Click here to switch to the map view.

The map label for this gene is pbpA2 [H]

Identifier: 15606014

GI number: 15606014

Start: 378689

End: 380425

Strand: Direct

Name: pbpA2 [H]

Synonym: aq_556

Alternate gene names: 15606014

Gene position: 378689-380425 (Clockwise)

Preceding gene: 15606013

Following gene: 15606018

Centisome position: 24.41

GC content: 42.03

Gene sequence:

>1737_bases
ATGGAATACCTTCGGGTTTATCAGAAGAGGGAGAGGGTTTTCAAAAGAAGGGTCATACTCTTCGTGATTTTAAGTTTTTT
AGCGGTATTACTCCTTTTAGGAAGGATTTTATATATAAACCTTTTTAAGGAAGATGCACTGAAAGGAGCCGTAAAAGACG
CAGAAGTAGTTCAGATCCAGACCTACCGCGGGAGCATAAAAACCTCTGACGGAAAGATCCTTGCACTCAGTTATCCCGTC
GCTTACGTCTACGCCAGCAAGTTCTATCGCTTTCGGGATACGGTAAAGAGGGAGAAATTCATTAAGGAATTATCAAAATT
ACTGGGTGTTAGAGAAAGTGTTTTAAGAAAAAGGATAAAGGAAAACGAGAGTAAGACCTTTTTTGAGTTAATAACCTTTC
CCGTTCATTTGAAAGACGAAGTCAGAAAGCTCATAAAGAGTATAGATTACGACGAAGAGAGTAAAGAGTTCACAAAACCT
TACCTCAGTTCCTTTGTGGGAGTGGATGAGCGTTATAAGAGGTACTATCCACACGGGAATTTTGCCTCAAACCTCCTGGG
CTTTGTAACGGAAAAGGGCTACGCCGCGGAGGGTATAGAGAGGCTGTTTGACGAGTACCTGAGGGGAGGAGAAGAACCGA
TAAAGTATTTAGTCTATAAGAATAAAGGAATAACGGTTGTGGAGTCTTTAGGAACGCAGATATACACACCGAAGGACTTA
ACCCTCTCCATAGACTTCAGAGTTCAAGCACTTCTGGAAGAGGTTAAGAAAAGAATCGTAAAGAAGTGGAGACCTAAAAA
AGTAGTCCTCATAGTTATGGAAACTTCTACGGGAAAGGTTAGAGGCTACACGACCTATCCCGACTACGATCCAAATAAAT
ACGAACGCTACCCTTACTGGAGGATAAGGAATTTCGGAGTGACGGACAGGTTTGAAGTGGGTTCCGTATTCAAGCCCTTT
TTAGTAGCGTTCGCTCTGGATAGGAGAAAGATAAGGAAAGACACTCTTATAAACATAAACTACGGGAAGATAAAGGTTCA
TAAGAAGTACGTGAGGGACGTTACACCTTACTTGTGGAAAAAAGAGTACATAACTCCTAGGGAACTCTTAGTCCACTCCT
CTAACGTGGGAGCTATAAGAGTTGGTCTTATGCTAAAGCCGGAAGAGTATTACGAACTATTTAAAACCTTTAAACTTTTA
CGTTCTCCCGGAGTTTTAGAAGGGGAAGTTAAACCCTCTATTTCTGATCTGAAGTATAAAGTAAACAGGGCTTACGCTTC
GATAGGACAGGGTGTGGCTTTTAACCCCCTTCATTTGATAACTTCCTTCAACGCTCTCGTAAACGGAAAGTACGTAAAGC
CTTCCTTCGTGGAAGAAGAGAAAACGGAAGCAGAAAAAATTCAAATAAAACCCTCAACCGTAAAGTGGATCAGGGACGTG
CTCATAGAAGTCGTTGAGAAGGGAACAGGAAAAAGGGCTAAGAGCGAGTATTACTTTGCGGGAGGAAAGACTGGAACAGC
TCAGAAGTACGATTCAGCTCTTAAGACGTACTCTAAGGAAAAGCTCGTAACTTACTTCCTCGGATTCTTTCCTTCAGAGC
CGAAGTTTACGGTTCTCATCCTAGTTGACGAGCCCAAGGGAAAAAACCTTTACGGCGGTACTGTAGCTGCTCCATATTTC
AAAGAGATTATAGAAAAAATCGGAGTTATTTACGGAGTGAAGCGGGATAGAACGTAG

