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The map label for this gene is hksP1 [H]

Identifier: 15606381

GI number: 15606381

Start: 778227

End: 780167

Strand: Direct

Name: hksP1 [H]

Synonym: aq_1115

Alternate gene names: 15606381

Gene position: 778227-780167 (Clockwise)

Preceding gene: 15606380

Following gene: 15606382

Centisome position: 50.16

GC content: 41.73

Gene sequence:

>1941_bases
ATGACGTTAAAGACAAAGATCATCTTACTCGTGATTCTCCTGACCGCTTTACCTGCACTCCTTTCGCTCCTTCACTACTA
CTCCATGAAAAGGGAATTAATACAGAAAGCTCTCGAACGAAACAGGGAAATCGTTGAAAAACTCGCGGACAGAGTGGATA
TGTACATATCAGAAACGCTTCATTCAATAGCTTCAAAGGTGAATCAGTACAAAGGTTACGGGCTTAACGAAAGGGAGATT
ATCTGGAAGATAACGGGAGAAGTTTACGGCGTTTTTGAAGGAGCCTTTTACTCCCCCGAAGGAAAACTAATCACGAGTGC
AAGCAGGGAAAAGGTAAATCCTAATTTTCCAGAAAGAATAAGCCCTGAGGGAAGGAGCAAACTCCTTTACACCCCGTACC
TTGAACCTTACGTTAGGGTACTTTACAAGGACGAAGAATTCGGAATTACGTTCGGTTACTACATCTTTTCTTTAGACCTT
TCTGCTTTCTGGAACAGGCTCGTGAACAGGTACAAAGGTCTGGAGGCGTTTTTACTGGACGAAAACTCCAGACTTATAGC
CTTTCCCGATACTAGATTTTACGACGGAAGGAAAATTCCCTTAAGGGAAGGGATTTACAGGTCGGATTTCTTGGGTACGG
ATGTTATCGGAACCTTTGCAAAGAGTAAGGGAGGTAAGTGGATCGTTTACGCAGAGGAGCCGTTAATTTACGTACTCTCC
CCTCTGGAAAACTACAGAAAGGAAGTAATACTCGCCGGATTGTTTACCTCCTTTTCGGGAGGAATACTCTGTCTTATCAT
CATCATCAGGATATTTAAGCCCCTTGAAAATTTCAAAGATTATGTAGTTTCCTGGGCAAAAGAAAACTTGAGTGAAAACT
TAAAACTAAAGGACGACGTTGAAATCTTCTTAAAAACTTTCAGGAGCCTGATTAAGAAAGTAGAGGAGGAAAAGAAGATA
TACGAAGCCTTCTTTAAAAACTCCTTTGACGGTGTAGTTTTGTTCGACACATCCCTGAAAGTTTCAAACGTGAACGAAAA
TTTCTGTGAAATATTTCAAGTGAAAAAAGACGAAGTCATAGGAAAGAGTATGGAGGACCTGATAGGTGAAAGATTGCCTT
TGAAGAACACCTTTATAAGGGAGGTAGAACTGAAGTTAGGGAAAAAACACTACTGCAGTTTGAGGCAGGGTATACTCATC
ATAGAAGACGTGCCGTACGTAGTCTGGTGGCTAAAGGATTTATCAAAGGAAAAAGAATTAAGGGGAATGCTAGAGAGAAC
CTCTAAGCTCGCTGTTGCAGGTGAGATAGCCTGTTCCTTAGCCCACCAGCTAAACACTCCCCTTGCGTCGATTATGGGAT
ATGCGGAACTCCTGAACCTCTCGGAAAAAGACCAGAGGACTAAGGAAAAACTGGATCTGATTATTAAGCAAGCTCACAGG
TGTAAGGAGATTATAGGAAAGATGCTTTACTTGGGAAAGGTGGATTCCCGACCAGCGTACGTAAACTTAGAAGAATTAAT
CCTTGAAGTTCTGGAAATACTCGAACCTAAAGCGCGGAAAAAGGGCGTTAACGTAAGGTTCGAGAATGGAGACGCGGGAA
AGATTTTCGGTTTTCCATGGCAGATTGAGCAGATATTGATTAACATTTTAGACAACGCAATAGACGCATTACCTGAGGGT
GAAAGTATCTACATAAAGCTCAAAAAGGAAGAAGAATACGTGGTTCTGGAAGTAAAGGACAAAGGAAAGGGATTTGAAGA
CCCGGAAAAGGCTTTTGAGCCCTTTTACACTACAAAACAAAACGGAACGGGACTGGGACTTTCCATAGTAAAAACTTTTG
TAGAAGGTATGAACGGAAAAATTGAAGTAAAAAACTGCAGCGGTGCTTTGGTTAAAGTGTATCTGCCGGAGGTAGCGGAA
AGTGAACGTTTTGGTAATTGA

Upstream 100 bases:

