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The map label for this gene is dcuP

Identifier: 15605850

GI number: 15605850

Start: 215954

End: 216970

Strand: Direct

Name: dcuP

Synonym: aq_334

Alternate gene names: 15605850

Gene position: 215954-216970 (Clockwise)

Preceding gene: 15605849

Following gene: 15605854

Centisome position: 13.92

GC content: 44.64

Gene sequence:

>1017_bases
ATGCCGAAAAACGACCTCCTTTTGAGAAGCCTCCGCGGAGAACCCATAGGGCGATTTCCCGTCTGGTTAATGAGACAGGC
AGGCAGGTACATGCCTGAGTACAGGAAAATAAGGAACAGAGTTAAAAACTTTCTTGAACTCTGTAAAAACGTAGACCTTG
CCACCGAAATCTCGCTCCTTCCTTTAAAAATTCTTGGTGTTGATGCGATAATCATCTTTTCCGATATCCTCGTTCCCTTG
GAACCCTTAGGTGTAAAGGTCGAGTTCGTAGAGGGAGAAGGTCCGAAGCTCTCTTGGAGCGGAAAGGTTTCTGATTTGAA
AAAGTACGACCCGTCTCAAAACGCATACGTTTACGAAATTATTAAAAGGGTTAAGGAAGCTCAGGACGAAGTTCCCGTTA
TAGGTTTTGCCGGAGCACCCTTTACACTCCTCTCGTACCTGATAGAAGGCGGGGCGAGCAAAGACTTCAAAAGTACTAAA
CTCTTTATGTGGGAAAATCCCAAGGAGTACAAAAGGTTGATGGACATACTTACGGAAACTGTACTGGCTTACTTGAAGGA
ACAGATAAAGGCTGGAGCGGATGTGGTTCAAATATTCGATAGCTGGGTCAACAACCTGAGCCTTGAGGATTACGGTGAGT
ACGTTTACCCTTACGTGAATTACTTAATTTCTGAGCTGAAAGACTTTTCGGATACACCCGTTATATACTTCTTCAGAGGT
TCTTCCTCATTTATAGACCTGGCGGTGGACTACAGAGCTGATGCCCTTTCTGTGGACTGGAGCGTTGATATACCCGAACT
CTTTAAAATCTACGATAAAGGCTTTCAGGGAAATCTTGAACCTGCGGTTCTGTACGCAAGCGAGGAGGTTATAGAAGAAA
AGACTTTAGGACTCCTCAGAAGAATTCCCGTAAAAACTAGGTACGTTTTTAACTTGGGGCACGGGCTTGCCCCCGACATG
GAACTTGAGAAAGTTAAGTACCTCGTGGATCTGGTCAAGTCCTTTCCTTTAACATAA

Upstream 100 bases:

>100_bases
CGGAACTGGCAGACGCGCCGTCTTGAGGGGACGGTGCCCTTTACGGGCGTGCGGGTTCGACTCCCGCCTCCGGCACCACA
AAATCCCTTAAAATAATCAA

Downstream 100 bases:

>100_bases
ATCTTCCCGCGTAGTCCTTTGCAAATTGATAGGCAACTCTTCCCGAAAAACTGCTCCTTTCCGTAGCCCACCTGAGGGCT
TCCCTCTTAACTTCTTCGTC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MPKNDLLLRSLRGEPIGRFPVWLMRQAGRYMPEYRKIRNRVKNFLELCKNVDLATEISLLPLKILGVDAIIIFSDILVPL
EPLGVKVEFVEGEGPKLSWSGKVSDLKKYDPSQNAYVYEIIKRVKEAQDEVPVIGFAGAPFTLLSYLIEGGASKDFKSTK
LFMWENPKEYKRLMDILTETVLAYLKEQIKAGADVVQIFDSWVNNLSLEDYGEYVYPYVNYLISELKDFSDTPVIYFFRG
SSSFIDLAVDYRADALSVDWSVDIPELFKIYDKGFQGNLEPAVLYASEEVIEEKTLGLLRRIPVKTRYVFNLGHGLAPDM
ELEKVKYLVDLVKSFPLT

Sequences:

