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The map label for this gene is hemH

Identifier: 15606267

GI number: 15606267

Start: 652890

End: 653819

Strand: Direct

Name: hemH

Synonym: aq_948

Alternate gene names: 15606267

Gene position: 652890-653819 (Clockwise)

Preceding gene: 15606266

Following gene: 15606268

Centisome position: 42.09

GC content: 40.75

Gene sequence:

>930_bases
ATGAAAAAAGGAGTAATACTTATAAACCTCGGCGGACCTGATTCTCTGGAAGCGGTAGAGCCGTTCCTTTATAACCTTTT
CTCAGATCCAGATATTTTCTCCTTACCCTTTCAAAAAGTTCTCGCAAAAATAATCGCAAAGTTAAGGGCTAAAAAAACGA
GACATTACTACGAGCTTATGGGAGGAAAGTCTCCCCAATACGAACAAACCCTTGAACAGGCTAAAGCACTTCAGGAAAGA
CTAGGAGAAGATTACAAGGTAGTTGTGGGAATGAGATACTGGAAACCTTACATAAAAGACGCACTTTCTGAACTCCTGAA
GGAAGGAATAAACGAAGTAATACTCCTTCCCCTGTACCCCCAGTACAGCAAAACGACAACTGGTTCCGCTTTTAACGAGT
TTGAAAGGAGCAAAAAAGCCCTCAAAGCGGACCACATTAAAGTTAAGAAAATAGAACACTTTTACGACCACCCCCTCTAT
ATAAAGGCGTGGGCCGAGCAGATAAAACAGAGCGTTGAAAAGCCCGAAGAATACCATTTTCTCTTTTCCGCCCACAGCCT
TCCCAAGAAATTGATAGAAGAAGGAGACCCTTATCAGGAACAAACCGAAAAAACGGTAAAACTCATTATGGAAAATTTCC
CTGAAGTAGAATACACGCTTGCTTACCAGAGTAAAGTGGGTTTCGGAAAGTGGCTCGAACCCTCAACAGACGAAGTAATC
AGAAACCTGATTAAGAAAGAAGTTAAAAAGTTATTAGTTATTCCCATATCCTTTGTTTCCGAACACAGCGAAACCCTTTA
CGAACTCGACAAACAATACAGAGAACTTGCCCAAGAACTGGGATACGAAGAATTCGTAAGAGTCCCTACTCTAAGAACAA
ACCCCTACTTCATATCTGCACTTGAAGATTTAGTAAAAAATGAAGTATAG

Upstream 100 bases:

>100_bases
CAAAAATAAAAGAGTACCGAACACTCGGCGAAGGAAAGAGCAAAAAGGAAGCTGAACAAAGGGCAGCCGAGGAATTAATT
AAATTACTGGAGGAATCAGA

Downstream 100 bases:

>100_bases
TAAAATTAAGTAAAGGGCTTTTTTAGCCCTCTCGTGGCTCCTTGGCAACTGAATAGGGTTTATGGGTCTTGATAAGTGAT
GCTTTGATGATGTGATGAAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKKGVILINLGGPDSLEAVEPFLYNLFSDPDIFSLPFQKVLAKIIAKLRAKKTRHYYELMGGKSPQYEQTLEQAKALQER
LGEDYKVVVGMRYWKPYIKDALSELLKEGINEVILLPLYPQYSKTTTGSAFNEFERSKKALKADHIKVKKIEHFYDHPLY
IKAWAEQIKQSVEKPEEYHFLFSAHSLPKKLIEEGDPYQEQTEKTVKLIMENFPEVEYTLAYQSKVGFGKWLEPSTDEVI
RNLIKKEVKKLLVIPISFVSEHSETLYELDKQYRELAQELGYEEFVRVPTLRTNPYFISALEDLVKNEV

Sequences:

>Translated_309_residues
MKKGVILINLGGPDSLEAVEPFLYNLFSDPDIFSLPFQKVLAKIIAKLRAKKTRHYYELMGGKSPQYEQTLEQAKALQER
LGEDYKVVVGMRYWKPYIKDALSELLKEGINEVILLPLYPQYSKTTTGSAFNEFERSKKALKADHIKVKKIEHFYDHPLY
IKAWAEQIKQSVEKPEEYHFLFSAHSLPKKLIEEGDPYQEQTEKTVKLIMENFPEVEYTLAYQSKVGFGKWLEPSTDEVI
RNLIKKEVKKLLVIPISFVSEHSETLYELDKQYRELAQELGYEEFVRVPTLRTNPYFISALEDLVKNEV
>Mature_309_residues
MKKGVILINLGGPDSLEAVEPFLYNLFSDPDIFSLPFQKVLAKIIAKLRAKKTRHYYELMGGKSPQYEQTLEQAKALQER
LGEDYKVVVGMRYWKPYIKDALSELLKEGINEVILLPLYPQYSKTTTGSAFNEFERSKKALKADHIKVKKIEHFYDHPLY
IKAWAEQIKQSVEKPEEYHFLFSAHSLPKKLIEEGDPYQEQTEKTVKLIMENFPEVEYTLAYQSKVGFGKWLEPSTDEVI
RNLIKKEVKKLLVIPISFVSEHSETLYELDKQYRELAQELGYEEFVRVPTLRTNPYFISALEDLVKNEV

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=322, Percent_Identity=38.5093167701863, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI60499021, Length=322, Percent_Identity=38.5093167701863, Blast_Score=198, Evalue=5e-51,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=32.3809523809524, Blast_Score=132, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324750, Length=322, Percent_Identity=35.4037267080745, Blast_Score=167, Evalue=1e-42,
Organism=Drosophila melanogaster, GI17864156, Length=322, Percent_Identity=35.7142857142857, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24651774, Length=253, Percent_Identity=33.596837944664, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI45552018, Length=171, Percent_Identity=39.766081871345, Blast_Score=127, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_AQUAE (O67083)

Other databases:

- EMBL:   AE000657
- PIR:   H70381
- RefSeq:   NP_213646.1
- ProteinModelPortal:   O67083
- SMR:   O67083
- GeneID:   1193625
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_948
- NMPDR:   fig|224324.1.peg.661
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- PhylomeDB:   O67083
- ProtClustDB:   CLSK2299560
- BioCyc:   AAEO224324:AQ_948-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36037; Mature: 36037

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGVILINLGGPDSLEAVEPFLYNLFSDPDIFSLPFQKVLAKIIAKLRAKKTRHYYELM
CCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GGKSPQYEQTLEQAKALQERLGEDYKVVVGMRYWKPYIKDALSELLKEGINEVILLPLYP
CCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
QYSKTTTGSAFNEFERSKKALKADHIKVKKIEHFYDHPLYIKAWAEQIKQSVEKPEEYHF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHH
LFSAHSLPKKLIEEGDPYQEQTEKTVKLIMENFPEVEYTLAYQSKVGFGKWLEPSTDEVI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHH
RNLIKKEVKKLLVIPISFVSEHSETLYELDKQYRELAQELGYEEFVRVPTLRTNPYFISA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHH
LEDLVKNEV
HHHHHCCCC
>Mature Secondary Structure
MKKGVILINLGGPDSLEAVEPFLYNLFSDPDIFSLPFQKVLAKIIAKLRAKKTRHYYELM
CCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GGKSPQYEQTLEQAKALQERLGEDYKVVVGMRYWKPYIKDALSELLKEGINEVILLPLYP
CCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
QYSKTTTGSAFNEFERSKKALKADHIKVKKIEHFYDHPLYIKAWAEQIKQSVEKPEEYHF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHH
LFSAHSLPKKLIEEGDPYQEQTEKTVKLIMENFPEVEYTLAYQSKVGFGKWLEPSTDEVI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHH
RNLIKKEVKKLLVIPISFVSEHSETLYELDKQYRELAQELGYEEFVRVPTLRTNPYFISA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHH
LEDLVKNEV
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320