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The map label for this gene is gor [H]

Identifier: 15603100

GI number: 15603100

Start: 1426890

End: 1428245

Strand: Direct

Name: gor [H]

Synonym: PM1235

Alternate gene names: 15603100

Gene position: 1426890-1428245 (Clockwise)

Preceding gene: 15603099

Following gene: 15603104

Centisome position: 63.21

GC content: 44.69

Gene sequence:

>1356_bases
ATGACAAAACATTATGATTATCTGGCGATTGGTGGCGGCAGTGGTGGAATTGCTTCCATTAACCGTGCAGCAAGCTACGG
CAAAAAATGTGCCATTATTGAAGCAAAAGCATTAGGTGGCACCTGTGTGAATGTCGGGTGTGTACCAAAAAAAGTCATGT
GGTATGGCGCACAAATTGCCGAAGCCATTCATCAGTATGCGCCAGATTATGGTTTTGATCTGCAAGTGAATAAATTTGAT
TTCGCCAAACTGGTAGAAAGTCGTCAAGCCTATATTAGCCGCATTCACACCTCTTATCACAACGTGTTAGCCAAAAATAA
TGTGGATGTTATTCAAGGTTTTGCAAAATTTGTGAATGCCAATACCGTTGAAGTCAATGGTGAACACATTACCGCCGATC
ATATTCTGATTGCCACTGGTGGACGCCCAAGTCATCCTGCCATTCCTGGCGCAGAATATGGCATTGATTCAGATGGCGTC
TTTGCCTTATCCGAATTACCAAAACGGGTTGCGGTAGTCGGTGCCGGCTACATTGCGGTTGAACTTGCCGGTGTGATGAA
TAGCTTTGGTGTAAAAACCCATTTATTTGTGCGTCAACACGCCCCATTGCGTCACTTCGATCCCTTAATCGTAGATACCC
TATTAGAAGTGATTCAACAAGATGGCATTCAATTACATACTCAAGCGATCCCACAAGAAGTGGTGAAAAATGCGGATGGT
TCACTCACGATTAAACTCGAAGATGGACGTAGCCAAGAGGTGGATTGTTTGATCTGGGCAATCGGTCGCCATCCAGCTAC
CGATACCATTAACCTTGAAGCAAGCGGAGTGGAAACCAACGCACGTGGTTTTGTTAAAGTGGATAAATACCAAAACACCA
ATGTGGAAGGTATCTATGCAGTGGGTGACATTATTGAAGGGGGAATTGAACTCACTCCAGTTGCCGTGGCTGCTGGACGT
CGTTTATCTGAGCGTTTATTTAACAACAAGCCCAATGAGCATTTAGATTACAATCTGGTGCCAACCGTAGTATTCAGCCA
CCCTCCTATCGGCACCATTGGTTTAACTGAACCCAAAGCGATTGAGCAATACGGTGAAGAAAATGTGAAAGTGTATAAAT
CCTCTTTCACCCCAATGTACAGTGCCGTGACGCAACACCGTCAGCCTTGTCGCATGAAATTAGTTTGTGTCGGCAAAGAA
GAGAAAATCGTCGGCTTGCATGGTATCGGTTTTGGTGTCGATGAAATGATCCAAGGTTTTGCTGTGGCAATCAAAATGGG
CGCCACTAAAGCAGATTTCGATAATACCGTGGCAATTCACCCAACAGGGTCAGAAGAATTTGTGACGATGCGTTAA

Upstream 100 bases:

>100_bases
GTAAAATAAAAGCGACAACATAAAACGTGTATTTGATAGGTAGCGTTGGAAAAGAGTACAGATTTTTATCATCCTCCCCT
GAATGAAAAGGAACAAGACA

Downstream 100 bases:

>100_bases
TCAGTGCAACAAAAGGCGGAGTGATTTTCCGCCTTTTCTCTGACAAAACTTCGTTAAAAATGACCGCACTTTTCAGCGTC
AATACGCTTAAAGTGCAATC

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTKHYDYLAIGGGSGGIASINRAASYGKKCAIIEAKALGGTCVNVGCVPKKVMWYGAQIAEAIHQYAPDYGFDLQVNKFD
FAKLVESRQAYISRIHTSYHNVLAKNNVDVIQGFAKFVNANTVEVNGEHITADHILIATGGRPSHPAIPGAEYGIDSDGV
FALSELPKRVAVVGAGYIAVELAGVMNSFGVKTHLFVRQHAPLRHFDPLIVDTLLEVIQQDGIQLHTQAIPQEVVKNADG
SLTIKLEDGRSQEVDCLIWAIGRHPATDTINLEASGVETNARGFVKVDKYQNTNVEGIYAVGDIIEGGIELTPVAVAAGR
RLSERLFNNKPNEHLDYNLVPTVVFSHPPIGTIGLTEPKAIEQYGEENVKVYKSSFTPMYSAVTQHRQPCRMKLVCVGKE
EKIVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Sequences:

>Translated_451_residues
MTKHYDYLAIGGGSGGIASINRAASYGKKCAIIEAKALGGTCVNVGCVPKKVMWYGAQIAEAIHQYAPDYGFDLQVNKFD
FAKLVESRQAYISRIHTSYHNVLAKNNVDVIQGFAKFVNANTVEVNGEHITADHILIATGGRPSHPAIPGAEYGIDSDGV
FALSELPKRVAVVGAGYIAVELAGVMNSFGVKTHLFVRQHAPLRHFDPLIVDTLLEVIQQDGIQLHTQAIPQEVVKNADG
SLTIKLEDGRSQEVDCLIWAIGRHPATDTINLEASGVETNARGFVKVDKYQNTNVEGIYAVGDIIEGGIELTPVAVAAGR
RLSERLFNNKPNEHLDYNLVPTVVFSHPPIGTIGLTEPKAIEQYGEENVKVYKSSFTPMYSAVTQHRQPCRMKLVCVGKE
EKIVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
>Mature_450_residues
TKHYDYLAIGGGSGGIASINRAASYGKKCAIIEAKALGGTCVNVGCVPKKVMWYGAQIAEAIHQYAPDYGFDLQVNKFDF
AKLVESRQAYISRIHTSYHNVLAKNNVDVIQGFAKFVNANTVEVNGEHITADHILIATGGRPSHPAIPGAEYGIDSDGVF
ALSELPKRVAVVGAGYIAVELAGVMNSFGVKTHLFVRQHAPLRHFDPLIVDTLLEVIQQDGIQLHTQAIPQEVVKNADGS
LTIKLEDGRSQEVDCLIWAIGRHPATDTINLEASGVETNARGFVKVDKYQNTNVEGIYAVGDIIEGGIELTPVAVAAGRR
LSERLFNNKPNEHLDYNLVPTVVFSHPPIGTIGLTEPKAIEQYGEENVKVYKSSFTPMYSAVTQHRQPCRMKLVCVGKEE
KIVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=54.4468546637744, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=39.0295358649789, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=36.2637362637363, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=36.2637362637363, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=36.2637362637363, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=36.2637362637363, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=36.2637362637363, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI291045266, Length=455, Percent_Identity=34.2857142857143, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI291045268, Length=455, Percent_Identity=30.5494505494506, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=28.9760348583878, Blast_Score=172, Evalue=6e-43,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=78.9356984478936, Blast_Score=728, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=449, Percent_Identity=28.5077951002227, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=26.6519823788546, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=26.9315673289183, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=54.1019955654102, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=54.1019955654102, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=34.7457627118644, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=35.1351351351351, Blast_Score=254, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=30.6695464362851, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17559934, Length=205, Percent_Identity=27.3170731707317, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=51.0729613733906, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321091, Length=474, Percent_Identity=28.0590717299578, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=25.531914893617, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=38.8059701492537, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=38.8059701492537, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=38.8059701492537, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=36.9426751592357, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI21358499, Length=471, Percent_Identity=30.5732484076433, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24585130, Length=197, Percent_Identity=27.4111675126904, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48896; Mature: 48765

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHYDYLAIGGGSGGIASINRAASYGKKCAIIEAKALGGTCVNVGCVPKKVMWYGAQIA
CCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
EAIHQYAPDYGFDLQVNKFDFAKLVESRQAYISRIHTSYHNVLAKNNVDVIQGFAKFVNA
HHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
NTVEVNGEHITADHILIATGGRPSHPAIPGAEYGIDSDGVFALSELPKRVAVVGAGYIAV
CEEEECCCEEEECEEEEEECCCCCCCCCCCHHCCCCCCCEEEHHHCCCEEEEEECCHHEE
ELAGVMNSFGVKTHLFVRQHAPLRHFDPLIVDTLLEVIQQDGIQLHTQAIPQEVVKNADG
HHHHHHHHCCCEEEEEEECCCCCHHCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCC
SLTIKLEDGRSQEVDCLIWAIGRHPATDTINLEASGVETNARGFVKVDKYQNTNVEGIYA
EEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEE
VGDIIEGGIELTPVAVAAGRRLSERLFNNKPNEHLDYNLVPTVVFSHPPIGTIGLTEPKA
EHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHH
IEQYGEENVKVYKSSFTPMYSAVTQHRQPCRMKLVCVGKEEKIVGLHGIGFGVDEMIQGF
HHHCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHH
AVAIKMGATKADFDNTVAIHPTGSEEFVTMR
EEEEEECCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure 
TKHYDYLAIGGGSGGIASINRAASYGKKCAIIEAKALGGTCVNVGCVPKKVMWYGAQIA
CCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
EAIHQYAPDYGFDLQVNKFDFAKLVESRQAYISRIHTSYHNVLAKNNVDVIQGFAKFVNA
HHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
NTVEVNGEHITADHILIATGGRPSHPAIPGAEYGIDSDGVFALSELPKRVAVVGAGYIAV
CEEEECCCEEEECEEEEEECCCCCCCCCCCHHCCCCCCCEEEHHHCCCEEEEEECCHHEE
ELAGVMNSFGVKTHLFVRQHAPLRHFDPLIVDTLLEVIQQDGIQLHTQAIPQEVVKNADG
HHHHHHHHCCCEEEEEEECCCCCHHCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCC
SLTIKLEDGRSQEVDCLIWAIGRHPATDTINLEASGVETNARGFVKVDKYQNTNVEGIYA
EEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEE
VGDIIEGGIELTPVAVAAGRRLSERLFNNKPNEHLDYNLVPTVVFSHPPIGTIGLTEPKA
EHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHH
IEQYGEENVKVYKSSFTPMYSAVTQHRQPCRMKLVCVGKEEKIVGLHGIGFGVDEMIQGF
HHHCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHH
AVAIKMGATKADFDNTVAIHPTGSEEFVTMR
EEEEEECCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]