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The map label for this gene is fba [H]

Identifier: 15603726

GI number: 15603726

Start: 2103110

End: 2104189

Strand: Direct

Name: fba [H]

Synonym: PM1861

Alternate gene names: 15603726

Gene position: 2103110-2104189 (Clockwise)

Preceding gene: 15603725

Following gene: 15603727

Centisome position: 93.16

GC content: 41.11

Gene sequence:

>1080_bases
ATGGCTAAATTATTAGATATTGTAAAACCCGGCGTTGTTACTGGTGATGATGTTCAGAAAGTATTTGCATATGCAAAAGC
AAACAATTTTGCGATTCCAGCGGTAAACTGCGTGGGTTCAGACTCTGTAAATGCCGTATTAGAAACCGCAGCACGTGTCA
AAGCACCTGTGATTATTCAATTCTCAAATGGTGGTGCACAATTTTATGCTGGTAAAGGCTTAAAACCAGCAAGTGGTGCA
CGTACAGATGTACTGGGTGCCATTGCAGGGGCAAAACATGTTCACGCGTTGGCAGAAGAATATGGTGTACCGGTGATTTT
ACATACTGACCATGCAGCGAAAAAACTTCTTCCATGGATTGACGGTTTATTAGAGGCGGGTGAAGAACATTTTGCTGAAA
CAGGCAAACCATTATTCTCTTCTCACATGATTGATCTTTCTGAAGAACCTATGGAAGAAAACATGGCTATTTGCCGTGAA
TACCTCGCGCGTATGGACAAAATGGGGATGACGTTAGAAATCGAAATCGGTATCACGGGTGGTGAAGAAGATGGAGTTGA
TAACTCTGATGTAGAAGAATCTAAACTTTATACGCAACCAGAAGATGTACTTTATGTTTATGATCAATTAAACCCAGTGA
GCCCGCGTTTCACAGTCGCTGCGGCATTCGGTAACGTACATGGTGTTTATAAGCCGGGTAATGTGAAATTAAAACCGTCT
ATCTTAGGTGCATCACAAGAATTTGTTTCTAAAGAACGTGGTTTGCCAGCGAAATCAATCGACTTTGTCTTCCATGGTGG
TTCAGGCTCAAGCCGTGAAGAGATCCGCGAAGCGATCAGTTACGGTGCGATCAAAATGAATATCGATACCGACACACAAT
GGGCATCTTGGGAAGGGATTTTGAAATTCTACAACGCAAATCAAGATTATCTTCAAGGTCAATTAGGTAACCCAGAAGGT
CCTGATGCACCAAACAAAAAATACTATGATCCACGTGTTTGGTTACGTAAAATGGAAGAATCCATGTCTAAACGTTTAGA
ACAATCTTTCGAAGATTTGAATTGTATTGATGTTCTATAA

Upstream 100 bases:

>100_bases
GGCTTGTGTAGTCGCCCCTCTCTATTTTGAATGAGAATAAGCATTAGGCTTATCAAGAAACGAAATTTCACTCTAATCAA
ATAAATAAAGGAAGCAGAAA

Downstream 100 bases:

>100_bases
GCAACTCAATTCAGTTACAATGAAGCCGCACGTTGATGTGCGGTTTTTTTTTGTTTCTTTATTAAGTTGTTAGATATTAT
GCAAAGCTTAAAAAAATCTT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MAKLLDIVKPGVVTGDDVQKVFAYAKANNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAQFYAGKGLKPASGA
RTDVLGAIAGAKHVHALAEEYGVPVILHTDHAAKKLLPWIDGLLEAGEEHFAETGKPLFSSHMIDLSEEPMEENMAICRE
YLARMDKMGMTLEIEIGITGGEEDGVDNSDVEESKLYTQPEDVLYVYDQLNPVSPRFTVAAAFGNVHGVYKPGNVKLKPS
ILGASQEFVSKERGLPAKSIDFVFHGGSGSSREEIREAISYGAIKMNIDTDTQWASWEGILKFYNANQDYLQGQLGNPEG
PDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCIDVL

Sequences:

>Translated_359_residues
MAKLLDIVKPGVVTGDDVQKVFAYAKANNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAQFYAGKGLKPASGA
RTDVLGAIAGAKHVHALAEEYGVPVILHTDHAAKKLLPWIDGLLEAGEEHFAETGKPLFSSHMIDLSEEPMEENMAICRE
YLARMDKMGMTLEIEIGITGGEEDGVDNSDVEESKLYTQPEDVLYVYDQLNPVSPRFTVAAAFGNVHGVYKPGNVKLKPS
ILGASQEFVSKERGLPAKSIDFVFHGGSGSSREEIREAISYGAIKMNIDTDTQWASWEGILKFYNANQDYLQGQLGNPEG
PDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCIDVL
>Mature_358_residues
AKLLDIVKPGVVTGDDVQKVFAYAKANNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAQFYAGKGLKPASGAR
TDVLGAIAGAKHVHALAEEYGVPVILHTDHAAKKLLPWIDGLLEAGEEHFAETGKPLFSSHMIDLSEEPMEENMAICREY
LARMDKMGMTLEIEIGITGGEEDGVDNSDVEESKLYTQPEDVLYVYDQLNPVSPRFTVAAAFGNVHGVYKPGNVKLKPSI
LGASQEFVSKERGLPAKSIDFVFHGGSGSSREEIREAISYGAIKMNIDTDTQWASWEGILKFYNANQDYLQGQLGNPEGP
DAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCIDVL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=359, Percent_Identity=71.3091922005571, Blast_Score=557, Evalue=1e-160,
Organism=Escherichia coli, GI87082041, Length=338, Percent_Identity=26.0355029585799, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789526, Length=322, Percent_Identity=26.0869565217391, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788072, Length=295, Percent_Identity=26.4406779661017, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322790, Length=352, Percent_Identity=49.1477272727273, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 39248; Mature: 39117

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00152 ATPASE_ALPHA_BETA ; PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLLDIVKPGVVTGDDVQKVFAYAKANNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQ
CCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEE
FSNGGAQFYAGKGLKPASGARTDVLGAIAGAKHVHALAEEYGVPVILHTDHAAKKLLPWI
ECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
DGLLEAGEEHFAETGKPLFSSHMIDLSEEPMEENMAICREYLARMDKMGMTLEIEIGITG
HHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GEEDGVDNSDVEESKLYTQPEDVLYVYDQLNPVSPRFTVAAAFGNVHGVYKPGNVKLKPS
CCCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCCEEECHH
ILGASQEFVSKERGLPAKSIDFVFHGGSGSSREEIREAISYGAIKMNIDTDTQWASWEGI
HHCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHH
LKFYNANQDYLQGQLGNPEGPDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCIDVL
HHHHCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
AKLLDIVKPGVVTGDDVQKVFAYAKANNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQ
CHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEE
FSNGGAQFYAGKGLKPASGARTDVLGAIAGAKHVHALAEEYGVPVILHTDHAAKKLLPWI
ECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
DGLLEAGEEHFAETGKPLFSSHMIDLSEEPMEENMAICREYLARMDKMGMTLEIEIGITG
HHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GEEDGVDNSDVEESKLYTQPEDVLYVYDQLNPVSPRFTVAAAFGNVHGVYKPGNVKLKPS
CCCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCCEEECHH
ILGASQEFVSKERGLPAKSIDFVFHGGSGSSREEIREAISYGAIKMNIDTDTQWASWEGI
HHCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHH
LKFYNANQDYLQGQLGNPEGPDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCIDVL
HHHHCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]