Click here to switch to the map view.

The map label for this gene is glmS

Identifier: 15605831

GI number: 15605831

Start: 194591

End: 196369

Strand: Direct

Name: glmS

Synonym: aq_301

Alternate gene names: 15605831

Gene position: 194591-196369 (Clockwise)

Preceding gene: 15605829

Following gene: 15605835

Centisome position: 12.54

GC content: 47.22

Gene sequence:

>1779_bases
ATGTGCGGGATAGTCGGATACGTAGGGAGGGATTTAGCCCTTCCTATAGTCCTCGGAGCTCTTGAGAGACTCGAATACAG
GGGTTACGACTCCGCGGGAGTTGCCCTTATAGAAGACGGGAAACTCATAGTTGAAAAGAAGAAGGGAAAGATAAGGGAAC
TCGTTAAAGCGCTATGGGGAAAGGATTACAAGGCTAAAACGGGTATAGGTCACACACGCTGGGCAACCCACGGAAAGCCC
ACGGACGAGAACGCCCACCCCCACACCGACGAAAAAGGTGAGTTTGCAGTAGTTCACAACGGGATAATAGAAAACTACTT
AGAACTAAAAGAGGAACTAAAGAAGGAAGGTGTAAAGTTCAGGTCCGAAACAGACACAGAAGTTATAGCCCACCTCATAG
CGAAGAACTACAGGGGGGACTTACTGGAGGCCGTTTTAAAAACCGTAAAGAAATTAAAGGGTGCTTTTGCCTTTGCGGTT
ATAACGGTTCACGAACCAAACAGACTAATAGGAGTGAAGCAGGGGAGTCCTTTAATCGTCGGACTCGGAGAAGGAGAAAA
CTTCCTCGCTTCAGATATTCCCGCAATACTTCCTTACACGAAAAAGATTATTGTTCTTGATGACGGGGAAATAGCGGACC
TGACTCCCGACACTGTGAACATTTACAACTTTGAGGGAGAGCCCGTTTCAAAGGAAGTAATGATTACGCCCTGGGATCTT
GTTTCTGCGGAAAAGGGTGGTTTTAAACACTTCATGCTAAAAGAGATATACGAACAGCCCAAAGCCATAAACGACACACT
CAAGGGTTTCCTCTCAACCGAAGACGCAATACCCTTTAAGTTAAAAGACTTCAGAAGGGTTTTAATAATAGCGTGCGGGA
CCTCTTACCACGCGGGCTTCGTCGGAAAGTACTGGATAGAGAGATTTGCAGGTGTTCCCACAGAGGTAATTTACGCTTCG
GAATTCAGGTATGCGGACGTTCCCGTTTCGGACAAGGATATCGTTATCGGAATTTCCCAGTCAGGAGAGACCGCTGACAC
AAAGTTTGCCCTTCAGTCCGCAAAGGAAAAGGGAGCCTTTACCGTGGGACTCGTAAACGTAGTGGGAAGTGCCATAGACA
GGGAGTCGGACTTTTCCCTTCACACACATGCGGGACCCGAAATAGGCGTGGCGGCTACAAAGACCTTCACCGCACAGCTC
ACCGCACTCTACGCCCTTTCGGTAAGGGAAAGTGAGGAGAGGGAAAATCTAATAAGACTCCTTGAAAAGGTTCCATCACT
CGTTGAACAAACACTGAACACCGCAGAAGAAGTGGAGAAGGTAGCGGAAAAGTACATGAAAAAGAAAAACATGCTTTACC
TCGGAAGGTACTTAAATTACCCCATAGCGCTGGAGGGAGCTCTTAAACTTAAAGAAATTTCTTACATACACGCGGAAGGT
TATCCCGCAGGGGAGATGAAGCACGGTCCCATAGCCCTCATAGACGAAAACATGCCGGTTGTGGTAATCGCACCGAAAGA
CAGGGTTTACGAGAAGATACTCTCAAACGTAGAAGAGGTTCTCGCAAGAAAGGGAAGGGTTATTTCTGTAGGCTTTAAAG
GAGACGAAACTCTCAAAAGCAAATCCGAGAGCGTTATGGAAATCCCGAAGGCAGAAGAACCGATAACTCCTTTCTTGACG
GTAATACCCCTGCAACTCTTTGCCTACTTTATAGCGAGCAAACTGGGACTGGATGTGGATCAGCCGAGAAATCTCGCCAA
AACGGTCACGGTGGAATAA

Upstream 100 bases:

>100_bases
TCTTTATCCCTCGTTGCGAGTCTTTCCTTCACGTAATCGGGTTTTTCCCTAATGAGGTTTATATCTATCATTTAAACAAG
AATTATAATTGAAGTTAGAC

Downstream 100 bases:

>100_bases
TCACTCTTCCTCTTCCACGAAGGTTGCGAGTATCGTCTCTATAATTCCGAGAATAATAGATACTATATTCGCCGCGAGGG
CTCCCATGGCGAGTCCCACA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MCGIVGYVGRDLALPIVLGALERLEYRGYDSAGVALIEDGKLIVEKKKGKIRELVKALWGKDYKAKTGIGHTRWATHGKP
TDENAHPHTDEKGEFAVVHNGIIENYLELKEELKKEGVKFRSETDTEVIAHLIAKNYRGDLLEAVLKTVKKLKGAFAFAV
ITVHEPNRLIGVKQGSPLIVGLGEGENFLASDIPAILPYTKKIIVLDDGEIADLTPDTVNIYNFEGEPVSKEVMITPWDL
VSAEKGGFKHFMLKEIYEQPKAINDTLKGFLSTEDAIPFKLKDFRRVLIIACGTSYHAGFVGKYWIERFAGVPTEVIYAS
EFRYADVPVSDKDIVIGISQSGETADTKFALQSAKEKGAFTVGLVNVVGSAIDRESDFSLHTHAGPEIGVAATKTFTAQL
TALYALSVRESEERENLIRLLEKVPSLVEQTLNTAEEVEKVAEKYMKKKNMLYLGRYLNYPIALEGALKLKEISYIHAEG
YPAGEMKHGPIALIDENMPVVVIAPKDRVYEKILSNVEEVLARKGRVISVGFKGDETLKSKSESVMEIPKAEEPITPFLT
VIPLQLFAYFIASKLGLDVDQPRNLAKTVTVE

Sequences:

>Translated_592_residues
MCGIVGYVGRDLALPIVLGALERLEYRGYDSAGVALIEDGKLIVEKKKGKIRELVKALWGKDYKAKTGIGHTRWATHGKP
TDENAHPHTDEKGEFAVVHNGIIENYLELKEELKKEGVKFRSETDTEVIAHLIAKNYRGDLLEAVLKTVKKLKGAFAFAV
ITVHEPNRLIGVKQGSPLIVGLGEGENFLASDIPAILPYTKKIIVLDDGEIADLTPDTVNIYNFEGEPVSKEVMITPWDL
VSAEKGGFKHFMLKEIYEQPKAINDTLKGFLSTEDAIPFKLKDFRRVLIIACGTSYHAGFVGKYWIERFAGVPTEVIYAS
EFRYADVPVSDKDIVIGISQSGETADTKFALQSAKEKGAFTVGLVNVVGSAIDRESDFSLHTHAGPEIGVAATKTFTAQL
TALYALSVRESEERENLIRLLEKVPSLVEQTLNTAEEVEKVAEKYMKKKNMLYLGRYLNYPIALEGALKLKEISYIHAEG
YPAGEMKHGPIALIDENMPVVVIAPKDRVYEKILSNVEEVLARKGRVISVGFKGDETLKSKSESVMEIPKAEEPITPFLT
VIPLQLFAYFIASKLGLDVDQPRNLAKTVTVE
>Mature_592_residues
MCGIVGYVGRDLALPIVLGALERLEYRGYDSAGVALIEDGKLIVEKKKGKIRELVKALWGKDYKAKTGIGHTRWATHGKP
TDENAHPHTDEKGEFAVVHNGIIENYLELKEELKKEGVKFRSETDTEVIAHLIAKNYRGDLLEAVLKTVKKLKGAFAFAV
ITVHEPNRLIGVKQGSPLIVGLGEGENFLASDIPAILPYTKKIIVLDDGEIADLTPDTVNIYNFEGEPVSKEVMITPWDL
VSAEKGGFKHFMLKEIYEQPKAINDTLKGFLSTEDAIPFKLKDFRRVLIIACGTSYHAGFVGKYWIERFAGVPTEVIYAS
EFRYADVPVSDKDIVIGISQSGETADTKFALQSAKEKGAFTVGLVNVVGSAIDRESDFSLHTHAGPEIGVAATKTFTAQL
TALYALSVRESEERENLIRLLEKVPSLVEQTLNTAEEVEKVAEKYMKKKNMLYLGRYLNYPIALEGALKLKEISYIHAEG
YPAGEMKHGPIALIDENMPVVVIAPKDRVYEKILSNVEEVLARKGRVISVGFKGDETLKSKSESVMEIPKAEEPITPFLT
VIPLQLFAYFIASKLGLDVDQPRNLAKTVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=682, Percent_Identity=36.8035190615836, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=37.280701754386, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI29570798, Length=147, Percent_Identity=34.6938775510204, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790167, Length=614, Percent_Identity=46.4169381107492, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI87082251, Length=299, Percent_Identity=22.4080267558528, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1788651, Length=203, Percent_Identity=26.1083743842365, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=39.3939393939394, Blast_Score=315, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI17532899, Length=434, Percent_Identity=39.63133640553, Blast_Score=313, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17532897, Length=434, Percent_Identity=39.63133640553, Blast_Score=312, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6322745, Length=454, Percent_Identity=38.3259911894273, Blast_Score=317, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6323731, Length=430, Percent_Identity=32.5581395348837, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=34.6341463414634, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=37.7001455604076, Blast_Score=445, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_AQUAE (O66648)