Upstream 100 bases:

>100_bases
CCCTTATTTAACACTTATTCCGAAGTTATATCCGTTAAAAAGACTGAAATTCCAGATTACATATACAAACTACCGGAGGG
CTACACTAAGATAAAGTAAG

Downstream 100 bases:

>100_bases
TCGGCGAGTCCAGTTCTGATATCTTTTGGTAGTTCAACATCTTGAATTCTGGGAACTTTGTAAGGTTTTATCCCCGTCAT
TTCTTCTATTATTTGAGGGT

Product: penicillin binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MEYLRVYQKRERVFKRRVILFVILSFLAVLLLLGRILYINLFKEDALKGAVKDAEVVQIQTYRGSIKTSDGKILALSYPV
AYVYASKFYRFRDTVKREKFIKELSKLLGVRESVLRKRIKENESKTFFELITFPVHLKDEVRKLIKSIDYDEESKEFTKP
YLSSFVGVDERYKRYYPHGNFASNLLGFVTEKGYAAEGIERLFDEYLRGGEEPIKYLVYKNKGITVVESLGTQIYTPKDL
TLSIDFRVQALLEEVKKRIVKKWRPKKVVLIVMETSTGKVRGYTTYPDYDPNKYERYPYWRIRNFGVTDRFEVGSVFKPF
LVAFALDRRKIRKDTLININYGKIKVHKKYVRDVTPYLWKKEYITPRELLVHSSNVGAIRVGLMLKPEEYYELFKTFKLL
RSPGVLEGEVKPSISDLKYKVNRAYASIGQGVAFNPLHLITSFNALVNGKYVKPSFVEEEKTEAEKIQIKPSTVKWIRDV
LIEVVEKGTGKRAKSEYYFAGGKTGTAQKYDSALKTYSKEKLVTYFLGFFPSEPKFTVLILVDEPKGKNLYGGTVAAPYF
KEIIEKIGVIYGVKRDRT

Sequences:

>Translated_578_residues
MEYLRVYQKRERVFKRRVILFVILSFLAVLLLLGRILYINLFKEDALKGAVKDAEVVQIQTYRGSIKTSDGKILALSYPV
AYVYASKFYRFRDTVKREKFIKELSKLLGVRESVLRKRIKENESKTFFELITFPVHLKDEVRKLIKSIDYDEESKEFTKP
YLSSFVGVDERYKRYYPHGNFASNLLGFVTEKGYAAEGIERLFDEYLRGGEEPIKYLVYKNKGITVVESLGTQIYTPKDL
TLSIDFRVQALLEEVKKRIVKKWRPKKVVLIVMETSTGKVRGYTTYPDYDPNKYERYPYWRIRNFGVTDRFEVGSVFKPF
LVAFALDRRKIRKDTLININYGKIKVHKKYVRDVTPYLWKKEYITPRELLVHSSNVGAIRVGLMLKPEEYYELFKTFKLL
RSPGVLEGEVKPSISDLKYKVNRAYASIGQGVAFNPLHLITSFNALVNGKYVKPSFVEEEKTEAEKIQIKPSTVKWIRDV
LIEVVEKGTGKRAKSEYYFAGGKTGTAQKYDSALKTYSKEKLVTYFLGFFPSEPKFTVLILVDEPKGKNLYGGTVAAPYF
KEIIEKIGVIYGVKRDRT
>Mature_578_residues
MEYLRVYQKRERVFKRRVILFVILSFLAVLLLLGRILYINLFKEDALKGAVKDAEVVQIQTYRGSIKTSDGKILALSYPV
AYVYASKFYRFRDTVKREKFIKELSKLLGVRESVLRKRIKENESKTFFELITFPVHLKDEVRKLIKSIDYDEESKEFTKP
YLSSFVGVDERYKRYYPHGNFASNLLGFVTEKGYAAEGIERLFDEYLRGGEEPIKYLVYKNKGITVVESLGTQIYTPKDL
TLSIDFRVQALLEEVKKRIVKKWRPKKVVLIVMETSTGKVRGYTTYPDYDPNKYERYPYWRIRNFGVTDRFEVGSVFKPF
LVAFALDRRKIRKDTLININYGKIKVHKKYVRDVTPYLWKKEYITPRELLVHSSNVGAIRVGLMLKPEEYYELFKTFKLL
RSPGVLEGEVKPSISDLKYKVNRAYASIGQGVAFNPLHLITSFNALVNGKYVKPSFVEEEKTEAEKIQIKPSTVKWIRDV
LIEVVEKGTGKRAKSEYYFAGGKTGTAQKYDSALKTYSKEKLVTYFLGFFPSEPKFTVLILVDEPKGKNLYGGTVAAPYF
KEIIEKIGVIYGVKRDRT

