAP
CCCCHHHHHHHHHCCCCCCCCCCCHHHHEEEEECCHHHHHHHCCCCCCCHHHCCCCC
>Mature Secondary Structure
MLSLLSSEIFFSAIQYNLSLMEEVRLKKLQELREKGINPYPYRFEVTDFIGNIRKQYEEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCC
PPENYKVRVKGVAKRVSRTENGYMVRLADEKGIEILVFTKEEGLKPKESYTFEGILKRVE
CCCCCEEEHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHH
GKLSLVEAVLTEEEGEEVYKIKEQFDYDPNFRPVSLAGRLVSMRSMGKAIFGHIQDLTGK
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IQIYLKKDVIGEEKLKFFNDYIDVGDIVGVRGKLFRTNTGELTVEVEEYQLLAKSLHPLP
EEEEEECCCCCHHHHHHHHHHHCHHHHHCCCCEEEECCCCCEEEEHHHHHHHHHHHCCCC
EKWHGLKDVEVRYRQRYLDLIANPEARRIFMLRTKLITEMRKFFEMHGFIEVETPILQPI
HHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHH
ASGANARPFVTYHNFLETELYLRIAPELYLKRLIVGGFPRVYEIGKNFRNESVDRTHNPE
HCCCCCCCEEHHHHHHHHHHHEEECHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCC
FTMVEFYAAYWDYHDLIKFTEDMFVYLLEKTLGTLKVKYGEWELDFSPPFKKVRYFDLLK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEECCCCCHHHHHHHHHHH
EKTGKDKDFFLKDLEGLRKLAKELEIPDVERMTHAKLLDKVFEKVAEEDLIQPTFVIDFP
HHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECH
KILSPLAKTHREDPDLVERFELIIARYEVANAYTELNDPFDQKERFLEQLKEKQMGDEEA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHH
MDMDEDFIRALEYGMPPTAGEGIGIDRLVMILANTDSIREVILFPQLKPEKKKKEAP
CCCCHHHHHHHHHCCCCCCCCCCCHHHHEEEEECCHHHHHHHCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320