Other databases:

- EMBL:   AE000657
- PIR:   D70327
- RefSeq:   NP_213208.1
- ProteinModelPortal:   O66648
- GeneID:   1192882
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_301
- NMPDR:   fig|224324.1.peg.223
- HOGENOM:   HBG645312
- OMA:   TGIFAYM
- PhylomeDB:   O66648
- ProtClustDB:   PRK00331
- BioCyc:   AAEO224324:AQ_301-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 65493; Mature: 65493

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 587-587

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYVGRDLALPIVLGALERLEYRGYDSAGVALIEDGKLIVEKKKGKIRELVKALWG
CCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHC
KDYKAKTGIGHTRWATHGKPTDENAHPHTDEKGEFAVVHNGIIENYLELKEELKKEGVKF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCC
RSETDTEVIAHLIAKNYRGDLLEAVLKTVKKLKGAFAFAVITVHEPNRLIGVKQGSPLIV
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEEECCCCCEEE
GLGEGENFLASDIPAILPYTKKIIVLDDGEIADLTPDTVNIYNFEGEPVSKEVMITPWDL
ECCCCCCCHHHCCCHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCEEECCHHH
VSAEKGGFKHFMLKEIYEQPKAINDTLKGFLSTEDAIPFKLKDFRRVLIIACGTSYHAGF
HCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCCCH
VGKYWIERFAGVPTEVIYASEFRYADVPVSDKDIVIGISQSGETADTKFALQSAKEKGAF
HHHHHHHHHCCCCHHEEEECCCEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCE
TVGLVNVVGSAIDRESDFSLHTHAGPEIGVAATKTFTAQLTALYALSVRESEERENLIRL
EEEHHHHHHHHHCCCCCCEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LEKVPSLVEQTLNTAEEVEKVAEKYMKKKNMLYLGRYLNYPIALEGALKLKEISYIHAEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCCCEEECCCEEEEHEEEEEECC
YPAGEMKHGPIALIDENMPVVVIAPKDRVYEKILSNVEEVLARKGRVISVGFKGDETLKS
CCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
KSESVMEIPKAEEPITPFLTVIPLQLFAYFIASKLGLDVDQPRNLAKTVTVE
HCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MCGIVGYVGRDLALPIVLGALERLEYRGYDSAGVALIEDGKLIVEKKKGKIRELVKALWG
CCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHC
KDYKAKTGIGHTRWATHGKPTDENAHPHTDEKGEFAVVHNGIIENYLELKEELKKEGVKF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCC
RSETDTEVIAHLIAKNYRGDLLEAVLKTVKKLKGAFAFAVITVHEPNRLIGVKQGSPLIV
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEEECCCCCEEE
GLGEGENFLASDIPAILPYTKKIIVLDDGEIADLTPDTVNIYNFEGEPVSKEVMITPWDL
ECCCCCCCHHHCCCHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCEEECCHHH
VSAEKGGFKHFMLKEIYEQPKAINDTLKGFLSTEDAIPFKLKDFRRVLIIACGTSYHAGF
HCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCCCH
VGKYWIERFAGVPTEVIYASEFRYADVPVSDKDIVIGISQSGETADTKFALQSAKEKGAF
HHHHHHHHHCCCCHHEEEECCCEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCE
TVGLVNVVGSAIDRESDFSLHTHAGPEIGVAATKTFTAQLTALYALSVRESEERENLIRL
EEEHHHHHHHHHCCCCCCEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LEKVPSLVEQTLNTAEEVEKVAEKYMKKKNMLYLGRYLNYPIALEGALKLKEISYIHAEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCCCEEECCCEEEEHEEEEEECC
YPAGEMKHGPIALIDENMPVVVIAPKDRVYEKILSNVEEVLARKGRVISVGFKGDETLKS
CCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
KSESVMEIPKAEEPITPFLTVIPLQLFAYFIASKLGLDVDQPRNLAKTVTVE
HCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320