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The map label for this gene is relA [H]

Identifier: 15603730

GI number: 15603730

Start: 2105920

End: 2108139

Strand: Reverse

Name: relA [H]

Synonym: PM1865

Alternate gene names: 15603730

Gene position: 2108139-2105920 (Counterclockwise)

Preceding gene: 15603731

Following gene: 15603729

Centisome position: 93.38

GC content: 42.57

Gene sequence:

>2220_bases
ATGGTTGCAGTGCGAGGATCACACTTACTCAATCCAAAAGATTTTGTTATTGAAACCTGGTGTGCCAGTTTAGAGGTTTC
ACCAGAAGTACGAGAAAATCTGGTCAACGCTTGGTATTACTCGCAAAAGTACATACCGCAACACCACGACGCCTCTTCTT
GCTCATTACACTCTGGCGTAGAAATGGTCGAAATTCTACACAGTCTGAATATGGATGCAGATAGCTTACTCACGGCAATG
CTCTATCCGACGATTCATCACAAGCTTGTCGAACTCAGCCAAATTAACGAAGATTTTGGGGCAAATATCTATAAATTGGC
AAAAGGCGTGATGGAAATGGATAACATTCGCCAATTAAATGCCAGCCAATCCGCCAATAACGCACAAGTAGATAATATCC
GCCGCATGTTACTCGCGATGGTAGATGATTTCCGTTGTGTGATTATCAAACTGGCAGAACGCATTACTTTTTTAAGGGAT
GCCGAACAAACCTGCTCTGAAGAAGATAAAGTCCTAGCCGCCAAAGAATGTGCCAATATTTATGCCCCACTGGCAAATCG
TTTAGGTATCGGGCAACTAAAATGGGAGTTAGAAGATTACTGTTTCCGTTATCTCCACCCTGAGCAATATCGTAGCATTG
CCAACTTATTGAAAGAAAGACGCCTTGATCGAGAACAATACATTGCCGATTTTGTCTCCGAAGTAAGCGACTATTTACGC
CATAACATTGATAAAGTGGACGTGTATGGTCGTCCTAAACACATCTATAGCATTTGGCGCAAAATGCAGAAAAAACATCT
TGAATTTAGCGATCTCTACGATGTTCGTGCAGTGCGAATTATCGTCCCTAAATTGCAAGATTGTTATACCGCACTTGGCA
TTGTGCATACCCACTTCAAACATATTCCGAAAGAATTTGATGATTACGTGGCGAACCCGAAACCCAATGGTTACCAATCT
ATCCATACTGTTGTCCTCGGCAAAGGCGGTAAACCGGTGGAAGTGCAAATTCGCACTCAACAAATGCATGATGATGCCGA
GCTTGGGGTAGCCGCCCACTGGAAATATAAAGAAGGCGCGACTGGCGGTCGTTCTGGCTATGAAGAAAAAATCACCTGGT
TACGCAAATTGCTTGCTTGGCAAGATGATATTACGGACTCCGGCGAAATTATGGCAGAAATGCGTAGCCAGGTCTTTGAC
GATCGCGTTTATGTGTTTACCCCCAAAGGTGAGGTTATCGATTTACCGACAGGCTCCACCCCATTAGATTTTGCCTATGC
TATTCATAGTGAAATTGGTCATCGCTGTATTGGTGCCAAAGTCAGTGGTCGTATTGTTCCGTTCACCTATCAGCTACAAA
TGGGTGATCAAATTGACATCATTACACAGAAAAATGCCAACCCAAGTCGCGACTGGTTAAATCCTAACTTAGGCTTTACA
CATACCGCCAAAGCACGGGCTAAAATCCATGCTTGGTTTAAAAAACAAGATCGTGAGAAAAATATTCCAGCAGGTAAAGA
AATGCTGGAAAATGAACTTACACGCTTAAACATCGGCTTAAAACAAATCGAACCACACGCCTTAGCGCGTTACAACCTAA
AAAATTTAGAGGATTTATACGCGGGTATCGGTGGCGGTGATATTCGCCTCAATCACCTCATCAACTTCTTACAAAACAAG
TTAATTAAAACGACGGCTCAAGAAGTTGATGAAGAAATCTTACGTCATGTAGCAAATAAAAGTGCGGCGAATAATCAACA
AAAAGAAAAGCCTCGGGGTTATGTGATCGTAGAGGGCGTCGGGAATTTAATGCATCACATTGCCCGTTGTTGTCAACCGA
TTCCGGGCGATCATATTATGGGTTATATCACAATGGGACGGGGGATTTCCATTCACCGTAGTGATTGCGAACAATTCCTC
GAGCTACAACAAGCCCATCCCGAACGAGTGGTAGAGTCCATTTGGGGTGATAACTATGCCAGTGGATTTAAAATCAGTAT
CCGTATTATCGCCAGTGATCGCAGTGGCTTATTACGTGATATCACGACGGTTTTAGCCAACGATAAAATTAGTGTCTTAG
GCGTATCGAGTCGTACTGATACTAAAAAACAATTAGCGACAATTGATATGGAAATTGAGCTGAATAATGTTCAAATTTTG
AGTAAAATTCTAGCTCGTCTTTCAAAACTCGACGATGTCATTGAAGCAAAACGACTGTAA

