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The map label for this gene is mltC [H]

Identifier: 15603186

GI number: 15603186

Start: 1512492

End: 1513574

Strand: Direct

Name: mltC [H]

Synonym: PM1321

Alternate gene names: 15603186

Gene position: 1512492-1513574 (Clockwise)

Preceding gene: 15603185

Following gene: 15603189

Centisome position: 67.0

GC content: 39.61

Gene sequence:

>1083_bases
ATGAAGATGAAGAAGTACATAATTTACGCATTAATCCCTTTTTTATTTGCTTGTGGTGGGACGAAAACACACCGCAGTTC
GCAATTTGATGAAGCATTCGCCAAAGATACTCGTGGATTAGATATTTTAACAGGGCAGTTTTCGCATAATATCGATCGTA
TTTGGGGAGTGAATGAATTACTCGTTGCGAGCCGTAAAGACTATGTAAAATATACCGATCGTTTCTATACGCGTAGCCAT
GTCAGTTTTGATGAAGGGTTGATTACGGTTGAAACACAAAGCGATTTACGTCACTTACAAAATGCGATTGTGCATATTTT
ATTAATGGGGTCTGATGCAAATGGTATCGATCTGTTTGCTTCGGGTGATGTGCCGATTAGCTCGCGTCCTTTTTTAGTGG
GGCAAGTGATCGATCATTTAGGCGGATCTATTACTAACACCACAACAGCAGGTAACTTTGCGAATTATTTATTACAGAAT
AAATTGCAAACGCGTCGTTTAAGTAATGGACATACTGTACAGTATGTGGTGATCCCGATGATTGCCAACCACGTTGCTGT
GCGTGCACAAAGATATTTACCGTTGGTGCGTAAAATGGCACGTCGTTACAATATGGATGAAAGTTTGATTTTAGGCATCA
TGCAAACAGAATCCAGTTTTAACCCTTACGCGATTAGTTATGCTAATGCGATTGGTTTAATGCAAGTTGTGCCAACAACC
GCTGGACGTGATATTTTCAAAATGAAAGGAAAAGGGGGACAACCGTCCAAATCCTATTTATTTGATCCTGAAAAGAATAT
CGATGCGGGGACCTCGTATTTATGGTTATTACAAAATAAATATTTAGACGGGATTACTAATCCAACCTCTAAACGTTTTG
CCATGATTTCTGCTTACAATAGTGGTGCAGGCGCGGTTTTACGTGTTTTTGACCAAGATCGTGATGCGGCGATTGTGAAG
ATCAATAGTCTTTATCCTGAACAGGTTTATCGGATTTTGACTACTCAACATCCATCTGCGCAAGCAAGAAATTACTTACT
TAAAGTGGATCAAGCACAGAAAAGTTATCGCGTAAGACGATAA

Upstream 100 bases:

>100_bases
GAATGCGGATCATAGACAACTACTTGAGCAAGAAATGGTTAACTTCTTGTTTGAAGGTAAAGATGTTCACATTGAAGGTT
ATGTTCCCCCAACGGAATAA

Downstream 100 bases:

>100_bases
TTAATAGGTAGGGTGAAAAAATGCTCGCTTTATTCCAAAGAATAGCGAGCATTTTGTTATTTATTTTTAATGAAAAAACA
TAAAAAATGTATGAAATTGT

Product: murein transglycosylase C

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKMKKYIIYALIPFLFACGGTKTHRSSQFDEAFAKDTRGLDILTGQFSHNIDRIWGVNELLVASRKDYVKYTDRFYTRSH
VSFDEGLITVETQSDLRHLQNAIVHILLMGSDANGIDLFASGDVPISSRPFLVGQVIDHLGGSITNTTTAGNFANYLLQN
KLQTRRLSNGHTVQYVVIPMIANHVAVRAQRYLPLVRKMARRYNMDESLILGIMQTESSFNPYAISYANAIGLMQVVPTT
AGRDIFKMKGKGGQPSKSYLFDPEKNIDAGTSYLWLLQNKYLDGITNPTSKRFAMISAYNSGAGAVLRVFDQDRDAAIVK
INSLYPEQVYRILTTQHPSAQARNYLLKVDQAQKSYRVRR

