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The map label for this gene is gcp

Identifier: 15606170

GI number: 15606170

Start: 551567

End: 552574

Strand: Direct

Name: gcp

Synonym: aq_801

Alternate gene names: 15606170

Gene position: 551567-552574 (Clockwise)

Preceding gene: 15606169

Following gene: 15606171

Centisome position: 35.55

GC content: 46.33

Gene sequence:

>1008_bases
ATGAGGACATTAGCAGTTGAGACCTCGTGTGATGAAACCGCTCTTGCTATTTATGACGACCAAAAAGGCGTACTGGGAAA
CGTAATACTTTCACAGGCCGTAGTTCACTCCCCCTTCGGTGGGGTCGTTCCCGAACTCTCTGCAAGGGAGCACACGAGAA
ACATACTTCCTATATTCGACAGACTCTTAAAGGAAAGCCGAATAAATCTTGAGGAGATAGACTTTATTTCCTTTACCCTA
ACTCCCGGATTGATACTTTCGCTCGTGGTGGGTGTAGCCTTTGCAAAGGCCCTTGCCTACGAGTACAGAAAACCTTTAGT
TCCCGTTCACCACCTGGAAGGTCACATATACTCTGTTTTCCTAGAAAAAAAGGTTGAATATCCCTTTCTCGCTCTGATAA
TTTCAGGTGGGCACACGGATCTTTACCTTGTAAGGGACTTTGGGAGGTACGATTTTCTCGGAGGTACTCTGGACGACGCT
GTCGGGGAAGCCTACGACAAAGTTGCAAAAATGCTCGGTCTGGGATACCCCGGAGGTCCCATAATAGACCGACTGGCTAA
AGAGGGAAAGAAATTATACCCTTTACCCAAACCACTTATGGAGGAAGGAAACTTAAACTTCTCCTTCAGTGGGCTTAAAA
CGGCGATACTGAACCTCTTAAAAAAGGAAAAAAACGTAAGGAAAGAGGATATCGCTTACTCATTCCAGGAAACGGTGGTA
GAAATACTACTCGAAAAAAGCCTCTGGGCTATGAAAAAAACGGGGATAAAAAGGCTTGTTGTGGTAGGAGGAGTGTCCGC
AAACTCGAGGCTGAGGGAAGTGTTCAAAAAAGCTTCTCAAGAGTACGGTTTTGAACTCTACATACCGCATCCGAGTCTCT
CTACGGACAACGCCCTTATGATAGCTTACGCCGGTATGGAGAGGTTCAAGAGGGGTGTTGTAGCACCTCTGGATGTAAAT
CCCCAACCCAATATTCCCCTGGAGGAGTTCGGAAGGATATGGACTTGA

Upstream 100 bases:

>100_bases
AAGGACACATGGAAAAAGTGATACTCCTTCCCGACATAGACGTTCAGCTGAGAAAGGCTATTGAAATACTGGAGAAAAAG
GCTAAACTCAAAAAGGCAGC

Downstream 100 bases:

>100_bases
AGCAAATTCCAAAAGTTTTATAATTTATTAATTGGCACGGGGTGTAGCGCAGGTGGTAGCGCGCTGGCATGGGGGGCCAG
AGGTCGCCGGTTCGAGTCCG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MRTLAVETSCDETALAIYDDQKGVLGNVILSQAVVHSPFGGVVPELSAREHTRNILPIFDRLLKESRINLEEIDFISFTL
TPGLILSLVVGVAFAKALAYEYRKPLVPVHHLEGHIYSVFLEKKVEYPFLALIISGGHTDLYLVRDFGRYDFLGGTLDDA
VGEAYDKVAKMLGLGYPGGPIIDRLAKEGKKLYPLPKPLMEEGNLNFSFSGLKTAILNLLKKEKNVRKEDIAYSFQETVV
EILLEKSLWAMKKTGIKRLVVVGGVSANSRLREVFKKASQEYGFELYIPHPSLSTDNALMIAYAGMERFKRGVVAPLDVN
PQPNIPLEEFGRIWT

Sequences:

>Translated_335_residues
MRTLAVETSCDETALAIYDDQKGVLGNVILSQAVVHSPFGGVVPELSAREHTRNILPIFDRLLKESRINLEEIDFISFTL
TPGLILSLVVGVAFAKALAYEYRKPLVPVHHLEGHIYSVFLEKKVEYPFLALIISGGHTDLYLVRDFGRYDFLGGTLDDA
VGEAYDKVAKMLGLGYPGGPIIDRLAKEGKKLYPLPKPLMEEGNLNFSFSGLKTAILNLLKKEKNVRKEDIAYSFQETVV
EILLEKSLWAMKKTGIKRLVVVGGVSANSRLREVFKKASQEYGFELYIPHPSLSTDNALMIAYAGMERFKRGVVAPLDVN
PQPNIPLEEFGRIWT
>Mature_335_residues
MRTLAVETSCDETALAIYDDQKGVLGNVILSQAVVHSPFGGVVPELSAREHTRNILPIFDRLLKESRINLEEIDFISFTL
TPGLILSLVVGVAFAKALAYEYRKPLVPVHHLEGHIYSVFLEKKVEYPFLALIISGGHTDLYLVRDFGRYDFLGGTLDDA
VGEAYDKVAKMLGLGYPGGPIIDRLAKEGKKLYPLPKPLMEEGNLNFSFSGLKTAILNLLKKEKNVRKEDIAYSFQETVV
EILLEKSLWAMKKTGIKRLVVVGGVSANSRLREVFKKASQEYGFELYIPHPSLSTDNALMIAYAGMERFKRGVVAPLDVN
PQPNIPLEEFGRIWT

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=353, Percent_Identity=35.1274787535411, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI8923380, Length=319, Percent_Identity=33.8557993730408, Blast_Score=152, Evalue=5e-37,
Organism=Escherichia coli, GI1789445, Length=334, Percent_Identity=45.5089820359281, Blast_Score=313, Evalue=7e-87,
Organism=Caenorhabditis elegans, GI17557464, Length=328, Percent_Identity=30.7926829268293, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71995670, Length=318, Percent_Identity=34.5911949685535, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320099, Length=375, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322891, Length=321, Percent_Identity=28.9719626168224, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20129063, Length=337, Percent_Identity=32.0474777448071, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21357207, Length=332, Percent_Identity=31.9277108433735, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_AQUAE (O66986)

Other databases:

- EMBL:   AE000657
- PIR:   G70369
- RefSeq:   NP_213547.1
- ProteinModelPortal:   O66986
- SMR:   O66986
- MEROPS:   M22.001
- GeneID:   1193436
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_801
- NMPDR:   fig|224324.1.peg.562
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   O66986
- ProtClustDB:   PRK09604
- BioCyc:   AAEO224324:AQ_801-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37371; Mature: 37371

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLAVETSCDETALAIYDDQKGVLGNVILSQAVVHSPFGGVVPELSAREHTRNILPIFD
CCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHH
RLLKESRINLEEIDFISFTLTPGLILSLVVGVAFAKALAYEYRKPLVPVHHLEGHIYSVF
HHHHHHCCCHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHH
LEKKVEYPFLALIISGGHTDLYLVRDFGRYDFLGGTLDDAVGEAYDKVAKMLGLGYPGGP
HHHCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCH
IIDRLAKEGKKLYPLPKPLMEEGNLNFSFSGLKTAILNLLKKEKNVRKEDIAYSFQETVV
HHHHHHHCCCEECCCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EILLEKSLWAMKKTGIKRLVVVGGVSANSRLREVFKKASQEYGFELYIPHPSLSTDNALM
HHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEE
IAYAGMERFKRGVVAPLDVNPQPNIPLEEFGRIWT
EEEHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MRTLAVETSCDETALAIYDDQKGVLGNVILSQAVVHSPFGGVVPELSAREHTRNILPIFD
CCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHH
RLLKESRINLEEIDFISFTLTPGLILSLVVGVAFAKALAYEYRKPLVPVHHLEGHIYSVF
HHHHHHCCCHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHH
LEKKVEYPFLALIISGGHTDLYLVRDFGRYDFLGGTLDDAVGEAYDKVAKMLGLGYPGGP
HHHCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCH
IIDRLAKEGKKLYPLPKPLMEEGNLNFSFSGLKTAILNLLKKEKNVRKEDIAYSFQETVV
HHHHHHHCCCEECCCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EILLEKSLWAMKKTGIKRLVVVGGVSANSRLREVFKKASQEYGFELYIPHPSLSTDNALM
HHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEE
IAYAGMERFKRGVVAPLDVNPQPNIPLEEFGRIWT
EEEHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320