Upstream 100 bases:

>100_bases
AATTTAACTACCGACTTAAGAAAGTCGCAATGATCGATATGTTCCCCAATACAGGACATTTAGAATCCATCAGTTTATTT
GAAAAAGAATAGGATAGATT

Downstream 100 bases:

>100_bases
TTCAGCCATTAAGGATAATAAAAATGTATAAAACAACAGGACTTACTCATCTGATTAAAGCCACTGGTTATTCACTCAAA
GGGTTAAAAAGTGCGGTTAA

Product: RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 739; Mature: 739

Protein sequence:

>739_residues
MVAVRGSHLLNPKDFVIETWCASLEVSPEVRENLVNAWYYSQKYIPQHHDASSCSLHSGVEMVEILHSLNMDADSLLTAM
LYPTIHHKLVELSQINEDFGANIYKLAKGVMEMDNIRQLNASQSANNAQVDNIRRMLLAMVDDFRCVIIKLAERITFLRD
AEQTCSEEDKVLAAKECANIYAPLANRLGIGQLKWELEDYCFRYLHPEQYRSIANLLKERRLDREQYIADFVSEVSDYLR
HNIDKVDVYGRPKHIYSIWRKMQKKHLEFSDLYDVRAVRIIVPKLQDCYTALGIVHTHFKHIPKEFDDYVANPKPNGYQS
IHTVVLGKGGKPVEVQIRTQQMHDDAELGVAAHWKYKEGATGGRSGYEEKITWLRKLLAWQDDITDSGEIMAEMRSQVFD
DRVYVFTPKGEVIDLPTGSTPLDFAYAIHSEIGHRCIGAKVSGRIVPFTYQLQMGDQIDIITQKNANPSRDWLNPNLGFT
HTAKARAKIHAWFKKQDREKNIPAGKEMLENELTRLNIGLKQIEPHALARYNLKNLEDLYAGIGGGDIRLNHLINFLQNK
LIKTTAQEVDEEILRHVANKSAANNQQKEKPRGYVIVEGVGNLMHHIARCCQPIPGDHIMGYITMGRGISIHRSDCEQFL
ELQQAHPERVVESIWGDNYASGFKISIRIIASDRSGLLRDITTVLANDKISVLGVSSRTDTKKQLATIDMEIELNNVQIL
SKILARLSKLDDVIEAKRL

Sequences:

>Translated_739_residues
MVAVRGSHLLNPKDFVIETWCASLEVSPEVRENLVNAWYYSQKYIPQHHDASSCSLHSGVEMVEILHSLNMDADSLLTAM
LYPTIHHKLVELSQINEDFGANIYKLAKGVMEMDNIRQLNASQSANNAQVDNIRRMLLAMVDDFRCVIIKLAERITFLRD
AEQTCSEEDKVLAAKECANIYAPLANRLGIGQLKWELEDYCFRYLHPEQYRSIANLLKERRLDREQYIADFVSEVSDYLR
HNIDKVDVYGRPKHIYSIWRKMQKKHLEFSDLYDVRAVRIIVPKLQDCYTALGIVHTHFKHIPKEFDDYVANPKPNGYQS
IHTVVLGKGGKPVEVQIRTQQMHDDAELGVAAHWKYKEGATGGRSGYEEKITWLRKLLAWQDDITDSGEIMAEMRSQVFD
DRVYVFTPKGEVIDLPTGSTPLDFAYAIHSEIGHRCIGAKVSGRIVPFTYQLQMGDQIDIITQKNANPSRDWLNPNLGFT
HTAKARAKIHAWFKKQDREKNIPAGKEMLENELTRLNIGLKQIEPHALARYNLKNLEDLYAGIGGGDIRLNHLINFLQNK
LIKTTAQEVDEEILRHVANKSAANNQQKEKPRGYVIVEGVGNLMHHIARCCQPIPGDHIMGYITMGRGISIHRSDCEQFL
ELQQAHPERVVESIWGDNYASGFKISIRIIASDRSGLLRDITTVLANDKISVLGVSSRTDTKKQLATIDMEIELNNVQIL
SKILARLSKLDDVIEAKRL
>Mature_739_residues
MVAVRGSHLLNPKDFVIETWCASLEVSPEVRENLVNAWYYSQKYIPQHHDASSCSLHSGVEMVEILHSLNMDADSLLTAM
LYPTIHHKLVELSQINEDFGANIYKLAKGVMEMDNIRQLNASQSANNAQVDNIRRMLLAMVDDFRCVIIKLAERITFLRD
AEQTCSEEDKVLAAKECANIYAPLANRLGIGQLKWELEDYCFRYLHPEQYRSIANLLKERRLDREQYIADFVSEVSDYLR
HNIDKVDVYGRPKHIYSIWRKMQKKHLEFSDLYDVRAVRIIVPKLQDCYTALGIVHTHFKHIPKEFDDYVANPKPNGYQS
IHTVVLGKGGKPVEVQIRTQQMHDDAELGVAAHWKYKEGATGGRSGYEEKITWLRKLLAWQDDITDSGEIMAEMRSQVFD
DRVYVFTPKGEVIDLPTGSTPLDFAYAIHSEIGHRCIGAKVSGRIVPFTYQLQMGDQIDIITQKNANPSRDWLNPNLGFT
HTAKARAKIHAWFKKQDREKNIPAGKEMLENELTRLNIGLKQIEPHALARYNLKNLEDLYAGIGGGDIRLNHLINFLQNK
LIKTTAQEVDEEILRHVANKSAANNQQKEKPRGYVIVEGVGNLMHHIARCCQPIPGDHIMGYITMGRGISIHRSDCEQFL
ELQQAHPERVVESIWGDNYASGFKISIRIIASDRSGLLRDITTVLANDKISVLGVSSRTDTKKQLATIDMEIELNNVQIL
SKILARLSKLDDVIEAKRL

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=744, Percent_Identity=62.3655913978495, Blast_Score=978, Evalue=0.0,
Organism=Escherichia coli, GI1790082, Length=677, Percent_Identity=32.3485967503693, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84240; Mature: 84240