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=569, Percent_Identity=27.5922671353251, Blast_Score=174, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 67203; Mature: 67203

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYLRVYQKRERVFKRRVILFVILSFLAVLLLLGRILYINLFKEDALKGAVKDAEVVQIQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
TYRGSIKTSDGKILALSYPVAYVYASKFYRFRDTVKREKFIKELSKLLGVRESVLRKRIK
EECCCEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENESKTFFELITFPVHLKDEVRKLIKSIDYDEESKEFTKPYLSSFVGVDERYKRYYPHGN
CCCCHHEEHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCC
FASNLLGFVTEKGYAAEGIERLFDEYLRGGEEPIKYLVYKNKGITVVESLGTQIYTPKDL
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEHHHCCCEEECCCCC
TLSIDFRVQALLEEVKKRIVKKWRPKKVVLIVMETSTGKVRGYTTYPDYDPNKYERYPYW
EEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCE
RIRNFGVTDRFEVGSVFKPFLVAFALDRRKIRKDTLININYGKIKVHKKYVRDVTPYLWK
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEHHHHHHHCCHHHHH
KEYITPRELLVHSSNVGAIRVGLMLKPEEYYELFKTFKLLRSPGVLEGEVKPSISDLKYK
HCCCCHHHHHEECCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHH
VNRAYASIGQGVAFNPLHLITSFNALVNGKYVKPSFVEEEKTEAEKIQIKPSTVKWIRDV
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEECCHHHHHHHHH
LIEVVEKGTGKRAKSEYYFAGGKTGTAQKYDSALKTYSKEKLVTYFLGFFPSEPKFTVLI
HHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
LVDEPKGKNLYGGTVAAPYFKEIIEKIGVIYGVKRDRT
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MEYLRVYQKRERVFKRRVILFVILSFLAVLLLLGRILYINLFKEDALKGAVKDAEVVQIQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
TYRGSIKTSDGKILALSYPVAYVYASKFYRFRDTVKREKFIKELSKLLGVRESVLRKRIK
EECCCEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENESKTFFELITFPVHLKDEVRKLIKSIDYDEESKEFTKPYLSSFVGVDERYKRYYPHGN
CCCCHHEEHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCC
FASNLLGFVTEKGYAAEGIERLFDEYLRGGEEPIKYLVYKNKGITVVESLGTQIYTPKDL
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEHHHCCCEEECCCCC
TLSIDFRVQALLEEVKKRIVKKWRPKKVVLIVMETSTGKVRGYTTYPDYDPNKYERYPYW
EEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCE
RIRNFGVTDRFEVGSVFKPFLVAFALDRRKIRKDTLININYGKIKVHKKYVRDVTPYLWK
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEHHHHHHHCCHHHHH
KEYITPRELLVHSSNVGAIRVGLMLKPEEYYELFKTFKLLRSPGVLEGEVKPSISDLKYK
HCCCCHHHHHEECCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHH
VNRAYASIGQGVAFNPLHLITSFNALVNGKYVKPSFVEEEKTEAEKIQIKPSTVKWIRDV
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEECCHHHHHHHHH
LIEVVEKGTGKRAKSEYYFAGGKTGTAQKYDSALKTYSKEKLVTYFLGFFPSEPKFTVLI
HHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
LVDEPKGKNLYGGTVAAPYFKEIIEKIGVIYGVKRDRT
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]