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The map label for this gene is tkt_1

Identifier: 15603107

GI number: 15603107

Start: 1434539

End: 1436545

Strand: Reverse

Name: tkt_1

Synonym: PM1242

Alternate gene names: 15603107

Gene position: 1436545-1434539 (Counterclockwise)

Preceding gene: 161723310

Following gene: 15603103

Centisome position: 63.63

GC content: 44.49

Gene sequence:

>2007_bases
ATGGCAACACGTAGAGAACTGGCAAATGCCATTCGTTTTTTAAGTATGGATGCGGTGCAAAAAGCAAAATCAGGGCATCC
AGGTGCACCGATGGGGATGGCAGATATTGCAGAAGTCTTATGGCGTGACTTTTTAAAACATAACCCAAGCAATCCACACT
GGGCCGATCGCGACCGTTTCATTTTATCCAATGGTCATGGTTCAATGCTGATTTACAGTTTATTACATTTAAGTGGTTAT
GACCTTTCTATTGAAGATTTAAAACAATTCCGTCAATTACATTCCAAAACACCGGGACACCCAGAATACGGTTATGCGCC
GGGTGTTGAAACCACAACAGGACCATTAGGTCAAGGGATTACGAACGCAGTGGGTTTTGCGATTGCGGAGAAAACCCTTG
CCCATCAATTTAACCGTCCAGGTCATGAAATTGTTGACCACCACACCTATGTGTTCTTAGGCGATGGTTGTTTAATGGAA
GGGATTTCTCATGAAGCCTGTTCTTTAGCGGGTACTCTTGGGTTAGGTAAATTAATTGCTTTCTATGACGACAACAATAT
CTCAATTGATGGTCATGTGGACGGTTGGTTCACTGATGATACGCAAAAACGGTTTGAAGCTTATGGTTGGCATGTCATTC
CAGCGGTAGATGGTCATAATCCAGAACAAATTCTTGAGGCGGTGAAACAAGCCCAAGCGGAGACAACCAAACCAACCTTA
ATTATTTGTAAAACCATTATCGGTTATGGTTCACCGAATAAAGCCAACTCACACGATTGTCATGGTGCTCCATTAGGTGA
TGATGAAATTGCGGCAGCACGTGAATTCTTAAAATGGGAGCATGCCCCGTTTGAAATTCCTGCGGAGATTTATGCACAAT
GGGATGCGAAAGAAAAAGGTCAAGTTGCTGAAAAAGCGTGGGAAGAAAAATTGGCAGCTTATGCCAAAGCTTACCCAGAA
TTAGCGGCGGAATTTACTCGTCGTGTGAATGCGGAGCTACCGGCAAACTGGGCGGCAGAATCGCAAGCTTTTATTGAACA
TTTACAAGCGAATCCGGCGAACATTGCCAGCCGTAAAGCGTCACAAAATGCGATTGAAGCCTATGCTAAATTATTACCGG
AGTTTTTAGGTGGGTCAGCGGATTTAGCCAGCTCAAACTTAACCCTCTGGTCAGGTTCCAAACCAATCCGTGCGGTAGAA
AATGCCGATGGTAACTACATCAACTACGGTGTGCGTGAGTTTGGTATGTCGGCGATTATGAACGGTATTGCGTTACATGG
TGGTTTCATTCCTTATGGTGCCACTTTCTTGATGTTTATGGAATACGCACATAATGCGGTGCGTATGGCGGCGTTAATGA
AACAACGCTCATTGTTTGTTTATACTCACGACTCTATTGGGCTTGGTGAAGACGGTCCAACTCACCAACCGGTTGAACAA
ACGTCTGCTTTACGTTTAATTCCAAATTTGGAAACATGGCGCCCATGTGACCAAGTGGAATCGGCGGTGGCGTGGAAAGC
GGCAGTGGAACGTAAAGAGGGACCTAGTGCGTTAATTTTTACTCGTCAAAATCTTGCGCAAATGGACCGCACTGCTGAGC
AGTTAGCCAATGTGGCACGTGGTGGTTATGTATTACGTCATTGCTGTGAAAACCAAAACTGTCCAGATTTAATTTTGATT
GCGACCGGTTCTGAGGTGGAATTGGCGATGAAAGCGGCGGATGTTTTAGATGCAGAAGGGGTAAAAGTACGTGTTGTCTC
TATGCCGAGCACCAATGTGTTTGATAAACAAGATGCGGCTTACCGTGAAAGTGTGTTACCAAGCCACATAACAAAACGTG
TTGCGATTGAAGCGGGTATTGCGGACTTCTGGTACAAATATGTGGGCTTTGAGGGACGTGTTGTGGGAATGAACAGTTTT
GGTGAATCCGCACCAGCTGACCAATTGTTCAAACTCTTTGGTTTTACAGTCGAGAATATAGTCGAAAAAGCAAAAGCGAT
TTTATAA

