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The map label for this gene is ubiE

Identifier: 15603551

GI number: 15603551

Start: 1895121

End: 1895927

Strand: Direct

Name: ubiE

Synonym: PM1686

Alternate gene names: 15603551

Gene position: 1895121-1895927 (Clockwise)

Preceding gene: 15603550

Following gene: 15603552

Centisome position: 83.95

GC content: 41.76

Gene sequence:

>807_bases
ATGACAGATCAACACGCTTTTGCGACCGAACAAGTGCAACTCGACCCGACTTTATCTCCTACCACAGAAGAAACCACGCA
TTTTGGCTTTAAAACCGTGGCAAAATCGGAAAAACAAAAAATGGTTGCCAATGTCTTCCATTCCGTCGCGGGCAAATACG
ATTTAATGAATGATTTACTTTCATTTGGTATTCATCGCGTTTGGAAACGCTTTACCATTGACTGCAGTGGAGTACGTAAA
GGACATAAGGTGTTAGATCTGGCGGGTGGAACAGGAGATTTTACGGCAAAATTCTCGCGCCTTGTAGGACCTAGCGGTGA
AGTGATCCTTGCCGATATAAATGATTCGATGTTACGGGTCGGTCGGGAAAAACTGCGTAACCTCGGCGTTGTCGGCAATG
TTAATTATGTACAAGCTAATGCTGAAGCACTGCCTTTTCCTGACAACACTTTTGATTGTGTGATCATCAGCTTTGGTTTA
CGTAACGTCACGGACAAAGACAAAGCACTACGTTCTATGTTTCGCGTGTTAAAACCCGGTGGTCGCTTATTGGTGTTGGA
GTTTTCCAAACCGATTTTAGATCCACTCAGTAAAATTTATAATTTCTACTCTTTCAATATTTTGCCTAAAATTGGCGAAG
TGGTGGTCAATGATAGTGAAAGTTATCGCTATCTTGCTGAATCTATCCGTATGCACCCCGCACAAGATGTTTTAAAACAA
ATGATGATTGACGCTGGCTTTGAACAAGTTAATTACTATAATTTAAGTGCGGGCATTGTGGCATTACACCGAGGTTATAA
GTTCTAA

Upstream 100 bases:

>100_bases
AATTTTTATTGTTCGATTTAGTATAACACAAGAAAAATAGCGGAATTCTCCGCTATTTTTTGTTATCCTTAGTCTAATTT
AAGCTCTATGGATATTTGCT

Downstream 100 bases:

>100_bases
CATTGAGGGGAGACCCACATGAAATATCGAGCTGAAAATCATTCAAAACAGGTCTTGATATTACTAGGACTCGATATTCT
GATTTATGTGGTACAAATAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MTDQHAFATEQVQLDPTLSPTTEETTHFGFKTVAKSEKQKMVANVFHSVAGKYDLMNDLLSFGIHRVWKRFTIDCSGVRK
GHKVLDLAGGTGDFTAKFSRLVGPSGEVILADINDSMLRVGREKLRNLGVVGNVNYVQANAEALPFPDNTFDCVIISFGL
RNVTDKDKALRSMFRVLKPGGRLLVLEFSKPILDPLSKIYNFYSFNILPKIGEVVVNDSESYRYLAESIRMHPAQDVLKQ
MMIDAGFEQVNYYNLSAGIVALHRGYKF

Sequences:

>Translated_268_residues
MTDQHAFATEQVQLDPTLSPTTEETTHFGFKTVAKSEKQKMVANVFHSVAGKYDLMNDLLSFGIHRVWKRFTIDCSGVRK
GHKVLDLAGGTGDFTAKFSRLVGPSGEVILADINDSMLRVGREKLRNLGVVGNVNYVQANAEALPFPDNTFDCVIISFGL
RNVTDKDKALRSMFRVLKPGGRLLVLEFSKPILDPLSKIYNFYSFNILPKIGEVVVNDSESYRYLAESIRMHPAQDVLKQ
MMIDAGFEQVNYYNLSAGIVALHRGYKF
>Mature_267_residues
TDQHAFATEQVQLDPTLSPTTEETTHFGFKTVAKSEKQKMVANVFHSVAGKYDLMNDLLSFGIHRVWKRFTIDCSGVRKG
HKVLDLAGGTGDFTAKFSRLVGPSGEVILADINDSMLRVGREKLRNLGVVGNVNYVQANAEALPFPDNTFDCVIISFGLR
NVTDKDKALRSMFRVLKPGGRLLVLEFSKPILDPLSKIYNFYSFNILPKIGEVVVNDSESYRYLAESIRMHPAQDVLKQM
MIDAGFEQVNYYNLSAGIVALHRGYKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=277, Percent_Identity=43.3212996389892, Blast_Score=225, Evalue=2e-59,
Organism=Escherichia coli, GI48994983, Length=247, Percent_Identity=79.7570850202429, Blast_Score=432, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17557039, Length=264, Percent_Identity=44.3181818181818, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323526, Length=279, Percent_Identity=39.0681003584229, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24641702, Length=260, Percent_Identity=44.6153846153846, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_PASMU (Q9CKD6)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246625.1
- ProteinModelPortal:   Q9CKD6
- SMR:   Q9CKD6
- GeneID:   1245033
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1686
- NMPDR:   fig|272843.1.peg.1687
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- ProtClustDB:   CLSK870572
- BioCyc:   PMUL272843:PM1686-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 30020; Mature: 29889

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQHAFATEQVQLDPTLSPTTEETTHFGFKTVAKSEKQKMVANVFHSVAGKYDLMNDLL
CCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SFGIHRVWKRFTIDCSGVRKGHKVLDLAGGTGDFTAKFSRLVGPSGEVILADINDSMLRV
HHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCHHHHHH
GREKLRNLGVVGNVNYVQANAEALPFPDNTFDCVIISFGLRNVTDKDKALRSMFRVLKPG
HHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCC
GRLLVLEFSKPILDPLSKIYNFYSFNILPKIGEVVVNDSESYRYLAESIRMHPAQDVLKQ
CCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHH
MMIDAGFEQVNYYNLSAGIVALHRGYKF
HHHHCCHHHCEEEECCHHHHHHHCCCCC
>Mature Secondary Structure 
TDQHAFATEQVQLDPTLSPTTEETTHFGFKTVAKSEKQKMVANVFHSVAGKYDLMNDLL
CCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SFGIHRVWKRFTIDCSGVRKGHKVLDLAGGTGDFTAKFSRLVGPSGEVILADINDSMLRV
HHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCHHHHHH
GREKLRNLGVVGNVNYVQANAEALPFPDNTFDCVIISFGLRNVTDKDKALRSMFRVLKPG
HHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCC
GRLLVLEFSKPILDPLSKIYNFYSFNILPKIGEVVVNDSESYRYLAESIRMHPAQDVLKQ
CCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHH
MMIDAGFEQVNYYNLSAGIVALHRGYKF
HHHHCCHHHCEEEECCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100