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The map label for this gene is pepP [H]

Identifier: 15603589

GI number: 15603589

Start: 1933310

End: 1934635

Strand: Direct

Name: pepP [H]

Synonym: PM1724

Alternate gene names: 15603589

Gene position: 1933310-1934635 (Clockwise)

Preceding gene: 15603588

Following gene: 15603590

Centisome position: 85.64

GC content: 40.72

Gene sequence:

>1326_bases
ATGGATTTAGCTTATATGGCTGCGATGCCTCAAGAAGAATTTGCTGAACGCCGCCATCGTGTCTTTCAACAAATGCAAGA
GGATTCTGTACTTATCGTTTTCTCTGAAATTGAAAAACGCCGTAGCAACGACTGTACTTATCCTTTCCGTCAAGACAGCT
ATTTTTGGTATTTAACTGGGTTTAATGAGCCCAATTCCGTCTTGATTCTGGCTAAACATGGACAAACAACCGAAAGCATT
ATTTTTGTTCGTCCTTCCGATCCCTTACGTGAAACTTGGGATGGCCGCCGTTTAGGTGTAGCCAATGCTCCCCAAAAGTT
GCAATTAGATCGTGCCTTCTCAATTGAAGATTTTCATACCGAGTTGCCTAAAATTTTAGCAAAAAGTACCGCACTTTATC
ATGTTAACGCGCTTCACCCTTGGGGCGATGCATTATTAGTTGAAAATGATATCAATTTAGAAACAACCCTTTGTTGGAAA
GGCATGTTAGATGAAATGCGCTTATTCAAATCTGACAACGAAATCGCCCTTATGCAACAAGCCGGACAAATCAGTGCCTT
GGCCCACATTCGAGCTATGCAAAAAACACGTCCAAATCGCCTTGAATATGAAATTGAAGGGGAGTTATTGCATGAATTTA
ACCGTTTTGGTGCGCGTTTTCCATCTTATAATGCGATTGTTGCCGGTGGTGAAAATGCCTGTATTCTGCATTACACTGAA
AATGATATGCCACTAAAAGATGGTGATTTAGTGCTGATTGATGCGGGTTGTGAGTTTGCGATGTATGCAGGCGATATTAC
ACGCACTTTCCCTGTGAATGGAAAATTTAGCCAAGCACAACGAGAAATTTATGACATCGTGTTAAAAGCACAAAAACGGG
CGATTGAATTATTAGTACCAGGCAATTCTATCCAACAAGCTAACGATGAAGTCGTTCGGATCAAAGTGGAAGGCTTAGTG
AAATTAGGTATTTTACAAGGTGATGTAGAAACCCTGATCCAAAATGAAACCTATCGCCAATTTTATATGCATGGGCTAGG
TCACTGGCTAGGGCTTGATGTCCATGATGTTGGTAGCTATAGCAAAGATCAGCAGAATAATAACCGCAATAGTAAAGTAC
GTGACCGTCCACTTGAAGTCGGTATGGTATTGACAGTTGAACCGGGGCTTTATATTTCAGAACAAGCAGATGTCCCTGAG
CAATACAAAGGAATTGGTATCAGAATTGAGGATAACCTGCTAATCACCGAATACGGTAATAAAAATCTCACTAGTGCTGT
ACCAAAAGAAATCGATGAGATTGAAAAATTAATGGCGGGCAAATAA

Upstream 100 bases:

>100_bases
ATGTCCGTACTCTAGCTTGTTTGTTATTCACACATTTTCAACCCCAACTCCCTGAACAAAAACCCGTATTACATTAAGTG
AGATGATAAAGGAGAATAAA

Downstream 100 bases:

>100_bases
AGGATCATTTTATGCTTGAAGCAGCAAACTACGATGTGATTATTGTAGGTGGGGCGATGACCGGAACAACGCTGGCCCTT
GCACTCAGTAGCAAAACAGC

Product: hypothetical protein

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MDLAYMAAMPQEEFAERRHRVFQQMQEDSVLIVFSEIEKRRSNDCTYPFRQDSYFWYLTGFNEPNSVLILAKHGQTTESI
IFVRPSDPLRETWDGRRLGVANAPQKLQLDRAFSIEDFHTELPKILAKSTALYHVNALHPWGDALLVENDINLETTLCWK
GMLDEMRLFKSDNEIALMQQAGQISALAHIRAMQKTRPNRLEYEIEGELLHEFNRFGARFPSYNAIVAGGENACILHYTE
NDMPLKDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQAQREIYDIVLKAQKRAIELLVPGNSIQQANDEVVRIKVEGLV
KLGILQGDVETLIQNETYRQFYMHGLGHWLGLDVHDVGSYSKDQQNNNRNSKVRDRPLEVGMVLTVEPGLYISEQADVPE
QYKGIGIRIEDNLLITEYGNKNLTSAVPKEIDEIEKLMAGK

Sequences:

>Translated_441_residues
MDLAYMAAMPQEEFAERRHRVFQQMQEDSVLIVFSEIEKRRSNDCTYPFRQDSYFWYLTGFNEPNSVLILAKHGQTTESI
IFVRPSDPLRETWDGRRLGVANAPQKLQLDRAFSIEDFHTELPKILAKSTALYHVNALHPWGDALLVENDINLETTLCWK
GMLDEMRLFKSDNEIALMQQAGQISALAHIRAMQKTRPNRLEYEIEGELLHEFNRFGARFPSYNAIVAGGENACILHYTE
NDMPLKDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQAQREIYDIVLKAQKRAIELLVPGNSIQQANDEVVRIKVEGLV
KLGILQGDVETLIQNETYRQFYMHGLGHWLGLDVHDVGSYSKDQQNNNRNSKVRDRPLEVGMVLTVEPGLYISEQADVPE
QYKGIGIRIEDNLLITEYGNKNLTSAVPKEIDEIEKLMAGK
>Mature_441_residues
MDLAYMAAMPQEEFAERRHRVFQQMQEDSVLIVFSEIEKRRSNDCTYPFRQDSYFWYLTGFNEPNSVLILAKHGQTTESI
IFVRPSDPLRETWDGRRLGVANAPQKLQLDRAFSIEDFHTELPKILAKSTALYHVNALHPWGDALLVENDINLETTLCWK
GMLDEMRLFKSDNEIALMQQAGQISALAHIRAMQKTRPNRLEYEIEGELLHEFNRFGARFPSYNAIVAGGENACILHYTE
NDMPLKDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQAQREIYDIVLKAQKRAIELLVPGNSIQQANDEVVRIKVEGLV
KLGILQGDVETLIQNETYRQFYMHGLGHWLGLDVHDVGSYSKDQQNNNRNSKVRDRPLEVGMVLTVEPGLYISEQADVPE
QYKGIGIRIEDNLLITEYGNKNLTSAVPKEIDEIEKLMAGK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=459, Percent_Identity=33.1154684095861, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI149589008, Length=470, Percent_Identity=29.5744680851064, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI260593665, Length=301, Percent_Identity=35.8803986710963, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI260593663, Length=464, Percent_Identity=28.2327586206897, Blast_Score=179, Evalue=6e-45,
Organism=Escherichia coli, GI1789275, Length=447, Percent_Identity=53.0201342281879, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1790282, Length=294, Percent_Identity=30.2721088435374, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788728, Length=274, Percent_Identity=30.2919708029197, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508215, Length=473, Percent_Identity=32.1353065539112, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71989583, Length=285, Percent_Identity=30.1754385964912, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320922, Length=447, Percent_Identity=33.7807606263982, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6321118, Length=433, Percent_Identity=30.0230946882217, Blast_Score=183, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21357079, Length=478, Percent_Identity=32.4267782426778, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI19920384, Length=433, Percent_Identity=33.7182448036951, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50317; Mature: 50317

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLAYMAAMPQEEFAERRHRVFQQMQEDSVLIVFSEIEKRRSNDCTYPFRQDSYFWYLTG
CCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCEECCCEEEEEEE
FNEPNSVLILAKHGQTTESIIFVRPSDPLRETWDGRRLGVANAPQKLQLDRAFSIEDFHT
CCCCCCEEEEEECCCCCCEEEEECCCCHHHHCCCCCEECCCCCCCCEEECCCCCHHHHHH
ELPKILAKSTALYHVNALHPWGDALLVENDINLETTLCWKGMLDEMRLFKSDNEIALMQQ
HHHHHHHCCCEEEEEEEECCCCCEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCEEEEHH
AGQISALAHIRAMQKTRPNRLEYEIEGELLHEFNRFGARFPSYNAIVAGGENACILHYTE
CCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEEC
NDMPLKDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQAQREIYDIVLKAQKRAIELLVP
CCCCCCCCCEEEEECCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
GNSIQQANDEVVRIKVEGLVKLGILQGDVETLIQNETYRQFYMHGLGHWLGLDVHDVGSY
CCCCCCCCCCEEEEEEECEEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHCCCC
SKDQQNNNRNSKVRDRPLEVGMVLTVEPGLYISEQADVPEQYKGIGIRIEDNLLITEYGN
CCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEECCCCCCHHHCCEEEEEECCEEEEECCC
KNLTSAVPKEIDEIEKLMAGK
CCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLAYMAAMPQEEFAERRHRVFQQMQEDSVLIVFSEIEKRRSNDCTYPFRQDSYFWYLTG
CCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCEECCCEEEEEEE
FNEPNSVLILAKHGQTTESIIFVRPSDPLRETWDGRRLGVANAPQKLQLDRAFSIEDFHT
CCCCCCEEEEEECCCCCCEEEEECCCCHHHHCCCCCEECCCCCCCCEEECCCCCHHHHHH
ELPKILAKSTALYHVNALHPWGDALLVENDINLETTLCWKGMLDEMRLFKSDNEIALMQQ
HHHHHHHCCCEEEEEEEECCCCCEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCEEEEHH
AGQISALAHIRAMQKTRPNRLEYEIEGELLHEFNRFGARFPSYNAIVAGGENACILHYTE
CCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEEC
NDMPLKDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQAQREIYDIVLKAQKRAIELLVP
CCCCCCCCCEEEEECCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
GNSIQQANDEVVRIKVEGLVKLGILQGDVETLIQNETYRQFYMHGLGHWLGLDVHDVGSY
CCCCCCCCCCEEEEEEECEEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHCCCC
SKDQQNNNRNSKVRDRPLEVGMVLTVEPGLYISEQADVPEQYKGIGIRIEDNLLITEYGN
CCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEECCCCCCHHHCCEEEEEECCEEEEECCC
KNLTSAVPKEIDEIEKLMAGK
CCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]