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The map label for this gene is gpsA

Identifier: 15603296

GI number: 15603296

Start: 1617208

End: 1618221

Strand: Reverse

Name: gpsA

Synonym: PM1431

Alternate gene names: 15603296

Gene position: 1618221-1617208 (Counterclockwise)

Preceding gene: 15603297

Following gene: 15603295

Centisome position: 71.68

GC content: 44.38

Gene sequence:

>1014_bases
ATGAATACGACTGTAGCCACTTCTCCAATTACGGTACTTGGTGCAGGTTCTTATGGTACCGCATTAGCGATTGCGTTTTC
TCGAAATGGTTTCCCTACTTATCTTTGGGGACATGATCCTGTTCACATGCAACGCTTAAGTGAAGAACGTCAGAATAACG
CCTTTTTGCCGAATATTGCTTTTCCAGATGCCTTGCATATTGAATTTGATTTAGCCAGTGCCTTAAGCCAATCACGTGAT
CTGTTAATTGTGGTGCCAAGTCATGTATTTGGGGAAGTGATTGATAAAATTAAGCCTTATTTACGCCCTGATCATCGCAT
TGCTTGGGCGACGAAAGGGTTAGAGCGCAATACGGGACGTTTATTGCAAGAAGTGATTGAGGAAAAGCTCGGTACACAAC
ACCCGTTAGCGGTATTATCTGGACCGACATTTGCGAAAGAGCTTGCTGCCGGTTTACCGACCGCAATTGCCCTAGCCTCC
AATAATGAACAATTTGCTTTGGAATTCCAAGCACGTATCCATTGCAGTAAACATTTCAGAGTTTATATTAATCAAGATAT
GATCGGTGTGCAGCTAGGTGGTGCGATTAAAAATGTGATTGCGATCAGTGCTGGGATGTCGGATGGTATGGGCTTTGGTG
CTAATGCACGAACAGCCTTGATTACTCGTGGTATTGCGGAAATTAGCCGTTTAGGCGCCTCATTAGGCGCGAATCCAAAT
ACTTTTATGGGCATGTCTGGCTTAGGTGATTTAGTGTTAACCTGTACTGACGATCAATCGCGTAACCGCCGATTTGGTAT
TATGCTCGGTCAGGGCTTTTCAGCCCAAACAGCAATGGACAATATCGGGCAAGTGGTAGAAGGCTTTTATAACGCGAAAG
AAGCCTATTTATTAGCGCAACGTCAAGGGATAGAAATGCCGATCACAGAGCAAGTTTATCAAGTTTTATTCTGTGGTAAA
AATGCACAAGACGTGGCGGCAAGCCTACTCGGACGTGAGCGTAAAGGGGAATAA

Upstream 100 bases:

>100_bases
CTCTTTTCGCTCTCGCTGTGAGAGCGAAATTTTATCACTTAATTTATTAAGATGATGTCCAATTGCCTCACTTAGTTTTA
TCATTTTTCGGGAGTATAAC

Downstream 100 bases:

>100_bases
TAAGGAAAGCAGAACGAGGTAAGTAACATGCCATTAGCGGTTTGGACTGACATCCGTCAGGAAGCAAAAACCTTAGCAGA
AAATGAGCCAATTTTGGCCA

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MNTTVATSPITVLGAGSYGTALAIAFSRNGFPTYLWGHDPVHMQRLSEERQNNAFLPNIAFPDALHIEFDLASALSQSRD
LLIVVPSHVFGEVIDKIKPYLRPDHRIAWATKGLERNTGRLLQEVIEEKLGTQHPLAVLSGPTFAKELAAGLPTAIALAS
NNEQFALEFQARIHCSKHFRVYINQDMIGVQLGGAIKNVIAISAGMSDGMGFGANARTALITRGIAEISRLGASLGANPN
TFMGMSGLGDLVLTCTDDQSRNRRFGIMLGQGFSAQTAMDNIGQVVEGFYNAKEAYLLAQRQGIEMPITEQVYQVLFCGK
NAQDVAASLLGRERKGE

Sequences:

