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The map label for this gene is fklB [H]

Identifier: 15603763

GI number: 15603763

Start: 2138281

End: 2138913

Strand: Reverse

Name: fklB [H]

Synonym: PM1898

Alternate gene names: 15603763

Gene position: 2138913-2138281 (Counterclockwise)

Preceding gene: 15603764

Following gene: 15603760

Centisome position: 94.75

GC content: 45.02

Gene sequence:

>633_bases
ATGAGTCAACAATTTTTCGACCAAGTATCATTAGAAAGCCTTTCAGCGAAAGGAAGCTACGGTATCGGTTTACAAATCGG
TCAACAATTATTAGAAAGCCAACTTGAAGTGAGCGCCGAAGCCGTCGCGAAAGGGATCTTTGATGTGTTAAATCAAAATC
CACCAGCACTTGAGTTAAATGAAGTGAGTCATGCCCTACAGACTTTGCAACAACAAGCCACTGAAGCACAACAAGCGAAA
TTCAAAGAAATTGAAGCCGTTGGTGCACAATTCTTAGCTGAAAACGCGCAAAAAGCGGGGGTAAATACTACGGAATCTGG
TTTACAGTATGAAGTGTTAGTGGCTGGCGAAGGGCAAATTCCGGCACGCGAAGACAAAGTGCGTGTGCATTACACTGGGA
CATTAATCGACGGTACCGTCTTTGACAGCTCAGTAAAACGTGGTCAACCTGCAGAATTCCCAGTGAATGGTGTGATCGCT
GGTTGGATTGAAGCCTTGTCCATGATGCCAGTGGGTTCAAAATGGCGTTTAACCATTCCTCACAACCTCGCTTATGGCGA
ACGTGGTGCCGGTGCATCCATTCCGCCATTCAGTACCTTAGTGTTTGAAGTCGAATTATTAGCCATTCTTTAA

Upstream 100 bases:

>100_bases
TCGTGTGCAACTGGCATCTCATTTACAAGTGGATAGCCCGGTACGTATGGGTGAAATTCTTGCCCACCAAAAATAATTTT
TAACCACAATAGGAAAAACA

Downstream 100 bases:

>100_bases
AGCTAAACGCTAGACAAAAAAAAGTGCGGTCATTTTCCGCACTTTTTTCTTTTCTATTGTTTATCGTTTCAAGCCTTGCT
GATAGCCACTGTTCCACGAA

Product: hypothetical protein

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSQQFFDQVSLESLSAKGSYGIGLQIGQQLLESQLEVSAEAVAKGIFDVLNQNPPALELNEVSHALQTLQQQATEAQQAK
FKEIEAVGAQFLAENAQKAGVNTTESGLQYEVLVAGEGQIPAREDKVRVHYTGTLIDGTVFDSSVKRGQPAEFPVNGVIA
GWIEALSMMPVGSKWRLTIPHNLAYGERGAGASIPPFSTLVFEVELLAIL

Sequences:

>Translated_210_residues
MSQQFFDQVSLESLSAKGSYGIGLQIGQQLLESQLEVSAEAVAKGIFDVLNQNPPALELNEVSHALQTLQQQATEAQQAK
FKEIEAVGAQFLAENAQKAGVNTTESGLQYEVLVAGEGQIPAREDKVRVHYTGTLIDGTVFDSSVKRGQPAEFPVNGVIA
GWIEALSMMPVGSKWRLTIPHNLAYGERGAGASIPPFSTLVFEVELLAIL
>Mature_209_residues
SQQFFDQVSLESLSAKGSYGIGLQIGQQLLESQLEVSAEAVAKGIFDVLNQNPPALELNEVSHALQTLQQQATEAQQAKF
KEIEAVGAQFLAENAQKAGVNTTESGLQYEVLVAGEGQIPAREDKVRVHYTGTLIDGTVFDSSVKRGQPAEFPVNGVIAG
WIEALSMMPVGSKWRLTIPHNLAYGERGAGASIPPFSTLVFEVELLAIL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=45.2830188679245, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=45.2830188679245, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=52.8735632183908, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=52.8735632183908, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=52.8735632183908, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4503729, Length=91, Percent_Identity=45.0549450549451, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI4503727, Length=109, Percent_Identity=44.954128440367, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=38.6792452830189, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI192448443, Length=87, Percent_Identity=43.6781609195402, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI33469985, Length=87, Percent_Identity=45.9770114942529, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI7706131, Length=109, Percent_Identity=39.4495412844037, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI87082390, Length=202, Percent_Identity=63.3663366336634, Blast_Score=259, Evalue=8e-71,
Organism=Escherichia coli, GI1789745, Length=204, Percent_Identity=37.2549019607843, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540882, Length=93, Percent_Identity=48.3870967741936, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=42.4528301886792, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=41, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=54.5454545454545, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324194, Length=108, Percent_Identity=47.2222222222222, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=52.2727272727273, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=52.2727272727273, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=45.2830188679245, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=40.5660377358491, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24647110, Length=110, Percent_Identity=41.8181818181818, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 22569; Mature: 22438

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQFFDQVSLESLSAKGSYGIGLQIGQQLLESQLEVSAEAVAKGIFDVLNQNPPALELN
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHH
EVSHALQTLQQQATEAQQAKFKEIEAVGAQFLAENAQKAGVNTTESGLQYEVLVAGEGQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCC
PAREDKVRVHYTGTLIDGTVFDSSVKRGQPAEFPVNGVIAGWIEALSMMPVGSKWRLTIP
CCCCCCEEEEEEEEEEECHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECC
HNLAYGERGAGASIPPFSTLVFEVELLAIL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQQFFDQVSLESLSAKGSYGIGLQIGQQLLESQLEVSAEAVAKGIFDVLNQNPPALELN
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHH
EVSHALQTLQQQATEAQQAKFKEIEAVGAQFLAENAQKAGVNTTESGLQYEVLVAGEGQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCC
PAREDKVRVHYTGTLIDGTVFDSSVKRGQPAEFPVNGVIAGWIEALSMMPVGSKWRLTIP
CCCCCCEEEEEEEEEEECHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECC
HNLAYGERGAGASIPPFSTLVFEVELLAIL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]