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The map label for this gene is cphA2 [H]

Identifier: 15606287

GI number: 15606287

Start: 673738

End: 674661

Strand: Direct

Name: cphA2 [H]

Synonym: aq_974

Alternate gene names: 15606287

Gene position: 673738-674661 (Clockwise)

Preceding gene: 15606286

Following gene: 15606288

Centisome position: 43.43

GC content: 42.97

Gene sequence:

>924_bases
GTGGGAGGTGCGGTCATGTTAAAAACGCTCTTTGTACTCCTGTTAATCATTAGCACAGCTTTTTCAATGACATTAAAGAA
AGTTGAAGAAAACCTCTACATGGTGAGAGGAAACGATGGACTTCCTTCCAAGGAAAACAAAGGTTTTATCTCCAACGCCT
ACGCGGTTTTAACAGAAGAGGGATGGGTGGTTATAGACACCTTAACCACTCCCGAGCTCTCCGAGGAATTTCTGAACCTT
CTTAAAAAGGTTTCAAACAAACCAGTAATTTACGCGATAGTAACTCACTACCACCTTGACCACTGGTACGGGGCAAAAAC
CTTCAAGGATAAAGGTGCTAAGGTAATAGCCCACGAAAAACTAAAAGAGTTCTACGATTCTGGCGAAGCCCTTCAAGTTC
TGGAGGCTCAGAAGAAGAGGTTTAAGGGAGTGCTTGACAGTGTAGAGCTCGTACCTCCCGACGAAGTTGTAAAGGATAAA
AAGGTTTTAAAAGTCGGTAAAGATGTATTTGAGATTTACGCAATGCCTCCCGCGCACACAAACTCCGACCTCGTAATTTA
CTGGAAGAACAGGAAAGTCCTTTTTGTAGGGGACCTCGTTTACATAAACAGGATTCCCTTTATGGGGGACAGGAACGCGA
GTTCCAAAGGGTGGTTAGAGGTTCTGGAAAGATTAAAAGAGTTTGACGCGAGAATGCTCCTCGGTGGGCACAACTATCCC
ATGAATAAGGATGCGATAGACTGGACCTACAACTACATAAAGTTCGTGAGAGACACGGTAAAGAAGCTAAAAGACGAGGG
CTACTTCATAGACGAGATAAAGGAGGCGTTTAAAGGAAACCCGTACGAAAAAGTTAAAATGTATGAAGTTTTTCACAACA
CAAACGTGTGGAAGGTTTACAACGAACTTGATTTAGAACTTTGA

Upstream 100 bases:

>100_bases
CTACTACGCAAAGGTGTTTTTAGATTTGCTTAACTCCCTAAAAATCCTAAAAATATGAAATTAATCATTCTTTCCTTTTC
CCTCAGGTTCTAACTTTTCC

Downstream 100 bases:

>100_bases
GGAGGCACGTTATGGACAAAGTTGAGAGGAGACTTTACGAGCTTTACGAGAAGGCTATCAATTACGAGCCCTTATCCAAG
GAGGAAGCCCTTTATATACT

Product: beta lactamase precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MGGAVMLKTLFVLLLIISTAFSMTLKKVEENLYMVRGNDGLPSKENKGFISNAYAVLTEEGWVVIDTLTTPELSEEFLNL
LKKVSNKPVIYAIVTHYHLDHWYGAKTFKDKGAKVIAHEKLKEFYDSGEALQVLEAQKKRFKGVLDSVELVPPDEVVKDK
KVLKVGKDVFEIYAMPPAHTNSDLVIYWKNRKVLFVGDLVYINRIPFMGDRNASSKGWLEVLERLKEFDARMLLGGHNYP
MNKDAIDWTYNYIKFVRDTVKKLKDEGYFIDEIKEAFKGNPYEKVKMYEVFHNTNVWKVYNELDLEL

Sequences:

>Translated_307_residues
MGGAVMLKTLFVLLLIISTAFSMTLKKVEENLYMVRGNDGLPSKENKGFISNAYAVLTEEGWVVIDTLTTPELSEEFLNL
LKKVSNKPVIYAIVTHYHLDHWYGAKTFKDKGAKVIAHEKLKEFYDSGEALQVLEAQKKRFKGVLDSVELVPPDEVVKDK
KVLKVGKDVFEIYAMPPAHTNSDLVIYWKNRKVLFVGDLVYINRIPFMGDRNASSKGWLEVLERLKEFDARMLLGGHNYP
MNKDAIDWTYNYIKFVRDTVKKLKDEGYFIDEIKEAFKGNPYEKVKMYEVFHNTNVWKVYNELDLEL
>Mature_306_residues
GGAVMLKTLFVLLLIISTAFSMTLKKVEENLYMVRGNDGLPSKENKGFISNAYAVLTEEGWVVIDTLTTPELSEEFLNLL
KKVSNKPVIYAIVTHYHLDHWYGAKTFKDKGAKVIAHEKLKEFYDSGEALQVLEAQKKRFKGVLDSVELVPPDEVVKDKK
VLKVGKDVFEIYAMPPAHTNSDLVIYWKNRKVLFVGDLVYINRIPFMGDRNASSKGWLEVLERLKEFDARMLLGGHNYPM
NKDAIDWTYNYIKFVRDTVKKLKDEGYFIDEIKEAFKGNPYEKVKMYEVFHNTNVWKVYNELDLEL

Specific function: Can hydrolyze carbapenem compounds [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 35482; Mature: 35350

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGAVMLKTLFVLLLIISTAFSMTLKKVEENLYMVRGNDGLPSKENKGFISNAYAVLTEE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHCEEEEEECC
GWVVIDTLTTPELSEEFLNLLKKVSNKPVIYAIVTHYHLDHWYGAKTFKDKGAKVIAHEK
CEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCHHHCCCCEEHHHHH
LKEFYDSGEALQVLEAQKKRFKGVLDSVELVPPDEVVKDKKVLKVGKDVFEIYAMPPAHT
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCC
NSDLVIYWKNRKVLFVGDLVYINRIPFMGDRNASSKGWLEVLERLKEFDARMLLGGHNYP
CCCEEEEECCCEEEEEECEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCHHEEECCCCCC
MNKDAIDWTYNYIKFVRDTVKKLKDEGYFIDEIKEAFKGNPYEKVKMYEVFHNTNVWKVY
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEE
NELDLEL
CCCCCCC
>Mature Secondary Structure 
GGAVMLKTLFVLLLIISTAFSMTLKKVEENLYMVRGNDGLPSKENKGFISNAYAVLTEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHCEEEEEECC
GWVVIDTLTTPELSEEFLNLLKKVSNKPVIYAIVTHYHLDHWYGAKTFKDKGAKVIAHEK
CEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCHHHCCCCEEHHHHH
LKEFYDSGEALQVLEAQKKRFKGVLDSVELVPPDEVVKDKKVLKVGKDVFEIYAMPPAHT
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCC
NSDLVIYWKNRKVLFVGDLVYINRIPFMGDRNASSKGWLEVLERLKEFDARMLLGGHNYP
CCCEEEEECCCEEEEEECEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCHHEEECCCCCC
MNKDAIDWTYNYIKFVRDTVKKLKDEGYFIDEIKEAFKGNPYEKVKMYEVFHNTNVWKVY
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEE
NELDLEL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1856163 [H]