>Translated_337_residues
MNTTVATSPITVLGAGSYGTALAIAFSRNGFPTYLWGHDPVHMQRLSEERQNNAFLPNIAFPDALHIEFDLASALSQSRD
LLIVVPSHVFGEVIDKIKPYLRPDHRIAWATKGLERNTGRLLQEVIEEKLGTQHPLAVLSGPTFAKELAAGLPTAIALAS
NNEQFALEFQARIHCSKHFRVYINQDMIGVQLGGAIKNVIAISAGMSDGMGFGANARTALITRGIAEISRLGASLGANPN
TFMGMSGLGDLVLTCTDDQSRNRRFGIMLGQGFSAQTAMDNIGQVVEGFYNAKEAYLLAQRQGIEMPITEQVYQVLFCGK
NAQDVAASLLGRERKGE
>Mature_337_residues
MNTTVATSPITVLGAGSYGTALAIAFSRNGFPTYLWGHDPVHMQRLSEERQNNAFLPNIAFPDALHIEFDLASALSQSRD
LLIVVPSHVFGEVIDKIKPYLRPDHRIAWATKGLERNTGRLLQEVIEEKLGTQHPLAVLSGPTFAKELAAGLPTAIALAS
NNEQFALEFQARIHCSKHFRVYINQDMIGVQLGGAIKNVIAISAGMSDGMGFGANARTALITRGIAEISRLGASLGANPN
TFMGMSGLGDLVLTCTDDQSRNRRFGIMLGQGFSAQTAMDNIGQVVEGFYNAKEAYLLAQRQGIEMPITEQVYQVLFCGK
NAQDVAASLLGRERKGE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=340, Percent_Identity=27.0588235294118, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI24307999, Length=350, Percent_Identity=24.2857142857143, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1790037, Length=330, Percent_Identity=69.0909090909091, Blast_Score=482, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI32564399, Length=339, Percent_Identity=26.5486725663717, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32564403, Length=348, Percent_Identity=25.8620689655172, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI193210136, Length=338, Percent_Identity=25.1479289940828, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17507425, Length=352, Percent_Identity=23.8636363636364, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI193210134, Length=315, Percent_Identity=23.8095238095238, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324513, Length=350, Percent_Identity=26.2857142857143, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320181, Length=340, Percent_Identity=26.4705882352941, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI22026922, Length=329, Percent_Identity=23.4042553191489, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136204, Length=329, Percent_Identity=24.6200607902736, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136202, Length=329, Percent_Identity=24.6200607902736, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136200, Length=329, Percent_Identity=24.6200607902736, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281362270, Length=237, Percent_Identity=27.8481012658228, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_PASMU (Q9CL17)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246370.1
- ProteinModelPortal:   Q9CL17
- SMR:   Q9CL17
- GeneID:   1244778
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1431
- NMPDR:   fig|272843.1.peg.1432
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   PRK00094
- BioCyc:   PMUL272843:PM1431-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 36477; Mature: 36477

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 197-197 BINDING 112-112 BINDING 112-112 BINDING 145-145 BINDING 261-261 BINDING 287-287

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTVATSPITVLGAGSYGTALAIAFSRNGFPTYLWGHDPVHMQRLSEERQNNAFLPNIA
CCCCEECCCEEEEECCCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCC
FPDALHIEFDLASALSQSRDLLIVVPSHVFGEVIDKIKPYLRPDHRIAWATKGLERNTGR
CCCEEEEEEEHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
LLQEVIEEKLGTQHPLAVLSGPTFAKELAAGLPTAIALASNNEQFALEFQARIHCSKHFR
HHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCEEEEEECCCCEEEEEEEEEEEECCEEE
VYINQDMIGVQLGGAIKNVIAISAGMSDGMGFGANARTALITRGIAEISRLGASLGANPN
EEECCCEEEEEECHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
TFMGMSGLGDLVLTCTDDQSRNRRFGIMLGQGFSAQTAMDNIGQVVEGFYNAKEAYLLAQ
CEECCCCCCCEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHH
RQGIEMPITEQVYQVLFCGKNAQDVAASLLGRERKGE
HCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNTTVATSPITVLGAGSYGTALAIAFSRNGFPTYLWGHDPVHMQRLSEERQNNAFLPNIA
CCCCEECCCEEEEECCCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCC
FPDALHIEFDLASALSQSRDLLIVVPSHVFGEVIDKIKPYLRPDHRIAWATKGLERNTGR
CCCEEEEEEEHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
LLQEVIEEKLGTQHPLAVLSGPTFAKELAAGLPTAIALASNNEQFALEFQARIHCSKHFR
HHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCEEEEEECCCCEEEEEEEEEEEECCEEE
VYINQDMIGVQLGGAIKNVIAISAGMSDGMGFGANARTALITRGIAEISRLGASLGANPN
EEECCCEEEEEECHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
TFMGMSGLGDLVLTCTDDQSRNRRFGIMLGQGFSAQTAMDNIGQVVEGFYNAKEAYLLAQ
CEECCCCCCCEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHH
RQGIEMPITEQVYQVLFCGKNAQDVAASLLGRERKGE
HCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100