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The map label for this gene is czcD [H]

Identifier: 15603202

GI number: 15603202

Start: 1529240

End: 1529827

Strand: Direct

Name: czcD [H]

Synonym: PM1337

Alternate gene names: 15603202

Gene position: 1529240-1529827 (Clockwise)

Preceding gene: 15603201

Following gene: 15603208

Centisome position: 67.74

GC content: 40.99

Gene sequence:

>588_bases
ATGGCACATCAGCATCAACATCCGCATACAAGCAATCGTAGCGTATTAGCAATCAGTTTTGCGCTTGTTAGTGTATTTAT
GCTAGTGGAGTTTTTAAGTGGTTATTATTTTAAAAGCTTAGCACTCATTGCAGACGCCGGGCATATGGCAAATGACAGTT
TCGCCTTATTGGTTGCGTTGATTGCGCTTTATTTAAGTCCAAAGAATCAACGTCGTGTTGCTGTGTTGAATGGGTTTTCG
TTGATCGTCGTTGCGCTATTTATTATTTGGGAGGCAATTGAGCGTTGGCAATCGCCGCAAATGATTCAATCGCTGCCAAT
GCTCGTTGTGGCCATATTAGGACTATGTGTAAACACCTTAGTGGCATGGTTACTGCTGAAAGGTGATTTGCATAATTTAA
ATCTTCGCGCAGCATATTTGCATGTATTGGCGGATTTACTTGGCTCAATTGTGGCGATTGTCGCGGCATTAAGTATTTTC
TTTTGGGGCTGGATATGGGTTGATACTGTAGCCAGTTTGATCCTGAGTTTATTTATTTTGAAAAGTGGTTATGCCGTGAC
AAAAGAGGCGATTTTGAATTTGGAATAA

Upstream 100 bases:

>100_bases
ATTGTTAAATATCATGACATGACGTCTATTATGTTTTGATTAGCGAGGTAAATTACCCTTCAATGGCATCACGCCTTATC
CTTGATGAAAAGGAAACACT

Downstream 100 bases:

>100_bases
TAAAACAGGGCTCAACATCATACACTTTTTAACCGCACATTTTCATTCAACAAGACGATTGATTTGGCTGTACTTTTAAA
AAAGGCAGTAGCAGTAACGC

Product: CzcD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MAHQHQHPHTSNRSVLAISFALVSVFMLVEFLSGYYFKSLALIADAGHMANDSFALLVALIALYLSPKNQRRVAVLNGFS
LIVVALFIIWEAIERWQSPQMIQSLPMLVVAILGLCVNTLVAWLLLKGDLHNLNLRAAYLHVLADLLGSIVAIVAALSIF
FWGWIWVDTVASLILSLFILKSGYAVTKEAILNLE

Sequences:

>Translated_195_residues
MAHQHQHPHTSNRSVLAISFALVSVFMLVEFLSGYYFKSLALIADAGHMANDSFALLVALIALYLSPKNQRRVAVLNGFS
LIVVALFIIWEAIERWQSPQMIQSLPMLVVAILGLCVNTLVAWLLLKGDLHNLNLRAAYLHVLADLLGSIVAIVAALSIF
FWGWIWVDTVASLILSLFILKSGYAVTKEAILNLE
>Mature_194_residues
AHQHQHPHTSNRSVLAISFALVSVFMLVEFLSGYYFKSLALIADAGHMANDSFALLVALIALYLSPKNQRRVAVLNGFSL
IVVALFIIWEAIERWQSPQMIQSLPMLVVAILGLCVNTLVAWLLLKGDLHNLNLRAAYLHVLADLLGSIVAIVAALSIFF
WGWIWVDTVASLILSLFILKSGYAVTKEAILNLE

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=202, Percent_Identity=25.7425742574257, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1786966, Length=200, Percent_Identity=41.5, Blast_Score=111, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI32564488, Length=180, Percent_Identity=35.5555555555556, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17555794, Length=224, Percent_Identity=26.7857142857143, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193210990, Length=226, Percent_Identity=30.0884955752212, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17555796, Length=204, Percent_Identity=27.9411764705882, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 21583; Mature: 21452

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHQHQHPHTSNRSVLAISFALVSVFMLVEFLSGYYFKSLALIADAGHMANDSFALLVAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
IALYLSPKNQRRVAVLNGFSLIVVALFIIWEAIERWQSPQMIQSLPMLVVAILGLCVNTL
HHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VAWLLLKGDLHNLNLRAAYLHVLADLLGSIVAIVAALSIFFWGWIWVDTVASLILSLFIL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSGYAVTKEAILNLE
HCCCHHHHHHHHCCC
>Mature Secondary Structure 
AHQHQHPHTSNRSVLAISFALVSVFMLVEFLSGYYFKSLALIADAGHMANDSFALLVAL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
IALYLSPKNQRRVAVLNGFSLIVVALFIIWEAIERWQSPQMIQSLPMLVVAILGLCVNTL
HHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VAWLLLKGDLHNLNLRAAYLHVLADLLGSIVAIVAALSIFFWGWIWVDTVASLILSLFIL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSGYAVTKEAILNLE
HCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA