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The map label for this gene is pncB2 [H]

Identifier: 15606339

GI number: 15606339

Start: 730704

End: 731984

Strand: Direct

Name: pncB2 [H]

Synonym: aq_1056

Alternate gene names: 15606339

Gene position: 730704-731984 (Clockwise)

Preceding gene: 15606337

Following gene: 15606341

Centisome position: 47.1

GC content: 46.06

Gene sequence:

>1281_bases
ATGAAATATTTAGGACTTTGCACAGACCTCTACGAACTCACCATGGCACAGAGTTACCTCTACGAAGGCAAAACCGGAAC
CGCTGTATTCTCCCTTTTTGTAAGGAAACTCCCCGAAAAGAGGAACTTCCTGATATCCGCAGGGCTCGAAACCTTGGTGG
AGAGGATAAAGAACTTCAAGTTCGGAGATGAGGAGATAAAGTATTTAAAGAGCCTGGGAATTTTTAAAGACGATTTTCTG
GACTACCTCAAGGACTTTGAATTTTCTGGAAATGTTTACGCAATTCCCGAGGGAAGGATAGTATTCCAAAACGAACCTCT
CGTTCAGGTAGAAGCTCCGATTCCCGAAGCCCAACTCCTTGAGACGTTGGTAATAAATACTATACAGTTTGAGACAATGA
TAGCTTCAAAGGCGGTGAGGAGTTATCTCGTGGCTAAAGGGAAGAAGCTCGTTGATTTCGGTTTCAGGCGGGCCCACGGC
TTAGAAGCGGGAATCCTTGCAGCGAGGGCTTCCTACATCGCCGGTTTTGACGGGACTTCAAACGTCGAGGCGGGAAGGGA
GTTCGGTATTCCCGTTGTGGGAACTATGGCACACTCCTACGTGATGATTTTTGACAAGGAAGAAGACGCCTTCAGGGCTT
TTGCCAAACTCTACCCCAAGAACGCTATATTCCTGATAGACACCTACGATACCATTGAGGCGGCAAAAAAGGTCGTAGAC
CTCGCAAAGGAAGGCGTACCCGTTGTGGGAGTCAGAATTGACAGCGGTGATATAGTGAAGCTTTCCAAGGAAGTGAGGAA
AATTCTGGACGAAAACGGACTGAAAAATGTAAGGATTATAGTGAGCGGTGGCGTTGACGAGTACAAAATCAAGGAATGGT
TTGACAGAGGCGCTCCCATAGACGCCTTCGGCGTAGGAACGAAGTTCATAACTTCCGCAGATGCCCCATACTTTGACATA
GCCTATAAGCTCGTTGAGTACGAAGGAAAACCAAAGTACAAACTCAGCCCCGGTAAAAAAACATTCCCATACAAGAGGCA
GGTCTACAGGTATTACGAAAACGGAAAGATGAAGTACGACGAGACCGCCAAGTGGGAGAGCAAAAGGGAAGGAGAACCTC
TGGTAGAACTCGTTATGAAAAACGGAAAGCTAATAAAGGAATTGCCTAGCCTGAAGGAAATAAGGGAAGTTGTGATGTCG
GAACTAGAAAAACTCCCCGAAAATTACAAGGACATAACGAAACACTACGAGTACGAAGTAAAGATCTTAGACTGGGAGTA
A

Upstream 100 bases:

>100_bases
TAGGCGCGGGGGGACTTGAACCCCCGACCTCCGGCGTGTCGGGCCGGCGCTCTCCCTACTGAGCTACGCGCCTTTGCAGA
ATATATTATACTTCAAATTT

Downstream 100 bases:

>100_bases
TTCTTCTTTCACAATTATCTTTTTATTCTCTTTATCCACTTTGAGGACTATATCCGAGACAAAGGGAACGAGTAAGTTTT
CCTTATCGAGAACCAGAGCG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB2 [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKYLGLCTDLYELTMAQSYLYEGKTGTAVFSLFVRKLPEKRNFLISAGLETLVERIKNFKFGDEEIKYLKSLGIFKDDFL
DYLKDFEFSGNVYAIPEGRIVFQNEPLVQVEAPIPEAQLLETLVINTIQFETMIASKAVRSYLVAKGKKLVDFGFRRAHG
LEAGILAARASYIAGFDGTSNVEAGREFGIPVVGTMAHSYVMIFDKEEDAFRAFAKLYPKNAIFLIDTYDTIEAAKKVVD
LAKEGVPVVGVRIDSGDIVKLSKEVRKILDENGLKNVRIIVSGGVDEYKIKEWFDRGAPIDAFGVGTKFITSADAPYFDI
AYKLVEYEGKPKYKLSPGKKTFPYKRQVYRYYENGKMKYDETAKWESKREGEPLVELVMKNGKLIKELPSLKEIREVVMS
ELEKLPENYKDITKHYEYEVKILDWE

Sequences:

>Translated_426_residues
MKYLGLCTDLYELTMAQSYLYEGKTGTAVFSLFVRKLPEKRNFLISAGLETLVERIKNFKFGDEEIKYLKSLGIFKDDFL
DYLKDFEFSGNVYAIPEGRIVFQNEPLVQVEAPIPEAQLLETLVINTIQFETMIASKAVRSYLVAKGKKLVDFGFRRAHG
LEAGILAARASYIAGFDGTSNVEAGREFGIPVVGTMAHSYVMIFDKEEDAFRAFAKLYPKNAIFLIDTYDTIEAAKKVVD
LAKEGVPVVGVRIDSGDIVKLSKEVRKILDENGLKNVRIIVSGGVDEYKIKEWFDRGAPIDAFGVGTKFITSADAPYFDI
AYKLVEYEGKPKYKLSPGKKTFPYKRQVYRYYENGKMKYDETAKWESKREGEPLVELVMKNGKLIKELPSLKEIREVVMS
ELEKLPENYKDITKHYEYEVKILDWE
>Mature_426_residues
MKYLGLCTDLYELTMAQSYLYEGKTGTAVFSLFVRKLPEKRNFLISAGLETLVERIKNFKFGDEEIKYLKSLGIFKDDFL
DYLKDFEFSGNVYAIPEGRIVFQNEPLVQVEAPIPEAQLLETLVINTIQFETMIASKAVRSYLVAKGKKLVDFGFRRAHG
LEAGILAARASYIAGFDGTSNVEAGREFGIPVVGTMAHSYVMIFDKEEDAFRAFAKLYPKNAIFLIDTYDTIEAAKKVVD
LAKEGVPVVGVRIDSGDIVKLSKEVRKILDENGLKNVRIIVSGGVDEYKIKEWFDRGAPIDAFGVGTKFITSADAPYFDI
AYKLVEYEGKPKYKLSPGKKTFPYKRQVYRYYENGKMKYDETAKWESKREGEPLVELVMKNGKLIKELPSLKEIREVVMS
ELEKLPENYKDITKHYEYEVKILDWE

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=504, Percent_Identity=29.3650793650794, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1787162, Length=328, Percent_Identity=25.3048780487805, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997947, Length=490, Percent_Identity=31.8367346938775, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71997952, Length=490, Percent_Identity=32.2448979591837, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI71997955, Length=210, Percent_Identity=39.5238095238095, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24581587, Length=509, Percent_Identity=32.0235756385069, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI161076680, Length=205, Percent_Identity=42.4390243902439, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24581595, Length=205, Percent_Identity=42.4390243902439, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI28574709, Length=205, Percent_Identity=42.4390243902439, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24581593, Length=205, Percent_Identity=42.4390243902439, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24581591, Length=205, Percent_Identity=42.4390243902439, Blast_Score=142, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 48590; Mature: 48590

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLGLCTDLYELTMAQSYLYEGKTGTAVFSLFVRKLPEKRNFLISAGLETLVERIKNFK
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCEEHHHHHHHHHHHHHCCC
FGDEEIKYLKSLGIFKDDFLDYLKDFEFSGNVYAIPEGRIVFQNEPLVQVEAPIPEAQLL
CCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEECCCCEEEECCCCEEEEECCCCHHHHH
ETLVINTIQFETMIASKAVRSYLVAKGKKLVDFGFRRAHGLEAGILAARASYIAGFDGTS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
NVEAGREFGIPVVGTMAHSYVMIFDKEEDAFRAFAKLYPKNAIFLIDTYDTIEAAKKVVD
CCCCCHHCCCCEEECCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHH
LAKEGVPVVGVRIDSGDIVKLSKEVRKILDENGLKNVRIIVSGGVDEYKIKEWFDRGAPI
HHHCCCCEEEEEECCCCEEHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCC
DAFGVGTKFITSADAPYFDIAYKLVEYEGKPKYKLSPGKKTFPYKRQVYRYYENGKMKYD
CHHCCCCHHHCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCC
ETAKWESKREGEPLVELVMKNGKLIKELPSLKEIREVVMSELEKLPENYKDITKHYEYEV
CCCCCCCCCCCCHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCEEEE
KILDWE
EEEECC
>Mature Secondary Structure
MKYLGLCTDLYELTMAQSYLYEGKTGTAVFSLFVRKLPEKRNFLISAGLETLVERIKNFK
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCEEHHHHHHHHHHHHHCCC
FGDEEIKYLKSLGIFKDDFLDYLKDFEFSGNVYAIPEGRIVFQNEPLVQVEAPIPEAQLL
CCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEECCCCEEEECCCCEEEEECCCCHHHHH
ETLVINTIQFETMIASKAVRSYLVAKGKKLVDFGFRRAHGLEAGILAARASYIAGFDGTS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
NVEAGREFGIPVVGTMAHSYVMIFDKEEDAFRAFAKLYPKNAIFLIDTYDTIEAAKKVVD
CCCCCHHCCCCEEECCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHH
LAKEGVPVVGVRIDSGDIVKLSKEVRKILDENGLKNVRIIVSGGVDEYKIKEWFDRGAPI
HHHCCCCEEEEEECCCCEEHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCC
DAFGVGTKFITSADAPYFDIAYKLVEYEGKPKYKLSPGKKTFPYKRQVYRYYENGKMKYD
CHHCCCCHHHCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCC
ETAKWESKREGEPLVELVMKNGKLIKELPSLKEIREVVMSELEKLPENYKDITKHYEYEV
CCCCCCCCCCCCHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCEEEE
KILDWE
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]