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The map label for this gene is aroE

Identifier: 15606233

GI number: 15606233

Start: 622364

End: 623173

Strand: Direct

Name: aroE

Synonym: aq_901

Alternate gene names: 15606233

Gene position: 622364-623173 (Clockwise)

Preceding gene: 15606232

Following gene: 15606234

Centisome position: 40.12

GC content: 42.22

Gene sequence:

>810_bases
ATGATTAACGCCCAAACGCAGCTATACGGAGTAATAGGCTTTCCCGTAAAGCATTCCCTATCCCCCGTTTTCCAGAATGC
CCTTATAAGATACGCTGGTCTTAATGCGGTATACCTCGCCTTTGAGATTAACCCCGAAGAACTAAAAAAAGCCTTTGAAG
GATTTAAGGCTCTTAAGGTTAAAGGGATTAACGTAACCGTCCCCTTCAAGGAAGAAATCATTCCCCTCCTTGACTACGTT
GAGGACACAGCTAAGGAAATAGGTGCCGTAAACACGGTAAAGTTTGAAAACGGAAAAGCTTACGGCTACAACACCGACTG
GATAGGTTTTTTAAAATCCCTAAAGAGCTTAATTCCAGAGGTAAAAGAAAAAAGTATTCTCGTCCTTGGAGCTGGAGGAG
CTTCCAGAGCGGTTATTTACGCTCTTGTAAAAGAAGGGGCAAAGGTATTTCTGTGGAACAGGACAAAGGAAAAGGCAATA
AAGCTAGCTCAAAAGTTTCCCTTAGAGGTTGTAAACTCTCCCGAAGAAGTAATTGACAAGGTTCAAGTAATTGTAAACAC
GACGAGCGTAGGACTAAAAGACAAGGATCCCGAAATTTTCAATTACGACTTAATAAAGAAAGACCACGTAGTCGTGGACA
TAATCTACAAAGAGACAAAGCTTTTAAAGAAGGCAAAAGAAAAGGGAGCTAAACTCTTTGACGGGCTTCCCATGCTTCTG
TGGCAGGGAATAGAAGCTTTCAAGATATGGAACGGATGTGAAGTTCCCTACTCTGTGGCAGAAAGATCTGTAAGAGATCT
CCGTGGGTAA

Upstream 100 bases:

>100_bases
CCCTCAAAAACCTCGTTGATACAGTAATTAAGGGAAACGTCAAGTGGGTTAAGAAAGTAGAAATAACTCAGCAGAAATTC
GACATACAGCAATTCGCTTA

Downstream 100 bases:

>100_bases
AGAGTATTTCTTGAAAGTAGCCTTAAGGGAAGCAAAAAGAGCCTTTGAGAAAGGAGAAGTTCCCGTAGGTGCAATAATCG
TAAAAGAAGGAGAAATAATA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKKAFEGFKALKVKGINVTVPFKEEIIPLLDYV
EDTAKEIGAVNTVKFENGKAYGYNTDWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGAKVFLWNRTKEKAI
KLAQKFPLEVVNSPEEVIDKVQVIVNTTSVGLKDKDPEIFNYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLFDGLPMLL
WQGIEAFKIWNGCEVPYSVAERSVRDLRG

Sequences:

>Translated_269_residues
MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKKAFEGFKALKVKGINVTVPFKEEIIPLLDYV
EDTAKEIGAVNTVKFENGKAYGYNTDWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGAKVFLWNRTKEKAI
KLAQKFPLEVVNSPEEVIDKVQVIVNTTSVGLKDKDPEIFNYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLFDGLPMLL
WQGIEAFKIWNGCEVPYSVAERSVRDLRG
>Mature_269_residues
MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKKAFEGFKALKVKGINVTVPFKEEIIPLLDYV
EDTAKEIGAVNTVKFENGKAYGYNTDWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGAKVFLWNRTKEKAI
KLAQKFPLEVVNSPEEVIDKVQVIVNTTSVGLKDKDPEIFNYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLFDGLPMLL
WQGIEAFKIWNGCEVPYSVAERSVRDLRG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=274, Percent_Identity=35.036496350365, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1789675, Length=254, Percent_Identity=32.6771653543307, Blast_Score=115, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320332, Length=270, Percent_Identity=33.7037037037037, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_AQUAE (O67049)

Other databases:

- EMBL:   AE000657
- PIR:   F70377
- RefSeq:   NP_213611.1
- PDB:   2HK7
- PDB:   2HK8
- PDB:   2HK9
- PDBsum:   2HK7
- PDBsum:   2HK8
- PDBsum:   2HK9
- ProteinModelPortal:   O67049
- SMR:   O67049
- GeneID:   1193591
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_901
- NMPDR:   fig|224324.1.peg.626
- HOGENOM:   HBG553408
- OMA:   EHMELDE
- PhylomeDB:   O67049
- ProtClustDB:   CLSK2748376
- BioCyc:   AAEO224324:AQ_901-MONOMER
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 30107; Mature: 30107

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKKAFEGFKALKV
CCCCCCEEEEEECCCHHHCCCHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHCCHHEEEE
KGINVTVPFKEEIIPLLDYVEDTAKEIGAVNTVKFENGKAYGYNTDWIGFLKSLKSLIPE
ECCEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHH
VKEKSILVLGAGGASRAVIYALVKEGAKVFLWNRTKEKAIKLAQKFPLEVVNSPEEVIDK
HCCCCEEEEECCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCHHHCCCHHHHHHH
VQVIVNTTSVGLKDKDPEIFNYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLFDGLPMLL
HHHHEEECCCCCCCCCCCEEEEEEEECCCEEEEEEHHHHHHHHHHHHCCHHHHCCCHHHH
WQGIEAFKIWNGCEVPYSVAERSVRDLRG
HCCCHHEEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKKAFEGFKALKV
CCCCCCEEEEEECCCHHHCCCHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHCCHHEEEE
KGINVTVPFKEEIIPLLDYVEDTAKEIGAVNTVKFENGKAYGYNTDWIGFLKSLKSLIPE
ECCEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHH
VKEKSILVLGAGGASRAVIYALVKEGAKVFLWNRTKEKAIKLAQKFPLEVVNSPEEVIDK
HCCCCEEEEECCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCHHHCCCHHHHHHH
VQVIVNTTSVGLKDKDPEIFNYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLFDGLPMLL
HHHHEEECCCCCCCCCCCEEEEEEEECCCEEEEEEHHHHHHHHHHHHCCHHHHCCCHHHH
WQGIEAFKIWNGCEVPYSVAERSVRDLRG
HCCCHHEEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320