>100_bases
GGGCGTATTCTCCTAAGTTCATTCTCAATTTATCCGCCTTAAAGGAACTTTACGTTCAATACAACGAAAGAATCCTCGTA
TACGCAGACGAGGTAGTGAA

Downstream 100 bases:

>100_bases
AGATGACAAGGTTTTCAGAGGTTTACTCGAGGAATACCTTTCCATGAAAGGTATAAAAGTTGAGAGTGCTGAGAGGGGAA
AGGAAGCGTACAAACTCCTT

Product: histidine kinase sensor protein

Products: NA

Alternate protein names: Stage II sporulation protein F; Stage II sporulation protein J [H]

Number of amino acids: Translated: 646; Mature: 645

Protein sequence:

>646_residues
MTLKTKIILLVILLTALPALLSLLHYYSMKRELIQKALERNREIVEKLADRVDMYISETLHSIASKVNQYKGYGLNEREI
IWKITGEVYGVFEGAFYSPEGKLITSASREKVNPNFPERISPEGRSKLLYTPYLEPYVRVLYKDEEFGITFGYYIFSLDL
SAFWNRLVNRYKGLEAFLLDENSRLIAFPDTRFYDGRKIPLREGIYRSDFLGTDVIGTFAKSKGGKWIVYAEEPLIYVLS
PLENYRKEVILAGLFTSFSGGILCLIIIIRIFKPLENFKDYVVSWAKENLSENLKLKDDVEIFLKTFRSLIKKVEEEKKI
YEAFFKNSFDGVVLFDTSLKVSNVNENFCEIFQVKKDEVIGKSMEDLIGERLPLKNTFIREVELKLGKKHYCSLRQGILI
IEDVPYVVWWLKDLSKEKELRGMLERTSKLAVAGEIACSLAHQLNTPLASIMGYAELLNLSEKDQRTKEKLDLIIKQAHR
CKEIIGKMLYLGKVDSRPAYVNLEELILEVLEILEPKARKKGVNVRFENGDAGKIFGFPWQIEQILINILDNAIDALPEG
ESIYIKLKKEEEYVVLEVKDKGKGFEDPEKAFEPFYTTKQNGTGLGLSIVKTFVEGMNGKIEVKNCSGALVKVYLPEVAE
SERFGN

Sequences:

>Translated_646_residues
MTLKTKIILLVILLTALPALLSLLHYYSMKRELIQKALERNREIVEKLADRVDMYISETLHSIASKVNQYKGYGLNEREI
IWKITGEVYGVFEGAFYSPEGKLITSASREKVNPNFPERISPEGRSKLLYTPYLEPYVRVLYKDEEFGITFGYYIFSLDL
SAFWNRLVNRYKGLEAFLLDENSRLIAFPDTRFYDGRKIPLREGIYRSDFLGTDVIGTFAKSKGGKWIVYAEEPLIYVLS
PLENYRKEVILAGLFTSFSGGILCLIIIIRIFKPLENFKDYVVSWAKENLSENLKLKDDVEIFLKTFRSLIKKVEEEKKI
YEAFFKNSFDGVVLFDTSLKVSNVNENFCEIFQVKKDEVIGKSMEDLIGERLPLKNTFIREVELKLGKKHYCSLRQGILI
IEDVPYVVWWLKDLSKEKELRGMLERTSKLAVAGEIACSLAHQLNTPLASIMGYAELLNLSEKDQRTKEKLDLIIKQAHR
CKEIIGKMLYLGKVDSRPAYVNLEELILEVLEILEPKARKKGVNVRFENGDAGKIFGFPWQIEQILINILDNAIDALPEG
ESIYIKLKKEEEYVVLEVKDKGKGFEDPEKAFEPFYTTKQNGTGLGLSIVKTFVEGMNGKIEVKNCSGALVKVYLPEVAE
SERFGN
>Mature_645_residues
TLKTKIILLVILLTALPALLSLLHYYSMKRELIQKALERNREIVEKLADRVDMYISETLHSIASKVNQYKGYGLNEREII
WKITGEVYGVFEGAFYSPEGKLITSASREKVNPNFPERISPEGRSKLLYTPYLEPYVRVLYKDEEFGITFGYYIFSLDLS
AFWNRLVNRYKGLEAFLLDENSRLIAFPDTRFYDGRKIPLREGIYRSDFLGTDVIGTFAKSKGGKWIVYAEEPLIYVLSP
LENYRKEVILAGLFTSFSGGILCLIIIIRIFKPLENFKDYVVSWAKENLSENLKLKDDVEIFLKTFRSLIKKVEEEKKIY
EAFFKNSFDGVVLFDTSLKVSNVNENFCEIFQVKKDEVIGKSMEDLIGERLPLKNTFIREVELKLGKKHYCSLRQGILII
EDVPYVVWWLKDLSKEKELRGMLERTSKLAVAGEIACSLAHQLNTPLASIMGYAELLNLSEKDQRTKEKLDLIIKQAHRC
KEIIGKMLYLGKVDSRPAYVNLEELILEVLEILEPKARKKGVNVRFENGDAGKIFGFPWQIEQILINILDNAIDALPEGE
SIYIKLKKEEEYVVLEVKDKGKGFEDPEKAFEPFYTTKQNGTGLGLSIVKTFVEGMNGKIEVKNCSGALVKVYLPEVAES
ERFGN

