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The map label for this gene is bioF [C]

Identifier: 15606058

GI number: 15606058

Start: 425550

End: 426671

Strand: Direct

Name: bioF [C]

Synonym: aq_626

Alternate gene names: 15606058

Gene position: 425550-426671 (Clockwise)

Preceding gene: 15606057

Following gene: 15606063

Centisome position: 27.43

GC content: 37.61

Gene sequence:

>1122_bases
ATGAGGTGGATTGAGGAGGAATTAAAGAGAATTAAGGAAGCAAACCTTTACAGGGAAAGGATACTCCTTGAGGGAGTAAA
GGATTTCTGCTCCAATGATTACTTGGGACTTAGAAAACACCCAGAAGTTGTAGAAGAAAGTATAAGGGTTTTAAAGGAAG
CAGGACTAGGTTCAGGTGCTTCTCAACTGGTTTCCGGATACACAAAGCACCACAGGGAACTTGAGGAAAAACTTGCGGAG
TTTAAGGGAACTGAAAGCTGTGTTCTCTTCGGAAGCGGTTTTTTAGCAAACGTAGGAACGATACCGGCCCTTGTGGAAGA
AGGAGATCTCGTCCTGAGTGACGAATTAAATCACGCATCTATAATAGACGGAGTAAGACTTTCTAAAGCTCAAAAAAGGG
TTTTTAAGCATAAAGATTACGAGGAACTTGAGGAGTTTTTAAAGAAAAACAGGAAAAAGTTTAGAAGAGTTCTAATAATT
ACGGACACCGTGTTCAGTATGGACGGAGATGTAGCGGATTTGAAAAGATTAACACAGATATGTGAAGAGTACGACTGTAT
GCTTTACATAGACGAGGCGCACACAACGGGAACGATAGGAAAAGGCGGACTTGATTACTTTGGAATAGAACACAAAGAGT
ACATAATCGTTATGGGAACATTATCAAAGGCTTTAGGAAGTTACGGAGCTTTTGTCTGCGGAACAAAATTACTGATAGAT
TACCTTGTGAACAAAGCGAGGAGTTTAATATTCTCAACCTCTTTACCGCCTTCCGTGTGTGCAGGTGCTAAAAAAGCTAT
TGAGATAATAGAAGAAAATCCAAAATTAATTGAGTTTTTAAGAAAAAAAGAAAAGGAAATTTTAGAAATTTTGGAACAAT
TTTCTTTAGATTACAAATATTACAGCACACCTATAATTCCCATAATGGTTTACGACGAAAAAGAAACAGTAAGGATAAAA
GAAGAACTTCTAAAGGAAGGTGTGTTTATTCAAGCTATAAGGTACCCCACAGTTCCTAAAGGAAAGGCGAGGCTCAGATT
AACAGCTTCCTTAAATTACACAAGGAAAGATTTAGAATTTCTGAAAAATGCTTTAGAAAAAGTTTTAAAAGGAAGGGCTT
AG

Upstream 100 bases:

>100_bases
TTCTCGCGGATGAGACTTGCGAAGGTGTCCCTATGGTTTTCGTAAAGGGAACAGAACCTCATATAACGTGCTCTGACTTG
AATGCCATACTGGGACTCAG

Downstream 100 bases:

>100_bases
AAAGCCCAGTTTAGCCCTACACCGATGGAGTGCTGAACCATTTTCGTAGAGACTTCCCCGGCTCCCTGTGCGGCTTTAGC
CGTAACAGTTTTGGGAAGAG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MRWIEEELKRIKEANLYRERILLEGVKDFCSNDYLGLRKHPEVVEESIRVLKEAGLGSGASQLVSGYTKHHRELEEKLAE
FKGTESCVLFGSGFLANVGTIPALVEEGDLVLSDELNHASIIDGVRLSKAQKRVFKHKDYEELEEFLKKNRKKFRRVLII
TDTVFSMDGDVADLKRLTQICEEYDCMLYIDEAHTTGTIGKGGLDYFGIEHKEYIIVMGTLSKALGSYGAFVCGTKLLID
YLVNKARSLIFSTSLPPSVCAGAKKAIEIIEENPKLIEFLRKKEKEILEILEQFSLDYKYYSTPIIPIMVYDEKETVRIK
EELLKEGVFIQAIRYPTVPKGKARLRLTASLNYTRKDLEFLKNALEKVLKGRA

Sequences:

>Translated_373_residues
MRWIEEELKRIKEANLYRERILLEGVKDFCSNDYLGLRKHPEVVEESIRVLKEAGLGSGASQLVSGYTKHHRELEEKLAE
FKGTESCVLFGSGFLANVGTIPALVEEGDLVLSDELNHASIIDGVRLSKAQKRVFKHKDYEELEEFLKKNRKKFRRVLII
TDTVFSMDGDVADLKRLTQICEEYDCMLYIDEAHTTGTIGKGGLDYFGIEHKEYIIVMGTLSKALGSYGAFVCGTKLLID
YLVNKARSLIFSTSLPPSVCAGAKKAIEIIEENPKLIEFLRKKEKEILEILEQFSLDYKYYSTPIIPIMVYDEKETVRIK
EELLKEGVFIQAIRYPTVPKGKARLRLTASLNYTRKDLEFLKNALEKVLKGRA
>Mature_373_residues
MRWIEEELKRIKEANLYRERILLEGVKDFCSNDYLGLRKHPEVVEESIRVLKEAGLGSGASQLVSGYTKHHRELEEKLAE
FKGTESCVLFGSGFLANVGTIPALVEEGDLVLSDELNHASIIDGVRLSKAQKRVFKHKDYEELEEFLKKNRKKFRRVLII
TDTVFSMDGDVADLKRLTQICEEYDCMLYIDEAHTTGTIGKGGLDYFGIEHKEYIIVMGTLSKALGSYGAFVCGTKLLID
YLVNKARSLIFSTSLPPSVCAGAKKAIEIIEENPKLIEFLRKKEKEILEILEQFSLDYKYYSTPIIPIMVYDEKETVRIK
EELLKEGVFIQAIRYPTVPKGKARLRLTASLNYTRKDLEFLKNALEKVLKGRA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=374, Percent_Identity=35.5614973262032, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI284448556, Length=340, Percent_Identity=37.0588235294118, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI83977442, Length=342, Percent_Identity=36.5497076023392, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI83977444, Length=342, Percent_Identity=36.5497076023392, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI83977440, Length=342, Percent_Identity=36.5497076023392, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4502025, Length=350, Percent_Identity=33.7142857142857, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI40316939, Length=350, Percent_Identity=33.7142857142857, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4758668, Length=372, Percent_Identity=31.7204301075269, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI119220554, Length=375, Percent_Identity=28.8, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI5454084, Length=280, Percent_Identity=30, Blast_Score=135, Evalue=8e-32,
Organism=Escherichia coli, GI1790046, Length=350, Percent_Identity=35.7142857142857, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=32.5648414985591, Blast_Score=190, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71994529, Length=385, Percent_Identity=36.6233766233766, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI32566772, Length=363, Percent_Identity=30.0275482093664, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17560914, Length=348, Percent_Identity=28.1609195402299, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17560912, Length=348, Percent_Identity=28.1609195402299, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71982617, Length=282, Percent_Identity=28.3687943262411, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71982625, Length=282, Percent_Identity=28.3687943262411, Blast_Score=121, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320438, Length=398, Percent_Identity=29.8994974874372, Blast_Score=190, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320267, Length=362, Percent_Identity=27.9005524861878, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6323954, Length=275, Percent_Identity=27.2727272727273, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24662918, Length=384, Percent_Identity=35.4166666666667, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI17137420, Length=348, Percent_Identity=35.3448275862069, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI17136286, Length=358, Percent_Identity=29.608938547486, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24653280, Length=291, Percent_Identity=28.5223367697594, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24653276, Length=291, Percent_Identity=28.5223367697594, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24653278, Length=291, Percent_Identity=28.5223367697594, Blast_Score=137, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_AQUAE (O66875)

Other databases:

- EMBL:   AE000657
- PIR:   G70355
- RefSeq:   NP_213435.1
- ProteinModelPortal:   O66875
- SMR:   O66875
- GeneID:   1193937
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_626
- NMPDR:   fig|224324.1.peg.450
- HOGENOM:   HBG649839
- OMA:   IQAIRYP
- PhylomeDB:   O66875
- ProtClustDB:   CLSK2299451
- BioCyc:   AAEO224324:AQ_626-MONOMER
- BRENDA:   2.3.1.47
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 42533; Mature: 42533

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 18-18 BINDING 118-118 BINDING 166-166 BINDING 337-337

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWIEEELKRIKEANLYRERILLEGVKDFCSNDYLGLRKHPEVVEESIRVLKEAGLGSGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCH
SQLVSGYTKHHRELEEKLAEFKGTESCVLFGSGFLANVGTIPALVEEGDLVLSDELNHAS
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCHHHHHCCCCEEEECCCCCHH
IIDGVRLSKAQKRVFKHKDYEELEEFLKKNRKKFRRVLIITDTVFSMDGDVADLKRLTQI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEEEHHHCCCCCHHHHHHHHHH
CEEYDCMLYIDEAHTTGTIGKGGLDYFGIEHKEYIIVMGTLSKALGSYGAFVCGTKLLID
HHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHCCCHHHHHHHHHHH
YLVNKARSLIFSTSLPPSVCAGAKKAIEIIEENPKLIEFLRKKEKEILEILEQFSLDYKY
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
YSTPIIPIMVYDEKETVRIKEELLKEGVFIQAIRYPTVPKGKARLRLTASLNYTRKDLEF
ECCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCHHHHHHH
LKNALEKVLKGRA
HHHHHHHHHCCCC
>Mature Secondary Structure
MRWIEEELKRIKEANLYRERILLEGVKDFCSNDYLGLRKHPEVVEESIRVLKEAGLGSGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCH
SQLVSGYTKHHRELEEKLAEFKGTESCVLFGSGFLANVGTIPALVEEGDLVLSDELNHAS
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCHHHHHCCCCEEEECCCCCHH
IIDGVRLSKAQKRVFKHKDYEELEEFLKKNRKKFRRVLIITDTVFSMDGDVADLKRLTQI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEEEHHHCCCCCHHHHHHHHHH
CEEYDCMLYIDEAHTTGTIGKGGLDYFGIEHKEYIIVMGTLSKALGSYGAFVCGTKLLID
HHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHCCCHHHHHHHHHHH
YLVNKARSLIFSTSLPPSVCAGAKKAIEIIEENPKLIEFLRKKEKEILEILEQFSLDYKY
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
YSTPIIPIMVYDEKETVRIKEELLKEGVFIQAIRYPTVPKGKARLRLTASLNYTRKDLEF
ECCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCHHHHHHH
LKNALEKVLKGRA
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320