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The map label for this gene is lpxA

Identifier: 15603861

GI number: 15603861

Start: 2237184

End: 2237972

Strand: Direct

Name: lpxA

Synonym: PM1996

Alternate gene names: 15603861

Gene position: 2237184-2237972 (Clockwise)

Preceding gene: 15603860

Following gene: 15603862

Centisome position: 99.1

GC content: 44.36

Gene sequence:

>789_bases
ATGATCCACCCAACCGCACAGATTCATCCTACCTCAATTGTGGAGGCTGGAGCAAAAATTGGTGAGAATGTTGTTATCGG
TCCCTTTTGTCTTGTTGGTGCAGAAGTCGAAATTGGTGCAGGTACGATCTTACATTCGCATGTTGTCGTCAAAGGCATTA
CTAAGATTGGGCGCGATAACCAAATTTTTCAATTCGCCAGTATTGGCGACACCAACCAAGATTTAAAATACCAAGGTGAG
CCAACCAGAACGATCATCGGTGATCGTAACCGCATTCGTGAGAGTGTGACGATTCACCGTGGTACAGCGCAGGGCGGTTC
TGTGACGGTAATTGGTGATGATAACTTATTGATGGTGAATGTGCATGTAGCACATGATTGCCGCATTAAGAATCGTTGTA
TTTTAGCCAATAATGCAACATTAGCAGGGCATGTTGAGCTCGATGATTTTGTGATTGTTGGTGGGATGTCTGCGATTCAT
CAATTTGTCATTGTCGGCGCACACGTGATGCTAGGTGGTGGTTCAATGGTCAGCCAAGATGTACCACCTTATGTGATGGC
GCAAGGCAATCACGCAAAACCGTTTGGTGTGAATATTGAAGGCTTGAAACGTCGTGGTTTTGATAAACCGACCTTACATG
CGATTCGCAATGTGTATAAACTGATTTACCGCAGTGGCAAAACGTTAGAAGAAGTGATGCCCGAAATTGAACAAGTGGCG
GCAAAAGAATCAGCGATTAGCTTCTTTGTTGAGTTTTTCAAGCGTTCAACACGCGGAATTATTCGTTAA

Upstream 100 bases:

>100_bases
TTACGCGTTTCACTGGTGTGGCAACCGTAGATGGTCAAGTGGTGTGCGAAGCAGAATTAATGTGTGCTCGTCGTCCCGCA
TAATAAGCAAGGAGTAAAAT

Downstream 100 bases:

>100_bases
TTAAGCGAAATTTGACTCAAATCGACCGCACTTTTTTCCTGAGAAGTGCGGTTGTTTTTTATCTAGGATTGAGAGATGAA
AGAAATACATAAACAGCCGC

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MIHPTAQIHPTSIVEAGAKIGENVVIGPFCLVGAEVEIGAGTILHSHVVVKGITKIGRDNQIFQFASIGDTNQDLKYQGE
PTRTIIGDRNRIRESVTIHRGTAQGGSVTVIGDDNLLMVNVHVAHDCRIKNRCILANNATLAGHVELDDFVIVGGMSAIH
QFVIVGAHVMLGGGSMVSQDVPPYVMAQGNHAKPFGVNIEGLKRRGFDKPTLHAIRNVYKLIYRSGKTLEEVMPEIEQVA
AKESAISFFVEFFKRSTRGIIR

Sequences:

>Translated_262_residues
MIHPTAQIHPTSIVEAGAKIGENVVIGPFCLVGAEVEIGAGTILHSHVVVKGITKIGRDNQIFQFASIGDTNQDLKYQGE
PTRTIIGDRNRIRESVTIHRGTAQGGSVTVIGDDNLLMVNVHVAHDCRIKNRCILANNATLAGHVELDDFVIVGGMSAIH
QFVIVGAHVMLGGGSMVSQDVPPYVMAQGNHAKPFGVNIEGLKRRGFDKPTLHAIRNVYKLIYRSGKTLEEVMPEIEQVA
AKESAISFFVEFFKRSTRGIIR
>Mature_262_residues
MIHPTAQIHPTSIVEAGAKIGENVVIGPFCLVGAEVEIGAGTILHSHVVVKGITKIGRDNQIFQFASIGDTNQDLKYQGE
PTRTIIGDRNRIRESVTIHRGTAQGGSVTVIGDDNLLMVNVHVAHDCRIKNRCILANNATLAGHVELDDFVIVGGMSAIH
QFVIVGAHVMLGGGSMVSQDVPPYVMAQGNHAKPFGVNIEGLKRRGFDKPTLHAIRNVYKLIYRSGKTLEEVMPEIEQVA
AKESAISFFVEFFKRSTRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=70.9923664122137, Blast_Score=393, Evalue=1e-111,
Organism=Escherichia coli, GI1786376, Length=216, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_PASMU (Q9CJK8)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246935.1
- ProteinModelPortal:   Q9CJK8
- SMR:   Q9CJK8
- GeneID:   1245343
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1996
- NMPDR:   fig|272843.1.peg.1997
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- BioCyc:   PMUL272843:PM1996-MONOMER
- BRENDA:   2.3.1.129
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28466; Mature: 28466

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHPTAQIHPTSIVEAGAKIGENVVIGPFCLVGAEVEIGAGTILHSHVVVKGITKIGRDN
CCCCCCCCCCHHHHHHHHHHCCCEEECCEEEECCEEEECCCEEHHHHHHHHHHHHCCCCC
QIFQFASIGDTNQDLKYQGEPTRTIIGDRNRIRESVTIHRGTAQGGSVTVIGDDNLLMVN
CEEEEEECCCCCCCCEECCCCCEEEECCHHHHHHEEEEEECCCCCCEEEEEECCCEEEEE
VHVAHDCRIKNRCILANNATLAGHVELDDFVIVGGMSAIHQFVIVGAHVMLGGGSMVSQD
EEEEECCEECCEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHEEEECCCCCCCCC
VPPYVMAQGNHAKPFGVNIEGLKRRGFDKPTLHAIRNVYKLIYRSGKTLEEVMPEIEQVA
CCCEEEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AKESAISFFVEFFKRSTRGIIR
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIHPTAQIHPTSIVEAGAKIGENVVIGPFCLVGAEVEIGAGTILHSHVVVKGITKIGRDN
CCCCCCCCCCHHHHHHHHHHCCCEEECCEEEECCEEEECCCEEHHHHHHHHHHHHCCCCC
QIFQFASIGDTNQDLKYQGEPTRTIIGDRNRIRESVTIHRGTAQGGSVTVIGDDNLLMVN
CEEEEEECCCCCCCCEECCCCCEEEECCHHHHHHEEEEEECCCCCCEEEEEECCCEEEEE
VHVAHDCRIKNRCILANNATLAGHVELDDFVIVGGMSAIHQFVIVGAHVMLGGGSMVSQD
EEEEECCEECCEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHEEEECCCCCCCCC
VPPYVMAQGNHAKPFGVNIEGLKRRGFDKPTLHAIRNVYKLIYRSGKTLEEVMPEIEQVA
CCCEEEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AKESAISFFVEFFKRSTRGIIR
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100