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=359, Percent_Identity=23.9554317548747, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=28.4518828451883, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790300, Length=339, Percent_Identity=25.0737463126844, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1790861, Length=198, Percent_Identity=28.7878787878788, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786783, Length=215, Percent_Identity=26.046511627907, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1786600, Length=204, Percent_Identity=25.9803921568627, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=24.901185770751, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=26.8398268398268, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790346, Length=215, Percent_Identity=28.8372093023256, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=25.3275109170306, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994928, Length=285, Percent_Identity=23.1578947368421, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR013655
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF08447 PAS_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74186; Mature: 74055

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKTKIILLVILLTALPALLSLLHYYSMKRELIQKALERNREIVEKLADRVDMYISETL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSIASKVNQYKGYGLNEREIIWKITGEVYGVFEGAFYSPEGKLITSASREKVNPNFPERI
HHHHHHHHHHCCCCCCCCEEEEEEECCEEEEECCCEECCCCCEEECCCCCCCCCCCCCCC
SPEGRSKLLYTPYLEPYVRVLYKDEEFGITFGYYIFSLDLSAFWNRLVNRYKGLEAFLLD
CCCCCCCEEECCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
ENSRLIAFPDTRFYDGRKIPLREGIYRSDFLGTDVIGTFAKSKGGKWIVYAEEPLIYVLS
CCCCEEECCCCCCCCCCCCCHHHCCCHHCCCCHHHHHHHHHCCCCEEEEEECCCEEEEEC
PLENYRKEVILAGLFTSFSGGILCLIIIIRIFKPLENFKDYVVSWAKENLSENLKLKDDV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
EIFLKTFRSLIKKVEEEKKIYEAFFKNSFDGVVLFDTSLKVSNVNENFCEIFQVKKDEVI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCHHHHHHHHHHHHHHH
GKSMEDLIGERLPLKNTFIREVELKLGKKHYCSLRQGILIIEDVPYVVWWLKDLSKEKEL
CCHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
RGMLERTSKLAVAGEIACSLAHQLNTPLASIMGYAELLNLSEKDQRTKEKLDLIIKQAHR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
CKEIIGKMLYLGKVDSRPAYVNLEELILEVLEILEPKARKKGVNVRFENGDAGKIFGFPW
HHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHCCHHHHCCCCEEECCCCCCCEECCCH
QIEQILINILDNAIDALPEGESIYIKLKKEEEYVVLEVKDKGKGFEDPEKAFEPFYTTKQ
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHCCCCCCCCC
NGTGLGLSIVKTFVEGMNGKIEVKNCSGALVKVYLPEVAESERFGN
CCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEECCHHHHHCCCCC
>Mature Secondary Structure 
TLKTKIILLVILLTALPALLSLLHYYSMKRELIQKALERNREIVEKLADRVDMYISETL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSIASKVNQYKGYGLNEREIIWKITGEVYGVFEGAFYSPEGKLITSASREKVNPNFPERI
HHHHHHHHHHCCCCCCCCEEEEEEECCEEEEECCCEECCCCCEEECCCCCCCCCCCCCCC
SPEGRSKLLYTPYLEPYVRVLYKDEEFGITFGYYIFSLDLSAFWNRLVNRYKGLEAFLLD
CCCCCCCEEECCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
ENSRLIAFPDTRFYDGRKIPLREGIYRSDFLGTDVIGTFAKSKGGKWIVYAEEPLIYVLS
CCCCEEECCCCCCCCCCCCCHHHCCCHHCCCCHHHHHHHHHCCCCEEEEEECCCEEEEEC
PLENYRKEVILAGLFTSFSGGILCLIIIIRIFKPLENFKDYVVSWAKENLSENLKLKDDV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
EIFLKTFRSLIKKVEEEKKIYEAFFKNSFDGVVLFDTSLKVSNVNENFCEIFQVKKDEVI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCHHHHHHHHHHHHHHH
GKSMEDLIGERLPLKNTFIREVELKLGKKHYCSLRQGILIIEDVPYVVWWLKDLSKEKEL
CCHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
RGMLERTSKLAVAGEIACSLAHQLNTPLASIMGYAELLNLSEKDQRTKEKLDLIIKQAHR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
CKEIIGKMLYLGKVDSRPAYVNLEELILEVLEILEPKARKKGVNVRFENGDAGKIFGFPW
HHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHCCHHHHCCCCEEECCCCCCCEECCCH
QIEQILINILDNAIDALPEGESIYIKLKKEEEYVVLEVKDKGKGFEDPEKAFEPFYTTKQ
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHCCCCCCCCC
NGTGLGLSIVKTFVEGMNGKIEVKNCSGALVKVYLPEVAESERFGN
CCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEECCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2104615; 2509430; 9384377 [H]