Sequences:

>Translated_360_residues
MKMKKYIIYALIPFLFACGGTKTHRSSQFDEAFAKDTRGLDILTGQFSHNIDRIWGVNELLVASRKDYVKYTDRFYTRSH
VSFDEGLITVETQSDLRHLQNAIVHILLMGSDANGIDLFASGDVPISSRPFLVGQVIDHLGGSITNTTTAGNFANYLLQN
KLQTRRLSNGHTVQYVVIPMIANHVAVRAQRYLPLVRKMARRYNMDESLILGIMQTESSFNPYAISYANAIGLMQVVPTT
AGRDIFKMKGKGGQPSKSYLFDPEKNIDAGTSYLWLLQNKYLDGITNPTSKRFAMISAYNSGAGAVLRVFDQDRDAAIVK
INSLYPEQVYRILTTQHPSAQARNYLLKVDQAQKSYRVRR
>Mature_360_residues
MKMKKYIIYALIPFLFACGGTKTHRSSQFDEAFAKDTRGLDILTGQFSHNIDRIWGVNELLVASRKDYVKYTDRFYTRSH
VSFDEGLITVETQSDLRHLQNAIVHILLMGSDANGIDLFASGDVPISSRPFLVGQVIDHLGGSITNTTTAGNFANYLLQN
KLQTRRLSNGHTVQYVVIPMIANHVAVRAQRYLPLVRKMARRYNMDESLILGIMQTESSFNPYAISYANAIGLMQVVPTT
AGRDIFKMKGKGGQPSKSYLFDPEKNIDAGTSYLWLLQNKYLDGITNPTSKRFAMISAYNSGAGAVLRVFDQDRDAAIVK
INSLYPEQVYRILTTQHPSAQARNYLLKVDQAQKSYRVRR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=348, Percent_Identity=54.5977011494253, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI87081855, Length=178, Percent_Identity=39.3258426966292, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40554; Mature: 40554

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKKYIIYALIPFLFACGGTKTHRSSQFDEAFAKDTRGLDILTGQFSHNIDRIWGVNEL
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEECCHHCCHHHHCCCHHH
LVASRKDYVKYTDRFYTRSHVSFDEGLITVETQSDLRHLQNAIVHILLMGSDANGIDLFA
HHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHEEEEEECCCCCCEEEEE
SGDVPISSRPFLVGQVIDHLGGSITNTTTAGNFANYLLQNKLQTRRLSNGHTVQYVVIPM
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHH
IANHVAVRAQRYLPLVRKMARRYNMDESLILGIMQTESSFNPYAISYANAIGLMQVVPTT
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCEEEEHHHHHHHHHCCCCC
AGRDIFKMKGKGGQPSKSYLFDPEKNIDAGTSYLWLLQNKYLDGITNPTSKRFAMISAYN
CCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHCCCCCCCCCCEEEEEECC
SGAGAVLRVFDQDRDAAIVKINSLYPEQVYRILTTQHPSAQARNYLLKVDQAQKSYRVRR
CCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHHEEEEHHHHHHCCCCC
>Mature Secondary Structure
MKMKKYIIYALIPFLFACGGTKTHRSSQFDEAFAKDTRGLDILTGQFSHNIDRIWGVNEL
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEECCHHCCHHHHCCCHHH
LVASRKDYVKYTDRFYTRSHVSFDEGLITVETQSDLRHLQNAIVHILLMGSDANGIDLFA
HHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHEEEEEECCCCCCEEEEE
SGDVPISSRPFLVGQVIDHLGGSITNTTTAGNFANYLLQNKLQTRRLSNGHTVQYVVIPM
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHH
IANHVAVRAQRYLPLVRKMARRYNMDESLILGIMQTESSFNPYAISYANAIGLMQVVPTT
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCEEEEHHHHHHHHHCCCCC
AGRDIFKMKGKGGQPSKSYLFDPEKNIDAGTSYLWLLQNKYLDGITNPTSKRFAMISAYN
CCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHCCCCCCCCCCEEEEEECC
SGAGAVLRVFDQDRDAAIVKINSLYPEQVYRILTTQHPSAQARNYLLKVDQAQKSYRVRR
CCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHHEEEEHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]