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVRGSHLLNPKDFVIETWCASLEVSPEVRENLVNAWYYSQKYIPQHHDASSCSLHSGV
CEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCH
EMVEILHSLNMDADSLLTAMLYPTIHHKLVELSQINEDFGANIYKLAKGVMEMDNIRQLN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHC
ASQSANNAQVDNIRRMLLAMVDDFRCVIIKLAERITFLRDAEQTCSEEDKVLAAKECANI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHH
YAPLANRLGIGQLKWELEDYCFRYLHPEQYRSIANLLKERRLDREQYIADFVSEVSDYLR
HHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
HNIDKVDVYGRPKHIYSIWRKMQKKHLEFSDLYDVRAVRIIVPKLQDCYTALGIVHTHFK
CCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HIPKEFDDYVANPKPNGYQSIHTVVLGKGGKPVEVQIRTQQMHDDAELGVAAHWKYKEGA
HCCHHHHHHCCCCCCCCHHHEEEEEEECCCCEEEEEEEHHHCCCCHHCCEEEEEECCCCC
TGGRSGYEEKITWLRKLLAWQDDITDSGEIMAEMRSQVFDDRVYVFTPKGEVIDLPTGST
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCCEEECCCCCC
PLDFAYAIHSEIGHRCIGAKVSGRIVPFTYQLQMGDQIDIITQKNANPSRDWLNPNLGFT
CHHHHHHHHHHHCCCEECCCCCCEEEEEEEEEECCCEEEEEEECCCCCCHHCCCCCCCCC
HTAKARAKIHAWFKKQDREKNIPAGKEMLENELTRLNIGLKQIEPHALARYNLKNLEDLY
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHCCHHHHHHHH
AGIGGGDIRLNHLINFLQNKLIKTTAQEVDEEILRHVANKSAANNQQKEKPRGYVIVEGV
HCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEHHH
GNLMHHIARCCQPIPGDHIMGYITMGRGISIHRSDCEQFLELQQAHPERVVESIWGDNYA
HHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHCCHHHHHHHHCCCCCC
SGFKISIRIIASDRSGLLRDITTVLANDKISVLGVSSRTDTKKQLATIDMEIELNNVQIL
CCEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHEEEEEEEEECHHHHH
SKILARLSKLDDVIEAKRL
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVAVRGSHLLNPKDFVIETWCASLEVSPEVRENLVNAWYYSQKYIPQHHDASSCSLHSGV
CEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCH
EMVEILHSLNMDADSLLTAMLYPTIHHKLVELSQINEDFGANIYKLAKGVMEMDNIRQLN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHC
ASQSANNAQVDNIRRMLLAMVDDFRCVIIKLAERITFLRDAEQTCSEEDKVLAAKECANI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHH
YAPLANRLGIGQLKWELEDYCFRYLHPEQYRSIANLLKERRLDREQYIADFVSEVSDYLR
HHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
HNIDKVDVYGRPKHIYSIWRKMQKKHLEFSDLYDVRAVRIIVPKLQDCYTALGIVHTHFK
CCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HIPKEFDDYVANPKPNGYQSIHTVVLGKGGKPVEVQIRTQQMHDDAELGVAAHWKYKEGA
HCCHHHHHHCCCCCCCCHHHEEEEEEECCCCEEEEEEEHHHCCCCHHCCEEEEEECCCCC
TGGRSGYEEKITWLRKLLAWQDDITDSGEIMAEMRSQVFDDRVYVFTPKGEVIDLPTGST
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCCEEECCCCCC
PLDFAYAIHSEIGHRCIGAKVSGRIVPFTYQLQMGDQIDIITQKNANPSRDWLNPNLGFT
CHHHHHHHHHHHCCCEECCCCCCEEEEEEEEEECCCEEEEEEECCCCCCHHCCCCCCCCC
HTAKARAKIHAWFKKQDREKNIPAGKEMLENELTRLNIGLKQIEPHALARYNLKNLEDLY
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHCCHHHHHHHH
AGIGGGDIRLNHLINFLQNKLIKTTAQEVDEEILRHVANKSAANNQQKEKPRGYVIVEGV
HCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEHHH
GNLMHHIARCCQPIPGDHIMGYITMGRGISIHRSDCEQFLELQQAHPERVVESIWGDNYA
HHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHCCHHHHHHHHCCCCCC
SGFKISIRIIASDRSGLLRDITTVLANDKISVLGVSSRTDTKKQLATIDMEIELNNVQIL
CCEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHEEEEEEEEECHHHHH
SKILARLSKLDDVIEAKRL
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]