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The map label for this gene is cysK [H]

Identifier: 15603558

GI number: 15603558

Start: 1901319

End: 1902266

Strand: Reverse

Name: cysK [H]

Synonym: PM1693

Alternate gene names: 15603558

Gene position: 1902266-1901319 (Counterclockwise)

Preceding gene: 15603559

Following gene: 161723307

Centisome position: 84.26

GC content: 44.62

Gene sequence:

>948_bases
ATGACCATTTACTCAGATAATTCTTATTCAATTGGTAATACACCACTTGTGCGCTTGAAACACTTTGGTCAAGGCAATAT
TGTGGTCAAAGTGGAAGGGCGTAATCCCAGTTTTAGTGTGAAGTGCCGTATTGGGGCGAATATGGTATGGCAAGCAGAAA
AAGACGGTATCTTGACGAAAGAAAAAGAAATTGTCGATGCTACCAGTGGGAATACTGGGATCGCCTTAGCCTATGTGGCA
GCTGCACGCGGTTATAAAATCACTTTAACGATGCCAGAAACCATGAGTGCAGAACGTAAACGTTTATTACGTGGATTGGG
CGTCAATTTAGTTTTAACGGAAGGTGCATTGGGCATGAAAGGGGCTATTGCCAAAGCAGAAGAAATTGTCGCGTCTGATC
CACAACGCTATGTAATGTTAAAGCAGTTTGAAAATCCGGCTAATCCAGCCATTCACCAACAAACAACCGGACCGGAAATT
TGGCGTGATACGGATGGTCAAATTGATGTGCTGGTTGCTGGTGTTGGCACCGGCGGGACGATTACAGGGATTAGCCGTTA
TATTAAACAAGATAAAGGTAAAGCGATTCTCTCTGTGGCAGTTGAACCTGCGGAATCACCAGTGATTAGTCAAACTTTAG
CCGGTGAAGAGATCAAGCCTGCCCCACATAAAATTCAAGGCATTGGCGCGGGCTTTATCCCTAAAAATTTAGACCTTGCA
TTAGTGGATCGTGTTGAAACCGTGAGTAGTGAGGAAGCCATGCAAACTGCACGTCGATTAATGGCAGAAGAAGGCATTTT
AGGGGGGATTTCATCAGGAGCGGCGGTGGCTGCCGCAGATCGTTTGGCAAAATTACCTGAATTTGCCGAGAAATTAATCG
TAGTGATTTTACCGTCTGCGTCAGAACGCTATTTAAGTACGGCATTATTTGAAGGCATTGAGGCTTAA

Upstream 100 bases:

>100_bases
ATAAAATATAGCAAATGGCTATTTTTGTGGGGATTGGAATTATGGTAGAACTAAGCTATGGCTTAATTACTCAATGGATT
GAACACAGAAGGAATACAAG

Downstream 100 bases:

>100_bases
GTCCTTCCCTTTATTACAAGCAAAGTGCGGTCAAAACGTATGAAATTTTGACCGCACTTTTTATTGCAAGAGACATTATT
GATGTTGTTTTTCCCAATAT

Product: hypothetical protein

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MTIYSDNSYSIGNTPLVRLKHFGQGNIVVKVEGRNPSFSVKCRIGANMVWQAEKDGILTKEKEIVDATSGNTGIALAYVA
AARGYKITLTMPETMSAERKRLLRGLGVNLVLTEGALGMKGAIAKAEEIVASDPQRYVMLKQFENPANPAIHQQTTGPEI
WRDTDGQIDVLVAGVGTGGTITGISRYIKQDKGKAILSVAVEPAESPVISQTLAGEEIKPAPHKIQGIGAGFIPKNLDLA
LVDRVETVSSEEAMQTARRLMAEEGILGGISSGAAVAAADRLAKLPEFAEKLIVVILPSASERYLSTALFEGIEA

Sequences:

>Translated_315_residues
MTIYSDNSYSIGNTPLVRLKHFGQGNIVVKVEGRNPSFSVKCRIGANMVWQAEKDGILTKEKEIVDATSGNTGIALAYVA
AARGYKITLTMPETMSAERKRLLRGLGVNLVLTEGALGMKGAIAKAEEIVASDPQRYVMLKQFENPANPAIHQQTTGPEI
WRDTDGQIDVLVAGVGTGGTITGISRYIKQDKGKAILSVAVEPAESPVISQTLAGEEIKPAPHKIQGIGAGFIPKNLDLA
LVDRVETVSSEEAMQTARRLMAEEGILGGISSGAAVAAADRLAKLPEFAEKLIVVILPSASERYLSTALFEGIEA
>Mature_314_residues
TIYSDNSYSIGNTPLVRLKHFGQGNIVVKVEGRNPSFSVKCRIGANMVWQAEKDGILTKEKEIVDATSGNTGIALAYVAA
ARGYKITLTMPETMSAERKRLLRGLGVNLVLTEGALGMKGAIAKAEEIVASDPQRYVMLKQFENPANPAIHQQTTGPEIW
RDTDGQIDVLVAGVGTGGTITGISRYIKQDKGKAILSVAVEPAESPVISQTLAGEEIKPAPHKIQGIGAGFIPKNLDLAL
VDRVETVSSEEAMQTARRLMAEEGILGGISSGAAVAAADRLAKLPEFAEKLIVVILPSASERYLSTALFEGIEA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=38.6075949367089, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=38.6075949367089, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=38.6075949367089, Blast_Score=185, Evalue=4e-47,
Organism=Escherichia coli, GI1788754, Length=309, Percent_Identity=72.8155339805825, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=40.1315789473684, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=50.328947368421, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17562970, Length=312, Percent_Identity=49.0384615384615, Blast_Score=274, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI32566674, Length=304, Percent_Identity=50, Blast_Score=269, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=51.7915309446254, Blast_Score=264, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17561720, Length=309, Percent_Identity=49.1909385113269, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI32566672, Length=223, Percent_Identity=48.4304932735426, Blast_Score=201, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=322, Percent_Identity=40.0621118012422, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=37.7777777777778, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17561716, Length=125, Percent_Identity=51.2, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321594, Length=312, Percent_Identity=35.5769230769231, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=33.030303030303, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24643623, Length=304, Percent_Identity=36.1842105263158, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI20129101, Length=304, Percent_Identity=36.1842105263158, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33513; Mature: 33382

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIYSDNSYSIGNTPLVRLKHFGQGNIVVKVEGRNPSFSVKCRIGANMVWQAEKDGILTK
CEEECCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEEEECCCEEEEECCCCCCCC
EKEIVDATSGNTGIALAYVAAARGYKITLTMPETMSAERKRLLRGLGVNLVLTEGALGMK
CHHHEECCCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCC
GAIAKAEEIVASDPQRYVMLKQFENPANPAIHQQTTGPEIWRDTDGQIDVLVAGVGTGGT
HHHHHHHHHHHCCCHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCH
ITGISRYIKQDKGKAILSVAVEPAESPVISQTLAGEEIKPAPHKIQGIGAGFIPKNLDLA
HHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCH
LVDRVETVSSEEAMQTARRLMAEEGILGGISSGAAVAAADRLAKLPEFAEKLIVVILPSA
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEECCC
SERYLSTALFEGIEA
CHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIYSDNSYSIGNTPLVRLKHFGQGNIVVKVEGRNPSFSVKCRIGANMVWQAEKDGILTK
EEECCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEEEECCCEEEEECCCCCCCC
EKEIVDATSGNTGIALAYVAAARGYKITLTMPETMSAERKRLLRGLGVNLVLTEGALGMK
CHHHEECCCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCC
GAIAKAEEIVASDPQRYVMLKQFENPANPAIHQQTTGPEIWRDTDGQIDVLVAGVGTGGT
HHHHHHHHHHHCCCHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCH
ITGISRYIKQDKGKAILSVAVEPAESPVISQTLAGEEIKPAPHKIQGIGAGFIPKNLDLA
HHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCH
LVDRVETVSSEEAMQTARRLMAEEGILGGISSGAAVAAADRLAKLPEFAEKLIVVILPSA
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEECCC
SERYLSTALFEGIEA
CHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]