Upstream 100 bases:

>100_bases
TCAAGCCTCATAGACAAGCAAGAAATTCATTATCCTTTAGCAGTAAAATAGCGTAAAATACTGCTCAAATTTGAGTCTTA
ATTACTTAGGAGTAATCACT

Downstream 100 bases:

>100_bases
TTCACATTATGTACTTAAATGAAAAGCCACTCGCTGACGAGTGGCTTTGATTGAATAGACTGGGAATAAATGAGATGCGT
TTCTCTTGGTTTCCATTATT

Product: transketolase

Products: NA

Alternate protein names: TK 1

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MATRRELANAIRFLSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPSNPHWADRDRFILSNGHGSMLIYSLLHLSGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGFAIAEKTLAHQFNRPGHEIVDHHTYVFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFTDDTQKRFEAYGWHVIPAVDGHNPEQILEAVKQAQAETTKPTL
IICKTIIGYGSPNKANSHDCHGAPLGDDEIAAAREFLKWEHAPFEIPAEIYAQWDAKEKGQVAEKAWEEKLAAYAKAYPE
LAAEFTRRVNAELPANWAAESQAFIEHLQANPANIASRKASQNAIEAYAKLLPEFLGGSADLASSNLTLWSGSKPIRAVE
NADGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFMEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
TSALRLIPNLETWRPCDQVESAVAWKAAVERKEGPSALIFTRQNLAQMDRTAEQLANVARGGYVLRHCCENQNCPDLILI
ATGSEVELAMKAADVLDAEGVKVRVVSMPSTNVFDKQDAAYRESVLPSHITKRVAIEAGIADFWYKYVGFEGRVVGMNSF
GESAPADQLFKLFGFTVENIVEKAKAIL

Sequences:

>Translated_668_residues
MATRRELANAIRFLSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPSNPHWADRDRFILSNGHGSMLIYSLLHLSGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGFAIAEKTLAHQFNRPGHEIVDHHTYVFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFTDDTQKRFEAYGWHVIPAVDGHNPEQILEAVKQAQAETTKPTL
IICKTIIGYGSPNKANSHDCHGAPLGDDEIAAAREFLKWEHAPFEIPAEIYAQWDAKEKGQVAEKAWEEKLAAYAKAYPE
LAAEFTRRVNAELPANWAAESQAFIEHLQANPANIASRKASQNAIEAYAKLLPEFLGGSADLASSNLTLWSGSKPIRAVE
NADGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFMEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
TSALRLIPNLETWRPCDQVESAVAWKAAVERKEGPSALIFTRQNLAQMDRTAEQLANVARGGYVLRHCCENQNCPDLILI
ATGSEVELAMKAADVLDAEGVKVRVVSMPSTNVFDKQDAAYRESVLPSHITKRVAIEAGIADFWYKYVGFEGRVVGMNSF
GESAPADQLFKLFGFTVENIVEKAKAIL
>Mature_667_residues
ATRRELANAIRFLSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPSNPHWADRDRFILSNGHGSMLIYSLLHLSGYD
LSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGFAIAEKTLAHQFNRPGHEIVDHHTYVFLGDGCLMEG
ISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFTDDTQKRFEAYGWHVIPAVDGHNPEQILEAVKQAQAETTKPTLI
ICKTIIGYGSPNKANSHDCHGAPLGDDEIAAAREFLKWEHAPFEIPAEIYAQWDAKEKGQVAEKAWEEKLAAYAKAYPEL
AAEFTRRVNAELPANWAAESQAFIEHLQANPANIASRKASQNAIEAYAKLLPEFLGGSADLASSNLTLWSGSKPIRAVEN
ADGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFMEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQT
SALRLIPNLETWRPCDQVESAVAWKAAVERKEGPSALIFTRQNLAQMDRTAEQLANVARGGYVLRHCCENQNCPDLILIA
TGSEVELAMKAADVLDAEGVKVRVVSMPSTNVFDKQDAAYRESVLPSHITKRVAIEAGIADFWYKYVGFEGRVVGMNSFG
ESAPADQLFKLFGFTVENIVEKAKAIL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family

Homologues:

Organism=Homo sapiens, GI205277463, Length=684, Percent_Identity=25.5847953216374, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI4507521, Length=684, Percent_Identity=25.5847953216374, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI133778974, Length=590, Percent_Identity=25.9322033898305, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI225637459, Length=689, Percent_Identity=21.4804063860668, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI225637461, Length=659, Percent_Identity=21.2443095599393, Blast_Score=107, Evalue=5e-23,
Organism=Homo sapiens, GI225637463, Length=610, Percent_Identity=21.4754098360656, Blast_Score=106, Evalue=9e-23,
Organism=Escherichia coli, GI48994911, Length=668, Percent_Identity=75.8982035928144, Blast_Score=1073, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=666, Percent_Identity=69.3693693693694, Blast_Score=992, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=674, Percent_Identity=23.8872403560831, Blast_Score=164, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=47.6831091180867, Blast_Score=605, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=44.7916666666667, Blast_Score=562, Evalue=1e-161,
Organism=Drosophila melanogaster, GI45551847, Length=269, Percent_Identity=33.8289962825279, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45550715, Length=269, Percent_Identity=33.8289962825279, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24666278, Length=262, Percent_Identity=29.7709923664122, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24645119, Length=235, Percent_Identity=33.1914893617021, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TKT1_PASMU (P57927)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246179.1
- ProteinModelPortal:   P57927
- SMR:   P57927
- GeneID:   1244589
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1242
- NMPDR:   fig|272843.1.peg.1242
- HOGENOM:   HBG565885
- OMA:   ANCLLLT
- ProtClustDB:   PRK05899
- BioCyc:   PMUL272843:PM1242-MONOMER
- BRENDA:   2.2.1.1
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- PANTHER:   PTHR11624:SF1
- SMART:   SM00861
- TIGRFAMs:   TIGR00232

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.1

Molecular weight: Translated: 73370; Mature: 73238

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRRELANAIRFLSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPSNPHWADRDRF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
ILSNGHGSMLIYSLLHLSGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGFAIAEKTLAHQFNRPGHEIVDHHTYVFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFTDDTQKRFEAYGWHVIPAVDGHNPEQILEAVKQAQAETTKPTL
EEECCCEEECCCCCCEECCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCE
IICKTIIGYGSPNKANSHDCHGAPLGDDEIAAAREFLKWEHAPFEIPAEIYAQWDAKEKG
EEHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCC
QVAEKAWEEKLAAYAKAYPELAAEFTRRVNAELPANWAAESQAFIEHLQANPANIASRKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
SQNAIEAYAKLLPEFLGGSADLASSNLTLWSGSKPIRAVENADGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHCCCCCEEECCHHHHHHHHHH
NGIALHGGFIPYGATFLMFMEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHH
TSALRLIPNLETWRPCDQVESAVAWKAAVERKEGPSALIFTRQNLAQMDRTAEQLANVAR
HHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
GGYVLRHCCENQNCPDLILIATGSEVELAMKAADVLDAEGVKVRVVSMPSTNVFDKQDAA
CHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHH
YRESVLPSHITKRVAIEAGIADFWYKYVGFEGRVVGMNSFGESAPADQLFKLFGFTVENI
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
VEKAKAIL
HHHHHHCC
>Mature Secondary Structure 
ATRRELANAIRFLSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPSNPHWADRDRF
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
ILSNGHGSMLIYSLLHLSGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGFAIAEKTLAHQFNRPGHEIVDHHTYVFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFTDDTQKRFEAYGWHVIPAVDGHNPEQILEAVKQAQAETTKPTL
EEECCCEEECCCCCCEECCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCE
IICKTIIGYGSPNKANSHDCHGAPLGDDEIAAAREFLKWEHAPFEIPAEIYAQWDAKEKG
EEHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCC
QVAEKAWEEKLAAYAKAYPELAAEFTRRVNAELPANWAAESQAFIEHLQANPANIASRKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
SQNAIEAYAKLLPEFLGGSADLASSNLTLWSGSKPIRAVENADGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHCCCCCEEECCHHHHHHHHHH
NGIALHGGFIPYGATFLMFMEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHH
TSALRLIPNLETWRPCDQVESAVAWKAAVERKEGPSALIFTRQNLAQMDRTAEQLANVAR
HHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
GGYVLRHCCENQNCPDLILIATGSEVELAMKAADVLDAEGVKVRVVSMPSTNVFDKQDAA
CHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHH
YRESVLPSHITKRVAIEAGIADFWYKYVGFEGRVVGMNSFGESAPADQLFKLFGFTVENI
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
VEKAKAIL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100