>Translated_338_residues
MPKNDLLLRSLRGEPIGRFPVWLMRQAGRYMPEYRKIRNRVKNFLELCKNVDLATEISLLPLKILGVDAIIIFSDILVPL
EPLGVKVEFVEGEGPKLSWSGKVSDLKKYDPSQNAYVYEIIKRVKEAQDEVPVIGFAGAPFTLLSYLIEGGASKDFKSTK
LFMWENPKEYKRLMDILTETVLAYLKEQIKAGADVVQIFDSWVNNLSLEDYGEYVYPYVNYLISELKDFSDTPVIYFFRG
SSSFIDLAVDYRADALSVDWSVDIPELFKIYDKGFQGNLEPAVLYASEEVIEEKTLGLLRRIPVKTRYVFNLGHGLAPDM
ELEKVKYLVDLVKSFPLT
>Mature_337_residues
PKNDLLLRSLRGEPIGRFPVWLMRQAGRYMPEYRKIRNRVKNFLELCKNVDLATEISLLPLKILGVDAIIIFSDILVPLE
PLGVKVEFVEGEGPKLSWSGKVSDLKKYDPSQNAYVYEIIKRVKEAQDEVPVIGFAGAPFTLLSYLIEGGASKDFKSTKL
FMWENPKEYKRLMDILTETVLAYLKEQIKAGADVVQIFDSWVNNLSLEDYGEYVYPYVNYLISELKDFSDTPVIYFFRGS
SSFIDLAVDYRADALSVDWSVDIPELFKIYDKGFQGNLEPAVLYASEEVIEEKTLGLLRRIPVKTRYVFNLGHGLAPDME
LEKVKYLVDLVKSFPLT

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=346, Percent_Identity=35.5491329479769, Blast_Score=210, Evalue=1e-54,
Organism=Escherichia coli, GI2367337, Length=342, Percent_Identity=38.0116959064327, Blast_Score=241, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=35.9773371104816, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI19921920, Length=345, Percent_Identity=36.5217391304348, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI221330099, Length=345, Percent_Identity=36.5217391304348, Blast_Score=223, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_AQUAE (O66667)

Other databases:

- EMBL:   AE000657
- PIR:   G70329
- RefSeq:   NP_213227.1
- PDB:   2EJA
- PDBsum:   2EJA
- ProteinModelPortal:   O66667
- SMR:   O66667
- GeneID:   1192901
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_334
- NMPDR:   fig|224324.1.peg.242
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   O66667
- ProtClustDB:   CLSK2299367
- BioCyc:   AAEO224324:AQ_334-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38687; Mature: 38556

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 44-44 BINDING 75-75 BINDING 146-146 BINDING 201-201 BINDING 314-314

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKNDLLLRSLRGEPIGRFPVWLMRQAGRYMPEYRKIRNRVKNFLELCKNVDLATEISLL
CCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
PLKILGVDAIIIFSDILVPLEPLGVKVEFVEGEGPKLSWSGKVSDLKKYDPSQNAYVYEI
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCHHHHHHCCCCCCCHHHHH
IKRVKEAQDEVPVIGFAGAPFTLLSYLIEGGASKDFKSTKLFMWENPKEYKRLMDILTET
HHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
VLAYLKEQIKAGADVVQIFDSWVNNLSLEDYGEYVYPYVNYLISELKDFSDTPVIYFFRG
HHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
SSSFIDLAVDYRADALSVDWSVDIPELFKIYDKGFQGNLEPAVLYASEEVIEEKTLGLLR
CCCEEEEEEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHH
RIPVKTRYVFNLGHGLAPDMELEKVKYLVDLVKSFPLT
HCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PKNDLLLRSLRGEPIGRFPVWLMRQAGRYMPEYRKIRNRVKNFLELCKNVDLATEISLL
CCHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
PLKILGVDAIIIFSDILVPLEPLGVKVEFVEGEGPKLSWSGKVSDLKKYDPSQNAYVYEI
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCHHHHHHCCCCCCCHHHHH
IKRVKEAQDEVPVIGFAGAPFTLLSYLIEGGASKDFKSTKLFMWENPKEYKRLMDILTET
HHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
VLAYLKEQIKAGADVVQIFDSWVNNLSLEDYGEYVYPYVNYLISELKDFSDTPVIYFFRG
HHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
SSSFIDLAVDYRADALSVDWSVDIPELFKIYDKGFQGNLEPAVLYASEEVIEEKTLGLLR
CCCEEEEEEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHH
RIPVKTRYVFNLGHGLAPDMELEKVKYLVDLVKSFPLT
HCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320